If you weren't already sick of me: here's a recording of a talk I gave in November at Jane Street on Intel's Skylake Microarchitecture:
youtu.be/BVVNtG5dgks?...
youtu.be/BVVNtG5dgks?...
Microarchitecture: What Happens Beneath
YouTube video by Jane Street
youtu.be
December 23, 2025 at 11:01 PM
If you weren't already sick of me: here's a recording of a talk I gave in November at Jane Street on Intel's Skylake Microarchitecture:
youtu.be/BVVNtG5dgks?...
youtu.be/BVVNtG5dgks?...
How much do amd64 microarchitecture levels help in Go? https://lemire.me/blog/2026/06/06/how-much-do-amd64-microarchitecture-levels-help-in-go/
June 6, 2026 at 8:25 PM
How much do amd64 microarchitecture levels help in Go? https://lemire.me/blog/2026/06/06/how-much-do-amd64-microarchitecture-levels-help-in-go/
Reading up about GPGPU microarchitecture ... these things are pretty fancy.
December 1, 2024 at 7:54 PM
Reading up about GPGPU microarchitecture ... these things are pretty fancy.
Visiting Florence with 20 students, day 1… Amongst other things I got to see Leon Battista Alberti’s Tempietto del San Sepolcro. Such a stunning work of microarchitecture #earlymodern #LeidenUniversity
January 29, 2024 at 10:44 PM
Visiting Florence with 20 students, day 1… Amongst other things I got to see Leon Battista Alberti’s Tempietto del San Sepolcro. Such a stunning work of microarchitecture #earlymodern #LeidenUniversity
Got some negative or unrealistic threat model results that still bring interesting insights? A side channel that requires root to leak something from the kernel? Reproducing prior work? Somewhat related to microarchitecture? Here's your venue: uasc.cc
1st Microarchitecture Security Conference (uASC '25)
uasc.cc
December 1, 2024 at 4:03 PM
Got some negative or unrealistic threat model results that still bring interesting insights? A side channel that requires root to leak something from the kernel? Reproducing prior work? Somewhat related to microarchitecture? Here's your venue: uasc.cc
Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model
Cankar et al. report that sleep loss suppresses NREM norepinephrine oscillations in
a murine model of Alzheimer’s disease along with a parallel buildup of amyloid-β.
Thus, overexpression of amyloid-β ...
www.cell.com
November 15, 2024 at 7:29 PM
Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Das gilt übrigens auch für diejenigen die #Covid für einen Witz halten ... Warum?
Nun unsere #Luftqualität hat definitif nichts mehr mit der #Atemluft aus Jurassic Park zu tun
Hier: #Urban #air #pollution disrupts #placental microarchitecture ...
www.sciencedirect.com/science/arti...
Nun unsere #Luftqualität hat definitif nichts mehr mit der #Atemluft aus Jurassic Park zu tun
Hier: #Urban #air #pollution disrupts #placental microarchitecture ...
www.sciencedirect.com/science/arti...
October 7, 2025 at 7:35 PM
Das gilt übrigens auch für diejenigen die #Covid für einen Witz halten ... Warum?
Nun unsere #Luftqualität hat definitif nichts mehr mit der #Atemluft aus Jurassic Park zu tun
Hier: #Urban #air #pollution disrupts #placental microarchitecture ...
www.sciencedirect.com/science/arti...
Nun unsere #Luftqualität hat definitif nichts mehr mit der #Atemluft aus Jurassic Park zu tun
Hier: #Urban #air #pollution disrupts #placental microarchitecture ...
www.sciencedirect.com/science/arti...
New blog post! "Load store conflicts", in which we look at some performance sensitive code that has surprisingly dramatic performance swings based on the compiler and the microarchitecture used. Reposts appreciated!
zeux.io/2025/05/03/l...
zeux.io/2025/05/03/l...
Load-store conflicts
meshoptimizer implements several geometry compression algorithms that are designed to take advantage of redundancies common in mesh data and decompress quickly - targeting many gigabytes per second in...
zeux.io
May 4, 2025 at 2:37 PM
New blog post! "Load store conflicts", in which we look at some performance sensitive code that has surprisingly dramatic performance swings based on the compiler and the microarchitecture used. Reposts appreciated!
zeux.io/2025/05/03/l...
zeux.io/2025/05/03/l...
I own and liked the processor microarchitecture and the virtualization one
January 2, 2025 at 5:41 PM
I own and liked the processor microarchitecture and the virtualization one
A review analyses the "evidence linking COVID-19 to skeletal deterioration, ranging from changes in bone mineral density, trabecular microarchitecture, and mechanical competence to osteocyte lacunar remodeling and altered bone-cell activity"
#LongCovid
www.frontiersin.org/journals/bio...
#LongCovid
www.frontiersin.org/journals/bio...
Frontiers | Multiscale bone remodeling in COVID-19: from osteoimmune signaling to structural and mechanical impairment
The skeletal consequences of COVID-19 have emerged as an important but still underrecognized component of post-viral systemic disease. Increasing clinical, e...
www.frontiersin.org
August 6, 2026 at 3:26 PM
A review analyses the "evidence linking COVID-19 to skeletal deterioration, ranging from changes in bone mineral density, trabecular microarchitecture, and mechanical competence to osteocyte lacunar remodeling and altered bone-cell activity"
#LongCovid
www.frontiersin.org/journals/bio...
