MyD88 cell biology explored in yeast. The fantastic @VictorJCid
and colleagues reveal an unexpected variety of organelles MyD88 can bind in budding yeast.
Kudos to all authors on this exciting finding.
link.springer.com/article/10.1...
and colleagues reveal an unexpected variety of organelles MyD88 can bind in budding yeast.
Kudos to all authors on this exciting finding.
link.springer.com/article/10.1...
MyD88 polymerization and association to cellular membranes in a yeast heterologous model - Cellular and Molecular Life Sciences
MyD88 is a key mediator of Toll-like receptor (TLR) signaling, orchestrating the innate immune response upon stimulation by pathogen-associated molecular patterns (PAMPs). Structurally, MyD88 consists...
link.springer.com
July 26, 2025 at 1:27 PM
MyD88 cell biology explored in yeast. The fantastic @VictorJCid
and colleagues reveal an unexpected variety of organelles MyD88 can bind in budding yeast.
Kudos to all authors on this exciting finding.
link.springer.com/article/10.1...
and colleagues reveal an unexpected variety of organelles MyD88 can bind in budding yeast.
Kudos to all authors on this exciting finding.
link.springer.com/article/10.1...
MyD88 determines T cell fate through BCAP-PI3K signaling @jimmunol.bsky.social
doi.org/10.1093/jimm...
doi.org/10.1093/jimm...
February 24, 2025 at 6:48 PM
MyD88 determines T cell fate through BCAP-PI3K signaling @jimmunol.bsky.social
doi.org/10.1093/jimm...
doi.org/10.1093/jimm...
Out now @nature.com! We report a new means of cell communication: receptor-free signal transduction. TLRs engage MyD88 for minutes, yet myddosomes signal for hours. TRAM releases myddosomes from TLRs, letting them mature and sustain signaling in the cytosol.
rdcu.be/jGdKxErXyAsa
Details below:
rdcu.be/jGdKxErXyAsa
Details below:
September 23, 2026 at 4:29 PM
Out now @nature.com! We report a new means of cell communication: receptor-free signal transduction. TLRs engage MyD88 for minutes, yet myddosomes signal for hours. TRAM releases myddosomes from TLRs, letting them mature and sustain signaling in the cytosol.
rdcu.be/jGdKxErXyAsa
Details below:
rdcu.be/jGdKxErXyAsa
Details below:
Today, the Toll-like Receptors reveal a new mechanism of signal transduction: Receptor-Free Signal Transduction.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
TRAM promotes Toll-like-receptor-free myddosome signal transduction - Nature
TRAM is a regulator of myddosome assembly through dissociating MyD88 from the TLR–TIRAP complex to enable myddosome maturation and durable downstream signal transduction.
www.nature.com
September 23, 2026 at 4:43 PM
Today, the Toll-like Receptors reveal a new mechanism of signal transduction: Receptor-Free Signal Transduction.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Which cells use Myd88 to control Segmented Filamentous Bacteria colonization? Here work explores the hematopoietic MyD88/IL-22 axis during SFB growth. www.mucosalimmunology.org/article/S193...
March 28, 2025 at 2:43 PM
Which cells use Myd88 to control Segmented Filamentous Bacteria colonization? Here work explores the hematopoietic MyD88/IL-22 axis during SFB growth. www.mucosalimmunology.org/article/S193...
MyD88 signaling in myeloid cells induces gastrointestinal tract injury and systemic inflammation after West Nile virus infection @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
January 18, 2026 at 7:04 PM
MyD88 signaling in myeloid cells induces gastrointestinal tract injury and systemic inflammation after West Nile virus infection @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
In 2024, we found small MyD88 clusters called proto-myddosomes forming around TLRs (link below). These clusters are released to build large signaling myddosomes. Is MyD88 release important for TLR signaling? To answer this question, we need to identify a regulator. Stay tuned...
September 22, 2026 at 8:42 PM
In 2024, we found small MyD88 clusters called proto-myddosomes forming around TLRs (link below). These clusters are released to build large signaling myddosomes. Is MyD88 release important for TLR signaling? To answer this question, we need to identify a regulator. Stay tuned...
Metformin indeed nature’s gift that keeps on giving: mechanism of protection against PM2.5 fine particle pollution www.sciencedirect.com/science/arti...
November 29, 2024 at 10:41 AM
Metformin indeed nature’s gift that keeps on giving: mechanism of protection against PM2.5 fine particle pollution www.sciencedirect.com/science/arti...
