Have you ever wondered what are the mediators and effects of mitohormesis in organisms? In our review, we explore the unexpected path of mitochondrial stress to systemic benefits. 🔥 #mitochondria #mitohormesis #integratedstressresponse @ucberkeleyofficial.bsky.social
Mammalian #mitohormesis:
Amanda Gunawan, Irene Liparulo and Andreas Stahl review the winding path from mitochondrial stressors to organismal benefits
www.embopress.org/doi/full/10....
Amanda Gunawan, Irene Liparulo and Andreas Stahl review the winding path from mitochondrial stressors to organismal benefits
www.embopress.org/doi/full/10....
September 11, 2025 at 3:31 PM
Have you ever wondered what are the mediators and effects of mitohormesis in organisms? In our review, we explore the unexpected path of mitochondrial stress to systemic benefits. 🔥 #mitochondria #mitohormesis #integratedstressresponse @ucberkeleyofficial.bsky.social
One of the most-viewed PNAS articles in the last week is “Antioxidants prevent health-promoting effects of physical exercise in humans.” Explore the article here: www.pnas.org/doi/10.1073/...
For more trending articles, visit ow.ly/Me2U50SkLRZ.
For more trending articles, visit ow.ly/Me2U50SkLRZ.
July 14, 2025 at 4:45 PM
One of the most-viewed PNAS articles in the last week is “Antioxidants prevent health-promoting effects of physical exercise in humans.” Explore the article here: www.pnas.org/doi/10.1073/...
For more trending articles, visit ow.ly/Me2U50SkLRZ.
For more trending articles, visit ow.ly/Me2U50SkLRZ.
Gerald Shadel (Salk Institute for Biological Studies @salkinstitute.bsky.social) on “mito-inflammaging” and finding ways to induce oxidative mitohormesis.
September 24, 2026 at 6:51 PM
Gerald Shadel (Salk Institute for Biological Studies @salkinstitute.bsky.social) on “mito-inflammaging” and finding ways to induce oxidative mitohormesis.
➡️ Guanosine 10 methylation by TRMT11-TRMT112 optimizes human mitochondrial tRNAs for efficient translation
➡️Mitochondrial superoxide-induced mitohormesis is mediated by citrate and cardioprotective
➡️Mitochondrial superoxide-induced mitohormesis is mediated by citrate and cardioprotective
September 6, 2026 at 1:44 PM
➡️ Guanosine 10 methylation by TRMT11-TRMT112 optimizes human mitochondrial tRNAs for efficient translation
➡️Mitochondrial superoxide-induced mitohormesis is mediated by citrate and cardioprotective
➡️Mitochondrial superoxide-induced mitohormesis is mediated by citrate and cardioprotective
"En conjunt, les nostres troballes identifiquen el citrat mitocondrial com un segon missatger sensible al redox que vincula l'estrès superòxid mitocondrial amb la remodelació epigenètica i mitohormètica duradora." www.science.org/doi/10.1126/...
Mitochondrial superoxide–induced mitohormesis is mediated by citrate and cardioprotective
Mitohormesis, whereby transient mitochondrial stress induces adaptive signaling, promotes organismal resilience and longevity in invertebrates, but how this operates in mammals and the underlying meta...
www.science.org
September 7, 2026 at 5:37 PM
"En conjunt, les nostres troballes identifiquen el citrat mitocondrial com un segon missatger sensible al redox que vincula l'estrès superòxid mitocondrial amb la remodelació epigenètica i mitohormètica duradora." www.science.org/doi/10.1126/...
Skin photoaging is not just a surface issue it’s a metabolic one.
PDT improves aging skin via mitohormesis and mitochondria
Aging & Gerontology – 11th Edition
🗓April 20–21, 2026
📍Dubai, UAE
Website: agingcongress.com/edition2/
#SkinAging #Photoaging
#PhotodynamicTherapy #Mitohormesis
PDT improves aging skin via mitohormesis and mitochondria
Aging & Gerontology – 11th Edition
🗓April 20–21, 2026
📍Dubai, UAE
Website: agingcongress.com/edition2/
#SkinAging #Photoaging
#PhotodynamicTherapy #Mitohormesis
December 29, 2025 at 4:13 AM
Skin photoaging is not just a surface issue it’s a metabolic one.
