How I turn "Sam Author" book to life 👇
Her book - 1 - bsky.app/profile/mpro...
book-2- bsky.app/profile/mpro...
book-3
bsky.app/profile/mpro...
About Sam Author - myfathersfavorite.now.site/home
thanks sam 👩❤️👩
Her book - 1 - bsky.app/profile/mpro...
book-2- bsky.app/profile/mpro...
book-3
bsky.app/profile/mpro...
About Sam Author - myfathersfavorite.now.site/home
thanks sam 👩❤️👩
November 14, 2025 at 2:00 PM
How I turn "Sam Author" book to life 👇
Her book - 1 - bsky.app/profile/mpro...
book-2- bsky.app/profile/mpro...
book-3
bsky.app/profile/mpro...
About Sam Author - myfathersfavorite.now.site/home
thanks sam 👩❤️👩
Her book - 1 - bsky.app/profile/mpro...
book-2- bsky.app/profile/mpro...
book-3
bsky.app/profile/mpro...
About Sam Author - myfathersfavorite.now.site/home
thanks sam 👩❤️👩
🩸A new study shows that adding SARS-CoV-2’s main protease (Mpro) enzyme to plasma from healthy donors can trigger blood clots by activating coagulation factors VII and XII. buff.ly/hWZB7aS
🩸This may help explain why COVID increases blood clot risk.
#medsky #hemesky #IDsky 🛟😷🧪
🩸This may help explain why COVID increases blood clot risk.
#medsky #hemesky #IDsky 🛟😷🧪
August 2, 2025 at 6:26 PM
🩸A new study shows that adding SARS-CoV-2’s main protease (Mpro) enzyme to plasma from healthy donors can trigger blood clots by activating coagulation factors VII and XII. buff.ly/hWZB7aS
🩸This may help explain why COVID increases blood clot risk.
#medsky #hemesky #IDsky 🛟😷🧪
🩸This may help explain why COVID increases blood clot risk.
#medsky #hemesky #IDsky 🛟😷🧪
A novel series of inhibitors that target #SARSCoV2's
'Mpro' have been discovered by scientists at Wistar Institute in Philadelphia. Mpro is a key coronavirus enzyme that possesses pivotal roles in viral replication & transcription. Inhibiting it is key to stopping infection phys.org/news/2024-10...
'Mpro' have been discovered by scientists at Wistar Institute in Philadelphia. Mpro is a key coronavirus enzyme that possesses pivotal roles in viral replication & transcription. Inhibiting it is key to stopping infection phys.org/news/2024-10...
October 11, 2024 at 9:31 AM
A novel series of inhibitors that target #SARSCoV2's
'Mpro' have been discovered by scientists at Wistar Institute in Philadelphia. Mpro is a key coronavirus enzyme that possesses pivotal roles in viral replication & transcription. Inhibiting it is key to stopping infection phys.org/news/2024-10...
'Mpro' have been discovered by scientists at Wistar Institute in Philadelphia. Mpro is a key coronavirus enzyme that possesses pivotal roles in viral replication & transcription. Inhibiting it is key to stopping infection phys.org/news/2024-10...
This is interesting: A second COVID protein, the main protease, triggers blood clotting. This protein is *not* in vaccines used in developed countries, but it is highly conserved in coronaviruses including common cold coronaviruses. Ref Pagotto et al, www.nature.com/articles/s42....
The main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII - Communications Biology
SARS-CoV-2 main protease (Mpro) directly activates coagulation by cleaving factors VII and XII, showing a broader protease specificity and revealing a novel mechanism linking COVID-19 infection to thr...
www.nature.com
August 4, 2025 at 12:49 AM
This is interesting: A second COVID protein, the main protease, triggers blood clotting. This protein is *not* in vaccines used in developed countries, but it is highly conserved in coronaviruses including common cold coronaviruses. Ref Pagotto et al, www.nature.com/articles/s42....
Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy | Science Advances www.science.org/doi/10.1126/...
Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy
This study describes a class of potent, bioavailable SARS-CoV-2 MPro inhibitors having an unusual mechanism of inhibition.
www.science.org
April 26, 2025 at 1:15 AM
Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy | Science Advances www.science.org/doi/10.1126/...
