Air pollution (particulate matter, PM 2.5) and worsened Alzheimer's neuropathology
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
September 8, 2025 at 3:45 PM
Air pollution (particulate matter, PM 2.5) and worsened Alzheimer's neuropathology
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
🎓 I finished my PhD at KU Leuven in the Neuropathology Lab, where I studied the link between Alzheimer's disease 🧠 and the eye 👁️. Now looking for a postdoc position to continue exploring neurodegeneration.
#KULeuven #Neuropathology #AlzheimersResearch #PostdocSearch #Science #Neuroscience
#KULeuven #Neuropathology #AlzheimersResearch #PostdocSearch #Science #Neuroscience
December 11, 2024 at 12:08 AM
🎓 I finished my PhD at KU Leuven in the Neuropathology Lab, where I studied the link between Alzheimer's disease 🧠 and the eye 👁️. Now looking for a postdoc position to continue exploring neurodegeneration.
#KULeuven #Neuropathology #AlzheimersResearch #PostdocSearch #Science #Neuroscience
#KULeuven #Neuropathology #AlzheimersResearch #PostdocSearch #Science #Neuroscience
biomarker, returned to normal, strengthening the case for true disease reversal. Researchers ALSO studied brain tissue from PEOPLE with Alzheimer’s and from individuals known as nondemented with Alzheimer’s neuropathology, or NDAN. These individuals had heavy plaque buildup but remained cognitively
December 28, 2025 at 5:11 PM
biomarker, returned to normal, strengthening the case for true disease reversal. Researchers ALSO studied brain tissue from PEOPLE with Alzheimer’s and from individuals known as nondemented with Alzheimer’s neuropathology, or NDAN. These individuals had heavy plaque buildup but remained cognitively
Yet more evidence that repeated COVID infection does very serious, cumulative damage to the human cardiopulmonary, circulatory, and neurological systems, and that everyone everywhere that COVID has ever been detected needs access to easy, recurrent EKG's, EEG's, and CT scans, for free, for Ever.
Fibrin drives thromboinflammation and neuropathology in COVID-19 - Nature
Fibrin drives inflammation and neuropathology in SARS-CoV-2 infection, and fibrin-targeting immunotherapy may represent a therapeutic intervention for patients with long COVID.
www.nature.com
August 30, 2024 at 5:24 AM
Yet more evidence that repeated COVID infection does very serious, cumulative damage to the human cardiopulmonary, circulatory, and neurological systems, and that everyone everywhere that COVID has ever been detected needs access to easy, recurrent EKG's, EEG's, and CT scans, for free, for Ever.
Ambient Air Pollution and the Severity of Alzheimer Disease Neuropathology
"Higher PM2.5 exposure may exacerbate Alzheimer disease neuropathologic change and cognitive dysfunction in the setting of dementia"
jamanetwork.com/journals/jam...
"Higher PM2.5 exposure may exacerbate Alzheimer disease neuropathologic change and cognitive dysfunction in the setting of dementia"
jamanetwork.com/journals/jam...
Ambient Air Pollution and the Severity of Alzheimer Disease Neuropathology
This study examines associations between fine particulate matter air pollution exposure, dementia severity, and dementia-associated neuropathologic change.
jamanetwork.com
September 22, 2025 at 3:56 PM
Ambient Air Pollution and the Severity of Alzheimer Disease Neuropathology
"Higher PM2.5 exposure may exacerbate Alzheimer disease neuropathologic change and cognitive dysfunction in the setting of dementia"
jamanetwork.com/journals/jam...
"Higher PM2.5 exposure may exacerbate Alzheimer disease neuropathologic change and cognitive dysfunction in the setting of dementia"
jamanetwork.com/journals/jam...
New via @erictopol.bsky.social
How fibrin drives inflammation in #longcovid
www.nature.com/articles/s41...
How fibrin drives inflammation in #longcovid
www.nature.com/articles/s41...
