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✅ Systemic Tx: Peri-op #IO & targeted adjuvant (osimertinib, alectinib) improve DFS/OS
✅ Stage III: CRT ➕ durvalumab (WT) / osimertinib (EGFR+) = new SoC

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www.annalsofoncology.org/article/S092...
Early and locally advanced non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up†
Surgical diagnosis should be limited to cases with small high-risk nodules, including those with negative positron emission tomography (PET)–CT findings and/or inability to obtain tissue by less invas...
www.annalsofoncology.org
August 29, 2025 at 2:49 PM
✅ 5-yr survival overall: 98%, but only 36–43% in metastatic stage

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💡 Clinical tip: Early detection + equitable access remain key. Discuss PSA screening with men 55–69y, start earlier for Black men & those with strong family history.
September 2, 2025 at 4:29 PM