Lipid metabolism encompasses the catabolism and anabolism of lipids, and is fundamental for the maintenance of cellular homeostasis, particularly within the lipid-rich CNS. Increasing evidence further underscores the importance of lipid remodelling and transfer within and between glial cells and neurons as key orchestrators of CNS lipid homeostasis. In this Review, we summarize and discuss the complex landscape of processes involved in lipid metabolism, remodelling and intercellular transfer in the CNS. Highlighted are key pathways, including those mediating lipid (and lipid droplet) biogenesis and breakdown, lipid oxidation and phospholipid metabolism, as well as cell–cell lipid transfer mediated via lipoproteins, extracellular vesicles and tunnelling nanotubes. We further explore how the dysregulation of these pathways contributes to the onset and progression of neurodegenerative diseases, and examine the homeostatic and pathogenic impacts of environment, diet and lifestyle on CNS li

New research uncovers how declining protective lipids, not their accumulation, may elevate cardiovascular risks in obesity. Discover the surprising findings.

This Review underscores the pivotal role of chemical biology in the discovery and characterization of fatty acid esters of hydroxy fatty acids, bioactive lipids linked to metabolic health and inflamma...

European Journal of Clinical Nutrition - Effects of cocoa products/dark chocolate on serum lipids: a meta-analysis

Alterations in bile acid metabolism have been described in type 2 diabetes mellitus, and are also associated with dysregulated lipid and glucose metabolism. This Review outlines the interplay between…

During the last few years, there has been an extraordinary increase in publications describing the manifold applications of monoolein, one of the most important lipids in the fields of drug delivery,…