PDT improves aging skin via mitohormesis and mitochondria
Aging & Gerontology – 11th Edition
🗓April 20–21, 2026
📍Dubai, UAE
Website: agingcongress.com/edition2/
#SkinAging #Photoaging
#PhotodynamicTherapy #Mitohormesis
PDT improves aging skin via mitohormesis and mitochondria
Aging & Gerontology – 11th Edition
🗓April 20–21, 2026
📍Dubai, UAE
Website: agingcongress.com/edition2/
#SkinAging #Photoaging
#PhotodynamicTherapy #Mitohormesis
The authors included RRIDs in their in Aging Cell paper! We value the author's support of reproducibility. #reproducibility #methodsmatter #ReproducibleResearch
Enhancing Late‐Life Survival and Mobility via Mitohormesis by Reducing Mitochondrial Calcium Levels
Read the full paper: Enhancing Late‐Life Survival and Mobility via Mitohormesis by Reducing Mitochondrial Calcium Levels
doi.org
April 27, 2026 at 7:00 AM
The authors included RRIDs in their in Aging Cell paper! We value the author's support of reproducibility. #reproducibility #methodsmatter #ReproducibleResearch
The authors included RRIDs in their in Bioorganic Chemistry paper! RRIDs improve reproducibility in scientific research. #BetterScience #RRID #OpenScience
Harnessing mitohormesis: A thiazole-based mitochondrial respiration inhibitor restores metabolic homeostasis in type 2 diabetes
Read the full paper: Harnessing mitohormesis: A thiazole-based mitochondrial respiration inhibitor restores metabolic homeostasis in type 2 diabetes
doi.org
April 30, 2026 at 7:00 AM
The authors included RRIDs in their in Bioorganic Chemistry paper! RRIDs improve reproducibility in scientific research. #BetterScience #RRID #OpenScience
Excited to share our latest paper on LRH‐1/NR5A2: targeting mitochondrial dynamics to reprogram macrophages and dendritic cells in T1D into an immune-tolerant phenotype! Thanks to the amazing team&collaborators 🙌 #T1D #Mitochondria #NuclearReceptors #Immunometabolism
doi.org/10.1002/ctm2...
doi.org/10.1002/ctm2...
LRH‐1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype
LRH-1/NR5A2 activation in inflammatory cells of individuals with type 1 diabetes (T1D) reduces pro-inflammatory cell surface markers and cytokine release. LRH-1/NR5A2 promotes a mitohormesis-induce...
doi.org
December 20, 2024 at 6:05 PM
Excited to share our latest paper on LRH‐1/NR5A2: targeting mitochondrial dynamics to reprogram macrophages and dendritic cells in T1D into an immune-tolerant phenotype! Thanks to the amazing team&collaborators 🙌 #T1D #Mitochondria #NuclearReceptors #Immunometabolism
doi.org/10.1002/ctm2...
doi.org/10.1002/ctm2...
How does superoxide, trapped inside mitochondria, signal the rest of the cell? We found out that mitochondrial citrate acts as second messenger for oxidative stress.
🔗 www.science.org/doi/10.1126/...
🔗 www.science.org/doi/10.1126/...
Mitochondrial superoxide–induced mitohormesis is mediated by citrate and cardioprotective
Mitohormesis, whereby transient mitochondrial stress induces adaptive signaling, promotes organismal resilience and longevity in invertebrates, but how this operates in mammals and the underlying meta...
www.science.org
September 4, 2026 at 8:23 PM
How does superoxide, trapped inside mitochondria, signal the rest of the cell? We found out that mitochondrial citrate acts as second messenger for oxidative stress.
🔗 www.science.org/doi/10.1126/...
🔗 www.science.org/doi/10.1126/...
Issue 20 cover & highlight:
Controlling synaptic autophagy from the neuronal soma @verstrekenlab.bsky.social
Comment:
Need for unified definition of cellular identity in enteric nervous system
Review:
Mammalian mitohormesis
...and many more articles…
www.embopress.org/toc/14602075...
Controlling synaptic autophagy from the neuronal soma @verstrekenlab.bsky.social
Comment:
Need for unified definition of cellular identity in enteric nervous system
Review:
Mammalian mitohormesis
...and many more articles…
www.embopress.org/toc/14602075...
October 15, 2025 at 12:05 PM
Issue 20 cover & highlight:
Controlling synaptic autophagy from the neuronal soma @verstrekenlab.bsky.social
Comment:
Need for unified definition of cellular identity in enteric nervous system
Review:
Mammalian mitohormesis
...and many more articles…
www.embopress.org/toc/14602075...
Controlling synaptic autophagy from the neuronal soma @verstrekenlab.bsky.social
Comment:
Need for unified definition of cellular identity in enteric nervous system
Review:
Mammalian mitohormesis
...and many more articles…
www.embopress.org/toc/14602075...