Here you can see a crystal structure of ZM-097 inhibitor in complex with SARS-CoV-2 main protease MPro (PDB code: 8ZBP)
Rendering by Francisco J. Enguita made with #ProteinImager
#SciArt #molecularart #protease #mpro #inhibitor #antiviral #sarscov2 #xtal #xray
Rendering by Francisco J. Enguita made with #ProteinImager
#SciArt #molecularart #protease #mpro #inhibitor #antiviral #sarscov2 #xtal #xray
June 29, 2026 at 10:25 AM
Here you can see a crystal structure of ZM-097 inhibitor in complex with SARS-CoV-2 main protease MPro (PDB code: 8ZBP)
Rendering by Francisco J. Enguita made with #ProteinImager
#SciArt #molecularart #protease #mpro #inhibitor #antiviral #sarscov2 #xtal #xray
Rendering by Francisco J. Enguita made with #ProteinImager
#SciArt #molecularart #protease #mpro #inhibitor #antiviral #sarscov2 #xtal #xray
Daiki has been chosen as Kumagai's debut opponent for the March 21st Mpro show. 😭💕
January 10, 2026 at 12:34 PM
Daiki has been chosen as Kumagai's debut opponent for the March 21st Mpro show. 😭💕
🦠 We’re excited to announce our first competition in partnership with @asapdiscovery.bsky.social and @omsf.io!
Test your skills across three sub-challenges revolving around SARS-CoV-2 and MERS-CoV Mpro🧵
Full details: polarishub.io/competitions
Blog: polarishub.io/blog/antivir...
Test your skills across three sub-challenges revolving around SARS-CoV-2 and MERS-CoV Mpro🧵
Full details: polarishub.io/competitions
Blog: polarishub.io/blog/antivir...
December 3, 2024 at 3:13 PM
🦠 We’re excited to announce our first competition in partnership with @asapdiscovery.bsky.social and @omsf.io!
Test your skills across three sub-challenges revolving around SARS-CoV-2 and MERS-CoV Mpro🧵
Full details: polarishub.io/competitions
Blog: polarishub.io/blog/antivir...
Test your skills across three sub-challenges revolving around SARS-CoV-2 and MERS-CoV Mpro🧵
Full details: polarishub.io/competitions
Blog: polarishub.io/blog/antivir...
Ko(mpro)miks - grafický román o umění dohody, udržování rovnováhy i ošidných smlouvách s ďáblem
#knihyconikdynenapíšu
#knihyconikdynenapíšu
October 21, 2024 at 2:31 PM
Ko(mpro)miks - grafický román o umění dohody, udržování rovnováhy i ošidných smlouvách s ďáblem
#knihyconikdynenapíšu
#knihyconikdynenapíšu
🦠💊 Powerful new COVID drug candidate
New drug candidates block coronaviruses by jamming the virus’s main enzyme.
They work against SARS-CoV-2, MERS & resistant strains – and could be ready for the next pandemic.
🔗 doi.org/10.1126/scia...
#SciComm #COVID19 #Antivirals 🧪
New drug candidates block coronaviruses by jamming the virus’s main enzyme.
They work against SARS-CoV-2, MERS & resistant strains – and could be ready for the next pandemic.
🔗 doi.org/10.1126/scia...
#SciComm #COVID19 #Antivirals 🧪
Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy
This study describes a class of potent, bioavailable SARS-CoV-2 MPro inhibitors having an unusual mechanism of inhibition.
doi.org
April 25, 2025 at 4:44 PM
🦠💊 Powerful new COVID drug candidate
New drug candidates block coronaviruses by jamming the virus’s main enzyme.
They work against SARS-CoV-2, MERS & resistant strains – and could be ready for the next pandemic.
🔗 doi.org/10.1126/scia...
#SciComm #COVID19 #Antivirals 🧪
New drug candidates block coronaviruses by jamming the virus’s main enzyme.
They work against SARS-CoV-2, MERS & resistant strains – and could be ready for the next pandemic.
🔗 doi.org/10.1126/scia...
#SciComm #COVID19 #Antivirals 🧪
SARS-CoV-2’s Mpro protein promotes blood clotting by activating key coagulation factors
www.thailandmedical.news/news/sars-co...
www.thailandmedical.news/news/sars-co...
