#MSH6
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stairwaytokevin.bsky.social
DNA repair is a fundamental biological process that prevents DNA damage from resulting in mutations. A new lab paper from the Monroe lab finds evidence that the DNA repair protein MSH6 convergently evolved histone reader domains,
that target histone modifications in active genes in plants & animals.
left: Predicted structure of human MSH6 PWWP domain interaction with H3K36me3, highlighting aromatic residues that form binding cage. Right: Predicted structure of Arabidopsis thaliana MSH6 Tudor domain interaction with H3K4me1, highlighting aromatic residues that form the binding cage Taxonomic diversity of MSH6 histone reader presence and absence. Tree is based on NCBI taxonomy, showing species for which unambiguous MSH6 orthologs and domain presence/absence could be called.
October 21, 2024 at 5:35 PM
stairwaytokevin.bsky.social
We argue that this pattern of convergence and evidence of evolutionary conservation MSH6 domain architecture and histone readers suggests that epigenome-guided DNA repair that preferentially repairs mutation rates in functionally important genome regions is an adaptive trait.
Conservation in MSH6 domain architecture and histone readers. a) MSH6 domain architecture for mSH6 proteins with and without histone reader domains, aligned to MutS1 domain of MSH6. Relationship between distance to H3 amino acids and amino acid Shannon entropy across all species, colored by conservation. b) PWWP domains and c) tudor domains. Consensus amino acids with corresponding functional class shown.
October 21, 2024 at 5:41 PM
sinamajidian.bsky.social
Convergent evolution of epigenome recruited DNA repair across the Tree of Life
elifesciences.org/reviewed-pre...
Overview of MSH6 structure and histone reader domains a) Predicted (Alphafold2) structures for MSH6 (MutS homolog), together with b) heatmaps showing predicted alignment error, a measure for predicted folding confidence. The “Linker” regions marks the region, predicted to be intrinsically disordered, that separates MutS repair domains from histone reader domains, c) Alignment between PWWP and Tudor domains of MSH6, with shared amino acids highlighted by black borders and arrows highlighted experimentally determined amino acids that bind histone PTMs. d) Predicted structure of human MSH6 PWWP domain interaction with H3K36me3, highlighting aromatic residues that form binding cage, e) Predicted structure of Arabidopsis MSH6 Tudor domain interaction with H3K4me1, highlighting aromatic residues that form binding cage. Taxonomic diversity of MSH6 histone reader presence and absence. Tree is based on NCBI taxonomy, showing species for which unambiguous MSH6 orthologs and domain presence/absence could be called. Tree generated with PhyloT, with branches representing taxonomic hierarchy, not time. See Supplemental Table 1 for complete list of species and MSH6 domain calls. For this visualization, fungal genera are represented by a single species. The color of branches indicates proportion of species containing histone reader domains in MSH6 (green = Tudor, orange = PWWP, gray = No reader).
April 20, 2025 at 2:36 AM
oncoalert.bsky.social
These findings support the continuation of PSA screening for MSH2 and MSH6 carriers, though further studies are needed to refine screening recommendations for other MMR gene carriers. #ProstateCancer
December 15, 2024 at 3:17 PM
smkavanaugh.bsky.social
#lynchsyndrome #msh6 #lynchies #lynchsyndromeawarenessday
#previvor
March 22, 2025 at 5:43 PM
jamesfasham.bsky.social
Something for those working in cancer genetics 🦀 #ESHG2025

Fulya Taylan
- Germline whole WGS
- childhood leukemia in Sweden
-inc T21, TP53, CEPBA
- incidental inc. MSH6, PALB2
May 24, 2025 at 3:45 PM
diedrereitz.bsky.social
Very happy to share that I’ve been awarded a K99 Career Development Award from NIGMS for my work on MSH2-MSH6 and its role in recombination-mediated rearrangements.

Big thanks to my mentor, Wolf Heyer, co-mentor, Megan Dennis, letter writers, and colleagues.

mmg.ucdavis.edu/news/two-mmg...
Two MMG rising academic stars, Diedre Reitz and Yuka Kitamura
Congratulations to Diedre Reitz and Yuka Kitamura, postdoctoral fellows in the Heyer and Namekawa laboratories, respectively, for being awarded prestigious K99 grants from the National Institutes of H...
mmg.ucdavis.edu
July 30, 2025 at 10:35 PM
yggdrasilhugger.bsky.social
Raises hand (msh6)
November 17, 2024 at 5:31 AM
bettycjung.bsky.social
The National Comprehensive Cancer Network (NCCN) guidelines recommend genetic testing for ovarian cancer susceptibility genes (ATM, BRCA1, BRCA2, BRIP1, MLH1, MSH2, MSH6, EPCAM, PALB2, RAD51C, and RAD51D) in individuals
July 21, 2025 at 10:28 PM
bjsurgery.bsky.social
Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database
➡️ doi.org/10.1093/bjs/...
Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database
This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on the risk of metachronous colorectal canc
doi.org
April 22, 2025 at 11:16 AM
racarr51.bsky.social
RAC9306. EVG & Discussion. I thought this was a mitotic sebaceoma / sebaceous adenoma. MSH6 & PMS2 requested. So far been sceptical about clear-cut Seb Ca & MTS. See a lot mitotically active lesions erroneously called carcinoma.
October 27, 2025 at 3:58 PM
genetionary.bsky.social
What are germline mutations and what role do they play in hereditary cancer?

