#MBD4
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infobot.bsky.social
🎵 Music Production 🎵
Audioblast release MBD4 for macOS and Windows (VST, AU & AAX)
(by )
Just a moment...
www.kvraudio.com
November 10, 2026 at 12:20 PM
biorxivpreprint.bsky.social
A Three-Axis Framework for Therapy Prioritization in MBD4-Deficient Tumors: De-confounded Synthetic Lethality Modeling, Replication-Stress Pharmacology, and PARP1 Trapping Decoupling https://www.biorxiv.org/content/10.64898/2026.11.10.765519v1
November 12, 2026 at 8:48 PM
biorxiv-cancer.bsky.social
A Three-Axis Framework for Therapy Prioritization in MBD4-Deficient Tumors: De-confounded Synthetic Lethality Modeling, Replication-Stress Pharmacology, and PARP1 Trapping Decoupling https://www.biorxiv.org/content/10.64898/2026.11.10.765519v1
November 12, 2026 at 8:48 PM
kvraudio.bsky.social
Audioblast release MBD4 for macOS and Windows (VST, AU & AAX) https://www.kvraudio.com/news/69545
November 10, 2026 at 11:45 AM
mapjournals.bsky.social
#EPI
A proposed UHRF1-MBD4 dialogue couples base excision repair of deamination-induced G:T mismatches with restoration of full DNA methylation fidelity at heterochromatin.
Details: https://www.maxapress.com/article/doi/10.48130/epi-0026-0009
#DNAMethylation #UHRF1 #MBD4 #BaseExcisionRepair
October 26, 2026 at 4:28 AM
rridrobot.bsky.social
The authors included RRIDs in their in Nucleic Acids Research paper! RRIDs improve reproducibility in scientific research. #methodsmatter #STMpublishing #RRID
Mbd4 and MutSα protect cells from spontaneous deamination of 5-methylcytosine
Read the full paper: Mbd4 and MutSα protect cells from spontaneous deamination of 5-methylcytosine
doi.org
October 9, 2026 at 7:10 AM
actu.fr
Découvrez son témoignage ici ➡️ https://l.actu.fr/mBD4
October 1, 2026 at 5:59 AM
phenomics.bsky.social
🫁 A Phenomics study of 839 Chinese lung cancer patients finds that MBD4 polymorphism rs140693 is associated with prognosis, highlighting its potential as a genetic marker for individualized prognostic assessment.

doi.org/10.1007/s436...

#Phenomics
September 16, 2026 at 2:02 PM
cjo-jco.bsky.social
From a team in Portugal, this case report highlights a key diagnostic challenge at the intersection of transplantation and genomics in MBD4-associated neoplasia syndrome.

bit.ly/cjo_neoplasi...

#Ophthalmology #OcularOncology #NeoplasiaSyndrome
Fundus photo of a large, nodular, dome-shaped choroidal mass located superonasal to the optic disc consistent with choroidal melanoma.
August 31, 2026 at 2:57 PM
cbgpmadrid.bsky.social
🆕📰‼️#PaperCBGP

🌱 Científicos del CBGP identifican un regulador que ajusta la floración de los cultivos al calor

🧬 La identificación del lector de cromatina MBD4 amplía el conocimiento sobre cómo se regula la respuesta de floración a temperaturas cálidas.

📎 www.cbgp.upm.es/index.php/es...
May 13, 2026 at 7:15 AM
obialik.bsky.social
Not every DNA mistake gets fixed. We know that; that's how mutations enter the gene pool. But it gets more interesting to look at what does get fixed, because repair enzymes apparently have a priority list. 🧪

