NETosis-mediated immunothrombosis yet again implicated in #longCOVID pathogenesis
Mass General Hospital 84 participants study suggests long COVID may persist because spike related immune complexes overactivate neutrophils which release DNA traps that damage blood vessels and promote microclots sustaining inflammation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Endovascular profiles linked to neutrophil activation in children and young adults with long COVID - Pediatric Research
Pediatric Research - Endovascular profiles linked to neutrophil activation in children and young adults with long COVID
www.nature.com
April 25, 2026 at 5:56 AM
NETosis-mediated immunothrombosis yet again implicated in #longCOVID pathogenesis
Erasmus Medical Center, 103 participants. After 3 years of Long COVID, three blood markers of NETosis were not elevated versus recovered controls, arguing against persistent systemic NETosis as a universal feature of long-term disease.
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
Frontiers | A brief report: absence of elevated circulating NETosis markers in long-term long COVID
BackgroundNeutrophil extracellular trap (NET) formation (NETosis) has been proposed as a contributor to the pathophysiology of Long COVID (LC). However, it r...
www.frontiersin.org
September 23, 2026 at 7:54 PM
Erasmus Medical Center, 103 participants. After 3 years of Long COVID, three blood markers of NETosis were not elevated versus recovered controls, arguing against persistent systemic NETosis as a universal feature of long-term disease.
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
NETosis is an integral part of the inflammasome youtu.be/-etkTCbnB1w?...
November 11, 2025 at 1:22 AM
NETosis is an integral part of the inflammasome youtu.be/-etkTCbnB1w?...
By Zdenek Vrozina:
"This may be one of the more important long COVID papers in a while. A new study in Frontiers in Immunology suggests that COVID can trigger new-onset insulin resistance - and that this may drive abnormal NETosis in neutrophils months after infection."
Published: 04 May 2026
"This may be one of the more important long COVID papers in a while. A new study in Frontiers in Immunology suggests that COVID can trigger new-onset insulin resistance - and that this may drive abnormal NETosis in neutrophils months after infection."
Published: 04 May 2026
Frontiers | De novo COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection
BackgroundGlucose metabolism disorders (GMDs) are established risk factors for severe COVID-19, but increasing evidence indicates that they may also develop ...
www.frontiersin.org
May 22, 2026 at 2:24 AM
By Zdenek Vrozina:
"This may be one of the more important long COVID papers in a while. A new study in Frontiers in Immunology suggests that COVID can trigger new-onset insulin resistance - and that this may drive abnormal NETosis in neutrophils months after infection."
Published: 04 May 2026
"This may be one of the more important long COVID papers in a while. A new study in Frontiers in Immunology suggests that COVID can trigger new-onset insulin resistance - and that this may drive abnormal NETosis in neutrophils months after infection."
Published: 04 May 2026
After almost a decade (started while I was a postdoc with @nizet.bsky.social and finished by my own stellar students), happy to see this finally out. We found that Tamm-Horsfall protein, the most abundant protein in urine, enhanced NETosis to protect against UTI. insight.jci.org/articles/vie...
JCI Insight -
Tamm-Horsfall protein augments neutrophil NETosis during urinary tract infection
insight.jci.org
January 10, 2025 at 9:28 PM
After almost a decade (started while I was a postdoc with @nizet.bsky.social and finished by my own stellar students), happy to see this finally out. We found that Tamm-Horsfall protein, the most abundant protein in urine, enhanced NETosis to protect against UTI. insight.jci.org/articles/vie...
Here's "NETosis", a white blood cell called a 'neutrophil' releasing sticky clouds of its DNA (in orange) that can envelop even giant parasitic worms, slowing their progress or killing them.
Another big kablooey!
(📷: Niall Geoghegan)
Another big kablooey!
(📷: Niall Geoghegan)
September 22, 2026 at 12:44 PM
Here's "NETosis", a white blood cell called a 'neutrophil' releasing sticky clouds of its DNA (in orange) that can envelop even giant parasitic worms, slowing their progress or killing them.
