Takes a shortcut straight up your nose to your brain, just like C19.
“Cranial nerves, especially the olfactory nerve, are important routes of neuroinvasion for HPAI H5Nx viruses.”
“Cranial nerves, especially the olfactory nerve, are important routes of neuroinvasion for HPAI H5Nx viruses.”
December 4, 2024 at 7:04 AM
Takes a shortcut straight up your nose to your brain, just like C19.
“Cranial nerves, especially the olfactory nerve, are important routes of neuroinvasion for HPAI H5Nx viruses.”
“Cranial nerves, especially the olfactory nerve, are important routes of neuroinvasion for HPAI H5Nx viruses.”
Once we thought it would be nearly impossible to modulate #LongCovid in rodent models, but science is getting there. More evidence for direct #COVID neuroinvasion, viral persistence in the brain , and more explanations for cognitive and psychiatric alterations... #NeuroCovid
July 25, 2025 at 12:00 PM
Once we thought it would be nearly impossible to modulate #LongCovid in rodent models, but science is getting there. More evidence for direct #COVID neuroinvasion, viral persistence in the brain , and more explanations for cognitive and psychiatric alterations... #NeuroCovid
Fresh IBCC chapter: Measles in the adult hospitalized patient
🤒 tx = mostly supportive, but there are important nuances
🤒 viral pneumonia has parallels to COVID
🤒 encephalitis appears to be ADEM (not neuroinvasion), treatable with steroid
chapter: emcrit.org/ibcc/measles/ #EMIMCC
🤒 tx = mostly supportive, but there are important nuances
🤒 viral pneumonia has parallels to COVID
🤒 encephalitis appears to be ADEM (not neuroinvasion), treatable with steroid
chapter: emcrit.org/ibcc/measles/ #EMIMCC
March 6, 2025 at 5:49 PM
Fresh IBCC chapter: Measles in the adult hospitalized patient
🤒 tx = mostly supportive, but there are important nuances
🤒 viral pneumonia has parallels to COVID
🤒 encephalitis appears to be ADEM (not neuroinvasion), treatable with steroid
chapter: emcrit.org/ibcc/measles/ #EMIMCC
🤒 tx = mostly supportive, but there are important nuances
🤒 viral pneumonia has parallels to COVID
🤒 encephalitis appears to be ADEM (not neuroinvasion), treatable with steroid
chapter: emcrit.org/ibcc/measles/ #EMIMCC
"Our findings provide evidence that SARS-CoV-2 neuroinvasion plays a critical role in the development of lasting behavioral sequelae observed in PASC." ...und weiter➡️
May 15, 2025 at 9:14 AM
"Our findings provide evidence that SARS-CoV-2 neuroinvasion plays a critical role in the development of lasting behavioral sequelae observed in PASC." ...und weiter➡️
DNA vaccine targeting betacoronavirus spike protein blocks neuroinvasion and neuroinflammation in swine via dual antiviral-immunomodulatory action
www.nature.com/articles/s41...
www.nature.com/articles/s41...
DNA vaccine targeting betacoronavirus spike protein blocks neuroinvasion and neuroinflammation in swine via dual antiviral-immunomodulatory action - npj Vaccines
npj Vaccines - DNA vaccine targeting betacoronavirus spike protein blocks neuroinvasion and neuroinflammation in swine via dual antiviral-immunomodulatory action
www.nature.com
August 8, 2025 at 4:50 PM
DNA vaccine targeting betacoronavirus spike protein blocks neuroinvasion and neuroinflammation in swine via dual antiviral-immunomodulatory action
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Direkte virale Neuroinvasion (z. B. Herpesviren, SARS-CoV-2) schädigt Nervenendigungen und gliale Zellen.
Postinfektiöse Autoimmunreaktion (Guillain‐Barré, Small-Fiber-Neuropathie nach COVID-19): Antikörper greifen periphere Fasern an.
Postinfektiöse Autoimmunreaktion (Guillain‐Barré, Small-Fiber-Neuropathie nach COVID-19): Antikörper greifen periphere Fasern an.
September 21, 2025 at 4:31 PM
Direkte virale Neuroinvasion (z. B. Herpesviren, SARS-CoV-2) schädigt Nervenendigungen und gliale Zellen.
