Can #MolecularResidualDisease predict transplant success in #AcuteMyeloidLeukemia?
Pre-transplant mMRD positivity predicts poorer survival after haploidentical #StemCellTransplantation, highlighting the need for risk-adapted treatment.
#currentmedicalscience: doi.org/10.1007/s115...
Pre-transplant mMRD positivity predicts poorer survival after haploidentical #StemCellTransplantation, highlighting the need for risk-adapted treatment.
#currentmedicalscience: doi.org/10.1007/s115...
October 30, 2026 at 2:03 PM
Can #MolecularResidualDisease predict transplant success in #AcuteMyeloidLeukemia?
Pre-transplant mMRD positivity predicts poorer survival after haploidentical #StemCellTransplantation, highlighting the need for risk-adapted treatment.
#currentmedicalscience: doi.org/10.1007/s115...
Pre-transplant mMRD positivity predicts poorer survival after haploidentical #StemCellTransplantation, highlighting the need for risk-adapted treatment.
#currentmedicalscience: doi.org/10.1007/s115...
OncoPharm
Dostarlimab's Journey in MMRd Rectal Cancer
OncoPharm · Episode
open.spotify.com
October 23, 2026 at 9:42 PM
OncoPharm
New paper: doi.org/10.1371/jour...
Why do hypermutant cancers have atypical 'weaker' driver mutations? Modelling clonal dynamics, shows that accelerated mutation rates and biases explain this enrichment in MMRd/POLEd colorectal cancers, shifting expected genotypes.
Why do hypermutant cancers have atypical 'weaker' driver mutations? Modelling clonal dynamics, shows that accelerated mutation rates and biases explain this enrichment in MMRd/POLEd colorectal cancers, shifting expected genotypes.
Hyper-mutational processes provide a head-start for weak cancer drivers: Explaining atypical KRAS variants
Author summary Considerable variability exists in the effectiveness of cancer driving mutations to promote cancer. Mutations which are thought to be less effective, ‘weak’ driver mutations, are common...
doi.org
October 13, 2026 at 10:46 AM
New paper: doi.org/10.1371/jour...
Why do hypermutant cancers have atypical 'weaker' driver mutations? Modelling clonal dynamics, shows that accelerated mutation rates and biases explain this enrichment in MMRd/POLEd colorectal cancers, shifting expected genotypes.
Why do hypermutant cancers have atypical 'weaker' driver mutations? Modelling clonal dynamics, shows that accelerated mutation rates and biases explain this enrichment in MMRd/POLEd colorectal cancers, shifting expected genotypes.
9/ The eight: MMRd; ROS-mediated mutagenesis; AR-mediated mutagenesis; mitotic defects + replication stress; non-canonical impaired HR; replication stress; APOBEC; canonical impaired HR.
September 12, 2026 at 10:28 AM
9/ The eight: MMRd; ROS-mediated mutagenesis; AR-mediated mutagenesis; mitotic defects + replication stress; non-canonical impaired HR; replication stress; APOBEC; canonical impaired HR.
According to a paper published in @cp-cancercell.bsky.social by the @su2c.bsky.social Colorectal Cancer Dream, they have been able to use mutagenic agents to engineer an MMRd genotype in immunoresistant cells to generate an immunogenic phenotype
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
Induction of a mismatch repair deficient genotype by tailored chemical mutagenesis in experimental models of cancer
Rousseau et al. show that tailored mutagenic chemical treatment induces a mismatch
repair deficient genotype by epigenetic Msh2 silencing leading to potent immune response
in immunoresistant tumor mod...
www.cell.com
July 21, 2025 at 6:02 PM
According to a paper published in @cp-cancercell.bsky.social by the @su2c.bsky.social Colorectal Cancer Dream, they have been able to use mutagenic agents to engineer an MMRd genotype in immunoresistant cells to generate an immunogenic phenotype
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
Great footage of the first gay-rights march in New Orleans history — in 1977, circa peak Anita Bryant.