Microglial MyD88-dependent signaling influences extracellular matrix development and interneuron maturation in the hippocampus https://www.biorxiv.org/content/10.64898/2025.12.08.692987v1
December 11, 2025 at 3:15 PM
Microglial MyD88-dependent signaling influences extracellular matrix development and interneuron maturation in the hippocampus https://www.biorxiv.org/content/10.64898/2025.12.08.692987v1
Nature research paper: TRAM promotes Toll-like-receptor-free myddosome signal transduction
go.nature.com/4hawVQj
go.nature.com/4hawVQj
TRAM promotes Toll-like-receptor-free myddosome signal transduction - Nature
TRAM is a regulator of myddosome assembly through dissociating MyD88 from the TLR–TIRAP complex to enable myddosome maturation and durable downstream signal transduction.
go.nature.com
September 28, 2026 at 2:52 PM
Nature research paper: TRAM promotes Toll-like-receptor-free myddosome signal transduction
go.nature.com/4hawVQj
go.nature.com/4hawVQj
Happy to share the latest paper from the lab on sex differences in the neuroimmune mechanisms underlying anxiety. www.sciencedirect.com/science/arti...
Sex-specific regulation of microglial MyD88 in HMGB1-Induced anxiety phenotype in mice
Stress is a significant risk factor for the development and recurrence of anxiety disorders. Stress can profoundly impact the immune system, and lead …
www.sciencedirect.com
March 31, 2025 at 5:03 PM
Happy to share the latest paper from the lab on sex differences in the neuroimmune mechanisms underlying anxiety. www.sciencedirect.com/science/arti...
Super excited to share this new story led by @jedziabis.bsky.social where she defines a critical role for microglial innate immune signaling in PV cell and perineuronal net (PNN) development in hippocampus, and consequences for plasticity and behavior in adulthood www.biorxiv.org/content/10.6...
Microglial MyD88-dependent signaling influences extracellular matrix development and interneuron maturation in the hippocampus
Parvalbumin interneurons (PVIs) are disrupted across diverse neurodevelopmental disorders, highlighting their vulnerability to developmental perturbations. Inflammation can perturb PVI development and...
www.biorxiv.org
December 11, 2025 at 4:03 PM
Super excited to share this new story led by @jedziabis.bsky.social where she defines a critical role for microglial innate immune signaling in PV cell and perineuronal net (PNN) development in hippocampus, and consequences for plasticity and behavior in adulthood www.biorxiv.org/content/10.6...
Macrophages engineered with mesothelin-specific CAR fused to MyD88 penetrate the blood brain barrier & decrease brain metastasis via antigen-specific phagocytosis & release of TNF on bystander angiten(-) tumor cells @natbiomedeng.nature.com @wakeforestmed.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
MyD88-mediated chimaeric antigen receptor macrophages suppress brain metastasis using target-specific phagocytosis - Nature Biomedical Engineering
Chimaeric antigen receptor macrophages including the MyD88 activation domain target mesothelin for treatment of lung cancer brain metastases.
www.nature.com
March 3, 2026 at 4:06 PM
Macrophages engineered with mesothelin-specific CAR fused to MyD88 penetrate the blood brain barrier & decrease brain metastasis via antigen-specific phagocytosis & release of TNF on bystander angiten(-) tumor cells @natbiomedeng.nature.com @wakeforestmed.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🧬Immune signalling can outlast receptor attachment. TRAM helps release MyD88 complexes from TLRs, sustaining inflammatory activity. A mechanistic study in macrophages.
doi.org/10.1038/s415...
#Immunology #immunesignalling #inflammation
doi.org/10.1038/s415...
#Immunology #immunesignalling #inflammation
TRAM promotes Toll-like-receptor-free myddosome signal transduction - Nature
TRAM is a regulator of myddosome assembly through dissociating MyD88 from the TLR–TIRAP complex to enable myddosome maturation and durable downstream signal transduction.
doi.org
September 24, 2026 at 5:57 PM
🧬Immune signalling can outlast receptor attachment. TRAM helps release MyD88 complexes from TLRs, sustaining inflammatory activity. A mechanistic study in macrophages.
doi.org/10.1038/s415...
#Immunology #immunesignalling #inflammation
doi.org/10.1038/s415...
