March 2, 2026 at 8:32 PM
Exciting🌱! Reprogramming stomatal precursor cells to totipotency -- Cooperation of LEC2 with SPEECHLESS induces auxin biosynthesis genes, inciting a bifurcation of stomatal differentiation trajectory into a new, somatic embryo founder cell state.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration
In Arabidopsis, transcriptional factors LEC2 and SPCH enhance local auxin biosynthesis,
establishing a transcriptional framework that enables differentiated single somatic
epidermal cells to regain to...
www.cell.com
September 23, 2025 at 3:40 AM
Exciting🌱! Reprogramming stomatal precursor cells to totipotency -- Cooperation of LEC2 with SPEECHLESS induces auxin biosynthesis genes, inciting a bifurcation of stomatal differentiation trajectory into a new, somatic embryo founder cell state.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
🌱🧬 LEC2 and SPEECHLESS reprogram a stomatal precursor into a totipotent somatic embryo founder cell.
A new insight into plant regeneration and stem cell reprogramming #plantscience @keikoutorii.bsky.social @cp-cellreports.bsky.social www.cell.com/current-biol...
A new insight into plant regeneration and stem cell reprogramming #plantscience @keikoutorii.bsky.social @cp-cellreports.bsky.social www.cell.com/current-biol...
Plant regeneration: Breaking the silence of totipotency by reprogramming a stomatal precursor cell
Plants have a remarkable ability to reprogram their somatic cells into stem cells.
A new study reveals that a transcription factor, LEC2, together with SPEECHLESS, directly
reprograms a stomatal precu...
www.cell.com
July 6, 2026 at 5:43 AM
🌱🧬 LEC2 and SPEECHLESS reprogram a stomatal precursor into a totipotent somatic embryo founder cell.
A new insight into plant regeneration and stem cell reprogramming #plantscience @keikoutorii.bsky.social @cp-cellreports.bsky.social www.cell.com/current-biol...
A new insight into plant regeneration and stem cell reprogramming #plantscience @keikoutorii.bsky.social @cp-cellreports.bsky.social www.cell.com/current-biol...
LEC2 and SPCH together lead to the reprogramming of somatic cells into somatic embryo founder cells.
From: www.cell.com/cell/fulltex...
From: www.cell.com/cell/fulltex...
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration
In Arabidopsis, transcriptional factors LEC2 and SPCH enhance local auxin biosynthesis,
establishing a transcriptional framework that enables differentiated single somatic
epidermal cells to regain to...
www.cell.com
September 18, 2025 at 1:25 AM
LEC2 and SPCH together lead to the reprogramming of somatic cells into somatic embryo founder cells.
From: www.cell.com/cell/fulltex...
From: www.cell.com/cell/fulltex...
Délicieuse causerie entre Nalini Anantharaman et William Marx, tous deux professeurs au @college-de-france.fr à partir de considérations sur la géométrie hyperbolique.
www.youtube.com/watch?v=lec2...
www.youtube.com/watch?v=lec2...
Promenade en géométrie hyperbolique / Nalini Anantharaman - William Marx
YouTube video by Fondation Hugot du Collège de France
www.youtube.com
June 20, 2025 at 6:12 AM
Délicieuse causerie entre Nalini Anantharaman et William Marx, tous deux professeurs au @college-de-france.fr à partir de considérations sur la géométrie hyperbolique.
www.youtube.com/watch?v=lec2...
www.youtube.com/watch?v=lec2...
One of the more unexpected finding was expression of LEC2 in cells with mature guard identity, hallmarked by FAMA and SCRM. LEC2 expression was also strongly associated with phytohormone status. We hope to further explore guard cells as a principal source of somatic embryogenesis.
May 23, 2026 at 2:54 PM
One of the more unexpected finding was expression of LEC2 in cells with mature guard identity, hallmarked by FAMA and SCRM. LEC2 expression was also strongly associated with phytohormone status. We hope to further explore guard cells as a principal source of somatic embryogenesis.
Great article in Cell:
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration
It's about #Arabidopsis and #auxin.
www.cell.com/cell/fulltex...
