#SciencePhoto_IN
“An Elegant Worm with a Rainbow of Thoughts”
Author: José Ignacio Jordá
Lab: @eleyvadiaz.bsky.social
"NeuroPAL is a Caenorhabditis elegans strain with a stereotyped multicolor fluorescent atlas of the entire nervous system of the worm. @zeiss-microscopy.bsky.social Airyscan Elyra".
“An Elegant Worm with a Rainbow of Thoughts”
Author: José Ignacio Jordá
Lab: @eleyvadiaz.bsky.social
"NeuroPAL is a Caenorhabditis elegans strain with a stereotyped multicolor fluorescent atlas of the entire nervous system of the worm. @zeiss-microscopy.bsky.social Airyscan Elyra".
September 23, 2026 at 4:48 PM
#SciencePhoto_IN
“An Elegant Worm with a Rainbow of Thoughts”
Author: José Ignacio Jordá
Lab: @eleyvadiaz.bsky.social
"NeuroPAL is a Caenorhabditis elegans strain with a stereotyped multicolor fluorescent atlas of the entire nervous system of the worm. @zeiss-microscopy.bsky.social Airyscan Elyra".
“An Elegant Worm with a Rainbow of Thoughts”
Author: José Ignacio Jordá
Lab: @eleyvadiaz.bsky.social
"NeuroPAL is a Caenorhabditis elegans strain with a stereotyped multicolor fluorescent atlas of the entire nervous system of the worm. @zeiss-microscopy.bsky.social Airyscan Elyra".
Promised thread:
C. elegans do a crazy thing -- when we inject DNA into their gonad, they package it all up into a big circular chromosome. This is great for transgenesis -- we can put whatever we want in there. Usually it's a small number of plasmids, but in NeuroPAL, it's something like 41!
C. elegans do a crazy thing -- when we inject DNA into their gonad, they package it all up into a big circular chromosome. This is great for transgenesis -- we can put whatever we want in there. Usually it's a small number of plasmids, but in NeuroPAL, it's something like 41!
November 13, 2025 at 7:29 PM
Promised thread:
C. elegans do a crazy thing -- when we inject DNA into their gonad, they package it all up into a big circular chromosome. This is great for transgenesis -- we can put whatever we want in there. Usually it's a small number of plasmids, but in NeuroPAL, it's something like 41!
C. elegans do a crazy thing -- when we inject DNA into their gonad, they package it all up into a big circular chromosome. This is great for transgenesis -- we can put whatever we want in there. Usually it's a small number of plasmids, but in NeuroPAL, it's something like 41!
Our new paper in @agsjournal.bsky.social compares dementia end-of-life caregiving experiences. Labor of love to use poetic analysis in this secondary analysis of qualitative data, comparing #prion & #ADRD #dementia types, and develop a new conceptual model #hapc #neuropal
doi.org/10.1111/jgs....
doi.org/10.1111/jgs....
February 5, 2025 at 6:38 PM
Our new paper in @agsjournal.bsky.social compares dementia end-of-life caregiving experiences. Labor of love to use poetic analysis in this secondary analysis of qualitative data, comparing #prion & #ADRD #dementia types, and develop a new conceptual model #hapc #neuropal
doi.org/10.1111/jgs....
doi.org/10.1111/jgs....
🎉 Really thrilled and excited to welcome the UCSD/Scripps Health Hospice and Palliative Medicine Fellowship Class of 2025! 🎉 IM, FM, EM, neuro stroke, and pulm crit represented!
#thentherewere8 #HPMClassof25 #hpm #hapc #neuropal #pallipulm
#thentherewere8 #HPMClassof25 #hpm #hapc #neuropal #pallipulm
July 2, 2024 at 11:01 PM
🎉 Really thrilled and excited to welcome the UCSD/Scripps Health Hospice and Palliative Medicine Fellowship Class of 2025! 🎉 IM, FM, EM, neuro stroke, and pulm crit represented!