Postinfektiöse Autoimmunreaktion (Guillain‐Barré, Small-Fiber-Neuropathie nach COVID-19): Antikörper greifen periphere Fasern an.
Postinfektiöse Autoimmunreaktion (Guillain‐Barré, Small-Fiber-Neuropathie nach COVID-19): Antikörper greifen periphere Fasern an.
Alterations in gut microbiota, immune activation & α-synuclein pathology are central to PD pathogenesis, while #COVID may exacerbate these processes through neuroinvasion, immune dysregulation & disruption of dopaminergic pathways.
November 19, 2025 at 5:14 AM
Alterations in gut microbiota, immune activation & α-synuclein pathology are central to PD pathogenesis, while #COVID may exacerbate these processes through neuroinvasion, immune dysregulation & disruption of dopaminergic pathways.
SARS-CoV-2 isn’t the only neurotropic betacoronavirus. Common cold human betacoronavirus OC43 is also neurotropic. Reference Arbour et al, "Neuroinvasion by human respiratory coronaviruses", Journal of Virology (2000), doi.org/10.1128/jvi.....
Neuroinvasion by Human Respiratory Coronaviruses | Journal of Virology
ABSTRACT Human coronaviruses (HCoV) cause common colds but can also infect neural cell cultures. To provide definitive experimental evidence for the neurotropism and neuroinvasion of HCoV and its possible association with multiple sclerosis (MS), we have ...
doi.org
July 23, 2025 at 12:34 AM
SARS-CoV-2 isn’t the only neurotropic betacoronavirus. Common cold human betacoronavirus OC43 is also neurotropic. Reference Arbour et al, "Neuroinvasion by human respiratory coronaviruses", Journal of Virology (2000), doi.org/10.1128/jvi.....
#SARSCoV2 Neuroinvasion, Brain Fog & Cognitive Dysfunction
youtu.be/Lmo4x8UZ_I4
@daniellebeckman.bsky.social Neuroscientist, discusses:
- neuroinflammation,
- brain fog,
- cognitive dysfunction
- neuronal damage
- persistent neurological symptoms
- mechanisms in #LongCOVID patients.
#neurosky
youtu.be/Lmo4x8UZ_I4
@daniellebeckman.bsky.social Neuroscientist, discusses:
- neuroinflammation,
- brain fog,
- cognitive dysfunction
- neuronal damage
- persistent neurological symptoms
- mechanisms in #LongCOVID patients.
#neurosky
Dr. Danielle Beckman: SARS-CoV-2 Neuroinvasion, Brain Fog & Cognitive Dysfunction (Day 2, Block 12)
YouTube video by UniteToFight
youtu.be
November 29, 2025 at 6:00 PM
#SARSCoV2 Neuroinvasion, Brain Fog & Cognitive Dysfunction
youtu.be/Lmo4x8UZ_I4
@daniellebeckman.bsky.social Neuroscientist, discusses:
- neuroinflammation,
- brain fog,
- cognitive dysfunction
- neuronal damage
- persistent neurological symptoms
- mechanisms in #LongCOVID patients.
#neurosky
youtu.be/Lmo4x8UZ_I4
@daniellebeckman.bsky.social Neuroscientist, discusses:
- neuroinflammation,
- brain fog,
- cognitive dysfunction
- neuronal damage
- persistent neurological symptoms
- mechanisms in #LongCOVID patients.
#neurosky
The first manuscript by my lab has been published🥳🎉
We investigated disease progression in B6 mice inoculated with bovine H5N1 or VN1203 via aerosols. Interestingly, although virus replication in the lung was similar, we observed drastic differences in neuroinvasion and pathology.
rdcu.be/enhQU
We investigated disease progression in B6 mice inoculated with bovine H5N1 or VN1203 via aerosols. Interestingly, although virus replication in the lung was similar, we observed drastic differences in neuroinvasion and pathology.