The infographic can be downloaded at: genetionary.org/resources/

#HereditaryCancerWeek #GermlineMutations #Cancer #GeneticTesting #LynchSyndrome #BRCA2 #BRCA1 #CHEK2 #ATM #PALB2 #PTEN #MLH1 #MSH2 #MSH6 #TP53 #DNA
September 29, 2025 at 2:37 PM
cp-cellreports.bsky.social
MSH6 regulates cGAS activity in antiviral and antitumor signaling pathways by governing its cytosolic/nuclear distribution
MSH6 regulates cGAS activity in antiviral and antitumor signaling pathways by governing its cytosolic/nuclear distribution
Yang et al. identify MSH6 as a negative regulator of cGAS that promotes cGAS nuclear localization by strengthening its interaction with importin-α protein, thereby suppressing cGAS condensation and activity, consequently dampening antiviral and antitumor immunity. In tumors, MSH6 loss enhances the antitumor effect of heat-inactivated MVA.
dlvr.it
March 27, 2026 at 12:35 PM
cikoria.net
Rettenetesen nehezemre esik, hogy ezt ne vegyem meg, pláne ennyiért: Zoom F1 + msh6 Digitális felvevő együtt 40.000 forint.

Nem mai darab, de amire kellene, arra egyszerűen tökéletes.
Zoom F1 + msh6 Digitális felvevő eladó | GS Fanatic
Hibátlan Zoom F1 digitális felvevő eladó. Eredetileg lavalier szett, így a gyári lav mikrofon jár hozzá, plusz egy MSH6 Zoom mid-side mikrofon kapszula, amiv...
gsfanatic.com
September 28, 2025 at 9:02 AM
apccc.bsky.social
Outcomes of 10 years of PSA screening for #ProstateCancer in Norwegian men w/ Lynch syndrome

onlinelibrary.wiley.com/doi/10.1002/...

findings support the continuation of PSA screening for MSH2 and MSH6 carriers, further studies needed to refine screening recommendations for other MMR gene carriers
Outcomes of 10 years of PSA screening for prostate cancer in Norwegian men with Lynch syndrome
Background Pathogenic germline variants in the mismatch repair (MMR) genes are associated with an increased risk of prostate cancer (PCa). Since 2010 we have recommended MMR carriers annual PSA test.....
onlinelibrary.wiley.com
December 13, 2024 at 6:06 PM
mderbecker.bsky.social
Can't forget this.

www.youtube.com/watch?v=MSH6...
Welcome to Zangaro - The Dogs Of War (1980)
YouTube video by zangaro77
www.youtube.com
August 20, 2026 at 3:28 PM
racarr51.bsky.social
RAC9306: EVG & Commentry. Then MSH6 (loss) & PMS2. Advised referral to medical genetics to rule out Muir Torre Syndrome (familial cancer associated syndrome).
November 4, 2025 at 7:05 AM
rridrobot.bsky.social
@proteintech.bsky.social's resource, RRID:AB_2881567, was just reported to be used in the paper. We value the author's support of reproducibility. #RRID #ReproducibleResearch #STMpublishing
MSH6 regulates cGAS activity in antiviral and antitumor signaling pathways by governing its cytosolic/nuclear distribution
Read the full paper: MSH6 regulates cGAS activity in antiviral and antitumor signaling pathways by governing its cytosolic/nuclear distribution
doi.org
March 14, 2026 at 7:01 AM
parabello.bsky.social
Found out this week that my two sons did NOT inherit the MSH6 Lynch Syndrome gene from me...so relieved for some good news in this world 😌
January 26, 2025 at 3:29 PM
brancolab.bsky.social
An SVA insertion explains 0.5% cases of Lynch syndrome, apparently.
Lynch syndrome caused by SINE-VNTR-Alu-F retrotransposon insert in MSH6 confirmed after 20 years of testing: a case report and literature review - PubMed
Although RTs insertions do not seem to be a common cause of Lynch syndrome, the number might be underestimated because of the difficulties in detecting these variants with well-established methods lik...
pubmed.ncbi.nlm.nih.gov
October 15, 2025 at 11:10 AM
mbottery.bsky.social
Here, we show that variants in the MMR gene, msh6, are almost uniquely found in strains harbouring azole resistance and result in up to 5-fold increase in mutation rates.
December 16, 2024 at 12:04 PM
tumorijournal.bsky.social
💥 Recent studies indicate that combining polygenic risk scores (PRS) with carrier status for germline pathogenic variants in #colorectalcancer genes, such as MLH1, MSH2, MSH6, and PMS2, enhances CRC #prediction.

buff.ly/ZMD7LEF
#CanSky #OncSky
March 12, 2025 at 5:00 PM
ibis-investigacion.bsky.social
La Dra. Giráldez ha sido reconocida por su trabajo en cáncer colorrectal de inicio temprano y sus investigaciones en la genética del proceso identificando los genes MSH6 y MUTYH, además de su contribución al desarrollo de técnicas innovadoras de análisis de biomarcadores como el “Phospho-RNA-seq”
March 21, 2025 at 1:26 PM