#MDACCPath
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draldehyde.bsky.social
🚨Spoiler alert: Primary cutaneous NUT adnexal carcinoma can metastasize—but long-term outcomes remain unclear. We're about to report an almost 20-year follow-up on this new entity. Stay tuned! 😆🔬🧬

#dermpath #pathology #molpath #IHCPath #MDACCPath
May 31, 2025 at 11:53 PM
draldehyde.bsky.social
🚨 Hot off the press! The most comprehensive open-access review of TRPS1 and its applications in #dermpath is now available. Everything you need to know, based on our 4+ years of experience, is in one place. Check it out! 😆🔬

www.jpatholtm.org/journal/view...

#MDACCPath #IHCPath #TRPS1
January 30, 2026 at 1:42 AM
draldehyde.bsky.social
Exciting news! The May issue of The American Journal of Dermatopathology is out, and our paper is featured on the cover! What a great way to kick off the month. That gene fusion schematic? Pretty much our signature move at this point! 😆🔬🧬🎉

#dermpath #pathology #molepath #MDACCPath
May 1, 2025 at 1:57 AM
draldehyde.bsky.social
Happy Friday #dermpath! 😆🔬

Two of our articles were selected as Editor’s Choices in this month’s AJDP — and one even landed the front cover, featuring this photogenic gene schematic! 🧬🎨🎉

#MDACCPath #molepath #pathology
April 18, 2025 at 10:47 PM
draldehyde.bsky.social
It’s been a while since I shared a case.

Did you know this immunoprofile, especially the diffuse TRPS1 immunoreactivity, strongly favors primary EMPD over secondary EMPD? Give it a try if you haven’t used it in your practice. 😆🔬

#dermpath #IHCPath #MDACCPath
August 6, 2025 at 6:22 PM
draldehyde.bsky.social
🚨 Hot off the press! Our review on current trends in melanocytic lesions has finally been published in Dermatologic Clinics. It was an honor to be part of this review series alongside so many outstanding authors in this month’s issue. 😆🔬#dermpath
#MDACCPath

www.sciencedirect.com/science/arti...
Current Trends in Melanocytic Lesions
www.sciencedirect.com
April 25, 2026 at 3:35 AM
draldehyde.bsky.social
Endocrine mucin-producing sweat gland carcinomas presenting as blue-gray papules, as reported by Likki et al. 😆🔬

#dermpath #dermatology #pathology #MDACCPath

onlinelibrary.wiley.com/doi/10.1002/...
<em>JEADV Clinical Practice</em> | Clinical Dermatology and Venereology Journal | Wiley Online Library
Click on the article title to read more.
onlinelibrary.wiley.com
March 3, 2026 at 1:54 AM
draldehyde.bsky.social
We share our experience with an unusual, diffuse cutaneous ALK-immunoreactive histiocytosis with a MEF2C::FLT3 fusion. Check it out if you love the #dermpath and #molepath combination. 😆🔬🧬

#MDACCPath

pubmed.ncbi.nlm.nih.gov/41211348/
Diffuse cutaneous ALK-immunoreactive histiocytosis with MEF2C::FLT3 fusion - PubMed
Diffuse cutaneous ALK-immunoreactive histiocytosis with MEF2C::FLT3 fusion
pubmed.ncbi.nlm.nih.gov
February 28, 2026 at 3:23 PM
draldehyde.bsky.social
My very 1st USCAP meeting was 9 years ago in San Antonio, and it opened my eyes to the possibility of a career in academic #pathology.

Residents, please attend #USCAP2026 if at all possible. It could truly change your career path! #dermpath #MDACCPath

Bonus: what do you 👀?
March 22, 2026 at 12:21 AM
draldehyde.bsky.social
Interested in #LungPath? Don’t miss HSCP’s Annual Spring Symposium in Houston next month! 😆🔬🫁

Hear from incredible speakers, including @smlungpathguy.bsky.social, and connect with leaders in the field!

#pathology #MDACCPath
April 1, 2026 at 2:25 AM
draldehyde.bsky.social
Thursday #DermPath special! 😆🔬

Many tumors unfortunately can metastasize to the skin, including this one. 😫

Cutaneous metastasis of pancreatic adenocarcinoma showing complete loss of DPC4 expression.