rdcu.be/enhQU
Enhanced neurotropism of bovine H5N1 compared to the Vietnam H5N1 isolate in C57BL/6J mice
npj Viruses - Enhanced neurotropism of bovine H5N1 compared to the Vietnam H5N1 isolate in C57BL/6J mice
rdcu.be
May 23, 2025 at 7:48 PM
The first manuscript by my lab has been published🥳🎉
We investigated disease progression in B6 mice inoculated with bovine H5N1 or VN1203 via aerosols. Interestingly, although virus replication in the lung was similar, we observed drastic differences in neuroinvasion and pathology.
rdcu.be/enhQU
We investigated disease progression in B6 mice inoculated with bovine H5N1 or VN1203 via aerosols. Interestingly, although virus replication in the lung was similar, we observed drastic differences in neuroinvasion and pathology.
rdcu.be/enhQU
The #H5N1 case below was reported as mild. The patient had normal respiratory effort and oxygen saturation of 97%.
The *only* symptom was intense hemorrhage in both eyes. A high indicative of viral neuroinvasion and blood-retina-brain disruption, as the retina is part of the central nervous system.
The *only* symptom was intense hemorrhage in both eyes. A high indicative of viral neuroinvasion and blood-retina-brain disruption, as the retina is part of the central nervous system.
December 4, 2024 at 8:26 PM
The #H5N1 case below was reported as mild. The patient had normal respiratory effort and oxygen saturation of 97%.
The *only* symptom was intense hemorrhage in both eyes. A high indicative of viral neuroinvasion and blood-retina-brain disruption, as the retina is part of the central nervous system.
The *only* symptom was intense hemorrhage in both eyes. A high indicative of viral neuroinvasion and blood-retina-brain disruption, as the retina is part of the central nervous system.
The anatomical proximity and direct connection between the olfactory bulb and the orbital prefrontal cortex (OFC) make it a key neuroinvasion route for #COVID in the brain. In patients with #NeuroCovid, we observe thrombotic events, hypometabolism and atrophy in this region.
June 8, 2026 at 8:56 PM
The anatomical proximity and direct connection between the olfactory bulb and the orbital prefrontal cortex (OFC) make it a key neuroinvasion route for #COVID in the brain. In patients with #NeuroCovid, we observe thrombotic events, hypometabolism and atrophy in this region.
A human blood-brain barrier model reveals pericytes as critical regulators of viral neuroinvasion @cp-iscience.bsky.social
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
A human blood-brain barrier model reveals pericytes as critical regulators of viral neuroinvasion
The blood-brain barrier (BBB) plays a vital role in regulating the passage of biomolecules
between the bloodstream and the central nervous system (CNS) while also protecting
the CNS from pathogens. Pe...
www.cell.com
December 13, 2025 at 4:33 AM
A human blood-brain barrier model reveals pericytes as critical regulators of viral neuroinvasion @cp-iscience.bsky.social
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
Neuroinflammation is expected to be at the core of Long Covid (and ME/CFS). This interesting new review from November 3th looks at potential mechanisms resulting in neuroinflammation: gut-brain axis disruption, neuroinvasion, reactivation of (herpes) viruses, and other.
November 21, 2024 at 6:57 PM
Neuroinflammation is expected to be at the core of Long Covid (and ME/CFS). This interesting new review from November 3th looks at potential mechanisms resulting in neuroinflammation: gut-brain axis disruption, neuroinvasion, reactivation of (herpes) viruses, and other.
Texas scientist warns of new SARS-CoV-2 neuroinvasion pathway involving the trigeminal nerve
www.thailandmedical.news/news/texas-s...
www.thailandmedical.news/news/texas-s...
Texas scientist warns of new SARS-CoV-2 neuroinvasion pathway involving the trigeminal nerve - Thailand Medical News
www.thailandmedical.news
September 26, 2024 at 1:47 PM
Texas scientist warns of new SARS-CoV-2 neuroinvasion pathway involving the trigeminal nerve
www.thailandmedical.news/news/texas-s...
www.thailandmedical.news/news/texas-s...
AFD Blog `Preprint: Hematogenous Neuroinvasion and Genotype-dependent Transmission of Influenza A #H5N1 Viruses in the #Cat Host' afludiary.blogspot.com/2026/02/prep...
