I feel like whoever named the kinase that phosphorylates MAP kinase "MAP kinase kinase" and the kinase that phosphorylates that one "MAP kinase kinase kinase" would be a really interesting person to speak with
October 29, 2025 at 11:36 PM
I feel like whoever named the kinase that phosphorylates MAP kinase "MAP kinase kinase" and the kinase that phosphorylates that one "MAP kinase kinase kinase" would be a really interesting person to speak with
God I hate protein naming conventions.
“What’s this one called?”
“Smoothened.”
“SMOOTHENED?!”
“Yep.”
“What about that one?”
“MAP kinase.”
“Did you say MAP kinase?”
“Perhaps you’re thinking of MAP kinase kinase?”
“What??”
“Or MAP kinase kinase kinase?”
(Yes all of these are real proteins)
“What’s this one called?”
“Smoothened.”
“SMOOTHENED?!”
“Yep.”
“What about that one?”
“MAP kinase.”
“Did you say MAP kinase?”
“Perhaps you’re thinking of MAP kinase kinase?”
“What??”
“Or MAP kinase kinase kinase?”
(Yes all of these are real proteins)
April 18, 2025 at 1:34 AM
God I hate protein naming conventions.
“What’s this one called?”
“Smoothened.”
“SMOOTHENED?!”
“Yep.”
“What about that one?”
“MAP kinase.”
“Did you say MAP kinase?”
“Perhaps you’re thinking of MAP kinase kinase?”
“What??”
“Or MAP kinase kinase kinase?”
(Yes all of these are real proteins)
“What’s this one called?”
“Smoothened.”
“SMOOTHENED?!”
“Yep.”
“What about that one?”
“MAP kinase.”
“Did you say MAP kinase?”
“Perhaps you’re thinking of MAP kinase kinase?”
“What??”
“Or MAP kinase kinase kinase?”
(Yes all of these are real proteins)
20 years ago my group published a paper that identified a target (a kinase) in pancreatic cancer that drove cell proliferation and chemotherapy resistance. We worked with a medicinal chemist who designed a small molecule inhibitor (SMI) to this kinase. In 2018, this SMI went into the clinic. 1/2
January 29, 2025 at 1:36 AM
20 years ago my group published a paper that identified a target (a kinase) in pancreatic cancer that drove cell proliferation and chemotherapy resistance. We worked with a medicinal chemist who designed a small molecule inhibitor (SMI) to this kinase. In 2018, this SMI went into the clinic. 1/2
Happy to see my Postdoc work out @natbiotech.nature.com. Using HaloTag and synthetic fluorophores instead of FPs enables us to shift the spectral properties of kinase activity reporters (KARs) to the far-red 🔬. Huge thanks to everyone involved @jinzhanglab.bsky.social!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks - Nature Biotechnology
Far-red kinase biosensors are applied to image kinase signaling networks at super resolution.
www.nature.com
April 21, 2025 at 9:28 AM
Happy to see my Postdoc work out @natbiotech.nature.com. Using HaloTag and synthetic fluorophores instead of FPs enables us to shift the spectral properties of kinase activity reporters (KARs) to the far-red 🔬. Huge thanks to everyone involved @jinzhanglab.bsky.social!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Structural basis of T-loop–independent recognition and activation of CDKs by the CDK-activating kinase
Cyclin-dependent kinases (CDKs) are prototypical regulators of the cell cycle. The CDK-activating kinase (CAK) acts as a master regulator of CDK activity by catalyzing the activating phosphorylation o...
www.science.org
October 16, 2025 at 7:17 PM
Now out in Science! Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. In @vcushing.bsky.social's magnum opus, we use #cryoEM to figure out how the CDK-activating kinase recognises CDKs to fully activate them - a key step in cell cycle control.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks - @michellefrei17.bsky.social @jinzhanglab.bsky.social go.nature.com/3GfqrzL
Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks - Nature Biotechnology
Far-red kinase biosensors are applied to image kinase signaling networks at super resolution.
go.nature.com
April 21, 2025 at 2:45 PM
Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks - @michellefrei17.bsky.social @jinzhanglab.bsky.social go.nature.com/3GfqrzL
1/5 How much phosphorylation can a single kinase deposit? In our new study with @typaslab.bsky.social out in @nature.com, phage T7's kinase (T7K) modifies almost all the E. coli proteome + more densely than all ~500 kinases do our own proteomes 🤯 www.nature.com/articles/s41...