Fibrin drives thromboinflammation and neuropathology in COVID-19 - Nature
Fibrin drives inflammation and neuropathology in SARS-CoV-2 infection, and fibrin-targeting immunotherapy may represent a therapeutic intervention for patients with long COVID.
www.nature.com
August 28, 2024 at 8:17 PM
New via @erictopol.bsky.social
How fibrin drives inflammation in #longcovid
www.nature.com/articles/s41...
How fibrin drives inflammation in #longcovid
www.nature.com/articles/s41...
🧠 How COVID-19 impacts the brain
Researchers found that blood clots linked to COVID-19 can cause inflammation and brain damage.
A new antibody treatment targeting these clots could help reduce long-term effects seen in long COVID.
🔗 www.nature.com/articles/s41...
#SciComm #COVID19 🧪
Researchers found that blood clots linked to COVID-19 can cause inflammation and brain damage.
A new antibody treatment targeting these clots could help reduce long-term effects seen in long COVID.
🔗 www.nature.com/articles/s41...
#SciComm #COVID19 🧪
Fibrin drives thromboinflammation and neuropathology in COVID-19 - Nature
Fibrin drives inflammation and neuropathology in SARS-CoV-2 infection, and fibrin-targeting immunotherapy may represent a therapeutic intervention for patients with long COVID.
www.nature.com
December 31, 2024 at 11:43 AM
🧠 How COVID-19 impacts the brain
Researchers found that blood clots linked to COVID-19 can cause inflammation and brain damage.
A new antibody treatment targeting these clots could help reduce long-term effects seen in long COVID.
🔗 www.nature.com/articles/s41...
#SciComm #COVID19 🧪
Researchers found that blood clots linked to COVID-19 can cause inflammation and brain damage.
A new antibody treatment targeting these clots could help reduce long-term effects seen in long COVID.
🔗 www.nature.com/articles/s41...
#SciComm #COVID19 🧪
Our paper examining the role of SARS-CoV-2 infection and its link to the development of Parkinson's disease has been published online in npj Parkinsons's disease. The article is open access. rdcu.be/ei1I6.
Environmental exposures and familial background alter the induction of neuropathology and inflammation after SARS-CoV-2 infection
npj Parkinson's Disease - Environmental exposures and familial background alter the induction of neuropathology and inflammation after SARS-CoV-2 infection
rdcu.be
April 23, 2025 at 5:19 PM
Our paper examining the role of SARS-CoV-2 infection and its link to the development of Parkinson's disease has been published online in npj Parkinsons's disease. The article is open access. rdcu.be/ei1I6.
Demyelination-derived lysophosphatidylserine promotes microglial dysfunction and neuropathology in a mouse model of Alzheimer’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 4, 2025 at 6:56 AM
Demyelination-derived lysophosphatidylserine promotes microglial dysfunction and neuropathology in a mouse model of Alzheimer’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nature.
“Here we show that fibrin binds to the SARS-CoV-2 spike protein, forming proinflammatory blood clots that drive systemic thromboinflammation and neuropathology in COVID-19”
www.nature.com/articles/s41...
#LongCovid
“Here we show that fibrin binds to the SARS-CoV-2 spike protein, forming proinflammatory blood clots that drive systemic thromboinflammation and neuropathology in COVID-19”
www.nature.com/articles/s41...
#LongCovid
Fibrin drives thromboinflammation and neuropathology in COVID-19 - Nature
Fibrin drives inflammation and neuropathology in SARS-CoV-2 infection, and fibrin-targeting immunotherapy may represent a therapeutic intervention for patients with long COVID.
www.nature.com
August 28, 2024 at 7:56 PM
Nature.
“Here we show that fibrin binds to the SARS-CoV-2 spike protein, forming proinflammatory blood clots that drive systemic thromboinflammation and neuropathology in COVID-19”
www.nature.com/articles/s41...
#LongCovid
“Here we show that fibrin binds to the SARS-CoV-2 spike protein, forming proinflammatory blood clots that drive systemic thromboinflammation and neuropathology in COVID-19”
www.nature.com/articles/s41...
