#KidneyInt
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haoyin.bsky.social
Non-hepatic #PCSK9

PCSK9 targets LRP2/Megalin to lysosomal degradation in renal proximal tubule cells

Megalin mediates PCSK9 uptake in renal epithelium

PCSK9 KO🐭 or Alirocumab in WT or nephrotic Nphs2-/-🐭
⏫renal Megalin & LDLR
⏬ #Proteinuria

#KidneyInt 2023
www.sciencedirect.com/science/arti...
July 21, 2025 at 11:49 AM
haoyin.bsky.social
Fibrillar collagen probe CNA35-Cy7 i.v. to monitor mouse kidney #Fibrosis (ischemia-reperfusion injury)

Can it be used for other organs in vivo?😄

#KidneyInt 2020
www.sciencedirect.com/science/arti...
May 8, 2024 at 3:52 AM
hswapnil.medsky.social
Interesting trial in @kidneyint@bsky.social

www.kidney-international.org/article/S008...

SLE with remission. No symptoms. When dsDNA becomes positive (or doubles) do you preemptively increase immunosuppression?

#NephSky #RheumSky
Figure 2 Survival at 24-month from randomization free of (A) renal flares, (B) extra-renal flares and (C) overall clinical flares in lupus nephritis patients presenting with asymptomatic serological reactivation and randomized to receive pre-emptive treatment (PT Group) or observant management (Control Group).
March 28, 2026 at 4:40 AM
haoyin.bsky.social
NONO protects SM22+ Arterial #SmoothMuscleCell from #Calcification Osteogenic reprogramming in🐭(5/6 Nephrectomy/Adenine diet/VitD)

BMP2 as a direct transcriptional (repressive) target gene of NONO (Any other NONO targets?🧐)

#KidneyInt 2024
www.sciencedirect.com/science/arti...
April 17, 2024 at 7:18 PM
realbiomassspec.bsky.social
Metabolic heavyweight: thick ascending limb or proximal tubule? Next round #KidneyInt #MassSpec www.kidney-international.org/article/S008...
Metabolic heavyweight: thick ascending limb or proximal tubule? Next round
In this issue of Kidney International, investigators define the thick ascending limb as the most metabolically active cell in the kidney using a combination of single-cell techniques and mass spectrom...
www.kidney-international.org
October 20, 2025 at 11:48 AM
realbiomassspec.bsky.social
Phospholipase A2receptor-positive membranous nephropathy detected by laser microdissection and mass spectrometry in patients negative by immunofluorescence for phospholipase A2receptor on kidney biopsy #KidneyInt #MassSpec www.kidney-international.org/article/S008...
Phospholipase A2receptor-positive membranous nephropathy detected by laser microdissection and mass spectrometry in patients negative by immunofluorescence for phospholipase A2receptor on kidney biops...
Membranous Nephropathy (MN) is characterized by subepithelial deposition of immune complexes along the glomerular basement membrane. The muscle-type phospholipase A2 receptor (PLA2R) has been identifi...
www.kidney-international.org
June 9, 2025 at 11:46 AM
realbiomassspec.bsky.social
In Situ molecular profiles of glomerular cells by integrated imaging mass spectrometry and multiplexed immunofluorescence microscopy #KidneyInt www.kidney-international.org/article/S008...
DEFINE_ME
www.kidney-international.org
November 22, 2024 at 7:24 PM
drjenkidney.bsky.social
www.kidney-international.org/article/S008...

#KidneyInt #BK
November 30, 2024 at 7:41 PM
haoyin.bsky.social
GATA6 as a pro-calcific/pro-senescent factor in #SmoothMuscleCell
via ⏬ATM->⏫DNA dmg

AAV9-SM22α-GATA6 shRNA⏬VitD3-induced 🐭#AorticCalcification+#SMC #Senescence

#SIRT6 deacetylates+destabilizes NKX2.5 protein->⏬GATA6 transcription

#KidneyInt 2023
www.sciencedirect.com/science/arti...
December 12, 2023 at 8:19 PM
kdjhaveri.bsky.social
@sfishbane on @nejm on @kidneyint...
December 13, 2024 at 10:09 AM
fhu-inflamme.bsky.social
Glomérulonéphrite : Abbad L. et al. (Kidney Int 2024) montrent que l’activation d’Epac1 protège les podocytes en reprogrammant leur métabolisme (↑ glycolyse, mitochondries préservées) et pourrait freiner la progression de la maladie.
#Nephrologie #Recherche #KidneyInt #Inflammation #CoRaKiD #Tenon
May 20, 2026 at 7:33 AM