SARS-CoV-2’s Mpro protein promotes blood clotting by activating key coagulation factors - Thailand Medical News
www.thailandmedical.news
November 13, 2024 at 8:12 AM
SARS-CoV-2’s Mpro protein promotes blood clotting by activating key coagulation factors
www.thailandmedical.news/news/sars-co...
www.thailandmedical.news/news/sars-co...
Wechselwirkungen mit dem Angiotensin-Converting-Enzym 2 (ACE2), die Hemmung der SARS-CoV-2-Protease Mpro, die Modulation des σ-1-Rezeptors und die Unterdrückung der ICAM-1-Hochregulierung.
Angesichts der überschaubaren Stichprobengröße und der geringen Anzahl von Infektionen
Angesichts der überschaubaren Stichprobengröße und der geringen Anzahl von Infektionen
September 2, 2025 at 4:17 PM
Wechselwirkungen mit dem Angiotensin-Converting-Enzym 2 (ACE2), die Hemmung der SARS-CoV-2-Protease Mpro, die Modulation des σ-1-Rezeptors und die Unterdrückung der ICAM-1-Hochregulierung.
Angesichts der überschaubaren Stichprobengröße und der geringen Anzahl von Infektionen
Angesichts der überschaubaren Stichprobengröße und der geringen Anzahl von Infektionen
Novel mechanism linking SARS-CoV-2 infection to thrombotic complications. It’s main protease (Mpro) triggers plasma clotting in vitro by activating coagulation factors VII and FXII.
Well that sound promising for a virus that is known to create permanent reservoirs in humans
Well that sound promising for a virus that is known to create permanent reservoirs in humans
The main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII - Communications Biology
SARS-CoV-2 main protease (Mpro) directly activates coagulation by cleaving factors VII and XII, showing a broader protease specificity and revealing a novel mechanism linking COVID-19 infection to thr...
www.nature.com
August 4, 2025 at 9:13 AM
Novel mechanism linking SARS-CoV-2 infection to thrombotic complications. It’s main protease (Mpro) triggers plasma clotting in vitro by activating coagulation factors VII and FXII.
Well that sound promising for a virus that is known to create permanent reservoirs in humans
Well that sound promising for a virus that is known to create permanent reservoirs in humans
#MedSky🧪 #IDSky #Drugdevelopment interesting study on An oral non-covalent non-peptidic inhibitor of #SARSCoV2 #Mpro ameliorates #viralreplication & pathogenesis in vivo
www.cell.com/cell-reports...
www.cell.com/cell-reports...
An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo
Zhou et al. describe NZ-804, a non-peptidic inhibitor of the SARS-CoV-2 Mpro. It shows
potent antiviral activity with low-nanomolar IC50 and EC50 in human lung cells and
primary airway epithelial cult...
www.cell.com
November 11, 2024 at 8:11 PM
#MedSky🧪 #IDSky #Drugdevelopment interesting study on An oral non-covalent non-peptidic inhibitor of #SARSCoV2 #Mpro ameliorates #viralreplication & pathogenesis in vivo
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Simplesmente acabou de acontecer um dos maiores absurdos que já vimos no mundo dos concursos: há 2 semanas, o MPRO divulgou lista com 105 candidatos aprovados para a prova oral e HOJE publicou uma nova lista com somente 37 nomes, alegando ERRO na anterior.
September 4, 2024 at 11:33 AM
Simplesmente acabou de acontecer um dos maiores absurdos que já vimos no mundo dos concursos: há 2 semanas, o MPRO divulgou lista com 105 candidatos aprovados para a prova oral e HOJE publicou uma nova lista com somente 37 nomes, alegando ERRO na anterior.
The main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII
Uncontrolled or systemic inflammation after SC2 infection is correlated with increased risk to coagulation (blood clotting).
www.nature.com/artic...
1/6
Uncontrolled or systemic inflammation after SC2 infection is correlated with increased risk to coagulation (blood clotting).
www.nature.com/artic...
1/6
The main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII
Communications Biology - SARS-CoV-2 main protease (Mpro) directly activates coagulation by cleaving factors VII and XII, showing a broader protease specificity and revealing a novel mechanism...
www.nature.com
August 3, 2025 at 2:28 PM
The main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII
Uncontrolled or systemic inflammation after SC2 infection is correlated with increased risk to coagulation (blood clotting).
www.nature.com/artic...