(Via the Historic New Orleans Collection, hnoc.org)
www.youtube.com/watch?v=Mmrd...
(Via the Historic New Orleans Collection, hnoc.org)
www.youtube.com/watch?v=Mmrd...
The Gay Panic That Brought the LGBT Rights Movement to New Orleans
YouTube video by The Historic New Orleans Collection
www.youtube.com
June 17, 2025 at 11:56 PM
Great footage of the first gay-rights march in New Orleans history — in 1977, circa peak Anita Bryant.
(Via the Historic New Orleans Collection, hnoc.org)
www.youtube.com/watch?v=Mmrd...
(Via the Historic New Orleans Collection, hnoc.org)
www.youtube.com/watch?v=Mmrd...
The MMRD (magical mishap rune division) are trained to contain the magic and then clean it. These people spend years learning how to contain magic and often have incredibly strong cores themselves.
December 21, 2024 at 10:16 AM
The MMRD (magical mishap rune division) are trained to contain the magic and then clean it. These people spend years learning how to contain magic and often have incredibly strong cores themselves.
PACSCL is delighted to have been a test site for the #MMRD model created by @StephanieMLuke & Sharon Mizota.
Read their article at link.springer.com/epdf/10.1007...
Read their article at link.springer.com/epdf/10.1007...
April 3, 2024 at 3:28 PM
PACSCL is delighted to have been a test site for the #MMRD model created by @StephanieMLuke & Sharon Mizota.
Read their article at link.springer.com/epdf/10.1007...
Read their article at link.springer.com/epdf/10.1007...
#Ecological–SociotechnicalIsomorphism & #StabilityLaw of Complex Adaptive Systems.
#Compression–Resonance–TensionIndex #CRTI and the Minimal Model of Resonance Dynamics (MMRD) as a framework to diagnose structural fragility and tipping points in complex systems.
doi.org/10.5281/zeno... 🖖
#Compression–Resonance–TensionIndex #CRTI and the Minimal Model of Resonance Dynamics (MMRD) as a framework to diagnose structural fragility and tipping points in complex systems.
doi.org/10.5281/zeno... 🖖
Ecological–Sociotechnical Isomorphism and the Stability Law of Complex Adaptive Systems
This paper introduces the Compression–Resonance–Tension Index (CRTI) and the Minimal Model of Resonance Dynamics (MMRD) as a diagnostic framework for structural fragility in complex adaptive systems. ...
doi.org
March 12, 2026 at 12:32 PM
#Ecological–SociotechnicalIsomorphism & #StabilityLaw of Complex Adaptive Systems.
#Compression–Resonance–TensionIndex #CRTI and the Minimal Model of Resonance Dynamics (MMRD) as a framework to diagnose structural fragility and tipping points in complex systems.
doi.org/10.5281/zeno... 🖖
#Compression–Resonance–TensionIndex #CRTI and the Minimal Model of Resonance Dynamics (MMRD) as a framework to diagnose structural fragility and tipping points in complex systems.
doi.org/10.5281/zeno... 🖖
Most systemic crises are not caused by chaos, but by excessive structural optimization.
The #MMRD framework derives a critical stability threshold for resonance-driven collapse in complex adaptive networks.
doi.org/10.5281/zeno... 🖖
The #MMRD framework derives a critical stability threshold for resonance-driven collapse in complex adaptive networks.
doi.org/10.5281/zeno... 🖖
The Minimal Model of Resonance Dynamics (MMRD): Structural Singularization and Critical Stability Thresholds in Complex Adaptive Networks
This preprint introduces the Minimal Model of Resonance Dynamics (MMRD), a theoretical framework for analyzing systemic fragility and critical transitions in complex adaptive systems. The model formal...
doi.org
March 12, 2026 at 9:21 AM
Most systemic crises are not caused by chaos, but by excessive structural optimization.