#LongCovid
www.frontiersin.org/journals/bio...
I just registered for uasc.cc -- uASC (the Microarchitecture Security Conference) is on February 3rd, in Leuven, Belgium.
**Registration is free but mandatory!**
I would be happy to see all of you there :)
Especially from the Cologne and Ruhr area, it's just a train ride to Leuven -> join us!
**Registration is free but mandatory!**
I would be happy to see all of you there :)
Especially from the Cologne and Ruhr area, it's just a train ride to Leuven -> join us!
2nd Microarchitecture Security Conference (uASC '26)
uasc.cc
January 7, 2026 at 11:23 AM
I just registered for uasc.cc -- uASC (the Microarchitecture Security Conference) is on February 3rd, in Leuven, Belgium.
**Registration is free but mandatory!**
I would be happy to see all of you there :)
Especially from the Cologne and Ruhr area, it's just a train ride to Leuven -> join us!
**Registration is free but mandatory!**
I would be happy to see all of you there :)
Especially from the Cologne and Ruhr area, it's just a train ride to Leuven -> join us!
CFP for uASC 25 is still open. We have rolling reviews, and 1 submission is already accepted. If you have interesting results on microarchitecture security (incl. weak threat models or reproducing prior work), check out the CFP at uasc.cc
The CFP closes **Jan 28**
The CFP closes **Jan 28**
1st Microarchitecture Security Conference (uASC '25)
uasc.cc
January 5, 2025 at 4:40 PM
CFP for uASC 25 is still open. We have rolling reviews, and 1 submission is already accepted. If you have interesting results on microarchitecture security (incl. weak threat models or reproducing prior work), check out the CFP at uasc.cc
The CFP closes **Jan 28**
The CFP closes **Jan 28**
@wolf.observer the Likely family has a long history of being branch predictors in microarchitecture!
September 15, 2026 at 11:22 PM
@wolf.observer the Likely family has a long history of being branch predictors in microarchitecture!
I recently had the honor of interviewing Zen’s chief architect Mike Clark! I tried to fit in as many microarchitecture questions as I could, including x64 vs ARM ISA power efficiency, 4k vs larger page sizes, 64-byte cache lines, scatter/gather and more:
www.computerenhance.com/p/an-intervi...
www.computerenhance.com/p/an-intervi...
An Interview with Zen Chief Architect Mike Clark
Zen is one of the most important microarchitectures in the history of the x86 ecosystem.
www.computerenhance.com
March 24, 2025 at 6:51 PM
I recently had the honor of interviewing Zen’s chief architect Mike Clark! I tried to fit in as many microarchitecture questions as I could, including x64 vs ARM ISA power efficiency, 4k vs larger page sizes, 64-byte cache lines, scatter/gather and more:
www.computerenhance.com/p/an-intervi...
www.computerenhance.com/p/an-intervi...
A brilliant talk by @matt.godbolt.org at @accuorg.bsky.social ACCU on Sea
about the microarchitecture of Skylake, explaining a lot of details about instruction decoders, register alias tables and how they affect compilers and developers. It goes above and beyond the Intel Developer Manual
about the microarchitecture of Skylake, explaining a lot of details about instruction decoders, register alias tables and how they affect compilers and developers. It goes above and beyond the Intel Developer Manual
June 20, 2026 at 1:12 PM
A brilliant talk by @matt.godbolt.org at @accuorg.bsky.social ACCU on Sea
about the microarchitecture of Skylake, explaining a lot of details about instruction decoders, register alias tables and how they affect compilers and developers. It goes above and beyond the Intel Developer Manual
about the microarchitecture of Skylake, explaining a lot of details about instruction decoders, register alias tables and how they affect compilers and developers. It goes above and beyond the Intel Developer Manual
Whoah. Just learned about Agner Fog's "The microarchitecture of Intel, AMD, and VIA CPUs": www.agner.org/optimize/mi...
What. a. reference.
What. a. reference.
May 22, 2025 at 7:58 AM
Whoah. Just learned about Agner Fog's "The microarchitecture of Intel, AMD, and VIA CPUs": www.agner.org/optimize/mi...
What. a. reference.
What. a. reference.
🧪 NEW STUDY: microplastics may play a role in osteoporosis.
• MPs found inhuman bone tissue
• animal studies show MPs induce cell senescence, promote osteoclastogenesis, impair bone marrow cells.
• MP accumulation in bones impair microarchitecture
link.springer.com/article/10.1...
• MPs found inhuman bone tissue
• animal studies show MPs induce cell senescence, promote osteoclastogenesis, impair bone marrow cells.
• MP accumulation in bones impair microarchitecture
link.springer.com/article/10.1...
Effects of microplastics on the bones: a comprehensive review - Osteoporosis International
A growing role for the skeleton in human health and longevity emerged recently. However, knowledge regarding the effects of new risk factors, linked to modern life, for bone diseases is not documented...
link.springer.com
September 21, 2025 at 1:32 PM
🧪 NEW STUDY: microplastics may play a role in osteoporosis.
