A major advance in cancer using multimodal AI to do virtual proteomics of H&E slides, unraveling the tumor microenvironment, key proteins, biomarkers, and informing prognosis
@cellcellpress.bsky.social @hoifungpoon.bsky.social
@msftresearch.bsky.social
cell.com/cell/fulltex...
@cellcellpress.bsky.social @hoifungpoon.bsky.social
@msftresearch.bsky.social
cell.com/cell/fulltex...
Multimodal AI generates virtual population for tumor microenvironment modeling
GigaTIME leverages multimodal AI to generate virtual multiplex immunofluorescence
(mIF) profiles from standard H&E slides, enabling comprehensive tumor immune microenvironment
modeling across a large ...
cell.com
December 9, 2025 at 4:41 PM
A major advance in cancer using multimodal AI to do virtual proteomics of H&E slides, unraveling the tumor microenvironment, key proteins, biomarkers, and informing prognosis
@cellcellpress.bsky.social @hoifungpoon.bsky.social
@msftresearch.bsky.social
cell.com/cell/fulltex...
@cellcellpress.bsky.social @hoifungpoon.bsky.social
@msftresearch.bsky.social
cell.com/cell/fulltex...
"This work was supported in part by...the NIH U01 CA224175 Pancreatic Cancer Microenvironment Network Cancer Moonshot Award (to V.P.B.)"
Unbelievable news.
Pancreatic is one of the deadliest cancers.
New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care.
www.nature.com/articles/s41...
Pancreatic is one of the deadliest cancers.
New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care.
www.nature.com/articles/s41...
February 27, 2025 at 5:26 PM
"This work was supported in part by...the NIH U01 CA224175 Pancreatic Cancer Microenvironment Network Cancer Moonshot Award (to V.P.B.)"
Thanks to @natmedicine.bsky.social for inviting this 'Turning Point' as part of their 30-yr anniversary 🎉
Back in 2013, we published a Nat Med study that not only impacted the #tumor #microenvironment field, but also the trajectory of our lab 🧪
Led by a great team- Pyonteck, Akkari & Schuhmacher 🙌
Back in 2013, we published a Nat Med study that not only impacted the #tumor #microenvironment field, but also the trajectory of our lab 🧪
Led by a great team- Pyonteck, Akkari & Schuhmacher 🙌
Reprogramming the tumor immune microenvironment to treat glioblastoma - Nature Medicine
Johanna Joyce describes how disrupting tumor-associated macrophages showed the importance of the tumor microenvironment in treating cancer.
www.nature.com
April 15, 2025 at 1:28 PM
Thanks to @natmedicine.bsky.social for inviting this 'Turning Point' as part of their 30-yr anniversary 🎉
Back in 2013, we published a Nat Med study that not only impacted the #tumor #microenvironment field, but also the trajectory of our lab 🧪
Led by a great team- Pyonteck, Akkari & Schuhmacher 🙌
Back in 2013, we published a Nat Med study that not only impacted the #tumor #microenvironment field, but also the trajectory of our lab 🧪
Led by a great team- Pyonteck, Akkari & Schuhmacher 🙌
Organoid avatars of colorectal cancer and its microenvironment model immune interactions and drug efficacy go.nature.com/3LblcjH
rdcu.be/em3Z8
rdcu.be/em3Z8
Patient-derived mini-colons enable long-term modeling of tumor–microenvironment complexity - Nature Biotechnology
Organoid avatars of colorectal cancer and its microenvironment model immune interactions and drug efficacy.
go.nature.com
May 28, 2025 at 1:18 AM
Organoid avatars of colorectal cancer and its microenvironment model immune interactions and drug efficacy go.nature.com/3LblcjH
rdcu.be/em3Z8
rdcu.be/em3Z8
Nature research paper: Immune evasion through mitochondrial transfer in the tumour microenvironment
https://go.nature.com/42lEXP9
https://go.nature.com/42lEXP9
Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature
Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.