#thentherewere8 #HPMClassof25 #hpm #hapc #neuropal #pallipulm
#thentherewere8 #HPMClassof25 #hpm #hapc #neuropal #pallipulm
bHLH genes have diverse roles during the development of the nervous system; this functional study of five #Celegans bHLH genes shows that some of them can regulate #neuropeptide secretion & significantly expand lifespan when mutated 🧪 @plosbiology.org plos.io/3W7OQMs
January 8, 2025 at 9:15 AM
bHLH genes have diverse roles during the development of the nervous system; this functional study of five #Celegans bHLH genes shows that some of them can regulate #neuropeptide secretion & significantly expand lifespan when mutated 🧪 @plosbiology.org plos.io/3W7OQMs
Lmao! I actually met with Nationwide Children’s PD but I would’ve had to add 3 extra years which sounded awful. So now my goal is to inherit complex neurodev kids transitioning to adult for neuropal care 💜
January 11, 2025 at 4:53 PM
Lmao! I actually met with Nationwide Children’s PD but I would’ve had to add 3 extra years which sounded awful. So now my goal is to inherit complex neurodev kids transitioning to adult for neuropal care 💜
bHLH genes have diverse roles during the development of the nervous system; this functional study of five #Celegans bHLH genes shows that some of them can regulate #neuropeptide secretion & significantly expand lifespan when mutated 🧪 @plosbiology.org plos.io/3W7OQMs
January 7, 2025 at 5:34 PM
bHLH genes have diverse roles during the development of the nervous system; this functional study of five #Celegans bHLH genes shows that some of them can regulate #neuropeptide secretion & significantly expand lifespan when mutated 🧪 @plosbiology.org plos.io/3W7OQMs
bHLH genes have diverse roles during the development of the nervous system; this functional study of five #Celegans bHLH genes shows that some of them can regulate #neuropeptide secretion & significantly expand lifespan when mutated 🧪 @plosbiology.org plos.io/3W7OQMs
January 7, 2025 at 1:29 PM
bHLH genes have diverse roles during the development of the nervous system; this functional study of five #Celegans bHLH genes shows that some of them can regulate #neuropeptide secretion & significantly expand lifespan when mutated 🧪 @plosbiology.org plos.io/3W7OQMs
Such an honor to have contributed to this very important JAMA Neurology (@jama.com) special communication on the critical needs of #neuropalliative care research, among many dedicated colleagues. 🙏 A must read for all interested in #neuropal and #Neurology ! ➡️ ja.ma/4hlgKNL
February 5, 2025 at 7:01 PM
Such an honor to have contributed to this very important JAMA Neurology (@jama.com) special communication on the critical needs of #neuropalliative care research, among many dedicated colleagues. 🙏 A must read for all interested in #neuropal and #Neurology ! ➡️ ja.ma/4hlgKNL
Issue 13 is now complete!
Cover: The tail of a ceh-20 (Exd/Pbx1-4) C.elegans mutant. NeuroPAL shows all neuronal nuclei (coloured dots). Mig-13::GFP labels the cytoplasm and axo-dendritic projections of nerve cord motor neurons. See Prahlad et al.
journals.biologists.com/dev/issue/15...
Cover: The tail of a ceh-20 (Exd/Pbx1-4) C.elegans mutant. NeuroPAL shows all neuronal nuclei (coloured dots). Mig-13::GFP labels the cytoplasm and axo-dendritic projections of nerve cord motor neurons. See Prahlad et al.
journals.biologists.com/dev/issue/15...
July 29, 2026 at 2:44 PM
Issue 13 is now complete!
Cover: The tail of a ceh-20 (Exd/Pbx1-4) C.elegans mutant. NeuroPAL shows all neuronal nuclei (coloured dots). Mig-13::GFP labels the cytoplasm and axo-dendritic projections of nerve cord motor neurons. See Prahlad et al.
journals.biologists.com/dev/issue/15...
Cover: The tail of a ceh-20 (Exd/Pbx1-4) C.elegans mutant. NeuroPAL shows all neuronal nuclei (coloured dots). Mig-13::GFP labels the cytoplasm and axo-dendritic projections of nerve cord motor neurons. See Prahlad et al.
journals.biologists.com/dev/issue/15...
underlying dynamical processes (oscillators) that, if they are synchronized with a motor plan oscillator, engage working memory - it is held even if the motor plan oscillator is disengaged from movement and is reengaged to orient the animal up the fictional, experimenter provided stimulus gradient.
August 15, 2024 at 1:49 AM
underlying dynamical processes (oscillators) that, if they are synchronized with a motor plan oscillator, engage working memory - it is held even if the motor plan oscillator is disengaged from movement and is reengaged to orient the animal up the fictional, experimenter provided stimulus gradient.
pEY46
Depositor: Oliver Hobert
Purpose: glr-1 fluorescent neural reporter driving nuclear mNeptune2.5 expression (refer to NeuroPAL paper for expression)
www.addgene.org/191050/
Depositor: Oliver Hobert
Purpose: glr-1 fluorescent neural reporter driving nuclear mNeptune2.5 expression (refer to NeuroPAL paper for expression)
www.addgene.org/191050/
August 22, 2024 at 8:00 PM
pEY46
Depositor: Oliver Hobert
Purpose: glr-1 fluorescent neural reporter driving nuclear mNeptune2.5 expression (refer to NeuroPAL paper for expression)
www.addgene.org/191050/
Depositor: Oliver Hobert
Purpose: glr-1 fluorescent neural reporter driving nuclear mNeptune2.5 expression (refer to NeuroPAL paper for expression)
www.addgene.org/191050/
Trailer for “The Soft Surrender” by Randy Bacon.