Link: https://www.nature.com/articles/s41467-026-74090-0​
a Global view of TDG binding preferences. The right half summarizes mean signals for all 3-mer contexts on the 3′ side of the lesion (+1 to +3), and the left half summarizes the 5′ side (−1 to −3). Colors indicate average binding intensity. Examples highlight strong binding in the GCA context and weak binding in CCT of 3′ side. b Sequence context contributions to UDG, TDG, and MBD4 binding, derived from a linear regression model with interaction terms. Vertical bars represent single-base coefficients from this model at each position, with height indicating coefficient magnitude and color denoting base identity. Curved arcs represent pairwise interaction coefficients from the same model: blue for positive and orange for negative effects. Arc width reflects interaction strength, and arc height corresponds to the predicted binding signal based on both the individual base effects (bars) and their interaction (arc). Interactions below |0.2| Δln(binding signal) are rendered faintly for clarity. The arrow in the TDG panel shows the interaction demonstrated in (c). c Positional interaction effects between position +2 and +3 for TDG damage binding. We focused on 6-mer contexts of the form 5′-NNNTCNN-3′, fixing the base at position +1 as C to reduce sequence diversity. Within this subset, grouped sequences by the base at position +2 (A, T, G, or C) and compared binding signals between matched pairs that differed only at position +3, containing either C (n = 64) or G (n = 64). The left panel shows TDG binding signals across matched pairs, with colored lines connecting sequences that differ only at position +3. Line color indicates whether the substitution increased (green) or decreased (red) binding. Statistical comparisons were performed using paired two-sided t‑tests within each +2 group, with significance shown above. The right panel summarizes these differences as Δln(binding signal) = G – C. Boxes indicate the median and the 25th and 75th percentiles.
August 12, 2026 at 2:17 PM
timtriche.bsky.social
IDH1/2 and DNMT3A are interesting in that they were discovered recurrent by WGS, then added to panels

We’ve seen familial cases where germline or early somatic DNMT3A (in the latter case often secondary to germline MBD4) is followed by IDH2 R172 and/or H3K27M/I, usually AYA, always refractory
April 6, 2026 at 1:03 PM
itougmakoto.bsky.social
今回理事会でも『こんな政府いらんやろ』という発言がでまくった、今の日本のクソ政府。
日本人なら余程脳味噌が壊れてなければこの言葉はわかるはずだ

『明日は我が身』

こんな政府も国もいらないし、他国では珍しくない事だ。以前も書いたネパール等権力者が民衆に追放される事は珍しくない。古くはフィリピンのマルコスだろう。

先ほど南米北部でマグニチュード７の地震が起きた。日本はどこの地域にいってもそれがどこで起きておかしくないのだ。

政府そして愚民も含めて全てが狂ってるのが日本人だ。

www.youtube.com/watch?v=MbD4...
【ちゅうちょなく予備費を活用】の話どこいった？１６７０億で熊本県全人口に１０万円給付できるのに「貸し付け」する政府 #高市早苗 #いのちの党(旧#れいわ新選組) #奥田ふみよ vol.864
YouTube video by 友資 / ミもフタも愛
www.youtube.com
August 11, 2026 at 4:50 AM
mplantpcom.bsky.social
The MBD4 chromatin reader regulates transcription related to temperature and flowering responses through recognition of histone arginine methylation in Arabidopsis thaliana and Brassica napus #research #PlantCommunications cell.com/plant-commun...
April 28, 2026 at 8:07 AM
cantrip7.bsky.social
www.youtube.com/watch?v=mBD4...
Sleepcore is the begin-all end-all of 'what do I put on in a voice call' social lubricant
self-described as "media for insomnia"
helpful links to video sources if something catches your eye
and their Halloween selection is primo
The Sleepcore Screamathon 2022 | Dreamy Horror and Halloween Nostalgia!
YouTube video by picsandportraits
www.youtube.com
October 31, 2024 at 1:57 PM
barbarianatthegate.bsky.social
www.youtube.com/watch?v=Mbd4...

certainly the kind of theme relevant for one interested in complexity science n tempted to reductionism for coping strategies.

catch me offline, like 4 real. I'm kinda single-minded when i figure out what the right kind of questions happen to be.

