#RockefellerScience
Thanks for recapping the most intriguing #RockefellerScience stories of 2025 with us, Happy New Year! 👩🏽‍🔬 🥂 🦠 🎉 🧬

See the full 2025 #YearInReview here: https://bit.ly/44LtGrW
January 1, 2026 at 5:01 AM
Scientists in the @alushinlab.bsky.social figured out how cells build a structure that lets them migrate. Unpacking these “finger-like” protein bundles that protrude from cells may lead to novel treatments for #metastasis. #RockefellerScience #YearInReview

🔗: https://bit.ly/3PKErmA
December 31, 2025 at 10:30 PM
A study from @danmucida.bsky.social and @victora.bsky.social showed how immune cells in the gut distinguish between food and harmful pathogens, shedding light on the origins of #foodallergies. #RockefellerScience #YearInReview

🔗: https://bit.ly/4hyS18b
December 31, 2025 at 3:24 PM
A study from the #RutaLab explained how the fruit fly brain coordinates courtship and aggressive competition—a framework which could help scientists understand how the human brain balances cooperation and competition. #RockefellerScience #YearInReview

🔗: https://bit.ly/4gI7phV
December 31, 2025 at 11:11 AM
A study from Erich Jarvis and @darnelr.bsky.social found that a single protein variant found only in humans may have helped shape the emergence of spoken language. When put in mice, the variant altered their vocalizations. #RockefellerScience #YearInReview

🔗: https://bit.ly/3Yfdcoh
December 31, 2025 at 12:01 AM
A study from the #FriedmanLab identified a neural mechanism involved in leptin resistance, a factor contributing to #obesity. Crucially, they also found a way to reverse it in mice using a well-known drug. #RockefellerScience #YearInReview

🔗: https://bit.ly/3MV0WqC
December 30, 2025 at 4:52 PM
Clinical trials based on work from the Nussenzweig lab showed that two broadly neutralizing antibodies can keep #HIV suppressed for months. The data suggest that the antibodies may even diminish the viral reservoir itself. #RockefellerScience #YearInReview

🔗: https://bit.ly/4pkY045
December 30, 2025 at 10:46 AM
A new method from @hirofunabiki.bsky.social dramatically improved cryo-EM’s imaging capabilities, enabling visualization of molecules that are very rare, very small, or hard to produce naturally—including some viruses. #RockefellerScience #YearInReview

🔗: https://bit.ly/4awR4gv
December 29, 2025 at 9:40 PM
The #StricklandLab discovered that amyloid-beta (Aβ) oligomers and the vascular protein fibrinogen may, when forming a complex, contribute to Alzheimer's disease. #RockefellerScience #YearInReview

🔗: https://bit.ly/44Eh31R
December 29, 2025 at 2:26 PM
The #StellerLab found that boosting PI31 can prevent neuronal degeneration, restore synaptic function, and significantly extend lifespan in fly and mouse models of rare genetic disorders similar to Parkinson’s. #RockefellerScience #YearInReview

🔗: https://bit.ly/3MOlmSc
December 28, 2025 at 6:56 PM
Research from the Fuchs lab showed that low levels of the amino acid serine trigger a process that turns hair follicle stem cells into skin repair specialists—and that diet may have a role to play. #RockefellerScience #YearInReview

🔗: https://bit.ly/4jfd9CA
December 28, 2025 at 12:45 PM
Rockefeller's Li Zhao spent nearly a decade cataloguing evolutionarily young genes. This year, her lab demonstrated how these new genes are regulated and expressed. #RockefellerScience #YearInReview

🔗: https://bit.ly/4jdvwb8
December 27, 2025 at 8:41 PM
Treatments for autoimmune diseases have big shortcomings, including high cost and supply shortages. A alternative developed this year from the #RavetchLab achieves the same effectiveness at a fraction of the dose. #RockefellerScience #YearInReview

🔗: https://bit.ly/3HFdsbs
December 27, 2025 at 1:42 PM
A study from the Birsoy lab showed that the antioxidant glutathione, when operating inside mitochondria, is a key factor enabling tumors to spread from the breast to the lung. #RockefellerScience #YearInReview

