Well, that was a rabbit hole I wasn't expecting - I had memory-holed 2008 Penguicon and the OSBP. I knew those folks, and I was at that con.
September 30, 2026 at 1:19 PM
Well, that was a rabbit hole I wasn't expecting - I had memory-holed 2008 Penguicon and the OSBP. I knew those folks, and I was at that con.
Merci à Life Sciences UPSaclay @univparissaclay.bsky.social pour cette mise en lumière de nos travaux sur la Macarangine B réalisés @icsnlab.bsky.social & à l'IPMC, publiés dans J. Med. Chem. @acsmedi.bsky.social.
👉 sco.lt/8ysbkO
👉 sco.lt/8ysbkO
Une nouvelle molécule naturelle, la macarangine B permet de préciser la fonction biologique de la protéine OSBP | Life Sciences Université Paris-Saclay
Les composés naturels ciblant la protéine OSBP (OxySterol Binding Protein), connus sous le nom d'ORPphilines, suscitent un intérêt croissant en raison de leurs propriétés anticancéreuses prometteuses,...
sco.lt
January 31, 2025 at 9:42 AM
Merci à Life Sciences UPSaclay @univparissaclay.bsky.social pour cette mise en lumière de nos travaux sur la Macarangine B réalisés @icsnlab.bsky.social & à l'IPMC, publiés dans J. Med. Chem. @acsmedi.bsky.social.
👉 sco.lt/8ysbkO
👉 sco.lt/8ysbkO
Wait.
The OSBP guy attached his real name to it?
Or at least...a name he's still using?
The OSBP guy attached his real name to it?
Or at least...a name he's still using?
August 21, 2026 at 11:48 PM
Wait.
The OSBP guy attached his real name to it?
Or at least...a name he's still using?
The OSBP guy attached his real name to it?
Or at least...a name he's still using?
sorry folks pack it up steampunk is dead
March 5, 2026 at 9:09 PM
sorry folks pack it up steampunk is dead
Nailbomb - For Fuck's Sake
YouTube video by TheFuckWhisperer555
www.youtube.com
January 26, 2025 at 1:10 PM
Check out our last article published in #ChemMedChem
@chemistryeurope.bsky.social about the synthesis of simplified analogs of antiviral macarangin B. Great work done by G. Jézéquel & J. Fargier @icsnlab.bsky.social @cnrs.fr @univparissaclay.bsky.social with #IPMC & #PIMIT.
👉 doi.org/10.1002/cmdc...
@chemistryeurope.bsky.social about the synthesis of simplified analogs of antiviral macarangin B. Great work done by G. Jézéquel & J. Fargier @icsnlab.bsky.social @cnrs.fr @univparissaclay.bsky.social with #IPMC & #PIMIT.
👉 doi.org/10.1002/cmdc...
Analogues of Natural Macarangin B Display Potent Antiviral Activity and Better Metabolic Stability
Simplified analogues of macarangin B, a natural compound with potent OSBP-targeted antiviral activity against Zika virus were elaborated with the aim of enhancing metabolic stability. The most promis...
doi.org
March 6, 2025 at 10:21 AM
Check out our last article published in #ChemMedChem
@chemistryeurope.bsky.social about the synthesis of simplified analogs of antiviral macarangin B. Great work done by G. Jézéquel & J. Fargier @icsnlab.bsky.social @cnrs.fr @univparissaclay.bsky.social with #IPMC & #PIMIT.
👉 doi.org/10.1002/cmdc...
@chemistryeurope.bsky.social about the synthesis of simplified analogs of antiviral macarangin B. Great work done by G. Jézéquel & J. Fargier @icsnlab.bsky.social @cnrs.fr @univparissaclay.bsky.social with #IPMC & #PIMIT.
👉 doi.org/10.1002/cmdc...
Happy to share our latest paper in @rscmedchem.rsc.org as part of their 5-year anniversary collection! We carried out comprehensive SAR analysis of natural and synthetic analogues of the #Schweinfurthins, highly potent and selective inhibitors of #OSBP! (1/n) pubs.rsc.org/en/content/a...
Schweinfurthins and their analogues are highly selective cellular probes for oxysterol-binding protein (OSBP)
Schweinfurthins (SWs) are natural products isolated from the plant genus Macaranga which display a unique cytotoxicity profile in human cancer cell lines with low nanomolar potency. Their known target...
pubs.rsc.org
December 2, 2025 at 1:17 PM
Happy to share our latest paper in @rscmedchem.rsc.org as part of their 5-year anniversary collection! We carried out comprehensive SAR analysis of natural and synthetic analogues of the #Schweinfurthins, highly potent and selective inhibitors of #OSBP! (1/n) pubs.rsc.org/en/content/a...
wait what the fuck
March 5, 2026 at 9:08 PM
wait what the fuck
He got "rehabilitated" as a fandom commentator without ever apologizing for the OSBP -- or for his fiction, which was misogynist and transphobic -- thanks to a certain "male feminist" in fandom.
September 27, 2026 at 4:54 PM
He got "rehabilitated" as a fandom commentator without ever apologizing for the OSBP -- or for his fiction, which was misogynist and transphobic -- thanks to a certain "male feminist" in fandom.
On Filmi Ladies we talk about the color white in Hindi films.
Did I talk about a Raj Kapoor classic or a masala widowed ma? No.
White instantly made me think of Abbas-Mastan and confusingly I went for Humraaz (2002). I am not immune to the Bobbyssaince!
www.youtube.com/watch?v=osBp...
Did I talk about a Raj Kapoor classic or a masala widowed ma? No.
White instantly made me think of Abbas-Mastan and confusingly I went for Humraaz (2002). I am not immune to the Bobbyssaince!
www.youtube.com/watch?v=osBp...
