A new paper from the #MacKinnonLab in @pnas.org finds that while Kv2.1 and EAG1 are from distinct architectural classes of voltage-dependent ion channels, the way the voltage sensors gate their pores is very similar. #RockefellerScience
Electric field–induced pore constriction in the human Kv2.1 channel | PNAS
Gating in voltage-dependent ion channels is regulated by the transmembrane voltage.
This form of regulation is enabled by voltage-sensing domains (...
www.pnas.org
May 19, 2025 at 3:56 PM
A new paper from the #MacKinnonLab in @pnas.org finds that while Kv2.1 and EAG1 are from distinct architectural classes of voltage-dependent ion channels, the way the voltage sensors gate their pores is very similar. #RockefellerScience
A new study from the #MacKinnonLab finds that many membrane proteins self-assemble into higher-order transient structures. These structures can explain a dynamic connectivity of components in membrane signaling pathways.
Higher-order transient membrane protein structures | PNAS
This study shows that five membrane proteins—three GPCRs, an ion channel, and an enzyme—form
self-clusters under natural expression levels in a car...
www.pnas.org
January 3, 2025 at 3:10 PM
A new study from the #MacKinnonLab finds that many membrane proteins self-assemble into higher-order transient structures. These structures can explain a dynamic connectivity of components in membrane signaling pathways.
In @ScienceAdvances: Findings from Rockefeller's #MacKinnonLab suggest that Piezo1 ion channels are activated by a specific membrane-derived cofactor that complements mechanical force. These channels help cells respond rapidly to mechanical cues.
Lipid composition and mechanical force underlie multi-modal regulation of Piezo1 gating
Piezo1 under mechanical force adopts a unique conformation that depends on lipid membrane composition.
bit.ly
June 11, 2026 at 8:00 PM
In @ScienceAdvances: Findings from Rockefeller's #MacKinnonLab suggest that Piezo1 ion channels are activated by a specific membrane-derived cofactor that complements mechanical force. These channels help cells respond rapidly to mechanical cues.
