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clinicalcanevo.com
Great talk by Wouter Karthaus at the #EACR2025 on uncovering resistance mechanisms in castration-resistant prostate cancer. Impressive use of organoids to study lineage plasticity. Lifting the veil on resistance mechanisms #CancerResearch #Organoids #LineagePlasticity
June 18, 2025 at 6:30 AM
chp-pivot.bsky.social
📘 CHP Archive Spotlight #05
Perspective (2024) | Jamroze, Liu & Tang
AR signaling inhibitors induce lineage plasticity in prostate cancer, promoting stem-like, mesenchymal & neural states driving CRPC & NEPC progression.
🔗 doi.org/10.47248/chp...
#LineagePlasticity #CRPC #CancerStemCells
Graphical abstract illustrating ARSI-induced lineage plasticity in prostate cancer. Androgen receptor signaling inhibition promotes transition from prostate adenocarcinoma (PRAD) to aggressive CRPC variants with increased mesenchymal, basal, stem-like, and neural cell states, highlighting reversibility and tumor heterogeneity.
February 27, 2026 at 2:32 AM
endosocjournals.bsky.social
3D genome architecture and epigenetic regulation of lineage identity in advanced prostate cancer. Read more in #Endocrinology: https://bit.ly/4pWziZV #ProstateCancer #LineagePlasticity @endocrinesociety.bsky.social
3D genome architecture and epigenetic regulation of lineage identity in advanced prostate cancer
Abstract. Prostate cancer development and progression depend on androgen receptor (AR) signaling. Therefore, androgen-deprivation therapy (ADT) and AR sign
bit.ly
August 10, 2026 at 5:13 PM
medchemexpress.bsky.social
🚀From Bench to Paper | Nature: Basal cells = origin of tuft-like SCLC, explaining NE–tuft plasticity & heterogeneity.
💡MedChemExpress’s Y-27632 (ROCK inhibitor) supports basal cell culture & plasticity models.
#CancerResearch #SCLC #LineagePlasticity
September 18, 2025 at 11:00 PM