🔗: https://bit.ly/44GfOPG
December 26, 2025 at 4:36 PM
Shortly before his death this year, James Hudspeth achieved a groundbreaking technological advancement: the ability to keep a tiny sliver of the cochlea alive and functional outside of the body for the first time. #RockefellerScience #YearInReview

🔗: https://bit.ly/49oaOlo
December 26, 2025 at 11:30 AM
The #BradyLab identified compounds that appear effective against drug-resistant bacteria using a new technique that could uncover many more antibiotics, as well as help illuminate a previously hidden microbial world. #RockefellerScience #YearInReview

🔗: https://bit.ly/4sjhV6j
December 25, 2025 at 6:26 PM
The first detailed look at how mosquitoes mate from the Vosshall lab reversed the assumption that male mosquitoes control the process, finding that a subtle female behavior dictates if mating will take place or not. #RockefellerScience #YearInReview

🔗: https://bit.ly/4huwEpL
December 25, 2025 at 12:13 PM
Neuroscientists have long posited that #memory functions like an on/off switch—either your brain remembers something or it doesn’t. The #RajasethupathyLab discovered that the truth is more complicated. #RockefellerScience #YearInReview

🔗: https://bit.ly/3MoSsrj
December 24, 2025 at 10:12 PM
The #WalzLab revealed key details about the T cell receptor, which is essential to T cell immunotherapies. The findings could expand T cell therapies, bringing their benefits to a broader group of #cancer patients. #RockefellerScience #YearInReview

🔗: https://bit.ly/3L0r3vK
December 24, 2025 at 5:21 PM
Winter break is upon us! Stay tuned as we count down the most intriguing #RockefellerScience stories of 2025. #YearInReview
December 24, 2025 at 5:01 PM
In a new @cp-cellstemcell.bsky.social study, scientists in the Brivanlou lab have used light-inducible gene expression to demonstrate that the formation of the body axes in human embryo models requires an interplay between chemical cues and mechanical forces. #RockefellerScience
Mechanical forces are key to embryonic self-organization - News
When placed on an array of microchips and dosed with a custom cocktail of signaling molecules, the stem cells organize themselves into “micro lungs” with full tissue complexity.
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November 21, 2025 at 2:43 PM
A new study in ants from @danielkronauer.bsky.social reveals a previously unknown mechanism that ensures that each olfactory neuron expresses only one odorant receptor, with broad implications for the study of gene regulation. #RockefellerScience
https://bit.ly/4pwPFLY
September 19, 2025 at 3:30 PM
A study from the #StellerLab in @pnas.org finds that boosting PI31 can prevent neuronal degeneration, restore synaptic function, and significantly extend lifespan in fly and mouse models of rare genetic disorders similar to Parkinson’s. #RockefellerScience
Increasing the level of the protein PI31 demonstrates neuroprotective effects in mice - News
One fundamental feature of neurodegenerative diseases is a breakdown in communication. Even before brain cells die, the delicate machinery that keeps neurons in touch—by clearing away protein waste at...
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September 17, 2025 at 2:41 PM
Now out in @natbiotech.nature.com: Newly identified compounds from the #BradyLab appear effective against drug-resistant bacteria. The technique used to reveal them could uncover many more antibiotics, as well as help illuminate a previously hidden microbial world. #RockefellerScience
Hundreds of new bacteria, and two potential antibiotics, found in soil - News
Most bacteria cannot be cultured in the lab—and that’s been bad news for medicine. Many of our frontline antibiotics originated from microbes, yet as antibiotic resistance spreads and drug pipelines r...
www.rockefeller.edu
September 12, 2025 at 6:09 PM
Shortly before his death last month, James Hudspeth and his team achieved a groundbreaking technological advancement: the ability to keep a tiny sliver of the cochlea alive and functional outside of the body for the first time. #RockefellerScience
Researchers keep a mammalian cochlea alive outside the body for the first time - News
The technological breakthrough may improve our understanding of the cellular mechanisms behind hearing loss.
www.rockefeller.edu
September 10, 2025 at 3:34 PM