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration
It's about #Arabidopsis and #auxin.
www.cell.com/cell/fulltex...
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration
In Arabidopsis, transcriptional factors LEC2 and SPCH enhance local auxin biosynthesis,
establishing a transcriptional framework that enables differentiated single somatic
epidermal cells to regain to...
www.cell.com
September 17, 2025 at 8:12 AM
Great article in Cell:
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration
It's about #Arabidopsis and #auxin.
www.cell.com/cell/fulltex...
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration
It's about #Arabidopsis and #auxin.
www.cell.com/cell/fulltex...
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration,
https://www.cell.com/cell/fulltext/S0092-8674(25)01020-7
https://www.cell.com/cell/fulltext/S0092-8674(25)01020-7
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration, https://www.cell.com/cell/fulltext/S0092-8674(25)01020-7
• LEC2 reprograms somatic epidermal cells into totipotent somatic embryo founder cells
• LEC2 and SPCH co-activate local auxin biosynthesis by targeting TAA1 and YUC4
• GMC-auxin state marks stomatal cells shifting from differentiation to totipotency
• Transcriptional rewiring and auxin signaling drive reprogramming of stomatal cells
www.scoop.it
September 20, 2025 at 8:36 AM
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration,
https://www.cell.com/cell/fulltext/S0092-8674(25)01020-7
https://www.cell.com/cell/fulltext/S0092-8674(25)01020-7
Warum sagt Spanien "Nein zum Krieg in Iran?" | ARTE #expresso
YouTube video by ARTEde
youtube.com
March 13, 2026 at 7:19 AM
totally check out youtu.be/tdSO9NqeJAg
MIT 6 050J Information & Entropy Lec2 Bits & Codes
YouTube video by Open Courseware
youtu.be
February 3, 2025 at 9:02 PM
totally check out youtu.be/tdSO9NqeJAg
These LEC2+SPCH somatic embryos have interesting implications. Since the stomatal lineage is derived from the L1 (dermal) layer of the shoot apical meristem, these somatic embryo will be from the L1, rather than L2 (gametes and therefore zygote are from L2).
LEC2 and SPCH together lead to the reprogramming of somatic cells into somatic embryo founder cells.
From: www.cell.com/cell/fulltex...
From: www.cell.com/cell/fulltex...
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration
In Arabidopsis, transcriptional factors LEC2 and SPCH enhance local auxin biosynthesis,
establishing a transcriptional framework that enables differentiated single somatic
epidermal cells to regain to...
www.cell.com
September 18, 2025 at 2:09 AM
These LEC2+SPCH somatic embryos have interesting implications. Since the stomatal lineage is derived from the L1 (dermal) layer of the shoot apical meristem, these somatic embryo will be from the L1, rather than L2 (gametes and therefore zygote are from L2).
Bacteriophage cocktail LEC2-LEC10 for broad-spectrum control of pathogenic and uncharacterized Escherichia coli in fresh produce.
DOI: 10.3389/fmicb.2025.1594533
https://pubmed.ncbi.nlm.nih.gov/40458707/
DOI: 10.3389/fmicb.2025.1594533
https://pubmed.ncbi.nlm.nih.gov/40458707/
Bacteriophage cocktail LEC2-LEC10 for broad-spectrum control of pathogenic and uncharacterized Escherichia coli in fresh produce - PubMed
These results demonstrate that LEC2 and LEC10, especially when used as a cocktail, are promising antibacterial agents for controlling <i>E. coli</i> contamination in fresh foods. Their complementary host ranges and strong lytic activity support their application in food safety strategies aimed at re …
pubmed.ncbi.nlm.nih.gov
June 6, 2025 at 9:51 AM
Bacteriophage cocktail LEC2-LEC10 for broad-spectrum control of pathogenic and uncharacterized Escherichia coli in fresh produce.
DOI: 10.3389/fmicb.2025.1594533
https://pubmed.ncbi.nlm.nih.gov/40458707/
DOI: 10.3389/fmicb.2025.1594533
https://pubmed.ncbi.nlm.nih.gov/40458707/
*Boy, the commentary fandom is going seriously ape over this makertainment video
www.youtube.com/watch?v=LEc2...
www.youtube.com/watch?v=LEc2...