Pervasive phosphorylation by phage T7 kinase disarms bacterial defences - Nature
The T7 bacteriophage deactivates bacterial defence systems through T7K phosphorylation of nearly all host and phage proteins during infection.
www.nature.com
August 20, 2026 at 5:15 AM
1/5 How much phosphorylation can a single kinase deposit? In our new study with @typaslab.bsky.social out in @nature.com, phage T7's kinase (T7K) modifies almost all the E. coli proteome + more densely than all ~500 kinases do our own proteomes 🤯 www.nature.com/articles/s41...
Once again, shoutout to rigorous, peer-reviewed science and the entire tyrosine kinase inhibitor family.
December 22, 2024 at 10:43 PM
Once again, shoutout to rigorous, peer-reviewed science and the entire tyrosine kinase inhibitor family.
MAP Kinase kinase kinase kinase kinase kinase kinase kinase-associated protein 3
May 30, 2024 at 6:59 PM
MAP Kinase kinase kinase kinase kinase kinase kinase kinase-associated protein 3
Beautiful work on the development of protein kinase reporters. Congrats all! www.nature.com/articles/s41...
Molecular recording of cellular protein kinase activity with chemical labeling - Nature Chemical Biology
Molecular recorders based on kinase activity-dependent protein labeling track specific kinase activities to understand their link to cellular phenotypes in heterogeneous cell populations and in vivo.
www.nature.com
July 13, 2025 at 9:53 AM
Beautiful work on the development of protein kinase reporters. Congrats all! www.nature.com/articles/s41...
#1: creatine kinase takes a *while* to elevate!
so the initial creatine kinase level may often be unremarkable.
key point: a single creatine kinase level doesn’t exclude rhabdo. 😬
so the initial creatine kinase level may often be unremarkable.
key point: a single creatine kinase level doesn’t exclude rhabdo. 😬
November 23, 2024 at 9:17 PM
#1: creatine kinase takes a *while* to elevate!
so the initial creatine kinase level may often be unremarkable.
key point: a single creatine kinase level doesn’t exclude rhabdo. 😬
so the initial creatine kinase level may often be unremarkable.
key point: a single creatine kinase level doesn’t exclude rhabdo. 😬
Can we program a kinase like a switch? Inspired by natural autoinhibitory complexes, we designed miniproteins against active- and inactive-like conformations of Focal Adhesion Kinase. Depending on the targeted state, the resulting binders either activated or inhibited the kinase.
July 14, 2026 at 4:25 AM
Can we program a kinase like a switch? Inspired by natural autoinhibitory complexes, we designed miniproteins against active- and inactive-like conformations of Focal Adhesion Kinase. Depending on the targeted state, the resulting binders either activated or inhibited the kinase.
Ever wondered which method to use to infer kinase activities from phosphoproteomics data? 💻💭Our revised comprehensive evaluation of kinase activity inference tools, done in collaboration with the Zhang lab @bcmhouston.bsky.social, is now out @natcomms.nature.com 🔬 tinyurl.com/4twuc6z4
May 23, 2025 at 7:38 AM
Ever wondered which method to use to infer kinase activities from phosphoproteomics data? 💻💭Our revised comprehensive evaluation of kinase activity inference tools, done in collaboration with the Zhang lab @bcmhouston.bsky.social, is now out @natcomms.nature.com 🔬 tinyurl.com/4twuc6z4
🚨 Our 4th example of metalloallosteric regulation of kinase activity. Out today in @CellReports with @KJSsci. The ER stress sensor kinase PERK needs copper to work. Without copper, PERK can’t protect cells under stress. cell.com/cell-reports/p…
September 27, 2025 at 2:13 PM
🚨 Our 4th example of metalloallosteric regulation of kinase activity. Out today in @CellReports with @KJSsci. The ER stress sensor kinase PERK needs copper to work. Without copper, PERK can’t protect cells under stress. cell.com/cell-reports/p…
Molecular recording of cellular protein kinase activity with chemical labeling:
www.nature.com/articles/s41...