go.nature.com
January 23, 2025 at 2:55 PM
Nature research paper: Immune evasion through mitochondrial transfer in the tumour microenvironment
https://go.nature.com/42lEXP9
https://go.nature.com/42lEXP9
Turn cold tumors hot by reprogramming the tumor microenvironment - @mdanderson.bsky.social go.nature.com/42Bo9lT
Turn cold tumors hot by reprogramming the tumor microenvironment - Nature Biotechnology
The identification of novel targets together with technological advances is transforming our ability to effectively modulate the tumor microenvironment.
go.nature.com
April 18, 2025 at 1:47 PM
Turn cold tumors hot by reprogramming the tumor microenvironment - @mdanderson.bsky.social go.nature.com/42Bo9lT
(3) Amyloid deposition in the islets constricts the space of intrinsic islet cells and alters the β cell microenvironment;58 (4) Activated stellate cells promote collagen fibers formation, leading to changes in the islet microenvironment.56
September 22, 2025 at 4:42 AM
(3) Amyloid deposition in the islets constricts the space of intrinsic islet cells and alters the β cell microenvironment;58 (4) Activated stellate cells promote collagen fibers formation, leading to changes in the islet microenvironment.56
Cancer-associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy – Lichtenberger & Kasper labs
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cancer-associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy - Nature Communications
Fibroblast heterogeneity in the tumor microenvironment can explain their multifaceted role in cancer. Here by single-cell transcriptomic analysis of basal cell carcinoma, squamous cell carcinoma and m...
www.nature.com
November 19, 2024 at 2:28 PM
Cancer-associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy – Lichtenberger & Kasper labs
www.nature.com/articles/s41...
www.nature.com/articles/s41...
vaccine in 2023) illuminated a remarkable mechanism whereby T-cells, part of the adaptive immune system, sustain the activation of innate immune cells in the lung microenvironment through cytokine signaling. This prolonged innate activation expands the horizon of immune protection to MONTHS rather
May 25, 2026 at 4:06 PM
vaccine in 2023) illuminated a remarkable mechanism whereby T-cells, part of the adaptive immune system, sustain the activation of innate immune cells in the lung microenvironment through cytokine signaling. This prolonged innate activation expands the horizon of immune protection to MONTHS rather
New paper from the lab🎈. Introducing Micro Immune Response On-chip (MIRO), a device that replicates tumors and their microenvironment to better understand responses to immunotherapies (cyan=immune cells, red=cancer, green=CAFs).
www.nature.com/articles/s41...
@ibecbarcelona.eu
www.nature.com/articles/s41...
@ibecbarcelona.eu
February 7, 2025 at 11:46 AM
New paper from the lab🎈. Introducing Micro Immune Response On-chip (MIRO), a device that replicates tumors and their microenvironment to better understand responses to immunotherapies (cyan=immune cells, red=cancer, green=CAFs).
www.nature.com/articles/s41...
@ibecbarcelona.eu
www.nature.com/articles/s41...
@ibecbarcelona.eu
For treatment and outcomes for cancer, the tumor microenvironment is pivotal, but we've never had a non-invasive way to assess it. Until now, a blood test breakthrough!
With sequencing >10 million cells + AI, discovery & validation of a blood test that informs response to therapy and prognosis.
With sequencing >10 million cells + AI, discovery & validation of a blood test that informs response to therapy and prognosis.
July 5, 2026 at 2:09 PM
For treatment and outcomes for cancer, the tumor microenvironment is pivotal, but we've never had a non-invasive way to assess it. Until now, a blood test breakthrough!
With sequencing >10 million cells + AI, discovery & validation of a blood test that informs response to therapy and prognosis.
With sequencing >10 million cells + AI, discovery & validation of a blood test that informs response to therapy and prognosis.
☕Zhao et al. describe an enhancer-dense nuclear microenvironment in the cerebellum that includes long neuronal genes and mega-enhancers. This microenvironment partly depends on Etv1 and is dynamic during neuronal maturation.
👉https://rdcu.be/fBGcW
www.nature.com/articles/s41...
👉https://rdcu.be/fBGcW
www.nature.com/articles/s41...
