Our gut microbiome and its metabolites have key interactions with our immune response to cancer and success from cancer immunotherapy. Nice perspective @jclinical-invest.bsky.social www.jci.org/articles/vie...
February 3, 2025 at 10:11 PM
Our gut microbiome and its metabolites have key interactions with our immune response to cancer and success from cancer immunotherapy. Nice perspective @jclinical-invest.bsky.social www.jci.org/articles/vie...
Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection:
rdcu.be/d8xLv (1/6)
rdcu.be/d8xLv (1/6)
Quantifying metabolites using structure-switching aptamers coupled to DNA sequencing
Nature Biotechnology - Metabolites can be quantified using a combination of aptamers and DNA barcodes.
rdcu.be
February 4, 2025 at 1:54 PM
Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection:
rdcu.be/d8xLv (1/6)
rdcu.be/d8xLv (1/6)
How eating fiber->short-chain fatty acid (SCFA) metabolites->anti-cancer effects
nature.com/articles/s42...
nature.com/articles/s42...
nature.com/articles/s42...
nature.com/articles/s42...
January 9, 2025 at 3:22 PM
How eating fiber->short-chain fatty acid (SCFA) metabolites->anti-cancer effects
nature.com/articles/s42...
nature.com/articles/s42...
nature.com/articles/s42...
nature.com/articles/s42...
Excited to share the first published paper from my lab! Postdoc Helen Jordan led this study on 1) how metabolites change differently in inflammation in tissues versus in cells in a dish and 2) the role of one of the most-increased metabolites, soluble sialic acid
www.jbc.org/article/S002...
www.jbc.org/article/S002...
Metabolomics of in vivo inflammation identifies soluble sialic acid as a conserved myeloid-cell metabolite
During an immune response, metabolism changes dramatically. Metabolites are oxidized
to power immune cell functions, serve as building blocks for proliferation, and act
as effectors to regulate pathog...
www.jbc.org
September 10, 2026 at 9:24 PM
Excited to share the first published paper from my lab! Postdoc Helen Jordan led this study on 1) how metabolites change differently in inflammation in tissues versus in cells in a dish and 2) the role of one of the most-increased metabolites, soluble sialic acid
www.jbc.org/article/S002...
www.jbc.org/article/S002...
It was my piss, full of drug metabolites so they overdose
January 17, 2026 at 8:58 PM
It was my piss, full of drug metabolites so they overdose
Sugar-sweetened beverages are associated with an increased risk of Type 2 diabetes. Now we may know why.
Changes in the gut microbiome and its metabolites
www.cell.com/cell-metabol...
Changes in the gut microbiome and its metabolites
www.cell.com/cell-metabol...
January 31, 2025 at 3:38 PM
Sugar-sweetened beverages are associated with an increased risk of Type 2 diabetes. Now we may know why.
Changes in the gut microbiome and its metabolites
www.cell.com/cell-metabol...
Changes in the gut microbiome and its metabolites
www.cell.com/cell-metabol...
An important new study on PEM showing abnormal spinal fluid metabolites before and after an exercise challenge:
In controls, metabolites were created in response to exercise, in ME/CFS they were consumed.
As with other research this shows an aberrant metabolic response to exertion in ME/CFS
In controls, metabolites were created in response to exercise, in ME/CFS they were consumed.
As with other research this shows an aberrant metabolic response to exertion in ME/CFS
New from the US:
Exertional Exhaustion (Post-Exertional Malaise, PEM) Evaluated by the Effects of Exercise on Cerebrospinal Fluid Metabolomics–Lipidomics and Serine Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
www.mdpi.com/1422-0067/26...
#MEcfs #CFS
Exertional Exhaustion (Post-Exertional Malaise, PEM) Evaluated by the Effects of Exercise on Cerebrospinal Fluid Metabolomics–Lipidomics and Serine Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
www.mdpi.com/1422-0067/26...
#MEcfs #CFS
February 2, 2025 at 3:47 PM
An important new study on PEM showing abnormal spinal fluid metabolites before and after an exercise challenge:
In controls, metabolites were created in response to exercise, in ME/CFS they were consumed.
As with other research this shows an aberrant metabolic response to exertion in ME/CFS
In controls, metabolites were created in response to exercise, in ME/CFS they were consumed.
As with other research this shows an aberrant metabolic response to exertion in ME/CFS
Harnessing microbial co-culture to increase the production of known secondary metabolites
- Nat Prod Rep @natprodreports.rsc.org Review
pubs.rsc.org/en/content/a...
- Nat Prod Rep @natprodreports.rsc.org Review
pubs.rsc.org/en/content/a...
