#Neuroinflammation+barrier
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meetjess.bsky.social
This is a virus that crosses the blood-brain barrier.
It causes microclots, neuroinflammation, and neuron death.
And yet the public message is:
“Just get it and move on.”
May 2, 2025 at 9:02 AM
daniellebeckman.bsky.social
In our study we showed how angry neutrophils are massively entering the brain after #COVID infection, which is associated with Blood-Brain-Barrier disruption & Neuroinflammation. The photo below shows neutrophils infected with SARS-CoV-2. More data coming! www.cell.com/cell-reports...
#NeuroCovid
Microscopy photo showing activated neutrophils positive for SARS-CoV-2 spike protein (orange) being recognized by astrocytes (cyan) after blood-brain-barrier disruption with Neurocovid in rhesus macaques. Nuclei of all cells in purple.
December 5, 2024 at 3:12 AM
ralfwittenbrink.bsky.social
weit verbreitete Entzündung des Gehirns auf, wie neue Forschungsergebnisse zeigen, die aktuell in der Zeitschrift Brain Behavior and Immunity veröffentlicht wurden. Die Studie, die von Forschern des Massachusetts General Hospital/Harvard/MIT Martinos Center for Biomedical
Highlights Neuroinflammation-related PET signal was measured in long COVID patients with diverse symptoms. • PET neuroimaging found neuroinflammation across multiple brain regions in long COVID vs. controls. Some neuroinflammation signal was found in brain areas known to have reduced blood-brain barrier. Neuroinflammation in Long COVID correlated with blood levels of factors related to vascular damage.
May 4, 2024 at 4:20 PM
plasticwars.bsky.social
Alert⚠️ Plastic particles from food packaging detected in the brain within 2 hours of ingestion, breaching the 🩸blood-brain🧠 barrier. Linked to neuroinflammation, Alzheimer's, and Parkinson's risks. Action is critical to counter this growing health threat!
interestingengineering.com/science/plas...
Plastic used in food packaging found in brain two hours after ingestion
A study reflects on how these plastic particles can increase the risk of neuroinflammation and neurodegeneration.
interestingengineering.com
December 2, 2024 at 6:57 PM
lauramiers.bsky.social
“Interestingly, this neuroinflammation was located in some brain areas that are exposed to circulating blood factors via normal anatomical gaps in the specialized ‘blood-brain barrier’ of the brain’s blood vessels.” polybio.org/polybio-supp...
PolyBio-supported team identifies neuroinflammation in Long COVID correlated with vascular disease m...
(Medford, MA) – Brain inflammation (neuroinflammation) has been proposed as a driver of Long COVID symptoms. However, no research team has...
polybio.org
October 22, 2023 at 2:15 AM
untonuggan.myatproto.social
But I do wonder if "post viral neuroinflammation" explains... A lot about POTS

Scientists used to think neuroinflammation was really rare because the blood brain barrier protected the brain from infections and inflammatory signals from the rest of the body
February 20, 2025 at 2:49 PM
rsankowski.bsky.social
Antigen presentation at the blood–brain barrier amplifies neuroinflammation | @cp-trendsimmuno.bsky.social

www.cell.com/trends/immun...
Antigen presentation at the blood–brain barrier amplifies neuroinflammation
Immune surveillance of the central nervous system (CNS) is regulated by the brain barriers. Antigen presentation at the blood–brain barrier (BBB) has been proposed to promote antigen-specific T-cell e...
www.cell.com
August 7, 2026 at 4:07 PM
blacoste.bsky.social
www.nature.com/articles/s41... #BloodBrainBarrier #Zebrafish
Activation of Wnt/β-catenin in neural progenitor cells regulates blood–brain barrier development and promotes neuroinflammation - Scientific Reports
Scientific Reports - Activation of Wnt/β-catenin in neural progenitor cells regulates blood–brain barrier development and promotes neuroinflammation
www.nature.com
February 4, 2025 at 10:48 AM
blacoste.bsky.social
Neuroinflammation affects the blood-brain barrier in many ways. This study from Yonsei University (Seoul) provides new insight into how peripheral LPS challenges the BBB doi.org/10.1038/s414... #BloodBrainBarrier #Cerebrovascular
Microglial NLRP3-gasdermin D activation impairs blood-brain barrier integrity through interleukin-1β-independent neutrophil chemotaxis upon peripheral inflammation in mice - Nature Communications
The biological mechanisms regulating blood-brain barrier integrity remain unclear. Here, the authors identify microglial NLRP3-gasdermin D signaling as a driver of blood-brain barrier disruption durin...
doi.org
January 19, 2025 at 5:12 PM
supercuriousphd.bsky.social
Astrocyte CB1 receptors drive blood-brain barrier disruption in central nervous system inflammatory disease- link.springer.com/article/10.1... #neuroskyence 🧪🌎
Astrocyte CB1 receptors drive blood-brain barrier disruption in central nervous system inflammatory disease - Journal of Neuroinflammation
Journal of Neuroinflammation - Reactive astrocytes shape central nervous system (CNS) inflammation and participate in myelin damage and repair mechanisms in multiple sclerosis (MS). Through the...
link.springer.com
February 3, 2026 at 9:18 PM
uwe689.bsky.social
Macrophage invasion into the Drosophila brain requires JAK/STAT-dependent MMP activation in the blood–brain barrier