PBM (600–1000 nm) targets mitochondrial CCO → ↑ATP, mild ROS (mitohormesis), Ca²⁺ signaling → M1→M2 macrophage shift, satellite cell activation, ↑VEGF. Reduces inflammation & fibrosis, accelerates muscle repair. Dose-dependent: low stimulates, high inhibits. Pulsed mode preferred.
Photobiomodulation in skeletal muscle repair: Mechanisms, parameters, and therapeutic potential - PubMed
The theoretical basis for the potentiating effect of photobiomodulation (PBM) on muscle tissue is related to various mechanisms. Muscle is one of the major subcutaneous tissues, and during treatment w...
pubmed.ncbi.nlm.nih.gov
April 13, 2026 at 6:17 PM
PBM (600–1000 nm) targets mitochondrial CCO → ↑ATP, mild ROS (mitohormesis), Ca²⁺ signaling → M1→M2 macrophage shift, satellite cell activation, ↑VEGF. Reduces inflammation & fibrosis, accelerates muscle repair. Dose-dependent: low stimulates, high inhibits. Pulsed mode preferred.
Endothelial Mfn2 loss triggers “vascular mitohormesis” — boosting antioxidant defenses, mitochondrial fitness & lipid oxidation in adipose vessels. Mice stay leaner, resist diet-induced obesity, show better glucose control, and age healthier (↑healthspan). www.cell.com/cell-metabol...
Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice
Chivite et al. show that the genetic inactivation of the mitochondrial fusion protein
MFN2 in the endothelium triggers a protective stress response that boosts fat burning,
increases secretion of the ...
www.cell.com
February 18, 2026 at 7:19 AM
Endothelial Mfn2 loss triggers “vascular mitohormesis” — boosting antioxidant defenses, mitochondrial fitness & lipid oxidation in adipose vessels. Mice stay leaner, resist diet-induced obesity, show better glucose control, and age healthier (↑healthspan). www.cell.com/cell-metabol...
🚨 New Research 🚨
Our latest study in Clin. Transl. Med. shows LRH-1/NR5A2 activation fosters immune tolerance in T1D by reducing inflammation, promoting tolerogenic dendritic cells, and expanding regulatory T-cells.
A step forward in T1D research. 🙌
dx.doi.org/10.1002/ctm2...
Our latest study in Clin. Transl. Med. shows LRH-1/NR5A2 activation fosters immune tolerance in T1D by reducing inflammation, promoting tolerogenic dendritic cells, and expanding regulatory T-cells.
A step forward in T1D research. 🙌
dx.doi.org/10.1002/ctm2...
LRH‐1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype
LRH-1/NR5A2 activation in inflammatory cells of individuals with type 1 diabetes (T1D) reduces pro-inflammatory cell surface markers and cytokine release. LRH-1/NR5A2 promotes a mitohormesis-induce...
dx.doi.org
December 20, 2024 at 10:43 AM
🚨 New Research 🚨
Our latest study in Clin. Transl. Med. shows LRH-1/NR5A2 activation fosters immune tolerance in T1D by reducing inflammation, promoting tolerogenic dendritic cells, and expanding regulatory T-cells.
A step forward in T1D research. 🙌
dx.doi.org/10.1002/ctm2...
Our latest study in Clin. Transl. Med. shows LRH-1/NR5A2 activation fosters immune tolerance in T1D by reducing inflammation, promoting tolerogenic dendritic cells, and expanding regulatory T-cells.
A step forward in T1D research. 🙌
dx.doi.org/10.1002/ctm2...
RRIDs were included in this in Science Advances paper. RRIDs improve reproducibility in scientific research. #accelerateopenscience #ReproducibleResearch #RRID
Mitochondrial superoxide–induced mitohormesis is mediated by citrate and cardioprotective
Read the full paper: Mitochondrial superoxide–induced mitohormesis is mediated by citrate and cardioprotective
doi.org
September 16, 2026 at 7:34 PM
RRIDs were included in this in Science Advances paper. RRIDs improve reproducibility in scientific research. #accelerateopenscience #ReproducibleResearch #RRID
Mitochondrial superoxide–induced mitohormesis is mediated by citrate and cardioprotective
Science Advances
www.science.org/doi/10.1126/...
Science Advances
www.science.org/doi/10.1126/...
Mitochondrial superoxide–induced mitohormesis is mediated by citrate and cardioprotective
Mitohormesis, whereby transient mitochondrial stress induces adaptive signaling, promotes organismal resilience and longevity in invertebrates, but how this operates in mammals and the underlying meta...
www.science.org
September 8, 2026 at 5:40 AM
Mitochondrial superoxide–induced mitohormesis is mediated by citrate and cardioprotective
Science Advances
www.science.org/doi/10.1126/...