#LongCovid
oh hey they have a blood plasma test for Alzheimer's now: www.thelancet.com/journals/lan...
Alzheimer's disease neuropathology plasma biomarkers and cognition in midlife: a community-based cohort study
Alzheimer's disease neuropathology is relatively uncommon in midlife but associated
with worse cognitive performance and accelerated decline and might have stronger association
among some groups. Earl...
www.thelancet.com
June 29, 2026 at 6:23 PM
oh hey they have a blood plasma test for Alzheimer's now: www.thelancet.com/journals/lan...
FATHER: [slapping son] just what the hell is this?? [thrusting medical school pamphlet menacingly] neuropathology lessons?! who's going to take over the family dick sucking business when i die? whos going to take care of your mother?
SON: [clutching face, weeping] i HATE YOU
SON: [clutching face, weeping] i HATE YOU
March 21, 2026 at 8:09 AM
FATHER: [slapping son] just what the hell is this?? [thrusting medical school pamphlet menacingly] neuropathology lessons?! who's going to take over the family dick sucking business when i die? whos going to take care of your mother?
SON: [clutching face, weeping] i HATE YOU
SON: [clutching face, weeping] i HATE YOU
The expertise required is in neuropathology
July 7, 2025 at 9:14 AM
The expertise required is in neuropathology
Die Links zur Studie und zum Artikel:
www.nature.com/articles/s41...
gladstone.org/news/discove...
#LongCovid #Coronavirus #COVID19 #SARSCoV2 #ImpfenSchuetzt #BrainDamage #VaccinesSaveLives #OrganDamage
www.nature.com/articles/s41...
gladstone.org/news/discove...
#LongCovid #Coronavirus #COVID19 #SARSCoV2 #ImpfenSchuetzt #BrainDamage #VaccinesSaveLives #OrganDamage
Fibrin drives thromboinflammation and neuropathology in COVID-19 - Nature
Fibrin drives inflammation and neuropathology in SARS-CoV-2 infection, and fibrin-targeting immunotherapy may represent a therapeutic intervention for patients with long COVID.
www.nature.com
August 29, 2024 at 3:29 PM
Die Links zur Studie und zum Artikel:
www.nature.com/articles/s41...
gladstone.org/news/discove...
#LongCovid #Coronavirus #COVID19 #SARSCoV2 #ImpfenSchuetzt #BrainDamage #VaccinesSaveLives #OrganDamage
www.nature.com/articles/s41...
gladstone.org/news/discove...
#LongCovid #Coronavirus #COVID19 #SARSCoV2 #ImpfenSchuetzt #BrainDamage #VaccinesSaveLives #OrganDamage
The progressive scientific conceptualization of clinical constructs, from illness to anatomopathological concepts of disease.
From our paper:
Neuropsychiatric Constructs as Bridges Between Psychopathology and Neuropathology Psychopathology: A Medical Perspective
link.springer.com/article/10.1...
From our paper:
Neuropsychiatric Constructs as Bridges Between Psychopathology and Neuropathology Psychopathology: A Medical Perspective
link.springer.com/article/10.1...
November 14, 2024 at 4:50 PM
The progressive scientific conceptualization of clinical constructs, from illness to anatomopathological concepts of disease.
From our paper:
Neuropsychiatric Constructs as Bridges Between Psychopathology and Neuropathology Psychopathology: A Medical Perspective
link.springer.com/article/10.1...
From our paper:
Neuropsychiatric Constructs as Bridges Between Psychopathology and Neuropathology Psychopathology: A Medical Perspective
link.springer.com/article/10.1...