Preprint: Hematogenous Neuroinvasion and Genotype-dependent Transmission of Influenza A H5N1 Viruses in the Cat Host
Based on USDA Data #19,063 Based on limited - and admittedly opportunistic - surveillance, felines ( domestic cats, mountain lions, bobcat...
afludiary.blogspot.com
February 23, 2026 at 11:48 AM
AFD Blog `Preprint: Hematogenous Neuroinvasion and Genotype-dependent Transmission of Influenza A #H5N1 Viruses in the #Cat Host' afludiary.blogspot.com/2026/02/prep...
Neuroinvasion und Anosmie: Unabhängige Phänomene bei SARS-CoV-2-Infektion und seinen Varianten www.dmz-news.eu/2023/09/19/n...
Neuroinvasion und Anosmie: Unabhängige Phänomene bei SARS-CoV-2-Infektion und seinen Varianten
DMZ – WISSENSCHAFT ¦ AA ¦ Die Frage, ob das SARS-CoV-2-Virus das Gehirn infizieren kann, ist nach wie vor umstritten. Einige Studien haben gezeigt, dass das Virus das Gehirn infizieren kann, einsc...
www.dmz-news.eu
September 19, 2023 at 5:39 AM
Neuroinvasion und Anosmie: Unabhängige Phänomene bei SARS-CoV-2-Infektion und seinen Varianten www.dmz-news.eu/2023/09/19/n...
Source
Neuroinvasion and neurotropism of severe acute respiratory syndrome coronavirus 2 infection
- ScienceDirect
share.google/7zkao2IwwQPA...
Neuroinvasion and neurotropism of severe acute respiratory syndrome coronavirus 2 infection
- ScienceDirect
share.google/7zkao2IwwQPA...
Neuroinvasion and neurotropism of severe acute respiratory syndrome coronavirus 2 infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019, contributes to neurological pathologies…
share.google
February 8, 2026 at 5:17 PM
Source
Neuroinvasion and neurotropism of severe acute respiratory syndrome coronavirus 2 infection
- ScienceDirect
share.google/7zkao2IwwQPA...
Neuroinvasion and neurotropism of severe acute respiratory syndrome coronavirus 2 infection
- ScienceDirect
share.google/7zkao2IwwQPA...
A nice calming read this week: "SARS-CoV-2 Rapidly Infects Peripheral Sensory and Autonomic Neurons, Contributing to Central Nervous System Neuroinvasion before Viremia"
August 2, 2024 at 3:49 PM
A nice calming read this week: "SARS-CoV-2 Rapidly Infects Peripheral Sensory and Autonomic Neurons, Contributing to Central Nervous System Neuroinvasion before Viremia"
Yes, COVID negatively impacts the brain, even if you are fully vaccinated.
Watch "Dr. Danielle Beckman: SARS-CoV-2 Neuroinvasion, Brain Fog & Cognitive Dysfunction (Day 2, Block 12)" on YouTube
youtu.be/Lmo4x8UZ_I4
Watch "Dr. Danielle Beckman: SARS-CoV-2 Neuroinvasion, Brain Fog & Cognitive Dysfunction (Day 2, Block 12)" on YouTube
youtu.be/Lmo4x8UZ_I4
Dr. Danielle Beckman: SARS-CoV-2 Neuroinvasion, Brain Fog & Cognitive Dysfunction (Day 2, Block 12)
YouTube video by UniteToFight
youtu.be
December 7, 2025 at 2:06 PM
Yes, COVID negatively impacts the brain, even if you are fully vaccinated.
Watch "Dr. Danielle Beckman: SARS-CoV-2 Neuroinvasion, Brain Fog & Cognitive Dysfunction (Day 2, Block 12)" on YouTube
youtu.be/Lmo4x8UZ_I4
Watch "Dr. Danielle Beckman: SARS-CoV-2 Neuroinvasion, Brain Fog & Cognitive Dysfunction (Day 2, Block 12)" on YouTube
youtu.be/Lmo4x8UZ_I4
These evidence of 🦠acting as a precipitating factor for various neurological autoimmune disorders such as ADEM, NMOSD, and Guillain‑Barré syndrome & suggests an immune-mediated process rather than direct neuroinvasion
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
May 4, 2026 at 5:36 AM
These evidence of 🦠acting as a precipitating factor for various neurological autoimmune disorders such as ADEM, NMOSD, and Guillain‑Barré syndrome & suggests an immune-mediated process rather than direct neuroinvasion
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Microglia protect the fetal brain from Zika virus, while primitive macrophages and monocytes drive infection and inflammation, highlighting diverse immune roles. Plus other great insights.
