Orthodontic mechanical forces activate Piezo1⁺ macrophage–B-cell signaling and pathogenic IgM release, driving systemic #Inflammation, #LiverDysfunction and impaired distal #BoneRepair, while metabolic intervention reverses these effects.

#STTT #OpenAccess: doi.org/10.1038/s413...

Mechanical force applied during #Orthodontic treatment induces adaptive immune responses, expanding CD69⁺ B cells and releasing pathogenic IgM that causes temporary #LiverDysfunction and impairs distant #BoneRepair. @PKU1898

#STTT #OpenAccess: doi.org/10.1038/s413...

#Skindeep #microneedle #sensor tracks #drugclearance & reveals early #kidney and #liverdysfunction

UCLA developed microneedle sensors for continuous, minimally invasive health tracking, enabling personalized dosing, early organ dysfunction detection
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