vimeo.com/1110046265
#hapc
#hapcSOTS23
#HAPCselfie
#HPMparty
#HAPCbaby
#HAPCfoodie
#hpmClassof23
#hapcRookie23
#pedPC
#pallonc
#palneph
#palCV
#Neuropal
#LiverPal
#PrognosisScience
vimeo.com/1110046265
#hapc
#hapcSOTS23
#HAPCselfie
#HPMparty
#HAPCbaby
#HAPCfoodie
#hpmClassof23
#hapcRookie23
#pedPC
#pallonc
#palneph
#palCV
#Neuropal
#LiverPal
#PrognosisScience
August 27, 2025 at 1:50 AM
Trailer for “The Soft Surrender” by Randy Bacon.
vimeo.com/1110046265
#hapc
#hapcSOTS23
#HAPCselfie
#HPMparty
#HAPCbaby
#HAPCfoodie
#hpmClassof23
#hapcRookie23
#pedPC
#pallonc
#palneph
#palCV
#Neuropal
#LiverPal
#PrognosisScience
vimeo.com/1110046265
#hapc
#hapcSOTS23
#HAPCselfie
#HPMparty
#HAPCbaby
#HAPCfoodie
#hpmClassof23
#hapcRookie23
#pedPC
#pallonc
#palneph
#palCV
#Neuropal
#LiverPal
#PrognosisScience
We extend this practice by mapping physiology to MIDI
Think of it the way anatomists use pseudocolor mappings to uniquely identify different neurons' processes in space (e.g., this example from www.hobertlab.org/neuropal/)
We use MIDI pitch to uniquely identify different neurons' spikes in time
Think of it the way anatomists use pseudocolor mappings to uniquely identify different neurons' processes in space (e.g., this example from www.hobertlab.org/neuropal/)
We use MIDI pitch to uniquely identify different neurons' spikes in time
March 25, 2026 at 12:53 PM
We extend this practice by mapping physiology to MIDI
Think of it the way anatomists use pseudocolor mappings to uniquely identify different neurons' processes in space (e.g., this example from www.hobertlab.org/neuropal/)
We use MIDI pitch to uniquely identify different neurons' spikes in time
Think of it the way anatomists use pseudocolor mappings to uniquely identify different neurons' processes in space (e.g., this example from www.hobertlab.org/neuropal/)
We use MIDI pitch to uniquely identify different neurons' spikes in time
Unfortunate overall findings, but I see that #neuropal care successfully decreased ED visits and hospitalizations community-dwelling people with dementia
D-CARE and IN-PEACE randomized clinical trials for persons with dementia (JAMA 2025) - "Despite the disappointing results, we must continue to innovate and find ways to improve care because the challenges caused by dementia remain"
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
January 31, 2025 at 2:36 AM
Unfortunate overall findings, but I see that #neuropal care successfully decreased ED visits and hospitalizations community-dwelling people with dementia
sleep and eating patterns, maladaptive explanatory styles, and gastrointestinal dysfunction. To bridge this gap in care and address these problems in a large-scale manner, we built NeuroPal, a large language model (LLM)-assistant that provides [2/8 of https://arxiv.org/abs/2505.06640v1]
May 13, 2025 at 6:15 AM
sleep and eating patterns, maladaptive explanatory styles, and gastrointestinal dysfunction. To bridge this gap in care and address these problems in a large-scale manner, we built NeuroPal, a large language model (LLM)-assistant that provides [2/8 of https://arxiv.org/abs/2505.06640v1]
Xiaoran Han: NeuroPal: A Clinically-Informed Multimodal LLM Assistant for Mental Health Combining Sleep Chronotherapy, Cognitive Behavioral Reframing, and Adaptive Phytochemical Intervention https://arxiv.org/abs/2505.06640 https://arxiv.org/pdf/2505.06640 https://arxiv.org/html/2505.06640
May 13, 2025 at 6:15 AM
Xiaoran Han: NeuroPal: A Clinically-Informed Multimodal LLM Assistant for Mental Health Combining Sleep Chronotherapy, Cognitive Behavioral Reframing, and Adaptive Phytochemical Intervention https://arxiv.org/abs/2505.06640 https://arxiv.org/pdf/2505.06640 https://arxiv.org/html/2505.06640
Shout out to the Awesome worm community! We got a lot of strains from fellow worm labs in the past few months. Of course the NeuroPAL below is the most flashy looking, but we are grateful for all the support from the community. https://x.com/MPINB_caesar/status/1240919886060191748
January 30, 2025 at 3:59 PM
Shout out to the Awesome worm community! We got a lot of strains from fellow worm labs in the past few months. Of course the NeuroPAL below is the most flashy looking, but we are grateful for all the support from the community. https://x.com/MPINB_caesar/status/1240919886060191748