The #MMRD framework derives a critical stability threshold for resonance-driven collapse in complex adaptive networks.
doi.org/10.5281/zeno... 🖖
The #MMRD framework derives a critical stability threshold for resonance-driven collapse in complex adaptive networks.
doi.org/10.5281/zeno... 🖖
Complex systems rarely collapse because of chaos …
they collapse when efficiency erodes structural diversity.
My newPreprint introduces the #MinimalModelOfResonanceDynamics #MMRD & derives a critical stability threshold for systemic collapse in complex adaptive networks. doi.org/10.5281/zeno... 🖖
they collapse when efficiency erodes structural diversity.
My newPreprint introduces the #MinimalModelOfResonanceDynamics #MMRD & derives a critical stability threshold for systemic collapse in complex adaptive networks. doi.org/10.5281/zeno... 🖖
The Minimal Model of Resonance Dynamics (MMRD): Structural Singularization and Critical Stability Thresholds in Complex Adaptive Networks
This preprint introduces the Minimal Model of Resonance Dynamics (MMRD), a theoretical framework for analyzing systemic fragility and critical transitions in complex adaptive systems. The model formal...
doi.org
March 12, 2026 at 9:17 AM
Complex systems rarely collapse because of chaos …
they collapse when efficiency erodes structural diversity.
My newPreprint introduces the #MinimalModelOfResonanceDynamics #MMRD & derives a critical stability threshold for systemic collapse in complex adaptive networks. doi.org/10.5281/zeno... 🖖
they collapse when efficiency erodes structural diversity.
My newPreprint introduces the #MinimalModelOfResonanceDynamics #MMRD & derives a critical stability threshold for systemic collapse in complex adaptive networks. doi.org/10.5281/zeno... 🖖
When complex systems optimize for efficiency, they often lose the ability to absorb disturbances.
This preprint proposes a minimal resonance model explaining the “ #WaterbedEffect” …
pressure never disappears in networks, it only moves. doi.org/10.5281/zeno... 🖖
This preprint proposes a minimal resonance model explaining the “ #WaterbedEffect” …
pressure never disappears in networks, it only moves. doi.org/10.5281/zeno... 🖖
Resonance Dynamics in Complex Adaptive Systems: A Minimal Model of the Waterbed Effect and Structural Singularization
This preprint introduces the Minimal Model of Resonance Dynamics (MMRD), a theoretical framework designed to analyze systemic fragility in complex adaptive systems (CAS). Modern socio-technical and ec...
doi.org
March 12, 2026 at 8:53 AM
When complex systems optimize for efficiency, they often lose the ability to absorb disturbances.
This preprint proposes a minimal resonance model explaining the “ #WaterbedEffect” …
pressure never disappears in networks, it only moves. doi.org/10.5281/zeno... 🖖
This preprint proposes a minimal resonance model explaining the “ #WaterbedEffect” …
pressure never disappears in networks, it only moves. doi.org/10.5281/zeno... 🖖
What happens when systems optimize efficiency until they lose the capacity to absorb shocks?
My new preprint proposes a minimal resonance model explaining why pressure in complex networks never disappears …
it redistributes. doi.org/10.5281/zeno... 🖖
My new preprint proposes a minimal resonance model explaining why pressure in complex networks never disappears …
it redistributes. doi.org/10.5281/zeno... 🖖
Resonance Dynamics in Complex Adaptive Systems: A Minimal Model of the Waterbed Effect and Structural Singularization
This preprint introduces the Minimal Model of Resonance Dynamics (MMRD), a theoretical framework designed to analyze systemic fragility in complex adaptive systems (CAS). Modern socio-technical and ec...
doi.org
March 12, 2026 at 8:48 AM
What happens when systems optimize efficiency until they lose the capacity to absorb shocks?