Nature research paper: mTORC1 drives cell-autonomous astrocyte reactivity in tuberous sclerosis
go.nature.com/4zgKxjl
go.nature.com/4zgKxjl
mTORC1 drives cell-autonomous astrocyte reactivity in tuberous sclerosis - Nature
Reactive astrocytes emerge as a primary consequence of TSC2 loss in tuberous sclerosis complex, implicating glial dysfunction as a primary driver of pathogenesis and highlighting the astrocytes as potential therapeutic targets for tuberous sclerosis complex-related neuropathology.
go.nature.com
September 29, 2026 at 4:44 PM
Nature research paper: mTORC1 drives cell-autonomous astrocyte reactivity in tuberous sclerosis
go.nature.com/4zgKxjl
go.nature.com/4zgKxjl
See also: www.nature.com/articles/s41...
Fibrin drives thromboinflammation and neuropathology in COVID-19 - Nature
Fibrin drives inflammation and neuropathology in SARS-CoV-2 infection, and fibrin-targeting immunotherapy may represent a therapeutic intervention for patients with long COVID.
www.nature.com
September 3, 2025 at 12:20 PM
See also: www.nature.com/articles/s41...
🚨The first #preprint of the #FalconeLab is OUT!🥹🚨
We found that varicose-projection astrocytes are not a physiological type of #astrocytes but they are rather associated with neuropathology.
Read more here, feedback is welcome!!
More details👇👇
1/
www.biorxiv.org/content/10.1...
We found that varicose-projection astrocytes are not a physiological type of #astrocytes but they are rather associated with neuropathology.
Read more here, feedback is welcome!!
More details👇👇
1/
www.biorxiv.org/content/10.1...
Varicose-projection astrocytes: a reactive phenotype associated with neuropathology
Glial cells are fundamental for the pathophysiology of all neurological disorders. Astrocytes, the primary homeostatic cells of the central nervous system (CNS), exhibit species-specific characteristi...
www.biorxiv.org
March 18, 2025 at 3:42 PM
🚨The first #preprint of the #FalconeLab is OUT!🥹🚨
We found that varicose-projection astrocytes are not a physiological type of #astrocytes but they are rather associated with neuropathology.
Read more here, feedback is welcome!!
More details👇👇
1/
www.biorxiv.org/content/10.1...
We found that varicose-projection astrocytes are not a physiological type of #astrocytes but they are rather associated with neuropathology.
Read more here, feedback is welcome!!
More details👇👇
1/
www.biorxiv.org/content/10.1...
NEW DATA - Alzheimer's Disease neuropathology images for STG & pre-frontal cortex are now available on the Brain Knowledge Platform!
Derived from donors to the Adult Changes in Thought Study with Kaiser Permanente & @uwmedicine.bsky.social.
🧠📈 community.brain-map.org/t/view-new-s...
#MedSky
Derived from donors to the Adult Changes in Thought Study with Kaiser Permanente & @uwmedicine.bsky.social.
🧠📈 community.brain-map.org/t/view-new-s...
#MedSky
View new SEA-AD neuropathology images for STG & PFC regions available in Data Catalog
This data release features neuropathology images from the Seattle Alzheimer’s Disease Brain Cell Atlas (SEA-AD) project for two new brain regions of interest: Superior Temporal Gyrus (STG) and Prefron...
community.brain-map.org
February 6, 2025 at 11:28 PM
NEW DATA - Alzheimer's Disease neuropathology images for STG & pre-frontal cortex are now available on the Brain Knowledge Platform!
Derived from donors to the Adult Changes in Thought Study with Kaiser Permanente & @uwmedicine.bsky.social.
🧠📈 community.brain-map.org/t/view-new-s...
#MedSky
Derived from donors to the Adult Changes in Thought Study with Kaiser Permanente & @uwmedicine.bsky.social.
🧠📈 community.brain-map.org/t/view-new-s...
#MedSky
I got to be the coolest person in the room yesterday when my friend asked if I've ever heard of Ologies.
Oh, you mean the #1 science podcast on the charts @ologies.bsky.social? Yeah... I've HEARD of ologies 😎
Bovine Neuropathology (HEADBUTTING) with Dr. Nicole Ackermans share.google/jXvaIJtZKvqw...