1/6
Uncontrolled or systemic inflammation after SC2 infection is correlated with increased risk to coagulation (blood clotting).
www.nature.com/artic...
1/6
Feeling utterly fucking insane for recognizing the Mpro superfans from Mirai & Haru. Just sitting here like "Hey it's that guy from Kenoh vs. Hayato 'Jr' Fujita 12/12/2009 Korakuen Hall". Like okay, freak.
June 8, 2026 at 9:26 PM
Feeling utterly fucking insane for recognizing the Mpro superfans from Mirai & Haru. Just sitting here like "Hey it's that guy from Kenoh vs. Hayato 'Jr' Fujita 12/12/2009 Korakuen Hall". Like okay, freak.
anyway guess who found their mpro DVDs and has decided to make it everyone's problem??
June 15, 2026 at 12:12 AM
anyway guess who found their mpro DVDs and has decided to make it everyone's problem??
Kenoh started talking about Kumagai's debut and someone in the chat suggested that Kenoh go to MPro to face Kumagai too.
"I can't do that just yet. I made a promise to wait for someone before I can fight in MPro again"
"I can't do that just yet. I made a promise to wait for someone before I can fight in MPro again"
January 11, 2026 at 1:20 PM
Kenoh started talking about Kumagai's debut and someone in the chat suggested that Kenoh go to MPro to face Kumagai too.
"I can't do that just yet. I made a promise to wait for someone before I can fight in MPro again"
"I can't do that just yet. I made a promise to wait for someone before I can fight in MPro again"
✨Please Repost! My newsletter is out.✨
In this issue:
🦀SARS-CoV-2 triggers rapid metastatic cancer growth
🩸SARS-2 Mpro activates clotting factors VII & XII
💊Larazotide treats MIS-C. Trial planned for Long COVID.
🫧Exosomes as biomarker for Long COVID
& much more buff.ly/dZRuMkX
#medsky #pedsky 🛟😷🧪
In this issue:
🦀SARS-CoV-2 triggers rapid metastatic cancer growth
🩸SARS-2 Mpro activates clotting factors VII & XII
💊Larazotide treats MIS-C. Trial planned for Long COVID.
🫧Exosomes as biomarker for Long COVID
& much more buff.ly/dZRuMkX
#medsky #pedsky 🛟😷🧪
August 4, 2025 at 4:41 AM
✨Please Repost! My newsletter is out.✨
In this issue:
🦀SARS-CoV-2 triggers rapid metastatic cancer growth
🩸SARS-2 Mpro activates clotting factors VII & XII
💊Larazotide treats MIS-C. Trial planned for Long COVID.
🫧Exosomes as biomarker for Long COVID
& much more buff.ly/dZRuMkX
#medsky #pedsky 🛟😷🧪
In this issue:
🦀SARS-CoV-2 triggers rapid metastatic cancer growth
🩸SARS-2 Mpro activates clotting factors VII & XII
💊Larazotide treats MIS-C. Trial planned for Long COVID.
🫧Exosomes as biomarker for Long COVID
& much more buff.ly/dZRuMkX
#medsky #pedsky 🛟😷🧪
ooo, cool - hay suzy- just droped the story - bsky.app/profile/mpro...
just dropped the story- "Pip the Penguin and the Lost Pebble"
September 14, 2025 at 3:28 PM
ooo, cool - hay suzy- just droped the story - bsky.app/profile/mpro...
MIRAI just joined Michinoku Pro after being revealed as Mayu Iwatani's mystery opponent during their "GRANDE UNO" (still happening rn). I'm assuming she joined instead of SENJO (basically joshi MPro) just bcos MPro does run more shows around Iwate pref.
Src: ShuPro (週刊プロレス)
#michipro 🤼♀️🇯🇵
Src: ShuPro (週刊プロレス)
#michipro 🤼♀️🇯🇵
November 2, 2025 at 7:38 AM
MIRAI just joined Michinoku Pro after being revealed as Mayu Iwatani's mystery opponent during their "GRANDE UNO" (still happening rn). I'm assuming she joined instead of SENJO (basically joshi MPro) just bcos MPro does run more shows around Iwate pref.
Src: ShuPro (週刊プロレス)
#michipro 🤼♀️🇯🇵
Src: ShuPro (週刊プロレス)
#michipro 🤼♀️🇯🇵
November 18, 2024 at 6:18 PM