My new preprint proposes a minimal resonance model explaining why pressure in complex networks never disappears …
it redistributes. doi.org/10.5281/zeno... 🖖
My new preprint proposes a minimal resonance model explaining why pressure in complex networks never disappears …
it redistributes. doi.org/10.5281/zeno... 🖖
Danny Fervent – Summer Dreams
Danny Fervent - Summer Dreams (2025) Label: Mental Madness Germany Catnum: MMRD 1992 Download: Danny_Fervent_-_Summer_Dreams-(MMRD_1992)-WEB-2025-iDC
Danny Fervent - Summer Dreams (2025) Label: Mental Madness Germany Catnum: MMRD 1992 Download: Danny_Fervent_-_Summer_Dreams-(MMRD_1992)-WEB-2025-iDC
Danny Fervent – Summer Dreams
Danny Fervent - Summer Dreams (2025) Label: Mental Madness Germany Catnum: MMRD 1992 Download: Danny_Fervent_-_Summer_Dreams-(MMRD_1992)-WEB-2025-iDC
dance1233.wordpress.com
June 28, 2025 at 9:11 AM
Danny Fervent – Summer Dreams
Danny Fervent - Summer Dreams (2025) Label: Mental Madness Germany Catnum: MMRD 1992 Download: Danny_Fervent_-_Summer_Dreams-(MMRD_1992)-WEB-2025-iDC
Danny Fervent - Summer Dreams (2025) Label: Mental Madness Germany Catnum: MMRD 1992 Download: Danny_Fervent_-_Summer_Dreams-(MMRD_1992)-WEB-2025-iDC
Just called the pediatrician to confirm my kids were all MMRd up and the lady helping me said they are getting nonstop calls like mine.
March 4, 2025 at 2:28 PM
Just called the pediatrician to confirm my kids were all MMRd up and the lady helping me said they are getting nonstop calls like mine.
🔴 LIVE IN YOUTUBE: Tin tức trực tiếp buổi sáng ở mỹ 25-5-2025
Nhấn vào đây để xem: www.youtube.com/watch?v=mMrD...
#tintuc #UNV #tiengviet #livenews #tructiep #hoaky#nguoiviet #live #youtubelive
#vietnamese #live #vietlive #tinmoi24h #tn24h #tinnong #tiengviet #nguoiviet #viet #vietnam
Nhấn vào đây để xem: www.youtube.com/watch?v=mMrD...
#tintuc #UNV #tiengviet #livenews #tructiep #hoaky#nguoiviet #live #youtubelive
#vietnamese #live #vietlive #tinmoi24h #tn24h #tinnong #tiengviet #nguoiviet #viet #vietnam
Tin tức trực tiếp buổi sáng ở mỹ 25-5-2025 | BREAKING NEWS | UNV Tin Buổi Sáng 【A5524】
YouTube video by UNV Tin Buổi Sáng
www.youtube.com
May 25, 2025 at 5:38 PM
🔴 LIVE IN YOUTUBE: Tin tức trực tiếp buổi sáng ở mỹ 25-5-2025
Nhấn vào đây để xem: www.youtube.com/watch?v=mMrD...
#tintuc #UNV #tiengviet #livenews #tructiep #hoaky#nguoiviet #live #youtubelive
#vietnamese #live #vietlive #tinmoi24h #tn24h #tinnong #tiengviet #nguoiviet #viet #vietnam
Nhấn vào đây để xem: www.youtube.com/watch?v=mMrD...
#tintuc #UNV #tiengviet #livenews #tructiep #hoaky#nguoiviet #live #youtubelive
#vietnamese #live #vietlive #tinmoi24h #tn24h #tinnong #tiengviet #nguoiviet #viet #vietnam
📑Immunotherapy responses differ markedly between MMR-proficient and -deficient colorectal cancers. A scRNA-seq study of 62 patients by @pelkalab.bsky.social et al. (Hacohen lab) reveals key immune–tumor communication differences that may explain this.
#JournalClub
www.cell.com/cell/fulltex...
#JournalClub
www.cell.com/cell/fulltex...