Making a Dog-Sized Furby Robot (and taking it on a walk)
Can we turn a robot dog into a Furby? Thanks to our sponsor Squarespace, go to https://www.squarespace.com/evanandkatelyn for 10% off your first purchase. Ch...
www.youtube.com
April 6, 2024 at 7:59 AM
*Boy, the commentary fandom is going seriously ape over this makertainment video
www.youtube.com/watch?v=LEc2...
www.youtube.com/watch?v=LEc2...
Reminded me of this: www.youtube.com/watch?v=LEc2...
Making a Dog-Sized Furby Robot (and taking it on a walk)
YouTube video by Evan and Katelyn
www.youtube.com
November 26, 2025 at 10:37 PM
Reminded me of this: www.youtube.com/watch?v=LEc2...
Commentary on "Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration" by Li Ping Tang et al. (2025) from @cellpress.bsky.social www.cell.com/cell/fulltex...
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration
In Arabidopsis, transcriptional factors LEC2 and SPCH enhance local auxin biosynthesis,
establishing a transcriptional framework that enables differentiated single somatic
epidermal cells to regain to...
www.cell.com
April 29, 2026 at 12:10 PM
Commentary on "Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration" by Li Ping Tang et al. (2025) from @cellpress.bsky.social www.cell.com/cell/fulltex...
*The Serbian wife patiently watched this Texan makertainment video with me, and then she pointed out that this is "animistic robot costume play" rather than "genuine art robotics"
*We have learned to make these fine critical distinctions because we hang out in Turin
www.youtube.com/watch?v=LEc2...
*We have learned to make these fine critical distinctions because we hang out in Turin
www.youtube.com/watch?v=LEc2...
Making a Dog-Sized Furby Robot (and taking it on a walk)
Can we turn a robot dog into a Furby? Thanks to our sponsor Squarespace, go to https://www.squarespace.com/evanandkatelyn for 10% off your first purchase. Ch...
www.youtube.com
April 7, 2024 at 6:43 AM
*The Serbian wife patiently watched this Texan makertainment video with me, and then she pointed out that this is "animistic robot costume play" rather than "genuine art robotics"
*We have learned to make these fine critical distinctions because we hang out in Turin
www.youtube.com/watch?v=LEc2...
*We have learned to make these fine critical distinctions because we hang out in Turin
www.youtube.com/watch?v=LEc2...
This commentary is about the recent publication by Tang et al. “Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration” appeared in Cell, placing it into historical and broader contexts.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration
In Arabidopsis, transcriptional factors LEC2 and SPCH enhance local auxin biosynthesis,
establishing a transcriptional framework that enables differentiated single somatic
epidermal cells to regain to...
www.cell.com
October 26, 2025 at 5:43 PM
This commentary is about the recent publication by Tang et al. “Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration” appeared in Cell, placing it into historical and broader contexts.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
The characterization of the LEAFY COTYLEDON 2 activation domains reveals its conserved dual mode of action in flowering plants (IJPB, SPS)
The characterization of the LEAFY COTYLEDON 2 activation domains reveals its conserved dual mode of action in flowering plants (IJPB, SPS)
Seed development in Arabidopsis thaliana is largely controlled by a set of transcription factors (TFs) called LAFL, including LEAFY COTYLEDON 2 (LEC2). In this study, we investigated the structure/function relationships of the protein LEC2 outside the well-described B3 DNA-binding domain. The results presented here unveil the presence of transcription activation domains (ADs) within the unstructured ends of the protein that are conserved in eudicots. Expression in both yeast and moss protoplasts of deleted and mutated versions of LEC2 confirmed the transcriptional activity of these ADs. Surprisingly, the expression of LEC2 variants lacking their ADs restored a wild-type seed phenotype in lec2 mutant, showing that these ADs are not essential for LEC2 function in seed development. Moreover, ZmAFL2/ZmABI19, a maize B3 factor related to LEC2 but deprived of N-ter AD, can also complement lec2 seed phenotype and induce abnormal vegetative development when overexpressed in Arabidopsis, supporting this observation. This work suggests that LEC2 can act both as a classical transcriptional activator or without transactivation activity, probably through its interaction with the pioneer factor LEC1. Taken together, the results provide important insights into the function of the LAFL master regulators during seed development, from cell differentiation to storage accumulation in seed.