Congratulations to De-en Sun and the entire team.
www.nature.com/articles/s41...
Congratulations to De-en Sun and the entire team.
Molecular recording of cellular protein kinase activity with chemical labeling - Nature Chemical Biology
Molecular recorders based on kinase activity-dependent protein labeling track specific kinase activities to understand their link to cellular phenotypes in heterogeneous cell populations and in vivo.
www.nature.com
July 10, 2025 at 5:46 PM
Molecular recording of cellular protein kinase activity with chemical labeling:
www.nature.com/articles/s41...
Congratulations to De-en Sun and the entire team.
www.nature.com/articles/s41...
Congratulations to De-en Sun and the entire team.
How can a Salmonella effector change the specificity of a host kinase? SteE mediates kinase reprogramming via mimicry of conserved eukaryotic-like motifs- doi.org/10.1038/s443... Great collaboration with @katrinrittinger.bsky.social + big thanks to all authors & congrats to lead PDRA Ioanna Panagi!
Bacterial effectors mediate kinase reprogramming through mimicry of conserved eukaryotic motifs | EMBO reports
imageimageA virulence protein from diverse bacteria switches the amino acid specificity of the
eukaryotic kinase GSK3. This kinase reprogramming depends on several short linear
motifs that each appear...
www.embopress.org
May 13, 2025 at 8:33 AM
How can a Salmonella effector change the specificity of a host kinase? SteE mediates kinase reprogramming via mimicry of conserved eukaryotic-like motifs- doi.org/10.1038/s443... Great collaboration with @katrinrittinger.bsky.social + big thanks to all authors & congrats to lead PDRA Ioanna Panagi!
The allosteric landscape of the Src kinase
by Toni Beltran, @ajfaure.bsky.social , @crg.eu @sangerinstitute.bsky.social @alloxbio.bsky.social
www.science.org/doi/10.1126/...
by Toni Beltran, @ajfaure.bsky.social , @crg.eu @sangerinstitute.bsky.social @alloxbio.bsky.social
www.science.org/doi/10.1126/...
The allosteric landscape of the Src kinase
Comprehensive allosteric mapping prioritizes all possible druggable surface pockets in the Src kinase for allosteric inhibition.
www.science.org
February 20, 2026 at 2:03 PM
The allosteric landscape of the Src kinase
by Toni Beltran, @ajfaure.bsky.social , @crg.eu @sangerinstitute.bsky.social @alloxbio.bsky.social
www.science.org/doi/10.1126/...
by Toni Beltran, @ajfaure.bsky.social , @crg.eu @sangerinstitute.bsky.social @alloxbio.bsky.social
www.science.org/doi/10.1126/...
Far-red kinase biosensors are applied to image kinase signaling networks at super resolution go.nature.com/3GfqrzL
rdcu.be/faNLM
rdcu.be/faNLM
Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks - Nature Biotechnology
Far-red kinase biosensors are applied to image kinase signaling networks at super resolution.
go.nature.com
March 31, 2026 at 12:29 AM
Far-red kinase biosensors are applied to image kinase signaling networks at super resolution go.nature.com/3GfqrzL
rdcu.be/faNLM
rdcu.be/faNLM
Pervasive phosphorylation by phage T7 kinase disarms bacterial defenses https://www.biorxiv.org/content/10.1101/2024.12.20.629319v1
December 21, 2024 at 7:16 AM
Pervasive phosphorylation by phage T7 kinase disarms bacterial defenses https://www.biorxiv.org/content/10.1101/2024.12.20.629319v1
A BRASSINOSTEROID INSENSISTIVE 1 receptor kinase ortholog is required for sex determination in Ceratopteris richardii (Katelin M Burow , Xi Yang , Yun Zhou , Brian P Dilkes , Jennifer H Wisecaver) doi.org/10.1093/plce... #PlantScience
A BRASSINOSTEROID INSENSISTIVE 1 receptor kinase ortholog is required for sex determination in Ceratopteris richardii
The receptor-like kinase HER7 is required for sex determination in the homosporous fern Ceratopteris richardii.
