#Kynurenine
1) 🇦🇺 This new study tested the kynurenine pathway in the plasma of 61 ME/CFS patients and 61 controls.

There were no differences in tryptophan or kynurenine, but further downstream, patients had increased levels of 3HK and lower levels of picolinic acid and quinolinic acid.
December 19, 2025 at 9:16 AM
Candidate mechanistic strata now have biomarker anchors:

Endothelial/thrombotic: P-selectin, vWF, D-dimer
Autoantibody: DN2 B-cell frequency
Autophagy: pATG13, beclin-1
Anemia/iron: heme-metabolism signature
Epigenetic: DNA methylation
Gut-brain: kynurenine/serotonin ratio

#LongCOVID
#medsky
September 26, 2026 at 10:56 PM
Could #tumor metabolism drive T-cell exhaustion?
CD147 enhances tryptophan uptake and kynurenine production in #NSCLC, promoting CD8+ T-cell exhaustion, while CD147-targeted CAR-T plus anti-PD-1 shows therapeutic potential.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
September 28, 2026 at 1:05 PM
New study links #Microbiome to creeping fat in #CrohnsDisease via #Kynurenine metabolism

Highlights:
Commensal A. pulmonis drives CrF via macrophage-derived L-kynurenine
Kynurenine activates AHR in adipocytes, promoting fat formation
Blocking IDO1 or degrading kynurenine reduces CrF in mice
Microbiota-induced alteration of kynurenine metabolism in macrophages drives formation of creeping fat in Crohn’s disease
Wu et al. reveal that the commensal Achromobacter pulmonis induces mesenteric adipogenesis through macrophages alteration. Mechanistically, macrophage-derived L-kynurenine via indoleamine 2,3-dioxygenase 1 (IDO1) promotes adipogenesis by aryl hydrocarbon receptor (AHR) activation in adipocytes. Targeting kynurenine metabolism with an IDO1 inhibitor or bacteria engineered to degrade L-kynurenine alleviates mesenteric adipogenesis.
www.cell.com
January 7, 2025 at 4:42 PM
Review
Could the kynurenine pathway be the key missing piece of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) complex puzzle? pubmed.ncbi.nlm.nih.gov/35821534/ #MECFS #Kynurenine
Could the kynurenine pathway be the key missing piece of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) complex puzzle? - PubMed
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex and debilitating disease with a substantial social and economic impact on individuals and their community. Despite its importan...
pubmed.ncbi.nlm.nih.gov
January 4, 2025 at 2:54 AM
Dysregulation of the Kynurenine Pathway, Cytokine Expression Pattern, and Proteomics Profile Link to Symptomology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) link.springer.com/article/10.1... #MECFS #KynureninePathway #Proteomics
Dysregulation of the Kynurenine Pathway, Cytokine Expression Pattern, and Proteomics Profile Link to Symptomology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - Molecular Neurobiolog...
Dysregulation of the kynurenine pathway (KP) is believed to play a significant role in neurodegenerative and cognitive disorders. While some evidence links the KP to myalgic encephalomyelitis/chronic ...
link.springer.com
January 26, 2025 at 7:49 PM
From Germany

Association of kynurenine metabolites with cognitive and psychological symptoms in post COVID-19 condition: A case-control study

www.sciencedirect.com/science/arti...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC
July 8, 2026 at 12:38 AM
I wrote the article ‘Disruptions in serotonin- and kynurenine pathway metabolism in post-COVID: biomarkers and treatment’ in Frontiers in Neurology.

doi.org/10.3389/fneu...
Frontiers | Disruptions in serotonin- and kynurenine pathway metabolism in post-COVID: biomarkers and treatment
This opinion article attempts to connect knowledge about post-Covid syndrome (PCS) gained in neuropsychiatry and immunology. It discusses some misunderstandi...
doi.org
February 15, 2025 at 4:03 PM
🚨Our NEW paper is out!!🚨

Sex-Specific Alterations of Kynurenine Pathway in Association with Risk and Remission of Depression in Adolescence

Great work from #IDEAteam 🤩
shorturl.at/TReuY

@mqmentalhealth.bsky.social
@nihrmaudsleybrc.bsky.social
@ckieling.bsky.social
@pixielabkcl.bsky.social
Sex-Specific Alterations of the Kynurenine Pathway in Association With Risk for and Remission of Depression in Adolescence
The imbalance between neurotoxic and neuroprotective metabolites of the kynurenine pathway has been implicated in the pathophysiology of major depress…
shorturl.at
March 25, 2025 at 8:33 AM
Tryptophan oder seine Abbauprodukte können helfen, den durch COVID-19 gestörten Stoffwechsel wieder ins Gleichgewicht zu bringen. Dies könnte besonders den NAD+-Spiegel verbessern und gegen die Erschöpfung nach COVID-19 wirken.