Harnessing microbial co-culture to increase the production of known secondary metabolites
Covering: 2019 to 2024Secondary metabolites (SMs) are naturally occurring defense or signaling molecules that are also utilized as human and animal drugs, crop protection agents, and fine chemicals. C...
pubs.rsc.org
February 23, 2025 at 11:52 AM
Harnessing microbial co-culture to increase the production of known secondary metabolites
- Nat Prod Rep @natprodreports.rsc.org Review
pubs.rsc.org/en/content/a...
- Nat Prod Rep @natprodreports.rsc.org Review
pubs.rsc.org/en/content/a...
Interesting study linking metabolites of gut flora to brain signaling 🧪
January 26, 2025 at 6:01 PM
Interesting study linking metabolites of gut flora to brain signaling 🧪
Very happy that our paper
Obligate cross-feeding of metabolites is common in soil microbial communities
just came out in Nature Microbiology.
See here 👇
Paywalled version:
www.nature.com/articles/s41...
Free read-only version:
rdcu.be/fBHAb
Obligate cross-feeding of metabolites is common in soil microbial communities
just came out in Nature Microbiology.
See here 👇
Paywalled version:
www.nature.com/articles/s41...
Free read-only version:
rdcu.be/fBHAb
Obligate cross-feeding of metabolites is common in soil microbial communities - Nature Microbiology
Cultivation-dependent techniques, computational analyses and genome-scale metabolic models show widespread amino acid auxotrophies, suggesting that soil microorganisms exist within integrated ecologic...
www.nature.com
August 24, 2026 at 10:51 AM
Very happy that our paper
Obligate cross-feeding of metabolites is common in soil microbial communities
just came out in Nature Microbiology.
See here 👇
Paywalled version:
www.nature.com/articles/s41...
Free read-only version:
rdcu.be/fBHAb
Obligate cross-feeding of metabolites is common in soil microbial communities
just came out in Nature Microbiology.
See here 👇
Paywalled version:
www.nature.com/articles/s41...
Free read-only version:
rdcu.be/fBHAb
Tracking consumption of ultra-processed foods via metabolites in blood or urine journals.plos.org/plosmedicine...
Identification and validation of poly-metabolite scores for diets high in ultra-processed food: An observational study and post-hoc randomized controlled crossover-feeding trial
Leila Abar and colleagues use data from an observational study and an RCT to assess poly-metabolites in diets high in ultra-processed food
journals.plos.org
May 20, 2025 at 9:23 PM
Tracking consumption of ultra-processed foods via metabolites in blood or urine journals.plos.org/plosmedicine...
Adherence to a Mediterranean diet linked to reduced dementia-related metabolites, many of which showed causal relationships (via MR), and lower risk Alzheimer's disease. Notable relationship with APOE4 genotyopes nature.com/articles/s41...
Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function - Nature Medicine
Genetic background, plasma metabolome and dietary data from 4,215 women and 1,490 men reveal 57 metabolites whose associations with dementia risk vary by APOE4 genotype and other risk variants.
nature.com
August 25, 2025 at 3:29 PM
Adherence to a Mediterranean diet linked to reduced dementia-related metabolites, many of which showed causal relationships (via MR), and lower risk Alzheimer's disease. Notable relationship with APOE4 genotyopes nature.com/articles/s41...
Keep Honking, I'm Producing Metabolites
May 12, 2026 at 7:53 PM
Keep Honking, I'm Producing Metabolites
I am so excited about this meeting. I will cover the discovery of 10,000s new metabolites, including an entirely new class of molecules. Looking forward to hearing and discussing your science on microbiome metabolites and metabolism.
⏳ Don’t miss it! Submit abstracts & scholarship apps for Microbiome Metabolism & Metabolites by Sept 23 (11:59 PM MT).
📍 Jan 19-22, 2026 | Banff, Canada
👉 keysym.us/KSMicroMetab26
#KSMicroMetab26 #Microbiome #Metabolomics @pieterdorrestein.bsky.social @inesthiele.bsky.social
📍 Jan 19-22, 2026 | Banff, Canada
👉 keysym.us/KSMicroMetab26
#KSMicroMetab26 #Microbiome #Metabolomics @pieterdorrestein.bsky.social @inesthiele.bsky.social
July 21, 2025 at 4:54 PM
I am so excited about this meeting. I will cover the discovery of 10,000s new metabolites, including an entirely new class of molecules. Looking forward to hearing and discussing your science on microbiome metabolites and metabolism.