Oh, you mean the #1 science podcast on the charts @ologies.bsky.social? Yeah... I've HEARD of ologies 😎
Bovine Neuropathology (HEADBUTTING) with Dr. Nicole Ackermans share.google/jXvaIJtZKvqw...
Bovine Neuropathology (HEADBUTTING) with Dr. Nicole Ackermans — alie ward
Slamming heads together to impress someone: why does this happen? Let’s ask Dr. Nicole Ackermans, whose current job involves receiving sheep heads and painstakingly counting damaged neurons from headb...
share.google
August 26, 2025 at 12:20 PM
I got to be the coolest person in the room yesterday when my friend asked if I've ever heard of Ologies.
Oh, you mean the #1 science podcast on the charts @ologies.bsky.social? Yeah... I've HEARD of ologies 😎
Bovine Neuropathology (HEADBUTTING) with Dr. Nicole Ackermans share.google/jXvaIJtZKvqw...
Oh, you mean the #1 science podcast on the charts @ologies.bsky.social? Yeah... I've HEARD of ologies 😎
Bovine Neuropathology (HEADBUTTING) with Dr. Nicole Ackermans share.google/jXvaIJtZKvqw...
🇪🇺 The Institut Pasteur is pleased to announce that two research units, "Lyssavirus, Epidemiology and Neuropathology" and "Biodiversity and Epidemiology of Bacterial Pathogens," have been designated as European Union Reference Laboratories (EURLs).
EU Reference Laboratories for public health
EU Reference Laboratories for public health
health.ec.europa.eu
June 6, 2025 at 7:34 AM
🇪🇺 The Institut Pasteur is pleased to announce that two research units, "Lyssavirus, Epidemiology and Neuropathology" and "Biodiversity and Epidemiology of Bacterial Pathogens," have been designated as European Union Reference Laboratories (EURLs).
The weight of the evidence shows the existence of a dose-response relationship btw collision sports and longterm neuropathology (i.e., the more & longer you play, the higher the risks).
(Also, there are now multiple studies correcting for the selection bias of brain donation, so that's no response)
(Also, there are now multiple studies correcting for the selection bias of brain donation, so that's no response)
“All but one of the former professional players — 27 of 28 in total, and 18 of 19 who played in the National Hockey League — showed signs of CTE…Of the donors whose hockey careers were limited to youth or high school hockey, researchers found CTE in only 10% of samples.” cc @profgoldberg.bsky.social
Longer careers in ice hockey are linked to a greater risk of CTE, a new study finds
A new Boston University study of 77 deceased male ice hockey players found that their chances of developing the degenerative brain disease known as CTE increased with each year they played the sport.
www.npr.org
December 5, 2024 at 1:58 AM
The weight of the evidence shows the existence of a dose-response relationship btw collision sports and longterm neuropathology (i.e., the more & longer you play, the higher the risks).
(Also, there are now multiple studies correcting for the selection bias of brain donation, so that's no response)
(Also, there are now multiple studies correcting for the selection bias of brain donation, so that's no response)
Senolytic treatment potential for Long Covid nature.com/articles/s43...
"Our findings therefore suggest a detrimental role for virus-induced senescence in acceleration of brain inflammation .. a potential therapeutic role for senolytics in the treatment of COVID-19 neuropathology."
"Our findings therefore suggest a detrimental role for virus-induced senescence in acceleration of brain inflammation .. a potential therapeutic role for senolytics in the treatment of COVID-19 neuropathology."
November 13, 2023 at 6:58 PM
Senolytic treatment potential for Long Covid nature.com/articles/s43...
"Our findings therefore suggest a detrimental role for virus-induced senescence in acceleration of brain inflammation .. a potential therapeutic role for senolytics in the treatment of COVID-19 neuropathology."
"Our findings therefore suggest a detrimental role for virus-induced senescence in acceleration of brain inflammation .. a potential therapeutic role for senolytics in the treatment of COVID-19 neuropathology."