Another big kablooey!
(📷: Niall Geoghegan)
Another big kablooey!
(📷: Niall Geoghegan)
www.nature.com/articles/s41...
Chromatin decompaction within the nucleus increases plasma membrane tension promoting NETosis execution, independently of transcription
Chromatin decompaction within the nucleus increases plasma membrane tension promoting NETosis execution, independently of transcription
August 20, 2026 at 6:32 AM
www.nature.com/articles/s41...
Chromatin decompaction within the nucleus increases plasma membrane tension promoting NETosis execution, independently of transcription
Chromatin decompaction within the nucleus increases plasma membrane tension promoting NETosis execution, independently of transcription
We've been learning a lot about how Enterococcus faecalis interacts with neutrophils lately.
In our latest preprint, @harisantypas.bsky.social describes how lactic acid from E. faecalis dampens neutrophil metabolism leading to NETosis and phagoytosis suppression.
#microsky
In our latest preprint, @harisantypas.bsky.social describes how lactic acid from E. faecalis dampens neutrophil metabolism leading to NETosis and phagoytosis suppression.
#microsky
Enterococcus faecalis biofilm rewires neutrophil metabolism to suppress antimicrobial functions https://www.biorxiv.org/content/10.64898/2026.06.18.733107v1
June 19, 2026 at 3:12 PM
We've been learning a lot about how Enterococcus faecalis interacts with neutrophils lately.
In our latest preprint, @harisantypas.bsky.social describes how lactic acid from E. faecalis dampens neutrophil metabolism leading to NETosis and phagoytosis suppression.
#microsky
In our latest preprint, @harisantypas.bsky.social describes how lactic acid from E. faecalis dampens neutrophil metabolism leading to NETosis and phagoytosis suppression.
#microsky
neutrophil-like cells release their chromatin to trap pathogens (NETosis) - nets are sticky and inflammatory bc they promote dead neutrophil adhesion matrices - in this article authors show that DNA methylation status impacts NETosis yield and outcomes www.sciencedirect.com/science/arti...
DNA demethylation increases NETosis
Neutrophil extracellular traps (NETs) occur during the development of autoimmune diseases, cancer and diabetes. A novel form of cell death that is ind…
www.sciencedirect.com
December 28, 2024 at 12:40 PM
neutrophil-like cells release their chromatin to trap pathogens (NETosis) - nets are sticky and inflammatory bc they promote dead neutrophil adhesion matrices - in this article authors show that DNA methylation status impacts NETosis yield and outcomes www.sciencedirect.com/science/arti...
Neutrophil & platelet activation were also found in folks with Long COVID.
There is a lot of info about neutrophils here, coming pretty fast. VanElzakker is describing spontaneous NETosis in cells from people with Long COVID.
You can find more about NETosis here: en.wikipedia.org/wiki/Neutrop...
There is a lot of info about neutrophils here, coming pretty fast. VanElzakker is describing spontaneous NETosis in cells from people with Long COVID.
You can find more about NETosis here: en.wikipedia.org/wiki/Neutrop...
Neutrophil extracellular traps - Wikipedia
en.wikipedia.org
September 23, 2024 at 6:37 PM
Neutrophil & platelet activation were also found in folks with Long COVID.
There is a lot of info about neutrophils here, coming pretty fast. VanElzakker is describing spontaneous NETosis in cells from people with Long COVID.
You can find more about NETosis here: en.wikipedia.org/wiki/Neutrop...
There is a lot of info about neutrophils here, coming pretty fast. VanElzakker is describing spontaneous NETosis in cells from people with Long COVID.
You can find more about NETosis here: en.wikipedia.org/wiki/Neutrop...
Turns out the way DNA is packed inside the nucleus can tune the mechanics of the entire cell!
Super excited that our first paper is out in Nature Communications! www.nature.com/articles/s41... !