portlandpress.com/bioscirep/ar...
The kynurenine pathway of tryptophan metabolism: a neglected therapeutic target of COVID-19 pathophysiology and immunotherapy
Abstract. SARS-CoV-2 (COVID-19) exerts profound changes in the kynurenine (Kyn) pathway (KP) of tryptophan (Trp) metabolism that may underpin its pathophysiology. The KP is the main source of the vita...
portlandpress.com
December 9, 2024 at 7:00 PM
October 14, 2025 at 5:50 AM
Pregnancy Impacts Maternal Sleep: Focus on Kynurenine Pathway Activation in Female Rats https://www.biorxiv.org/content/10.64898/2026.09.14.751544v1
September 21, 2026 at 7:24 PM
Dysregulation of the Kynurenine Pathway, Cytokine Expression Pattern, and Proteomics Profile Link to Symptomology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome #ME/CFS (2023 🇦🇺)

#KynureninePathway
Dysregulation of the Kynurenine Pathway, Cytokine Expression Pattern, and Proteomics Profile Link to Symptomology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - Molecular Neurobiolog...
Dysregulation of the kynurenine pathway (KP) is believed to play a significant role in neurodegenerative and cognitive disorders. While some evidence links the KP to myalgic encephalomyelitis/chronic ...
link.springer.com
August 3, 2026 at 7:46 PM
EWSR1::ETS-low cells promote metabolic reprogramming of the tryptophan-kynurenine-AHR axis, immunosuppression, and poor outcome in Ewing sarcoma https://www.biorxiv.org/content/10.1101/2025.05.16.654502v1
May 21, 2025 at 12:48 PM
RESEARCH | R Sun, X Liang et al (Shandong Uni, CN)

Psychological stress-mediated dysregulation of catecholamine signaling rewires hepatic kynurenine pathway which impairs liver CD8+ T cell function & promotes liver cancer progression 🧪
Chronic stress drives liver cancer by impairing the hepatic kynurenine pathway and immune surveillance - Nature Metabolism
Psychological stress-mediated dysregulation of catecholamine signalling rewires the hepatic kynurenine pathway, which in turn impairs liver CD8+ T cell function and promotes liver cancer progression.
dlvr.it
February 12, 2026 at 4:57 PM
New from Australia:
Dysregulation of the Kynurenine Pathway, Cytokine Expression Pattern, and Proteomics Profile Link to Symptomology in #MyalgicEncephalomyelitis/ #ChronicFatigueSyndrome (ME/CFS)

Pay-walled:
link.springer.com/article/10.1...

#MEcfs #CFS #PwME #MyalgicE
November 28, 2023 at 4:50 PM
Boston scientists found COVID-19 reprograms tryptophan metabolism, boosting kynurenine levels and triggering clotting pathways.

www.biorxiv.org/content/10.1...
Tryptophan metabolism reprogramming contributes to the prothrombotic milieu in mice and humans infected with SARS-CoV-2
SARS-CoV-2 infection disturbs the coagulation balance in the blood, triggering thrombosis and contributing to organ failure. The role of prothrombotic metabolites in COVID-19-associated coagulopathy r...
www.biorxiv.org
January 21, 2025 at 1:24 PM
From Germany

Cerebral gray matter volumes in long-term post-COVID patients are associated with peripheral kynurenine pathway metabolites and the severity of depressive symptoms

www.sciencedirect.com/science/arti...

Screenshot from Science for ME weekly update

#LongCovid #COVIDBrain #NeuroPASC
July 30, 2026 at 5:01 PM
Kynurenine and NAD+ Pathways are Associated with Macrophage Content and Polarization in Carotid Plaques https://www.biorxiv.org/content/10.1101/2025.04.14.648852v1
April 20, 2025 at 4:17 AM
Dysregulation of the Kynurenine Pathway, Cytokine Expression Pattern, and Proteomics Profile Link to Symptomology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) link.springer.com/article/10.1...
November 28, 2023 at 5:24 PM
#TellUsAboutYourResearch:

Meet Dr. Florian Javelle @npi-dshs.bsky.social, Head of the NeuroPsychoImmunology research unit and Postdoctoral Fellow at GSU Cologne! Dr. Javelle studies how the immune system, brain, and exercise interact in mental health, focusing on kynurenine–inflammation links
February 12, 2026 at 6:00 PM
Disruptions in serotonin- and kynurenine pathway metabolism in post-COVID: biomarkers and treatment

@carlarus.bsky.social

Neuropsychiatrist, Independent Researcher, The Hague, Netherlands
www.frontiersin.org/journals/neu...
Frontiers | Disruptions in serotonin- and kynurenine pathway metabolism in post-COVID: biomarkers and treatment
This opinion article attempts to connect knowledge about post-Covid syndrome (PCS) gained in neuropsychiatry and immunology. It discusses some misunderstandi...
www.frontiersin.org
February 18, 2025 at 5:05 PM