We also examined lipid data, which comprised eight essential exposure factors. We gathered GWAS data on important biomarkers, such as TC, TG, HDL-C, low-density lipoprotein cholesterol (LDL_C), lipoprotein A (Lp (a)), and apolipoprotein B (Apo B) from the UK Biobank (UKB). Additionally, we

The LDL-C–MH-MARS machine learning equation matched the Martin-Hopkins equation for #LDL_C accuracy and outperformed Friedewald, Sampson-NIH, and Modified Sampson equations in nearly 5 million US patients. ja.ma/4hee7Qq

A digitally enabled quality improvement strategy modestly improved #LDL_C control and increased prescription of combination lipid-lowering therapy for patients with #ASCVD, but many remained above guideline targets.

ja.ma/4yxMEiP

#Review in #MedComm
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9): The Multifaceted Biology, Diseases, and Pharmaceutical Interventions doi.org/10.1002/mco2...

#PCSK9 #LDL_C #IschemicStroke #Intervention #Strategies #PrecisionTherapy #therapeutics

RCT: Opportunistic #GenomicScreening for familial hypercholesterolemia + telegenetic counseling did not substantially lower #LDL_C at 6 months vs delayed results; further research is needed for clinical implementation. ja.ma/4jH5rBy

youtube.com/shorts/LdL_C...