Introduction: The C-reactive protein-albumin-lymphocyte (CALLY) index represents a novel composite biomarker integrating inflammatory, nutritional, and immune parameters. We aim to examine the relati...

Background: The urban environment is an important determinant of frailty, primarily through factors such as infrastructure that supports physical activity, availability of social and medical support, and access to nutritious food. Given the increasing aging population, understanding the link between urban quality, frailty, and metabolic health is crucial for effective public health and urban planning interventions. Objective: To investigate the impact of urban quality on frailty and its correlation with nutritional status and hematological/biochemical parameters using geospatial analysis. Methods: A cohort of 251 older adults (aged 65+) was studied. Frailty was assessed using the Frailty Trait Scale 5 (FTS-5), and nutritional status was determined using the Controlling Nutritional Status (CONUT) score. Hematological and biochemical parameters were evaluated in a subset of 70 participants by MINDRAY automatic equipment. A spatial analysis of frailty was conducted by incorporating GIS layers that mapped the distribution of urban facilities, including fruit and vegetable shops, senior centers, pharmacies, emergency health centers, parks and squares, community centers, and exercise facilities. Statistical analyses included t-tests, Mann-Whitney, ANOVA, and correlation analyses. Results: The prevalence of frailty was 17.5%. Frail individuals exhibited significantly higher BMI (31.5 ± 4.4 vs 28.5 ± 4.5 kg/m²; P=.0001). When comparing the upper (Q4) and lower (Q1) quartiles of urban quality, Q4 participants had higher FTS-5 scores (15.2 ± 7.4 vs 11.8 ± 6.4; P=.0334) and lower handgrip strength (19.1 ± 4.4 vs 22.8 ± 7.3 kg; P=.0059). Frail individuals resided significantly closer to emergency health centers (P=.0010), family health centers (P=.0412), and exercise facilities (P=.0322). Additionally, bilirubin (Spearman R=0.33, P=.0049), serum iron (Spearman R=0.27, P=.0272), transferrin saturation (Spearman R=0.24, P=.0386), RBC (Spearman R=0.26, P=.0303), and RDW (Spearman R=0.23, P=.0462) were positively correlated with urban quality. Frail participants also had higher CONUT scores (P=.0323), which were positively correlated with urban quality (Spearman R=0.25, P=.0359). Conclusions: Urban quality was significantly associated with hematological parameters, nutritional status, and frailty. Frail individuals in areas with better urban quality exhibit lower handgrip strength, higher frailty scores, and greater proximity to emergency rooms, community health centers, and exercise facilities. This spatial distribution may reflect higher accessibility to healthcare and recreational resources among frail participants. Urban planning and public health strategies should focus on creating age-friendly environments to prevent frailty and improve health outcomes.

This article aims to demonstrate the real-life effectiveness of the fluorouracil, leucovorin, oxaliplatin and docetaxel (FLOT) regimen by comparing it with traditional chemotherapy regimens and aims t...

Major study reveals standard magnesium blood tests measure less than 1% of body stores and may miss deficiency in nearly … #Biomarkers #Clinicalassessment #Laboratorytesting #Magnesiumdeficiency #Nutritionalstatus

Major study reveals standard magnesium blood tests measure less than 1% of body stores and may miss deficiency in nearly … #Biomarkers #Clinicalassessment #Laboratorytesting #Magnesiumdeficiency #Nutritionalstatus