journals.plos.org/Plosbiology/...
Macrophage invasion into the Drosophila brain requires JAK/STAT-dependent MMP activation in the blood–brain barrier
The blood-brain barrier prevents immune cells and pathogens from entering the brain. This study shows that during neuroinflammation in Drosophila, immune cells can cross the blood-brain barrier by deg...
journals.plos.org
February 25, 2025 at 11:52 AM
exceedhergrasp1.bsky.social
Slide titled “Mast Cell Contributions to Neuroinflammation.” A diagram shows mast cells communicating with microglia and astrocytes through histamine, tryptase, IL-33, cytokines, and chemokines, potentially promoting acute and chronic neuroinflammation. The slide notes that CNS mast cells can release inflammatory mediators, influence blood–brain barrier permeability, activate glial cells, and possibly contribute to cortical spreading depression in migraine. It identifies mast cells near blood vessels, the area postrema, choroid plexus, amygdala, thalamus, hypothalamus, lower brainstem, craniocervical junction, and cranial nerves, where abnormal activation could affect stress, sensory processing, hormones, sleep, heart rate, breathing, and digestion.
September 11, 2026 at 7:23 PM
jeffgilchrist.bsky.social
Another amazing image from @DaniBeckman@X.com showing COVID-19 infected cells arriving in the brain which indicates neuroinflammation and blood-brain barrier disruption. Learn more about why we should care about a virus with a "99.8% survival rate" here ( docs.google.com/document/d/1... ).
An unwelcome guest: a photo of #SARSCoV2 infected cells arriving in the brain. This indicates neuroinflammation and blood-brain barrier disruption. The staining is for SARS-Cov-2 nucleocapsid protein (pink color), astrocytes (yellow), and nuclei of all cells (blue). Image from Danielle Beckman ( https://x.com/DaniBeckman/status/1798143904283508802 )
June 5, 2024 at 11:25 AM
atranscendedman.bsky.social
University of Texas researchers found that Omicron BA.1 caused lasting neurological issues in hACE2 mice, linked to blood-brain barrier breakdown, clotting, and inflammation.

Viral RNA and spike protein lingered in the brain even without live virus.

www.biorxiv.org/content/10.1...
Crosstalk Among Disrupted Blood-Brain Barrier, Neuroinflammation, and Coagulopathy in AC70 hACE2 Tg Mice with Prolonged Neurological Manifestations Induced by the Omicron BA.1 Variant of SARS-CoV-2
Long COVID, or post-acute sequela of COVID (PASC), has emerged as a major post-pandemic challenge, with lasting neurological effects in a substantial number of patients. The underlying pathophysiologi...
www.biorxiv.org
April 5, 2025 at 11:47 AM
psypost.bsky.social
Smoldering eucalyptus wood smoke extract increases inflammation and disrupts the blood-brain barrier by reducing tight junction proteins, suggesting wildfire smoke may contribute to neuroinflammation and elevate the… #WildfireSmoke #Neuroinflammation #BrainHealth #EnvironmentalScience #HealthRisks
Scientists reveal the disturbing impact of wildfire smoke on key brain cells
Smoldering eucalyptus wood smoke extract increases inflammation and disrupts the blood-brain barrier by reducing tight junction proteins, suggesting wildfire smoke may contribute to neuroinflammation and elevate the risk of neurological disorders.
www.psypost.org
January 24, 2025 at 11:08 AM
blacoste.bsky.social
#BloodBrainBarrier #Neuroinflammation
Innate immune sensors and regulators at the blood brain barrier: focus on toll-like receptors and inflammasomes as mediators of neuro-immune crosstalk and inflammation - Journal of Neuroinflammation
Cerebral endothelial cells (CEC) that form the brain capillaries are the principal constituents of the blood brain barrier (BBB), the main active interface between the blood and the brain which plays ...
doi.org
February 15, 2025 at 8:46 PM
ralfwittenbrink.bsky.social
einem Verlust von weiteren 2 IQ-Punkten verbunden. Eine gerade veröffentlichte, von Experten überprüfte Studie berichtet, dass 90 % der Long COVID-Patienten leichte oder asymptomatische Erstinfektionen hatten. Ich vermute, dass die Mehrheit der Menschen davon keine Ahnung hat.“
Danielle Beckman @DaniBeckman An unwelcome guest: a photo of #SARSCoV2 infected cells arriving in the brain. This indicates neuroinflammation and blood-brain barrier disruption. The staining is for SARS-Cov-2 nucleocapsid protein (pink color), astrocytes (yellow), and nuclei of all cells (blue). #neuroCovid
June 8, 2024 at 10:32 PM
sailorrooscout.bsky.social
In preclinical models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer’s biomarkers (in HUMAN models as well).
• case.edu/news/new-stu...