Super excited that our first paper is out in Nature Communications! www.nature.com/articles/s41... !
Chromatin decompaction within the nucleus increases plasma membrane tension promoting NETosis execution, independently of transcription - Nature Communications
Chromatin organizes nuclear DNA, but whether it actively regulates whole-cell mechanics remains unknown. Here, we used NETosis to show that chromatin decompaction within the nucleus increases plasma membrane tension and cell volume, establishing chromatin as a regulator of cell mechanics.
www.nature.com
August 20, 2026 at 5:20 PM
Turns out the way DNA is packed inside the nucleus can tune the mechanics of the entire cell!
Super excited that our first paper is out in Nature Communications! www.nature.com/articles/s41... !
Super excited that our first paper is out in Nature Communications! www.nature.com/articles/s41... !
Lipid nanoparticle used in mRNA vaccine promotes tumor metastasis in mouse model via mtDNA-induced neutrophil activation and NETosis
Yes, that paper, which is abused to make very wrong claims about vaccines and "turbocancer", by the usual players.
www.sciencedirect.co...
1/10
Yes, that paper, which is abused to make very wrong claims about vaccines and "turbocancer", by the usual players.
www.sciencedirect.co...
1/10
Lipid nanoparticle used in mRNA vaccine promotes tumor metastasis in mouse model via mtDNA-induced neutrophil activation and NETosis
mRNA vaccines have advanced immunotherapy against infectious diseases and cancer, with lipid nanoparticles (LNPs) playing a crucial role as delivery s…
www.sciencedirect.com
September 8, 2026 at 9:20 AM
Lipid nanoparticle used in mRNA vaccine promotes tumor metastasis in mouse model via mtDNA-induced neutrophil activation and NETosis
Yes, that paper, which is abused to make very wrong claims about vaccines and "turbocancer", by the usual players.
www.sciencedirect.co...
1/10
Yes, that paper, which is abused to make very wrong claims about vaccines and "turbocancer", by the usual players.
www.sciencedirect.co...
1/10
Researchers link excessive NETosis—neutrophil trap formation—to COVID-19 severity, long COVID, and autoimmunity.
This process fuels inflammation, blood clots, and immune dysfunction, making it a key target for future treatments.
www.sciencedirect.com/science/arti...
This process fuels inflammation, blood clots, and immune dysfunction, making it a key target for future treatments.
www.sciencedirect.com/science/arti...
NETosis: A key player in autoimmunity, COVID-19, and long COVID
NETosis, the process through which neutrophils release neutrophil extracellular traps (NETs), has emerged as a crucial mechanism in host defense and t…
www.sciencedirect.com
March 2, 2025 at 5:17 PM
Researchers link excessive NETosis—neutrophil trap formation—to COVID-19 severity, long COVID, and autoimmunity.
This process fuels inflammation, blood clots, and immune dysfunction, making it a key target for future treatments.
www.sciencedirect.com/science/arti...
This process fuels inflammation, blood clots, and immune dysfunction, making it a key target for future treatments.
www.sciencedirect.com/science/arti...
My continued biomedical education
Shaping neutrophil morphology & function
The importance of a segmented nucleus
Polylobular nuclei likely help Neutrophil with
👉Motile flexibility
👉Differentiation
👉NETosis
👉Rapid switching b/w A/B compartments
#NatRevImmunol 2025
www.nature.com/articles/s41...
Shaping neutrophil morphology & function
The importance of a segmented nucleus
Polylobular nuclei likely help Neutrophil with
👉Motile flexibility
👉Differentiation
👉NETosis
👉Rapid switching b/w A/B compartments
#NatRevImmunol 2025
www.nature.com/articles/s41...
November 15, 2025 at 12:17 PM
My continued biomedical education
Shaping neutrophil morphology & function
The importance of a segmented nucleus
Polylobular nuclei likely help Neutrophil with
👉Motile flexibility
👉Differentiation
👉NETosis
👉Rapid switching b/w A/B compartments
#NatRevImmunol 2025
www.nature.com/articles/s41...