with others ofc
August 4, 2026 at 12:49 AM
dpastoors.bsky.social
Check out poster 1115 on MBD4 deficiency to model clonal hematopoeisis ⬇️⬇️ #EHA2025 🩸🧪
massaarsanne.bsky.social Sanne Massaar @massaarsanne.bsky.social · Jun 13
This evening I'll be presenting our work on MBD4 knockout as a tool for modelling mutagenesis and clonal outgrowth at the poster session of #EHA2025. Come visit me at PF1115 if you're interested! #Hemesky 🩸🧪
June 13, 2025 at 2:21 PM
yurakuan.bsky.social
後から「返せ」って言うつもりなんかぃ!!
#終わらせよう人の心のない政府

【ちゅうちょなく予備費を活用】の話どこいった？１６７０億で熊本県全人口に１０万円給付できるのに「貸し付け」する政府 #高市早苗 #いのちの党(旧#れいわ新選組) #奥田ふみよ vol.864
www.youtube.com/watch?v=MbD4...
【ちゅうちょなく予備費を活用】の話どこいった？１６７０億で熊本県全人口に１０万円給付できるのに「貸し付け」する政府 #高市早苗 #いのちの党(旧#れいわ新選組) #奥田ふみよ vol.864
YouTube video by 友資 / ミもフタも愛
www.youtube.com
August 9, 2026 at 1:36 PM
springermedicine.com
#MedNews - The presence of MBD4 pathogenic variants is associated with a more than 30-fold increased risk for developing uveal melanoma relative to the general population.

👉️ buff.ly/Tl7TqcT

#OncSky #EyeSky
Link between MBD4 mutations and uveal melanoma stronger than previously reported
The presence of MBD4 pathogenic variants is associated with a more than 30-fold increased risk for developing uveal melanoma relative to the general population.
www.springermedicine.com
May 14, 2026 at 6:25 PM
biorxiv-molbio.bsky.social
Human PMS1-dependent non-canonical mismatch repair converges with MBD4 to repair 5-methylcytosine deamination https://www.biorxiv.org/content/10.64898/2026.01.16.698129v1
January 17, 2026 at 7:16 PM
biorxiv-molbio.bsky.social
Mbd4 and MutSα protect cells from spontaneous deamination of 5-methylcytosine. https://www.biorxiv.org/content/10.1101/2024.12.17.628571v1
December 18, 2024 at 12:25 PM
tokyo-ondo.bsky.social
【ちゅうちょなく予備費を活用】の話どこいった？１６７０億で熊本県全人口に１０万円給付できるのに「貸し付け」する政府 #高市早苗 #いのちの党(旧#れいわ新選組) #奥田ふみよ vol.864
友資 / ミもフタも愛
2026/08/09
www.youtube.com/watch?v=MbD4...
【ちゅうちょなく予備費を活用】の話どこいった？１６７０億で熊本県全人口に１０万円給付できるのに「貸し付け」する政府 #高市早苗 #いのちの党(旧#れいわ新選組) #奥田ふみよ vol.864
YouTube video by 友資 / ミもフタも愛
www.youtube.com
August 9, 2026 at 10:05 PM
aurino.bsky.social
#YayáMassemba - De Umbigo a Umbigo - Clipe Oficial: www.youtube.com/watch?v=mBD4... (16.11.2024 - #ChapadaDiamantina).
Observei superficialmente via pesquisas com palavras-chave em línguas diferentes e aparentemente apenas no #Brasil com determinados hábitos ao coto: www.youtube.com/results?sear...?
De Umbigo a Umbigo - Clipe Oficial
YouTube video by YAYÁ MASSEMBA
www.youtube.com
December 7, 2024 at 3:10 PM
biorxivpreprint.bsky.social
Human PMS1-dependent non-canonical mismatch repair converges with MBD4 to repair 5-methylcytosine deamination https://www.biorxiv.org/content/10.64898/2026.01.16.698129v1
January 17, 2026 at 7:16 PM
biorxivpreprint.bsky.social
Mbd4 and MutSα protect cells from spontaneous deamination of 5-methylcytosine. https://www.biorxiv.org/content/10.1101/2024.12.17.628571v1
December 18, 2024 at 12:24 PM