The study has been published in Cell. YES, it is PEER-REVIEWED.
• www.cell.com/cell-reports...

🧪🧵⬇️
Highlights •Severity of Alzheimer's disease (AD) correlates with NAD+ homeostasis dysregulation •Preserving brain NAD+ homeostasis prevents AD in mice • Restoring brain NAD+ homeostasis reverses advanced AD in mice • Multiomics across human and mouse AD brain identifies nodes for human AD reversal Summary Alzheimer's has long been considered irreversible, but new research challenges that assumption. Scientists discovered that severe drops in the brain's energy supply help drive the disease-and restoring that balance can reverse damage, even in advanced cases. In mouse models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer's biomarkers. The results offer fresh hope that recovery may be possible. Abstract Alzheimer's disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which restores nicotinamide adenine dinucleotide (NAD+) homeostasis, reverses tau phosphorylation, blood-brain barrier deterioration, oxidative stress, DNA damage, and neuroinflammation and enhances hippocampal neurogenesis and synaptic plasticity, resulting in full cognitive recovery and reduction of plasma levels of the clinical AD biomarker p-tau217. P7C3-A20 also reverses advanced disease in tau-driven PS19 mice and protects human brain microvascular endothelial cells from oxidative stress. In humans and mice, pathology severity correlates with disruption of brain NAD+ homeostasis, and the brains of nondemented people with Alzheimer's neuropathology exhibit gene expression patterns suggestive of preserved NAD+ homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care. Graphical Abstract (CREDIT: Cell Reports Medicine)
December 28, 2025 at 5:03 PM
jblainefoster.bsky.social
In fact, using medications to reduce neuroinflammation can *help* reduce those upstream causes, for instance, less neuroinflammation can result in improved blood-brain barrier function, a reduction in ROS, and more efficient use of glucose.
April 1, 2025 at 8:48 PM
togetherwemask.bsky.social
“Neuro-Long COVID” thru direct infection, viral persistence, neuroinflammation, T-cell infiltration, autoimmunity, impaired neurotransmitter metabolism, vascular complications, tissue hypoxia, & exacerbation of Parkinson’s & Alzheimer’s demands prevention and care. doi.org/10.1111/pcn.... 🧵
Neuroimmune pathophysiology of Long COVID https://doi.org/10.1111/pcn.13855 Illustrations show Systemic neuroimmune manifestations of Long COVID demonstrated in the reviewed studies, divided into 5 sections: Neuroinflammation, Barrier Dysfunction, Vascular Dysfunction, Neurotransmitter Metabolism and Neurodegeneration, with text outlining the mechanism of different pathways SARS-CoV-2 can trigger Neuro-Long COVID. The caption also included: “† denotes results from autopsy studies, animal models, or in vitro experiments that have not been directly measured in Long COVID. Figures generated using Biorender.”   Quote: “Overall, these data highlight the need for better approaches to both treat and prevent Long COVID.”
July 8, 2025 at 9:15 PM
biorxiv-neursci.bsky.social
Cerebral microthrombi promote focal Cav-1-dependent blood-brain barrier impairment, triggering neuroinflammation and neuronal damage after traumatic brain injury https://www.biorxiv.org/content/10.64898/2026.09.24.754043v1
September 29, 2026 at 11:15 PM
biorxivpreprint.bsky.social
Cerebral microthrombi promote focal Cav-1-dependent blood-brain barrier impairment, triggering neuroinflammation and neuronal damage after traumatic brain injury https://www.biorxiv.org/content/10.64898/2026.09.24.754043v1
September 29, 2026 at 11:15 PM
rrust.bsky.social
Electroacupuncture alleviates blood-brain barrier disruption and neuroinflammation via astrocytic MC4R in a mouse model of multiple sclerosis
January 4, 2026 at 4:16 PM
fioname.bsky.social
"Suggests proteins that may contribute to neuroinflammation in ME/CFS ... can dysregulate neuronal functions and disrupt the blood–brain barrier, and proinflammatory cytokines [are] overexpressed ... "

It's almost like "encephalomyelitis" was the right term all along 🤔🙄

tinyurl.com/6jrxuyn3
July 30, 2025 at 2:08 AM
david.notesforfriends.com
conditions like Alzheimer's disease.

COVID-19 and cognitive impairment: neuroinvasive and blood‒brain barrier dysfunction | Journal of Neuroinflammation | Full Text](jneuroinflammation.biomedcentral.com/articles/10.11…)

COVID-19 infections increase risk of long-term brain problems – (9/26)
October 19, 2024 at 5:59 PM