Spatially organized multicellular immune hubs in human colorectal cancer
Single-cell transcriptomics-based co-variation analysis of human colorectal cancer
identifies a spatially resolved myeloid-rich inflammatory hub that is shared by mismatch
repair-deficient (MMRd) and ...
www.cell.com
August 8, 2025 at 11:07 AM
📑Immunotherapy responses differ markedly between MMR-proficient and -deficient colorectal cancers. A scRNA-seq study of 62 patients by @pelkalab.bsky.social et al. (Hacohen lab) reveals key immune–tumor communication differences that may explain this.
#JournalClub
www.cell.com/cell/fulltex...
#JournalClub
www.cell.com/cell/fulltex...
A multicenter study of 33 advanced EC tumors treated with ICIs reveals:
MMRd/MSI‑H tumors show ~81% TLS/LA vs 17% in MMRp/MSS, with strong CD8–B cell interactions; Low stromal CD68⁺ TAM density strongly predicts ICI response (OR=11.7; AUC=0.75)
🔗 Read more: buff.ly/3GlHjtf
#EndometrialCancer
MMRd/MSI‑H tumors show ~81% TLS/LA vs 17% in MMRp/MSS, with strong CD8–B cell interactions; Low stromal CD68⁺ TAM density strongly predicts ICI response (OR=11.7; AUC=0.75)
🔗 Read more: buff.ly/3GlHjtf
#EndometrialCancer
December 19, 2025 at 8:15 AM
A multicenter study of 33 advanced EC tumors treated with ICIs reveals:
MMRd/MSI‑H tumors show ~81% TLS/LA vs 17% in MMRp/MSS, with strong CD8–B cell interactions; Low stromal CD68⁺ TAM density strongly predicts ICI response (OR=11.7; AUC=0.75)
🔗 Read more: buff.ly/3GlHjtf
#EndometrialCancer
MMRd/MSI‑H tumors show ~81% TLS/LA vs 17% in MMRp/MSS, with strong CD8–B cell interactions; Low stromal CD68⁺ TAM density strongly predicts ICI response (OR=11.7; AUC=0.75)
🔗 Read more: buff.ly/3GlHjtf
#EndometrialCancer
This new study provides crucial evidence on the predictive role of pre-HSCT mMRD in haplo-HSCT for #AcuteMyeloidLeukemia patients. #medsky
Click:
Click:
Haploidentical Hematopoietic Stem Cell Transplantation for AML Patients with Persistent Molecular MRD - Current Medical Science
Objective The combined use of quantitative real-time polymerase chain reaction (qPCR) and next-generation sequencing (NGS) to detect molecular measurable residual disease (mMRD) has been shown to…
link.springer.com
August 29, 2025 at 5:58 AM
This new study provides crucial evidence on the predictive role of pre-HSCT mMRD in haplo-HSCT for #AcuteMyeloidLeukemia patients. #medsky
Click:
Click:
ctDNA after surgery for MMRd tumors can prevent cancer recurrence – Yelena Janjigian at AACR25
@mskcancercenter.bsky.social @theaacr.bsky.social
oncodaily.com/insight/yele...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #AACR25 #AACR2025 #MMRd #CancerRecurrence #ctDNA
@mskcancercenter.bsky.social @theaacr.bsky.social
oncodaily.com/insight/yele...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #AACR25 #AACR2025 #MMRd #CancerRecurrence #ctDNA
ctDNA after surgery for MMRd tumors can prevent cancer recurrence - Yelena Janjigian at AACR25 - OncoDaily
Yelena Janjigian presents new clinical trial findings at AACR 2025 showing that ctDNA testing after cancer surgery can guide personalized immunotherapy and help prevent recurrence.
oncodaily.com
April 28, 2025 at 6:53 PM
ctDNA after surgery for MMRd tumors can prevent cancer recurrence – Yelena Janjigian at AACR25
@mskcancercenter.bsky.social @theaacr.bsky.social
oncodaily.com/insight/yele...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #AACR25 #AACR2025 #MMRd #CancerRecurrence #ctDNA
@mskcancercenter.bsky.social @theaacr.bsky.social
oncodaily.com/insight/yele...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #AACR25 #AACR2025 #MMRd #CancerRecurrence #ctDNA