doi.org
May 15, 2025 at 4:47 PM
A BRASSINOSTEROID INSENSISTIVE 1 receptor kinase ortholog is required for sex determination in Ceratopteris richardii (Katelin M Burow , Xi Yang , Yun Zhou , Brian P Dilkes , Jennifer H Wisecaver) doi.org/10.1093/plce... #PlantScience
Nature research paper: Spatiotemporal orchestration of mitosis by cyclin-dependent kinase
https://go.nature.com/444lRhe
https://go.nature.com/444lRhe
Spatiotemporal orchestration of mitosis by cyclin-dependent kinase - Nature
Experiments in fission yeast show that cyclin-dependent kinase is first activated in the nucleus, from which the mitotic signal is propagated from CDK at the centrosome to the cytoplasm.
go.nature.com
June 25, 2025 at 5:50 PM
Nature research paper: Spatiotemporal orchestration of mitosis by cyclin-dependent kinase
https://go.nature.com/444lRhe
https://go.nature.com/444lRhe
Ruhr University Bochum scientists show that JNK kinase activates during coronavirus infection and phosphorylates the nucleocapsid protein.
Blocking JNK cut replication of both HCoV-229E and SARS-CoV-2, suggesting a new antiviral target.
www.nature.com/articles/s44...
Blocking JNK cut replication of both HCoV-229E and SARS-CoV-2, suggesting a new antiviral target.
www.nature.com/articles/s44...
JNK kinase regulates phosphorylation of HCoV-229E nucleocapsid protein - npj Viruses
npj Viruses - JNK kinase regulates phosphorylation of HCoV-229E nucleocapsid protein
www.nature.com
September 21, 2025 at 12:23 AM
Ruhr University Bochum scientists show that JNK kinase activates during coronavirus infection and phosphorylates the nucleocapsid protein.
Blocking JNK cut replication of both HCoV-229E and SARS-CoV-2, suggesting a new antiviral target.
www.nature.com/articles/s44...
Blocking JNK cut replication of both HCoV-229E and SARS-CoV-2, suggesting a new antiviral target.
www.nature.com/articles/s44...
Excited to share our paper with @savitski-lab.bsky.social, led by @tarabartolec.bsky.social, Karin Mitosch & Clément Potel, out now in @nature.com.
We show that T7 phage broadly disables bacterial defenses using a unique ‘loose cannon’ protein kinase.
www.nature.com/articles/s41...
We show that T7 phage broadly disables bacterial defenses using a unique ‘loose cannon’ protein kinase.
www.nature.com/articles/s41...
August 20, 2026 at 7:48 AM
Excited to share our paper with @savitski-lab.bsky.social, led by @tarabartolec.bsky.social, Karin Mitosch & Clément Potel, out now in @nature.com.
We show that T7 phage broadly disables bacterial defenses using a unique ‘loose cannon’ protein kinase.
www.nature.com/articles/s41...
We show that T7 phage broadly disables bacterial defenses using a unique ‘loose cannon’ protein kinase.
www.nature.com/articles/s41...
Dual role of the receptor kinase FERONIA in regulating tissue mechanics and growth | Science Advances www.science.org/doi/10.1126/...
Dual role of the receptor kinase FERONIA in regulating tissue mechanics and growth
The receptor kinase FERONIA mediates a double feedback from tissue mechanics on growth rate.
www.science.org
July 24, 2026 at 8:12 PM
Dual role of the receptor kinase FERONIA in regulating tissue mechanics and growth | Science Advances www.science.org/doi/10.1126/...