"There is a dissociation where the body disconnects before the mind does—a way the body remembers pain that words cannot express." Written by pioneering trauma and medical-scientific thinkers Jinseong Min and Mola Mola, The Body's Unspoken Atlas delivers an uncompromising, deeply technical, and philosophically profound map of the silent terrain where advanced neurobiology meets raw human suffering. Move beyond traditional psychiatry that reduces dissociation to a simple "disconnection of the psyche." This groundbreaking text uncovers the cold, physiological realities of somatized dissociation, autonomic nervous system dysfunction, and the boundaries of medical authority. Discover a revolutionary framework that bridges the gap between precision clinical technology and the environmental design of public recovery.

Insilico Medicine has teamed up with SK Biopharmaceuticals on a wide-ranging, $2.5bn partnership to use AI to find neuroimmune drug candidates.

Geng, L. N. et al. 2024 update of the RECOVER-Adult long COVID research index. JAMA 333, 694–700 (2025). Kuri-Cervantes, L. et al. Comprehensive mapping of immune perturbations associated with severe COVID-19. Sci. Immunol. 5, eabd7114 (2020). Rahimi, R. A. et al. Advancing lung immunology research: an official American Thoracic Society workshop report. Am. J. Respir. Cell Mol. Biol. 67, e1–e18 (2022). Talbot, S., Foster, S. L. & Woolf, C. J. Neuroimmunity: physiology and pathology. Annu. Rev. Immunol. 34, 421–447 (2016). Almanzar, N. et al. Vagal TRPV1+ sensory neurons protect against influenza virus infection by regulating lung myeloid cell dynamics. Sci. Immunol. 10, eads6243 (2025). This paper shows that vagal TRPV1-positive sensory neurons protect the host from lung injury during influenza A infection by skewing pulmonary myeloid cell responses, including those of neutrophils and macrophages, towards less tissue-damaging states, revealing a key neuroimmune mechanism that regulates disease severity during viral respiratory infection. Hiroki, C. H. et al. Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis. Immunity 58, 2054–2068.e6 (2025). This paper shows that TRPV1-positive nociceptor sensory neurons protect the host against pulmonary fibrosis by restraining alveolar macrophage-driven VIP/TGFβ signalling and the subsequent recruitment of NET-producing Siglec-F-positive...

The kynurenine (KYN) metabolic pathway sits at the crossroads of immunity, metabolism, and neurobiology, yet its clinical translation remains fragmented. Emerging spatial omics, wearable chronobiology, and synthetic microbiota studies reveal that tryptophan (Trp) metabolism is regulated by distinct cellular “checkpoints” along the gut–brain axis, finely modulated by sex differences, circadian rhythms, and microbiome composition. However, current interventions tackle single levers in isolation, leaving a key gap in the precision control of Trp’s fate. To address this, we drew upon an extensive body of the primary literature and databases, mapping enzyme expression across tissues at single-cell resolution and linking these profiles to clinical trials investigating dual indoleamine 2,3-dioxygenase 1 (IDO1)/tryptophan 2,3-dioxygenase (TDO) inhibitors, engineered probiotics, and chrono-modulated dosing strategies. We then developed decision-tree algorithms that rank therapeutic combinations against biomarker feedback loops derived from real-time saliva, plasma, and stool metabolomics. This synthesis pinpoints microglial and endothelial KYN hotspots, quantifies sex-specific chronotherapeutic windows, and identifies engineered Bifidobacterium consortia and dual inhibitors as synergistic nodes capable of reducing immunosuppressive KYN while preserving neuroprotective kynurenic acid. Here, we highlight a framework that couples lifestyle levers, bio-engineered microbes, and adaptive pharmaco-regimens into closed-loop “smart protocols.” By charting these intersections, this study offers a roadmap for biomarker-guided, multidisciplinary interventions that could recalibrate KYN metabolic activity across cancer, mood, neurodegeneration, and metabolic disorders, appealing to clinicians, bioengineers, and systems biologists alike.

The 2025 Gordon Research Conference on Neuroimmune Communication in Health and Disease will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.

Project summary:  A project to determine the extent to which glial activation (part of neuroinflammation) is contributing to ‘brain fog’ cognitive...