#MDACCPath #pathology #GIpath #IHCpath
December 12, 2024 at 9:51 PM
draldehyde.bsky.social
Weekend non-#dermpath special. 😆🔬

Here are photogenic intracytoplasmic inclusions or morulae ("mulberry-like" microcolonies of bacteria) in human granulocytotropic anaplasmosis (formerly known as human granulocytic ehrlichiosis). 🐛🧫🦠

#pathology #hemepath #MDACCPath
April 13, 2025 at 6:08 PM
draldehyde.bsky.social
Do you see what I see? 😆🔬

Pseudoepitheliomatous hyperplasia and dermal granulomatous inflammation with multinucleated giant cells. That’s it? Nope, keep looking and you will find the cause of these histopathologic changes—Medlar bodies of chromoblastomycosis!

#dermpath #IDpath #MDACCpath
March 19, 2025 at 1:44 AM
draldehyde.bsky.social
🚨Spoiler alert: Here’s a key pitfall almost no #dermpath textbook covers—SPTCLs can often show marked gamma/delta T-cell populations, mimicking pcGDTCL. A diagnostic trap you’ll want to know about. Our paper is coming soon—stay tuned! 😆🔬

#dermpath #hemepath #MDACCPath
June 10, 2025 at 9:21 PM
draldehyde.bsky.social
The presence of a gene fusion doesn’t always indicate a Spitz melanocytic neoplasm. Here’s our example featuring the new RNF11::BRAF fusion in non-Spitz melanoma. Check it out if you love #dermpath and #molepath! 😆🔬🧬

#MDACCPath

pubmed.ncbi.nlm.nih.gov/40036483/
Melanoma With RNF11::BRAF Fusion: A Novel Fusion Previously Undescribed in Melanoma - PubMed
B-Raf Proto-Oncogene ( BRAF ) fusions are rare in melanomas. We present a case of cutaneous melanoma with a Ring Finger Protein 11 ( RNF11 ) ::BRAF fusion in a 63-year-old man with a history of stage IB melanoma on the right upper back (pT2apN0cM0; nonulcerated with a Breslow thickness of 1.2 mm). D …
pubmed.ncbi.nlm.nih.gov
March 18, 2026 at 1:17 AM
draldehyde.bsky.social
🚨 Hot off the press! A MAP4::RAF1 fusion identified in a bona fide non-Spitz melanoma can be fatal.

Check it out if you are #dermpath and #molepath combo enthusiasts. 😆🔬🧬

#MDACCPath

journals.lww.com/amjdermatopa...
Fatal Melanoma With MAP4::RAF1 Fusion: Expanding the... : The American Journal of Dermatopathology
earranged in non-Spitz melanomas (ie, bona fide melanomas without Spitz-nevus-like cytomorphology), with a reported frequency of less than 1%. As a result, the clinicopathologic features and prognosti...
journals.lww.com
May 9, 2026 at 1:09 PM
draldehyde.bsky.social
🚨 Hot off the press! My correspondence has been published in JCP, highlighting the importance of post-publication peer review. 😆🔬

The article is open access. Check it out if you love #dermpath & are interested in NUT adnexal carcinoma. #MDACCPath #pathology

onlinelibrary.wiley.com/doi/10.1111/...
Correspondence: Primary Cutaneous NUT Adnexal Carcinoma: A Case Report With Novel Clinical and Pathological Observations
Click on the article title to read more.
onlinelibrary.wiley.com
May 9, 2026 at 1:41 AM
draldehyde.bsky.social
Our #dermpath society is very small, and therefore the audience is limited, but it appears our study has been cited enough to be selected as one of the top 10 most-cited papers by JCP in 2024! 😆🔬

onlinelibrary.wiley.com/doi/10.1111/...