Shaping neutrophil morphology & function
The importance of a segmented nucleus
Polylobular nuclei likely help Neutrophil with
👉Motile flexibility
👉Differentiation
👉NETosis
👉Rapid switching b/w A/B compartments
#NatRevImmunol 2025
www.nature.com/articles/s41...
Ok but I’m interested in NETosis in cats
Another example that cats are cuter than dogs - to draw attention to a paper about bronchiectasis in dogs, a veterinary journal uses a cat photo!
There’re less charitable interpretations, but, fact is I noticed the paper!
Note to myself: add a cat photo to next paper
#WhateverItTakes
#CatsAndDogs
There’re less charitable interpretations, but, fact is I noticed the paper!
Note to myself: add a cat photo to next paper
#WhateverItTakes
#CatsAndDogs
March 18, 2026 at 9:46 PM
Ok but I’m interested in NETosis in cats
NETosis of neutrophils isolated from zebrafishlarvae fed with a normal diet or with a high-cholesterol diet.
Look at that beautiful fireworks 🎆 by Cassia Michael (3rd year grad student)
Look at that beautiful fireworks 🎆 by Cassia Michael (3rd year grad student)
November 12, 2024 at 1:37 AM
NETosis of neutrophils isolated from zebrafishlarvae fed with a normal diet or with a high-cholesterol diet.
Look at that beautiful fireworks 🎆 by Cassia Michael (3rd year grad student)
Look at that beautiful fireworks 🎆 by Cassia Michael (3rd year grad student)
Our first foray into Enterococcal-neutrophil interactions! 🤠 We found that E. faecalis suppresses S. aureus-induced NETosis and promotes bacterial survival in polymicrobial infections. Stay tuned...more to come on this. academic.oup.com/femsmicrobes...
Enterococcus faecalis suppresses Staphylococcus aureus-induced NETosis and promotes bacterial surviv...
Enterococcus faecalis actively suppresses neutrophil extracellular trap formation.
academic.oup.com
November 18, 2023 at 8:04 AM
Our first foray into Enterococcal-neutrophil interactions! 🤠 We found that E. faecalis suppresses S. aureus-induced NETosis and promotes bacterial survival in polymicrobial infections. Stay tuned...more to come on this. academic.oup.com/femsmicrobes...
From Chile
De novo COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection
www.frontiersin.org/journals/imm...
Screenshot from science for ME weekly update
#LongCovid #COVID19 #COVID #COVID_19
1/
De novo COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection
www.frontiersin.org/journals/imm...
Screenshot from science for ME weekly update
#LongCovid #COVID19 #COVID #COVID_19
1/
June 14, 2026 at 8:30 PM
From Chile
De novo COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection
www.frontiersin.org/journals/imm...
Screenshot from science for ME weekly update
#LongCovid #COVID19 #COVID #COVID_19
1/
De novo COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection
www.frontiersin.org/journals/imm...
Screenshot from science for ME weekly update
#LongCovid #COVID19 #COVID #COVID_19
1/
pmc.ncbi.nlm.nih.gov/articles/PMC...
They invented NETosis. When is NEETosis happening.
The current administration has no interest in answering that.
They invented NETosis. When is NEETosis happening.
The current administration has no interest in answering that.
NETosis: Molecular Mechanisms, Role in Physiology and Pathology
NETosis is a program for formation of neutrophil extracellular traps (NETs), which consist of modified chromatin decorated with bactericidal proteins from granules and cytoplasm. Various pathogens, an...
pmc.ncbi.nlm.nih.gov
May 9, 2026 at 6:35 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
They invented NETosis. When is NEETosis happening.
The current administration has no interest in answering that.
They invented NETosis. When is NEETosis happening.
The current administration has no interest in answering that.