Science Advances
www.science.org/doi/10.1126/...
Transcriptomic analysis of mitohormesis associated with lifespan extension in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.04.15.648933v1
April 20, 2025 at 4:03 AM
Transcriptomic analysis of mitohormesis associated with lifespan extension in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.04.15.648933v1
Look under the streetlamps labeled mitohormesis, UPRmt, cGas-Sting, curiously linked to longevity in C. Elegans- G complexes are a biomarker and tetracyclines modulate all of these- a beta is downstream and an after-event
February 24, 2025 at 8:09 PM
Look under the streetlamps labeled mitohormesis, UPRmt, cGas-Sting, curiously linked to longevity in C. Elegans- G complexes are a biomarker and tetracyclines modulate all of these- a beta is downstream and an after-event
The authors included RRIDs in their in Nature Communications paper! Thanks for making your methods matter! #STMpublishing #reproducibility #BetterScience
Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models - Nature Communications
Reversible mitochondrial stress leading to improved mitochondrial function (mitohormesis) has been reported as an anti-aging mechanism. Here the authors report that harmol (a beta-carboline compound) induces mitohormesis in peripheral organs, alleviates aging-related phenotypes in mice, and extends lifespan in invertebrate models.
doi.org
June 30, 2026 at 7:01 AM
The authors included RRIDs in their in Nature Communications paper! Thanks for making your methods matter! #STMpublishing #reproducibility #BetterScience
Mammalian #mitohormesis:
Amanda Gunawan, Irene Liparulo and Andreas Stahl review the winding path from mitochondrial stressors to organismal benefits
www.embopress.org/doi/full/10....
Amanda Gunawan, Irene Liparulo and Andreas Stahl review the winding path from mitochondrial stressors to organismal benefits
www.embopress.org/doi/full/10....
September 9, 2025 at 9:48 AM
Mammalian #mitohormesis:
Amanda Gunawan, Irene Liparulo and Andreas Stahl review the winding path from mitochondrial stressors to organismal benefits
www.embopress.org/doi/full/10....
Amanda Gunawan, Irene Liparulo and Andreas Stahl review the winding path from mitochondrial stressors to organismal benefits
www.embopress.org/doi/full/10....
Upcoming seminar by Jean-Emmanuel Sarry: Mitohormesis and metabolic adaptations in response to therapeutic stress in acute myeloid leukemia at Institut Necker Enfants Malades, Friday 20 June 2025 at 12:00. More info
April 26, 2025 at 12:42 AM
Upcoming seminar by Jean-Emmanuel Sarry: Mitohormesis and metabolic adaptations in response to therapeutic stress in acute myeloid leukemia at Institut Necker Enfants Malades, Friday 20 June 2025 at 12:00. More info
🗓️ Join us on June 20, for a #seminar with Jean-Emmanuel Sarry, team leader at CRCT Oncopole. Dr. Sarry will explore Mitohormesis and metabolic adaptations in response to therapeutic stress in acute myeloid leukemia. Don’t miss it!
June 13, 2025 at 12:02 PM
🗓️ Join us on June 20, for a #seminar with Jean-Emmanuel Sarry, team leader at CRCT Oncopole. Dr. Sarry will explore Mitohormesis and metabolic adaptations in response to therapeutic stress in acute myeloid leukemia. Don’t miss it!
The ketogenic diet triggers mitohormesis, improving mitochondrial health and resilience. It boosts antioxidants, reduces ROS, and enhances energy efficiency.
- end🙂
- end🙂
December 11, 2024 at 10:50 AM
The ketogenic diet triggers mitohormesis, improving mitochondrial health and resilience. It boosts antioxidants, reduces ROS, and enhances energy efficiency.
- end🙂
- end🙂
Neuroprotection - Studies on KD show:
• Enhanced hippocampal mitochondria function.
• Increased resistance to oxidative stress (less ROS, more antioxidants).
• Mitohormesis extends beyond the brain—KD protects liver, muscle, and other tissues.
• Enhanced hippocampal mitochondria function.
• Increased resistance to oxidative stress (less ROS, more antioxidants).
• Mitohormesis extends beyond the brain—KD protects liver, muscle, and other tissues.
December 11, 2024 at 10:50 AM
Neuroprotection - Studies on KD show:
• Enhanced hippocampal mitochondria function.
• Increased resistance to oxidative stress (less ROS, more antioxidants).
• Mitohormesis extends beyond the brain—KD protects liver, muscle, and other tissues.
• Enhanced hippocampal mitochondria function.
• Increased resistance to oxidative stress (less ROS, more antioxidants).
• Mitohormesis extends beyond the brain—KD protects liver, muscle, and other tissues.