#Orpathys
#Hutchmed and #AstraZeneca's #Orpathys is now under review in #Europe and #Japan for MET-driven, EGFR-mutated #lungcancer, a few weeks after the drug was filed in the US.

pharmaphorum.com/news/hutchme...
November 2, 2026 at 11:19 AM
Tagrisso-Orpathys Combination Extends Survival in MET-Driven Lung Cancer Trial The Phase III SAFFRON trial showed longer progression-free and overall survival with...

https://www.narrowit.com/news/astrazeneca-tagrisso-orpathys-saffron-survival-2026-10-25
#Astrazeneca #HUTCHMED #Tagrisso #Orpathys
Tagrisso Plus Orpathys Improves Survival in SAFFRON Phase III Trial | Narrowit.com
AstraZeneca reported that Tagrisso plus Orpathys extended progression-free and overall survival in MET-driven EGFR-mutated lung cancer after Tagrisso.
www.narrowit.com
October 26, 2026 at 12:12 AM
AstraZeneca files for US FDA approval of HUTCHMED lung cancer drug combination reut.rs/3VkeKiC
AstraZeneca files for US FDA approval of HUTCHMED lung cancer drug combination
HUTCHMED (China) said on Tuesday ​that Anglo-Swedish drugmaker AstraZeneca ‌had applied to the US Food and Drug Administration for approval of the ORPATHYS-TAGRISSO ​combination to treat patients with advanced ​lung cancer.
reut.rs
September 29, 2026 at 5:25 AM
AstraZeneca & HUTCHMED submitted a US NDA for all-oral ORPATHYS + TAGRISSO in EGFRm NSCLC with MET overexpression/amplification post-EGFR-TKI. Phase III SAFFRON trial reported improved survival vs chemotherapy; detailed results follow at ESMO 2026. Filing acceptance pending. #Pharma
September 29, 2026 at 7:07 AM
AstraZeneca & HUTCHMED submitted a US NDA for all-oral ORPATHYS + TAGRISSO in EGFRm NSCLC with MET overexpression/amplification post-EGFR-TKI. Phase III SAFFRON trial reported improved survival vs chemotherapy; detailed results follow at ESMO 2026. Filing acceptance pending.
September 29, 2026 at 6:52 AM
More encouraging lung cancer research. Tagrisso plus Orpathys significantly improved progression-free survival in a Phase 3 trial for patients with advanced EGFR-mutated lung cancer and MET overexpression.

www.astrazeneca.com/media-centre...

#LungCancer #CancerResearch #TCSC
Tagrisso plus Orpathys demonstrated statistically significant and highly clinically meaningful improvement in progression-free survival in 1st-line MET-overexpressing EGFR-mutated lung cancer
www.astrazeneca.com
September 14, 2026 at 7:53 AM
AstraZeneca's Tagrisso-Orpathys combo hits goal in first-line lung cancer trial
AstraZeneca's Tagrisso-Orpathys combo hits goal in first-line lung cancer trial
The Phase III SANOVO trial showed Tagrisso plus Orpathys significantly improved progression-free survival in treatment-naïve, MET-overexpressing EGFR-mutated lung cancer patients, extending the combination's reach into first-line treatment.
dlvr.it
September 1, 2026 at 6:44 AM
🚨 #BREAKING : ASTRAZENECA PLC - TAGRISSO + ORPATHYS IMPROVED PFS IN 1L EGFRM LUNG, AS PER REUTERS
X
September 1, 2026 at 6:00 AM
It’s normal for drug development to have ups and downs. Drug development isn’t a straight line. Some treatments work out, and others don’t… each result helps us figure out where a treatment can best help people, even if it’s frustrating after years of work.
AstraZeneca touts Enhertu, Orpathys dual lung cancer wins amid bispecific failure
AstraZeneca reported positive results from two non-small cell lung cancer trials for Enhertu and an Orpathys-Tagrisso combination, although the dual wins provided little cover for the company amid | AstraZeneca reported phase 3 lung cancer wins for Enhertu and a combination of Orpathys and Tagrisso, but the victories were eclipsed by the failure of its PD-1/CTLA-4 bispecific antibody in a simultan
www.fiercepharma.com
August 31, 2026 at 7:26 AM
HUTCHMED Reports Positive Phase III SANOVO Results for ORPATHYS Plus TAGRISSO in First-Line EGFR-Mutated NSCLC with MET Overexpression | HCM Stock News