We look forward to hearing feedback from the community on our #preprint where we used #NETosis as a platform to show that chromatin decompaction inside the nucleus directly regulates cell mechanics. This work identifies long-range biophysical impacts of chromatin in mammalian cells.
Chromatin is a long-range force generator that regulates plasma membrane tension and cell integrity independently of gene expression https://www.biorxiv.org/content/10.1101/2025.10.02.680155v1
October 6, 2025 at 10:18 AM
The final talk of the 2026 #BlackInBiophysics Symposium has begun!
Dr. Hawa Racine Thiam from Stanford University is presenting on “Neutrophil biophysics through the lens on netosis.”
#BPS2026 @biophysicalsoc.bsky.social
Dr. Hawa Racine Thiam from Stanford University is presenting on “Neutrophil biophysics through the lens on netosis.”
#BPS2026 @biophysicalsoc.bsky.social
February 24, 2026 at 5:40 PM
The final talk of the 2026 #BlackInBiophysics Symposium has begun!
Dr. Hawa Racine Thiam from Stanford University is presenting on “Neutrophil biophysics through the lens on netosis.”
#BPS2026 @biophysicalsoc.bsky.social
Dr. Hawa Racine Thiam from Stanford University is presenting on “Neutrophil biophysics through the lens on netosis.”
#BPS2026 @biophysicalsoc.bsky.social
"Children & young adults with long COVID with cardiovascular symptoms display increased microclots, endothelial injury, & neutrophil inflammation, which warrant further evaluation and suggest intravascular NETosis as key driver of endovascular pathology in long COVID"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 25, 2026 at 5:49 PM
"Children & young adults with long COVID with cardiovascular symptoms display increased microclots, endothelial injury, & neutrophil inflammation, which warrant further evaluation and suggest intravascular NETosis as key driver of endovascular pathology in long COVID"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
RBFOX2 suppresses NETosis and glioma growth via 5hmC-dependent PDGFB decay
RBFOX2 suppresses NETosis and glioma growth via 5hmC-dependent PDGFB decay
Mechanisms driving NETosis in the glioma microenvironment remain poorly understood. Chen et al. reveal RBFOX2 as a key regulator that binds 5hmC-modified PDGFB mRNA to promote its degradation and restrain NETosis, coupling RNA modification to glioma immune evasion.
dlvr.it
July 8, 2026 at 2:38 PM
RBFOX2 suppresses NETosis and glioma growth via 5hmC-dependent PDGFB decay
Lower airway dysbiosis fuels NETosis in nontuberculous mycobacterial bronchiectasis: rethinking the microbiome-host axis
doi.org/10.1093/ajrc...
@atscommunity.bsky.social
doi.org/10.1093/ajrc...
@atscommunity.bsky.social
June 10, 2026 at 9:28 PM
Lower airway dysbiosis fuels NETosis in nontuberculous mycobacterial bronchiectasis: rethinking the microbiome-host axis
doi.org/10.1093/ajrc...
@atscommunity.bsky.social
doi.org/10.1093/ajrc...
@atscommunity.bsky.social
Want to do a PhD in maternal-fetal health? I have a fully funded MRC DTP project available from September 2025, to study neutrophil function and NETosis in pregnant women at risk of preeclampsia. You'll work with me and Prof Jenny Myers in @mfh-research.bsky.social and David Brough too! DM me 🤰🩸
(MRC DTP) Longitudinal analysis of NETosis in pregnant women at risk of hypertension at The University of Manchester on FindAPhD.com
PhD Project - (MRC DTP) Longitudinal analysis of NETosis in pregnant women at risk of hypertension at The University of Manchester, listed on FindAPhD.com
www.findaphd.com
October 10, 2025 at 9:37 AM
Want to do a PhD in maternal-fetal health? I have a fully funded MRC DTP project available from September 2025, to study neutrophil function and NETosis in pregnant women at risk of preeclampsia. You'll work with me and Prof Jenny Myers in @mfh-research.bsky.social and David Brough too! DM me 🤰🩸