The common MTHFR gene allele (C677T) plus methionine metabolites may predict the severity of Covid and risk of #LongCovid @pnas.org
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
December 20, 2025 at 3:53 PM
The common MTHFR gene allele (C677T) plus methionine metabolites may predict the severity of Covid and risk of #LongCovid @pnas.org
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
We can detect viagra metabolites in wastewater
The EPA is recommending that states test their water for abortion pills & birth control, labeling them as potential "contaminants"
The move comes after years of anti-abortion pressure—and clears the way for Republicans to restrict abortion & contraception under the guise of environmental protection
The move comes after years of anti-abortion pressure—and clears the way for Republicans to restrict abortion & contraception under the guise of environmental protection
The EPA Tells States to Test the Water for Birth Control and Abortion Pills
The government just cosigned the anti-abortion movement's craziest claim
jessica.substack.com
April 28, 2026 at 3:58 PM
We can detect viagra metabolites in wastewater
Was wondering why my allergies were flaring up super hard... Then the cat drooled on me and I broke out in hives.
I'm allergic to the metabolites in her new food. Oh no. It's the only recent change with her.
She's not a fan anyway, so we're switching back, but yuck.
I'm allergic to the metabolites in her new food. Oh no. It's the only recent change with her.
She's not a fan anyway, so we're switching back, but yuck.
December 3, 2025 at 4:43 PM
Was wondering why my allergies were flaring up super hard... Then the cat drooled on me and I broke out in hives.
I'm allergic to the metabolites in her new food. Oh no. It's the only recent change with her.
She's not a fan anyway, so we're switching back, but yuck.
I'm allergic to the metabolites in her new food. Oh no. It's the only recent change with her.
She's not a fan anyway, so we're switching back, but yuck.
Nature research paper: Language model-guided anticipation and discovery of mammalian metabolites
go.nature.com/4b1vrFk
go.nature.com/4b1vrFk
Language model-guided anticipation and discovery of mammalian metabolites - Nature
Chemical language models trained on known metabolites can identify previously unknown metabolites from mass spectrometry-based metabolomics data with high accuracy.
go.nature.com
January 15, 2026 at 5:36 PM
Nature research paper: Language model-guided anticipation and discovery of mammalian metabolites
go.nature.com/4b1vrFk
go.nature.com/4b1vrFk
Our gut microbiome and its metabolites play a critical role for our glucose regulation, as does diet and exercise for improving it, through modulating the gut microbiome
@naturemedicine.bsky.social
www.nature.com/articles/s41...
@naturemedicine.bsky.social
www.nature.com/articles/s41...
Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes - Nature Medicine
A map of microbiome–metabolome dynamics in people with type 2 diabetes identifies over 500 blood metabolites associated with impaired glucose control, with approximately one-third linked to an altered...
www.nature.com
April 8, 2025 at 2:19 PM
Our gut microbiome and its metabolites play a critical role for our glucose regulation, as does diet and exercise for improving it, through modulating the gut microbiome
@naturemedicine.bsky.social
www.nature.com/articles/s41...
@naturemedicine.bsky.social
www.nature.com/articles/s41...
Metabolites from intact phage-infected Synechococcus chemotactically attract heterotrophic marine bacteria www.nature.com/articles/s41... #jcampubs
Metabolites from intact phage-infected Synechococcus chemotactically attract heterotrophic marine bacteria - Nature Microbiology
The authors use time-resolved metabolomics and microfluidics to characterize enhanced heterotroph chemoattraction to metabolites released from cyanobacteria during early stages of phage infection.
www.nature.com
November 15, 2024 at 2:11 PM
Metabolites from intact phage-infected Synechococcus chemotactically attract heterotrophic marine bacteria www.nature.com/articles/s41... #jcampubs
Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism
Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...
www.nature.com
April 18, 2025 at 4:18 PM
Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics
www.nature.com/articles/s42...
www.nature.com/articles/s42...
the prog thing is not that complicated. some notable jobs prog and its metabolites perform:
- important neuromodulator
- helps your brain protect against and recover from damage
- probably important for long term skin and bone health
- probably an important component of managing libido
- important neuromodulator
- helps your brain protect against and recover from damage
- probably important for long term skin and bone health
- probably an important component of managing libido
we don't really know exactly what it does for us but it's an essential hormone for women that does or assists with dozens of different tasks in cis womens bodies. until we have evidence that suggests otherwise it is reasonable to assume it is important for long term health outcomes in trans women.
October 29, 2025 at 7:01 PM
the prog thing is not that complicated. some notable jobs prog and its metabolites perform:
- important neuromodulator
- helps your brain protect against and recover from damage
- probably important for long term skin and bone health
- probably an important component of managing libido
- important neuromodulator
- helps your brain protect against and recover from damage
- probably important for long term skin and bone health
- probably an important component of managing libido
Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intestinal lumen regulate vagal activity
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
Select microbial metabolites in the small intestinal lumen regulates vagal activity via receptor-mediated signaling
Neuroscience; Microbiome
www.cell.com
January 29, 2025 at 9:28 PM
Delighted to highlight new work by Kelly Jameson and colleagues showing that select microbial metabolites in the small intestinal lumen regulate vagal activity
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...