https://doi.org/10.1111/tpj.70380
doi.org
August 21, 2025 at 11:25 AM
The characterization of the LEAFY COTYLEDON 2 activation domains reveals its conserved dual mode of action in flowering plants (IJPB, SPS)
#SeedBio
LEC2-induced somatic embryogenesis starts from stomatal progenitors via auxin-driven reprogramming!
Details: https://maxapress.com/article/doi/10.48130/seedbio-0025-0019
#SomaticEmbryogenesis #LEC2
LEC2-induced somatic embryogenesis starts from stomatal progenitors via auxin-driven reprogramming!
Details: https://maxapress.com/article/doi/10.48130/seedbio-0025-0019
#SomaticEmbryogenesis #LEC2
December 26, 2025 at 2:37 AM
#SeedBio
LEC2-induced somatic embryogenesis starts from stomatal progenitors via auxin-driven reprogramming!
Details: https://maxapress.com/article/doi/10.48130/seedbio-0025-0019
#SomaticEmbryogenesis #LEC2
LEC2-induced somatic embryogenesis starts from stomatal progenitors via auxin-driven reprogramming!
Details: https://maxapress.com/article/doi/10.48130/seedbio-0025-0019
#SomaticEmbryogenesis #LEC2
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration
In Arabidopsis, transcriptional factors LEC2 and SPCH enhance local auxin biosynthesis,
establishing a transcriptional framework that enables differentiated single somatic
epidermal cells to regain to...
www.cell.com
September 23, 2025 at 7:08 PM
Time-resolved reprogramming of single somatic cells into totipotent states during plant regeneration
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
LEC2 unlocks totipotency by unlocking chromatin #plantscience
LEC2 unlocks totipotency by unlocking chromatin
Plants exhibit a unique regenerative capacity, exemplified by somatic embryogenesis (SE), that is, the formation of embryos from somatic cells. In a recent study, Peng et al. identified LEAFY COTYLEDON2 (LEC2) as a central regulator of SE by remodeling chromatin and activating totipotency regulators through epigenetic and hormonal pathways, enabling somatic cells to reset their developmental fate.
dlvr.it
December 4, 2025 at 1:40 PM
LEC2 unlocks totipotency by unlocking chromatin #plantscience
Another interesting paper from @kmikolajczyk.bsky.social! Knockout of the B4GALT5 gene encoding β1,4-galactosyltransferase 5 prevents the synthesis of Gb3, rendering cells resistant to Shiga toxin Stx1 but not Stx2. Great model for studying Stx-receptor interactions.
tinyurl.com/5awxkfxk
#glycotime
tinyurl.com/5awxkfxk
#glycotime
B4GALT5-deficient CHO-Lec2 cells expressing human α1,4-galactosyltransferase: A glycoengineered cell model for studying Shiga toxin receptors
Human α1,4-galactosyltransferase (A4galt) is a glycosyltransferase existing in humans as two isoforms, widespread A4galt (named A4G) and its rare vari…
tinyurl.com
March 5, 2025 at 11:10 AM
Another interesting paper from @kmikolajczyk.bsky.social! Knockout of the B4GALT5 gene encoding β1,4-galactosyltransferase 5 prevents the synthesis of Gb3, rendering cells resistant to Shiga toxin Stx1 but not Stx2. Great model for studying Stx-receptor interactions.
tinyurl.com/5awxkfxk
#glycotime
tinyurl.com/5awxkfxk
#glycotime
Maybe they are epigenetically locked too. I remember reading something about wounding activates WIND1, which modulates H3K27me3 and activates LEC2 and other genes involved in regeneration.
August 22, 2025 at 8:30 PM
Maybe they are epigenetically locked too. I remember reading something about wounding activates WIND1, which modulates H3K27me3 and activates LEC2 and other genes involved in regeneration.