Filmi Ladies episode 174: Kati Patang and Humraaz 🤍
YouTube video by FilmiLadies
youtu.be
December 18, 2025 at 3:59 AM
On Filmi Ladies we talk about the color white in Hindi films.
Did I talk about a Raj Kapoor classic or a masala widowed ma? No.
White instantly made me think of Abbas-Mastan and confusingly I went for Humraaz (2002). I am not immune to the Bobbyssaince!
www.youtube.com/watch?v=osBp...
Did I talk about a Raj Kapoor classic or a masala widowed ma? No.
White instantly made me think of Abbas-Mastan and confusingly I went for Humraaz (2002). I am not immune to the Bobbyssaince!
www.youtube.com/watch?v=osBp...
When a Knight Won His Spurs
YouTube video by Salisbury Cathedral Choir - Topic
m.youtube.com
January 16, 2026 at 7:47 PM
Our data collectively support a model according to which VPS13C acts upstream of OSBP/ORP lipid transport proteins to orchestrate bulk lipid transport in synchrony with lysosomal damage and repair, thereby maintaining lysosome integrity
October 25, 2025 at 1:40 PM
Our data collectively support a model according to which VPS13C acts upstream of OSBP/ORP lipid transport proteins to orchestrate bulk lipid transport in synchrony with lysosomal damage and repair, thereby maintaining lysosome integrity
Next up, we have our first trainee talk for this session from Ashwin D'Souza from Dr. Julie Brill's lab @sickkidsto.bsky.social who is telling us about Osbp and PI4KII and secretory granule biogenesis. The microscopy images are beautiful 😍🔬
@csmb-scbm.bsky.social
@csmb-scbm.bsky.social
May 28, 2025 at 6:58 PM
Next up, we have our first trainee talk for this session from Ashwin D'Souza from Dr. Julie Brill's lab @sickkidsto.bsky.social who is telling us about Osbp and PI4KII and secretory granule biogenesis. The microscopy images are beautiful 😍🔬
@csmb-scbm.bsky.social
@csmb-scbm.bsky.social
Cholesterol transfer proteins promote Atg-independent ER clearance by lysosomes
Cholesterol transfer proteins promote Atg-independent ER clearance by lysosomes
The selective removal of endoplasmic reticulum (ER) is important for cell health. Wang et al. show that ER clearance occurs in a macroautophagy (Atg) gene-independent manner during development, and identify Vap33, Osbp, and Start1 as regulators of ER clearance by lysosomes that are associated with cholesterol trafficking.
dlvr.it
June 28, 2026 at 11:24 PM
Cholesterol transfer proteins promote Atg-independent ER clearance by lysosomes
#Energy101 #AI
US Dept of #ENERGY #OSBP webinar 1pm ET Wed 19Aug2026: Access. Match. Pursue. (AMP): Using free and low-cost AI tools to support bizdev.
By DOE Office of Small Business Programs.
No word if a recording will be available.
Registration link: bit.ly/45kYvUn
US Dept of #ENERGY #OSBP webinar 1pm ET Wed 19Aug2026: Access. Match. Pursue. (AMP): Using free and low-cost AI tools to support bizdev.
By DOE Office of Small Business Programs.
No word if a recording will be available.
Registration link: bit.ly/45kYvUn
August 12, 2026 at 8:35 PM
#Energy101 #AI
US Dept of #ENERGY #OSBP webinar 1pm ET Wed 19Aug2026: Access. Match. Pursue. (AMP): Using free and low-cost AI tools to support bizdev.
By DOE Office of Small Business Programs.
No word if a recording will be available.
Registration link: bit.ly/45kYvUn
US Dept of #ENERGY #OSBP webinar 1pm ET Wed 19Aug2026: Access. Match. Pursue. (AMP): Using free and low-cost AI tools to support bizdev.
By DOE Office of Small Business Programs.
No word if a recording will be available.
Registration link: bit.ly/45kYvUn
Thank you !
Your story on OSBP came at the right time to help moving forward !
Your story on OSBP came at the right time to help moving forward !
January 8, 2025 at 10:15 PM
Thank you !
Your story on OSBP came at the right time to help moving forward !
Your story on OSBP came at the right time to help moving forward !
Last up this morning at METPHYS2025 is a killer short talk from Gregory Francis about how OSBP inactivation synergizes with GPX4 inhibition
April 30, 2025 at 4:15 PM
Last up this morning at METPHYS2025 is a killer short talk from Gregory Francis about how OSBP inactivation synergizes with GPX4 inhibition
Led by Michael Zott, with excellent work from Laura Depta from our group, we show that potency against sterol transport proteins OSBP, ORP1 and ORP2 can be modulated by photoswitching azobenzene containing sterols. (2/3)
November 27, 2025 at 12:39 PM
Led by Michael Zott, with excellent work from Laura Depta from our group, we show that potency against sterol transport proteins OSBP, ORP1 and ORP2 can be modulated by photoswitching azobenzene containing sterols. (2/3)
A preprint using: EGFP-OSBP-PH (RRID:Addgene_49571) from @addgene.bsky.social was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #OpenScience
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #OpenScience
www.biorxiv.org
September 30, 2026 at 12:00 PM
A preprint using: EGFP-OSBP-PH (RRID:Addgene_49571) from @addgene.bsky.social was published.
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #OpenScience
SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #OpenScience
they let this lady go to put a 25yo white man in charge
(tip from my state small business friend)
business.defense.gov/About/
(tip from my state small business friend)
business.defense.gov/About/
November 6, 2025 at 1:45 PM
they let this lady go to put a 25yo white man in charge
(tip from my state small business friend)
business.defense.gov/About/
(tip from my state small business friend)
business.defense.gov/About/