Mega-enhancers compartmentalize transcriptionally active long genes in the brain - Nature Cell Biology
Zhao et al. describe an enhancer-dense nuclear microenvironment in the cerebellum that includes long neuronal genes and mega-enhancers. This microenvironment partly depends on the transcription factor...
www.nature.com
August 24, 2026 at 6:45 AM
☕Zhao et al. describe an enhancer-dense nuclear microenvironment in the cerebellum that includes long neuronal genes and mega-enhancers. This microenvironment partly depends on Etv1 and is dynamic during neuronal maturation.
👉https://rdcu.be/fBGcW
www.nature.com/articles/s41...
👉https://rdcu.be/fBGcW
www.nature.com/articles/s41...
Absolutely thrilled to present our latest review, where we discuss how host microenvironment and bacterial subversion strategies can undermine traditional antimicrobial sensitivity testing, and whether better models may one day get us "beyond the MIC" #IDSKy
rdcu.be/emYoh
rdcu.be/emYoh
Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing
npj Antimicrobials and Resistance - Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing
rdcu.be
May 21, 2025 at 10:43 AM
Absolutely thrilled to present our latest review, where we discuss how host microenvironment and bacterial subversion strategies can undermine traditional antimicrobial sensitivity testing, and whether better models may one day get us "beyond the MIC" #IDSKy
rdcu.be/emYoh
rdcu.be/emYoh
📢 New preprint led by former postdoc in my group Lisa Cole.
We asked: are microbially-mediated carbon transformations governed principally by the composition of the microbial community or by the soil microenvironment?
lnkd.in/ez9TniYP
We asked: are microbially-mediated carbon transformations governed principally by the composition of the microbial community or by the soil microenvironment?
lnkd.in/ez9TniYP
September 24, 2026 at 6:07 PM
📢 New preprint led by former postdoc in my group Lisa Cole.
We asked: are microbially-mediated carbon transformations governed principally by the composition of the microbial community or by the soil microenvironment?
lnkd.in/ez9TniYP
We asked: are microbially-mediated carbon transformations governed principally by the composition of the microbial community or by the soil microenvironment?
lnkd.in/ez9TniYP
2/3
Political demolition of mRNA infrastructure will not simply delay publications/grants; it will collapse developmental pipelines. Science is cumulative—pull one keystone & years of incremental advances in immunotherapy, tumor microenvironment targeting & personalized treatment disintegrate.
Political demolition of mRNA infrastructure will not simply delay publications/grants; it will collapse developmental pipelines. Science is cumulative—pull one keystone & years of incremental advances in immunotherapy, tumor microenvironment targeting & personalized treatment disintegrate.
August 9, 2025 at 4:19 PM
2/3
Political demolition of mRNA infrastructure will not simply delay publications/grants; it will collapse developmental pipelines. Science is cumulative—pull one keystone & years of incremental advances in immunotherapy, tumor microenvironment targeting & personalized treatment disintegrate.
Political demolition of mRNA infrastructure will not simply delay publications/grants; it will collapse developmental pipelines. Science is cumulative—pull one keystone & years of incremental advances in immunotherapy, tumor microenvironment targeting & personalized treatment disintegrate.
Delighted to introduce our new spatial transcriptomics tool, SpottedPy, allowing the identification of tumour hotspots at different scales and the exploration of distances and overlap with tumour microenvironment niches: genomebiology.biomedcentral.com/articles/10....
December 2, 2024 at 12:00 PM
Delighted to introduce our new spatial transcriptomics tool, SpottedPy, allowing the identification of tumour hotspots at different scales and the exploration of distances and overlap with tumour microenvironment niches: genomebiology.biomedcentral.com/articles/10....
Hi I’m Ashi! A cancer biologist interested in the intersection of aging and cancer, and all things microenvironment!
This is a great post introducing people in the #bluesky community! Biology/genomics/cancer friends - Should we start a thread introducing ourselves?
I am Daniela and I work doing #cancer #genomics research at LIIGH UNAM, Mexico 🇲🇽 I enjoy learning to play violin 🎻 and #pilates 💪🏽
I am Daniela and I work doing #cancer #genomics research at LIIGH UNAM, Mexico 🇲🇽 I enjoy learning to play violin 🎻 and #pilates 💪🏽
There are now over 14,000,000 people here!