#Immunology #immunesignalling #inflammation
#ChangeTheDogma! #TLRpower! @jkagan1.bsky.social @danielhfisch.bsky.social &co show @nature.com that TRAM, so far believed to control endosomal TLR4 signaling & interferon #IFN production, is essential to release the #myddosome from #TIRAP & the plasma membrane allowing full NFkB signaling!
TRAM promotes Toll-like-receptor-free myddosome signal transduction - Nature
TRAM is a regulator of myddosome assembly through dissociating MyD88 from the TLR–TIRAP complex to enable myddosome maturation and durable downstream signal transduction.
www.nature.com
September 23, 2026 at 4:50 PM
#ChangeTheDogma! #TLRpower! @jkagan1.bsky.social @danielhfisch.bsky.social &co show @nature.com that TRAM, so far believed to control endosomal TLR4 signaling & interferon #IFN production, is essential to release the #myddosome from #TIRAP & the plasma membrane allowing full NFkB signaling!
Commensal fungi on the skin, like Malassezia, drive protective Th17 responses. Read on to find out how Card9 and Myd88 are used to induce these responses: www.mucosalimmunology.org/article/S193...
December 13, 2024 at 2:22 PM
Commensal fungi on the skin, like Malassezia, drive protective Th17 responses. Read on to find out how Card9 and Myd88 are used to induce these responses: www.mucosalimmunology.org/article/S193...
Inflammatory phenotype of Smooth Muscle Cell needed for Muscular Atherosclerotic Lesion Cap formation
Smooth Muscle Cell MyD88 KO🐭 +AAV8-PCSK9 +HFD
👉↔️aortic plaque burden, Mφ, collagen, necrotic core
👉⏬Plaque SMC, Cap SMC ⏫Medial SMC
#Atherosclerosis 2025
www.sciencedirect.com/science/arti...
Smooth Muscle Cell MyD88 KO🐭 +AAV8-PCSK9 +HFD
👉↔️aortic plaque burden, Mφ, collagen, necrotic core
👉⏬Plaque SMC, Cap SMC ⏫Medial SMC
#Atherosclerosis 2025
www.sciencedirect.com/science/arti...
November 19, 2025 at 8:06 PM
Inflammatory phenotype of Smooth Muscle Cell needed for Muscular Atherosclerotic Lesion Cap formation
Smooth Muscle Cell MyD88 KO🐭 +AAV8-PCSK9 +HFD
👉↔️aortic plaque burden, Mφ, collagen, necrotic core
👉⏬Plaque SMC, Cap SMC ⏫Medial SMC
#Atherosclerosis 2025
www.sciencedirect.com/science/arti...
Smooth Muscle Cell MyD88 KO🐭 +AAV8-PCSK9 +HFD
👉↔️aortic plaque burden, Mφ, collagen, necrotic core
👉⏬Plaque SMC, Cap SMC ⏫Medial SMC
#Atherosclerosis 2025
www.sciencedirect.com/science/arti...
might even work!
Frankincense-Myrrh treatment alleviates neuropathic pain via the inhibition of neuroglia activation mediated by the TLR4/MyD88 pathway and TRPV1 signaling - PubMed
These data suggest that Frankincense-Myrrh treatment was sufficient to alleviate NP in part via inhibiting TLR4/MyD88 pathway and TRPV1 signaling activity. Blocking TLR4 and MyD88 activation may thus ...
pubmed.ncbi.nlm.nih.gov
July 3, 2025 at 4:33 PM
might even work!