#TopCitedArticle #MDACCPath
April 4, 2026 at 1:34 AM
draldehyde.bsky.social
🚨 Hot off the press! What a timely delivery during #USCAP2026. This is one of the very first molecular characterizations of true MBNs in one of the largest cohorts ever studied. Open access. Check it out if you love #dermpath & #molepath! 😆🔬🧬 #MDACCPath

link.springer.com/article/10.1...
Melanomas arising in blue nevi exhibit absence of TERT promoter mutations, low tumor mutational burden, and high frequency of distant metastases and disease-related mortality: a clinicopathologic and ...
Melanoma arising in blue nevus (MBN) is a rare melanoma subtype with distinct molecular characteristics and biological behaviors compared to other cutaneous melanomas. However, limited data exists on ...
link.springer.com
March 27, 2026 at 10:41 AM
draldehyde.bsky.social
What a pleasant surprise! Our article has been selected as the front cover of this month’s issue of JPTM. I’m glad that the editorial team was impressed by the comprehensiveness of our review article and its high-quality images. 😆🔬

#dermpath #MDACCpath

jpatholtm.org/journal/view...
March 14, 2026 at 2:50 PM
draldehyde.bsky.social
Want to maximize Merkel cell carcinoma detection in sentinel lymph nodes? Go with panCK + INSM1 or panCK + SOX11. CK20’s sensitivity is just too low; its expression can be absent in up to 24% of MCCs. Check it out if you love #dermpath and #IHCpath. 😆🔬

#MDACCPath

pubmed.ncbi.nlm.nih.gov/40505699/
INSM1: A highly sensitive marker for primary and metastatic Merkel cell carcinoma, superior to SOX11, pancytokeratin, and CK20 - PubMed
Detection of Merkel cell carcinoma (MCC) micrometastases in sentinel lymph nodes (SLNs) often necessitates immunohistochemical studies like pancytokeratin (panCK) or CK20. However, panCK can label non-epithelial cells, particularly dendritic reticulum cells, complicating interpretation, while CK20 i …
pubmed.ncbi.nlm.nih.gov
March 11, 2026 at 1:57 PM
draldehyde.bsky.social
#USCAP2026 in TX is just around the corner! 😆🔬🤠

Excited to connect with incredible pathologists and #pathology trainees and to see the latest studies in #dermpath.

As a bonus, here’s a special stain that turned into a bit of pareidolia. 👀
What do you see in it? #MDACCPath
March 5, 2026 at 4:07 PM
draldehyde.bsky.social
When was the last time you encountered a gene fusion in Merkel cell carcinoma?

Here is the first documented case of MCPyV-positive MCC harboring a novel NSD3::FGFR1 gene fusion. Check it out if you love #dermpath and #molepath! 😆🔬🧬

#MDACCPath

pubmed.ncbi.nlm.nih.gov/40036479/
NSD3::FGFR1 : A Novel Gene Fusion First to Be Described in Merkel Cell Carcinoma - PubMed
Merkel cell carcinomas (MCCs) exhibit diverse molecular profiles, often categorized by their association with Merkel cell polyoma virus (MCPyV). MCPyV-associated MCCs typically display a low tumor mutational burden (TMB), lacking both somatic mutations and ultraviolet signature. By contrast, MCPyV-n …
pubmed.ncbi.nlm.nih.gov
March 3, 2026 at 6:24 PM
draldehyde.bsky.social
Lastly, when in doubt, read this most comprehensive review on TRPS1 #IHCPath, which incorporates our extensive experience with this marker over the past 4–5 years in #dermpath. Free access! 😆🔬

#MDACCPath

pubmed.ncbi.nlm.nih.gov/41605620/
The evolving role of TRPS1 in dermatopathology: insights from the past 4 years - PubMed
Over the past 4 years, trichorhinophalangeal syndrome type 1 (TRPS1) has rapidly gained attention among practicing pathologists, with numerous studies emerging that both support and question its diagnostic utility. Initially regarded as a highly specific marker for tumors of mammary origin, TRPS1 is …
pubmed.ncbi.nlm.nih.gov
February 28, 2026 at 2:37 PM
draldehyde.bsky.social
And this was by far the largest study on this topic, including more than 90 cases of EMPD, and it was the first to demonstrate that primary perianal EMPDs lack TRPS1 expression, an important diagnostic pitfall. 😆🔬

#MDACCPath #dermpath

pubmed.ncbi.nlm.nih.gov/38000676/
TRPS1 expression in primary and secondary extramammary Paget diseases: An immunohistochemical analysis of 93 cases - PubMed
Extramammary Paget disease (EMPD) predominantly manifests de novo as primary EMPD, with less than 30 % of cases associated with underlying internal malignancy (secondary EMPD). Differentiating primary from secondary EMPDs based solely on histopathology poses challenges, often necessitating supplemen …
pubmed.ncbi.nlm.nih.gov
February 28, 2026 at 2:35 PM