Science and conservation friends, reply and reintroduce/reintroduce yourselves-
I’m David. I study shark conservation, and post about that as well as marine biology and the environment in general. I’m in the Washington, DC area.
🌎🦑🧪🦈🐠 #SciComm
Science and conservation friends, reply and reintroduce/reintroduce yourselves-
I’m David. I study shark conservation, and post about that as well as marine biology and the environment in general. I’m in the Washington, DC area.
🌎🦑🧪🦈🐠 #SciComm
November 9, 2024 at 2:37 PM
Hi I’m Ashi! A cancer biologist interested in the intersection of aging and cancer, and all things microenvironment!
Integrating histopathology and transcriptomics for spatial tumor microenvironment profiling in a melanoma case study 🧬🖥️ #SingleCell www.nature.com/articles/s41...
Integrating histopathology and transcriptomics for spatial tumor microenvironment profiling in a melanoma case study - npj Precision Oncology
npj Precision Oncology - Integrating histopathology and transcriptomics for spatial tumor microenvironment profiling in a melanoma case study
www.nature.com
November 16, 2024 at 5:01 PM
Integrating histopathology and transcriptomics for spatial tumor microenvironment profiling in a melanoma case study 🧬🖥️ #SingleCell www.nature.com/articles/s41...
We have hundreds of PanINs in our pancreas, especially after age 40. They are a pre-cancerous lesion, but it is rare for one to progress to cancer (PDAC). Now we know a reason for that. The microenvironment.
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
May 21, 2026 at 3:57 PM
We have hundreds of PanINs in our pancreas, especially after age 40. They are a pre-cancerous lesion, but it is rare for one to progress to cancer (PDAC). Now we know a reason for that. The microenvironment.
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
The inflammaging microenvironment induces dysfunctional rewiring of Tfh cell differentiation @jci-insight.bsky.social
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
March 4, 2025 at 9:27 PM
The inflammaging microenvironment induces dysfunctional rewiring of Tfh cell differentiation @jci-insight.bsky.social
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
Reprogramming the tumor immune microenvironment to treat glioblastoma 🧠
Nature Medicine, Turning Point 🧪 🩺
www.nature.com/articles/s41...
www.unil.ch/news/1744719...
@natmedicine.bsky.social
Nature Medicine, Turning Point 🧪 🩺
www.nature.com/articles/s41...
www.unil.ch/news/1744719...
@natmedicine.bsky.social
Reprogramming the tumor microenvironment: a turning point in brain cancer research
In Nature Medicine, Prof. Johanna A. Joyce reflects on her lab’s 2013 breakthrough showing that reprogramming, rather than eliminating, tumor-associated macrophages can slow glioblastoma—marking a tur...
www.unil.ch
April 22, 2025 at 5:04 PM
Reprogramming the tumor immune microenvironment to treat glioblastoma 🧠
Nature Medicine, Turning Point 🧪 🩺
www.nature.com/articles/s41...
www.unil.ch/news/1744719...
@natmedicine.bsky.social
Nature Medicine, Turning Point 🧪 🩺
www.nature.com/articles/s41...
www.unil.ch/news/1744719...
@natmedicine.bsky.social
Anyway, betwixt everything, here is a really cool discovery that could potentially really help in the treatment of cancer in the future:
Tumors prevent effective immune responses from T cells by transferring their mitochondria (which have mutations) and having those replace...
Tumors prevent effective immune responses from T cells by transferring their mitochondria (which have mutations) and having those replace...
Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature
Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.
www.nature.com
January 23, 2025 at 10:43 PM
Anyway, betwixt everything, here is a really cool discovery that could potentially really help in the treatment of cancer in the future:
Tumors prevent effective immune responses from T cells by transferring their mitochondria (which have mutations) and having those replace...
Tumors prevent effective immune responses from T cells by transferring their mitochondria (which have mutations) and having those replace...
Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...
November 27, 2024 at 10:17 PM
Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...