Fungus on the brain. @deepanshund.bsky.social @aliciahidalgolab.bsky.social &co show that the #fungus Beauveria bassiana exploits the Toll-1 host response to activate the MyD88 inhibitor Sarm, enabling immune evasion and triggering #neurodegeneration in #Drosophila 🧪 @plosbiology.org plos.io/3EIxgZN
February 17, 2025 at 2:09 PM
Fungus on the brain. @deepanshund.bsky.social @aliciahidalgolab.bsky.social &co show that the #fungus Beauveria bassiana exploits the Toll-1 host response to activate the MyD88 inhibitor Sarm, enabling immune evasion and triggering #neurodegeneration in #Drosophila 🧪 @plosbiology.org plos.io/3EIxgZN
Fungus on the brain. @deepanshund.bsky.social @aliciahidalgolab.bsky.social &co show that the #fungus Beauveria bassiana exploits the Toll-1 host response to activate the MyD88 inhibitor Sarm, enabling immune evasion and triggering #neurodegeneration in #Drosophila 🧪 @plosbiology.org plos.io/3EIxgZN
February 17, 2025 at 10:16 AM
Fungus on the brain. @deepanshund.bsky.social @aliciahidalgolab.bsky.social &co show that the #fungus Beauveria bassiana exploits the Toll-1 host response to activate the MyD88 inhibitor Sarm, enabling immune evasion and triggering #neurodegeneration in #Drosophila 🧪 @plosbiology.org plos.io/3EIxgZN
Fungus on the brain. @deepanshund.bsky.social @aliciahidalgolab.bsky.social &co show that the #fungus Beauveria bassiana exploits the Toll-1 host response to activate the MyD88 inhibitor Sarm, enabling immune evasion and triggering #neurodegeneration in #Drosophila 🧪 @plosbiology.org plos.io/3EIxgZN
February 17, 2025 at 6:08 PM
Fungus on the brain. @deepanshund.bsky.social @aliciahidalgolab.bsky.social &co show that the #fungus Beauveria bassiana exploits the Toll-1 host response to activate the MyD88 inhibitor Sarm, enabling immune evasion and triggering #neurodegeneration in #Drosophila 🧪 @plosbiology.org plos.io/3EIxgZN
@biorxivpreprint.bsky.social TLR7-independent control of murine retrovirus infections (MLV, MMTV) in BALB.J and C57BL/6N is determined by the same recessive mechanism that is independent of MyD88 and STING
www.biorxiv.org/content/10.6... @cornymel.bsky.social
www.biorxiv.org/content/10.6... @cornymel.bsky.social
May 1, 2026 at 2:04 PM
@biorxivpreprint.bsky.social TLR7-independent control of murine retrovirus infections (MLV, MMTV) in BALB.J and C57BL/6N is determined by the same recessive mechanism that is independent of MyD88 and STING
www.biorxiv.org/content/10.6... @cornymel.bsky.social
www.biorxiv.org/content/10.6... @cornymel.bsky.social
Thrilled to see our paper out today @plosbiology.org! By wonderful PhD student @deepanshund.bsky.social & great team of collaborating authors. Fungi hack immune receptor to drive immune evasion in the brain & cause neurodegeration. Thanx DarwinTrust @wellcometrust.bsky.social @BBSRC for funding. 😃
Toll-1-dependent immune evasion induced by fungal infection leads to cell loss in the Drosophila brain
This study identifies a new step in the evolutionary arms race between host and fungus in the Drosophila brain. The fungus B. bassiana exploits the Toll-1 host response to activate the MyD88 inhibitor...
journals.plos.org
February 13, 2025 at 9:27 PM
Thrilled to see our paper out today @plosbiology.org! By wonderful PhD student @deepanshund.bsky.social & great team of collaborating authors. Fungi hack immune receptor to drive immune evasion in the brain & cause neurodegeration. Thanx DarwinTrust @wellcometrust.bsky.social @BBSRC for funding. 😃
CRISPR screen for regulators of plasma cell longevity (CD98) & secretory capacity IDs subunits of the V-type ATPase complex, PI4KB, Ddx3x, and MYD88
doi.org/10.1101/2025...
@deeptabhattacha.bsky.social
doi.org/10.1101/2025...
@deeptabhattacha.bsky.social
March 4, 2025 at 2:52 PM
CRISPR screen for regulators of plasma cell longevity (CD98) & secretory capacity IDs subunits of the V-type ATPase complex, PI4KB, Ddx3x, and MYD88
doi.org/10.1101/2025...
@deeptabhattacha.bsky.social
doi.org/10.1101/2025...
@deeptabhattacha.bsky.social
Hepatocyte PLAGL2 deficiency alleviates MASH through MYD88-licensed inactivation of inflammasome
Hepatocyte PLAGL2 deficiency alleviates MASH through MYD88-licensed inactivation of inflammasome
Duan et al. systematically delineate the spatiotemporal dynamics and key regulators of pyroptosis during MASLD progression. Hepatocyte-specific Plagl2 deletion alleviates MASH by suppressing MYD88-mediated inflammasome activation and restoring metabolic homeostasis. Pyroptosis-driven IL-1β release promotes macrophage differentiation into a phagocytosis-enhanced, JAK/STAT-activated, NASH-associated phenotype.
dlvr.it
March 2, 2026 at 8:50 PM
Hepatocyte PLAGL2 deficiency alleviates MASH through MYD88-licensed inactivation of inflammasome