Great work from @stjohnlab.bsky.social
www.cell.com/cell/abstrac...
Great work from @stjohnlab.bsky.social
www.cell.com/cell/abstrac...
Differential contributions of fetal mononuclear phagocytes to Zika virus neuroinvasion versus neuroprotection during congenital infection
Fetal microglia are protective against Zika virus, but primitive macrophages and monocytes promote neuroinflammation and are disease promoting. Different fetal immune and neuronal cell types are targeted by different Zika lineages.
www.cell.com
December 28, 2024 at 10:56 AM
Microglia protect the fetal brain from Zika virus, while primitive macrophages and monocytes drive infection and inflammation, highlighting diverse immune roles. Plus other great insights.
Great work from @stjohnlab.bsky.social
www.cell.com/cell/abstrac...
Great work from @stjohnlab.bsky.social
www.cell.com/cell/abstrac...
Long-COVID cognitive impairments & reproductive hormone deficits in men may stem from GnRH neuronal death buff.ly/3PP5FJB
Neuroinvasion of GnRH neurons in hypothalamus by SARS-CoV-2 can lead to ⬇️⬇️ in GnRH in the brain, cognitive defects and low testosterone (hypogonadism). 🩺
photo: buff.ly/3LwDEUq
Neuroinvasion of GnRH neurons in hypothalamus by SARS-CoV-2 can lead to ⬇️⬇️ in GnRH in the brain, cognitive defects and low testosterone (hypogonadism). 🩺
photo: buff.ly/3LwDEUq
September 22, 2023 at 5:24 AM
Long-COVID cognitive impairments & reproductive hormone deficits in men may stem from GnRH neuronal death buff.ly/3PP5FJB
Neuroinvasion of GnRH neurons in hypothalamus by SARS-CoV-2 can lead to ⬇️⬇️ in GnRH in the brain, cognitive defects and low testosterone (hypogonadism). 🩺
photo: buff.ly/3LwDEUq
Neuroinvasion of GnRH neurons in hypothalamus by SARS-CoV-2 can lead to ⬇️⬇️ in GnRH in the brain, cognitive defects and low testosterone (hypogonadism). 🩺
photo: buff.ly/3LwDEUq
Differential contributions of fetal mononuclear phagocytes to Zika virus neuroinvasion versus neuroprotection during congenital infection
Muhammad Abdelbasset et al. 🧪
www.cell.com/cell/abstrac...
Muhammad Abdelbasset et al. 🧪
www.cell.com/cell/abstrac...
Differential contributions of fetal mononuclear phagocytes to Zika virus neuroinvasion versus neuroprotection during congenital infection
Fetal microglia are protective against Zika virus, but primitive macrophages and monocytes
promote neuroinflammation and are disease promoting. Different fetal immune and neuronal
cell types are targe...
www.cell.com
November 15, 2024 at 8:37 PM
Differential contributions of fetal mononuclear phagocytes to Zika virus neuroinvasion versus neuroprotection during congenital infection
Muhammad Abdelbasset et al. 🧪
www.cell.com/cell/abstrac...
Muhammad Abdelbasset et al. 🧪
www.cell.com/cell/abstrac...
There are asumptions not based on solid data "The neuroinvasion of SARS-CoV-2 is well established$, with virus persistence detected up to 230 days post-infection*"
$= organoids and hACE2 mice, +old people who died of SC2
*=1 patient who died of severe C19, RNA, no virus
3/10
$= organoids and hACE2 mice, +old people who died of SC2
*=1 patient who died of severe C19, RNA, no virus
3/10
July 23, 2025 at 6:23 PM
There are asumptions not based on solid data "The neuroinvasion of SARS-CoV-2 is well established$, with virus persistence detected up to 230 days post-infection*"
$= organoids and hACE2 mice, +old people who died of SC2
*=1 patient who died of severe C19, RNA, no virus
3/10
$= organoids and hACE2 mice, +old people who died of SC2
*=1 patient who died of severe C19, RNA, no virus
3/10