• MPs found inhuman bone tissue
• animal studies show MPs induce cell senescence, promote osteoclastogenesis, impair bone marrow cells.
• MP accumulation in bones impair microarchitecture
link.springer.com/article/10.1...
• MPs found inhuman bone tissue
• animal studies show MPs induce cell senescence, promote osteoclastogenesis, impair bone marrow cells.
• MP accumulation in bones impair microarchitecture
link.springer.com/article/10.1...
Hello you fine Internet folks,
Today's article is on SiFive's P550 microarchitecture. The P550 core is one of the fastest RISC-V cores available currently and is claimed to be comparable to ARM's Cortex A75.
Hope y'all enjoy!
old.chipsandcheese.com/2025/01/26/i...
open.substack.com/pub/chipsand...
Today's article is on SiFive's P550 microarchitecture. The P550 core is one of the fastest RISC-V cores available currently and is claimed to be comparable to ARM's Cortex A75.
Hope y'all enjoy!
old.chipsandcheese.com/2025/01/26/i...
open.substack.com/pub/chipsand...
Inside SiFive’s P550 Microarchitecture
RISC-V is a relatively young and open source instruction set. So far, it has gained traction in microcontrollers and academic applications. For example, Nvidia replaced the Falcon microcontrollers …
old.chipsandcheese.com
January 26, 2025 at 10:14 PM
Hello you fine Internet folks,
Today's article is on SiFive's P550 microarchitecture. The P550 core is one of the fastest RISC-V cores available currently and is claimed to be comparable to ARM's Cortex A75.
Hope y'all enjoy!
old.chipsandcheese.com/2025/01/26/i...
open.substack.com/pub/chipsand...
Today's article is on SiFive's P550 microarchitecture. The P550 core is one of the fastest RISC-V cores available currently and is claimed to be comparable to ARM's Cortex A75.
Hope y'all enjoy!
old.chipsandcheese.com/2025/01/26/i...
open.substack.com/pub/chipsand...
The Intel Pentium Pro CPU (Socket 8) was released on November 1, 1995. It was designed for high-end desktops and servers and introduced Intel's P6 microarchitecture, which later evolved into the Pentium II and III.
Shown below in order, with the first 133Mhz Engineering Sample:
Shown below in order, with the first 133Mhz Engineering Sample:
May 10, 2025 at 11:56 AM
The Intel Pentium Pro CPU (Socket 8) was released on November 1, 1995. It was designed for high-end desktops and servers and introduced Intel's P6 microarchitecture, which later evolved into the Pentium II and III.
Shown below in order, with the first 133Mhz Engineering Sample:
Shown below in order, with the first 133Mhz Engineering Sample:
(pluvial cope, mitre, book and crozier) and the gilded microarchitecture of the monumental throne reflect a pictorial illusionism of Flemish inspiration.
March 9, 2026 at 12:49 AM
(pluvial cope, mitre, book and crozier) and the gilded microarchitecture of the monumental throne reflect a pictorial illusionism of Flemish inspiration.
Articular calcified cartilage microarchitecture has a predictive role in abnormal osteochondral strain distributions in murine age-related osteoarthritis https://www.biorxiv.org/content/10.64898/2026.09.18.752585v1
September 25, 2026 at 1:00 AM
Articular calcified cartilage microarchitecture has a predictive role in abnormal osteochondral strain distributions in murine age-related osteoarthritis https://www.biorxiv.org/content/10.64898/2026.09.18.752585v1
Bretherton I, et al. (2022), a recent cross-sectional analysis involving 41 trans men & 40 trans women compared with cisgender comparison groups of the same birth-recorded sex found that trans women had compromised bone microarchitecture.
scholar.google.com/scholar_look...
scholar.google.com/scholar_look...
Google Scholar
scholar.google.com
December 2, 2024 at 10:58 AM
Bretherton I, et al. (2022), a recent cross-sectional analysis involving 41 trans men & 40 trans women compared with cisgender comparison groups of the same birth-recorded sex found that trans women had compromised bone microarchitecture.
scholar.google.com/scholar_look...
scholar.google.com/scholar_look...
Articular calcified cartilage microarchitecture has a predictive role in abnormal osteochondral strain distributions in murine age-related osteoarthritis https://www.biorxiv.org/content/10.64898/2026.09.18.752585v1
September 25, 2026 at 1:00 AM
Articular calcified cartilage microarchitecture has a predictive role in abnormal osteochondral strain distributions in murine age-related osteoarthritis https://www.biorxiv.org/content/10.64898/2026.09.18.752585v1
Impact of Realistic 3D Tumor Microarchitecture on Cellular Dosimetry and Radiobiological Response in Targeted Radionuclide Therapy https://www.biorxiv.org/content/10.64898/2026.09.23.753948v1
September 24, 2026 at 12:46 PM
Impact of Realistic 3D Tumor Microarchitecture on Cellular Dosimetry and Radiobiological Response in Targeted Radionuclide Therapy https://www.biorxiv.org/content/10.64898/2026.09.23.753948v1