HONG KONG and SHANGHAI and FLORHAM PARK, N.J., Aug. 31, 2026 (GLOBE NEWSWIRE) -- HUTCHMED (China) Limited (“ HUTCHMED “) (Nasdaq/AIM: HCM;…
HUTCHMED Reports Positive Phase III SANOVO Results for ORPATHYS Plus TAGRISSO in First-Line EGFR-Mutated NSCLC with MET Overexpression | HCM Stock News
HONG KONG and SHANGHAI and FLORHAM PARK, N.J., Aug. 31, 2026 (GLOBE NEWSWIRE) -- HUTCHMED (China) Limited (“ HUTCHMED “) (Nasdaq/AIM: HCM; HKEX: 13) today announces positive high-level results from the SANOVO China Phase III trial in treatment-naïve patients with locally advanced or metastatic non-small cell lung cancer (“NSCLC”) whose tumors harbor epidermal growth factor receptor (“EGFR”) mutation and MET overexpression.
ytvmarketnews.com
August 31, 2026 at 12:25 AM
Mon news: AZ touts Enhertu, Orpathys lung cancer wins amid bispecific failure. Lilly's $370M deal with OmniAb for ion channel collab. FDA nod is first hurdle for Moderna’s flu vax. Appeals court backs Gilead in ruling that threatens overseas Rx programs. —https://bit.ly/3JeBlY5
August 17, 2026 at 4:18 PM
DESTINY-Lung04: #Enhertu melhorou a PFS vs. terapia de 1ª linha no NSCLC não escamoso avançado com mutação HER2. Uma opção direcionada de 1ª linha da AstraZeneca (#$AZN ) & #DaiichiSankyo ipharmacenter.com/post/astraze...
#Cancer #Oncologia #CancerDePulmao #ESMO26 #OncoTwitter #OncoAlert
AstraZeneca–Daiichi Sankyo’s Enhertu Wins DESTINY-Lung04; HUTCHMED’s Tagrisso–Orpathys Pair Wins SAFFRON in MET-Selected EGFR NSCLC
AstraZeneca and Daiichi Sankyo reported that Enhertu (trastuzumab deruxtecan) met its primary endpoint in the DESTINY-Lung04 study, showing a clear and meaningful extension of progression-free surviva...
ipharmacenter.com
August 17, 2026 at 3:00 PM
DESTINY-Lung04:HER2変異陽性の進行非扁平上皮NSCLCにおいて、#Enhertu が一次治療と比較してPFSを改善。アストラゼネカ (NYSE: #$AZN) と #DaiichiSankyo による標的一次治療の選択肢。https://ipharmacenter.com/post/astrazeneca-daiichi-sankyo-s-enhertu-wins-destiny-lung04-hutchmed-s-tagrisso-orpathys-pair-wins-saf
#がん #腫瘍学 #肺がん #ESMO26 #OncoTwitter #OncoAlert
August 17, 2026 at 3:00 PM
DESTINY-Lung04:在 HER2 突变晚期非鳞状 NSCLC 中,与一线疗法相比,#Enhertu 显著改善了 PFS。阿斯利康 (NYSE: #$AZN) 和 #DaiichiSankyo 提供的一线靶向选择。https://ipharmacenter.com/post/astrazeneca-daiichi-sankyo-s-enhertu-wins-destiny-lung04-hutchmed-s-tagrisso-orpathys-pair-wins-saf
#癌症 #肿瘤学 #肺癌 #ESMO26 #OncoTwitter #OncoAlert
August 17, 2026 at 3:01 PM
DESTINY-Lung04: #Enhertu verbesserte das PFS vs. 1L-Therapie bei HER2-mutiertem, fortgeschrittenem nicht-kleinzelligem NSCLC. Eine zielgerichtete 1L-Option von AstraZeneca (NYSE #$AZN) & #DaiichiSankyo ipharmacenter.com/post/astraze...
#Krebs #Onkologie #Lungenkrebs #ESMO26 #OncoTwitter #OncoAlert
AstraZeneca–Daiichi Sankyo’s Enhertu Wins DESTINY-Lung04; HUTCHMED’s Tagrisso–Orpathys Pair Wins SAFFRON in MET-Selected EGFR NSCLC
AstraZeneca and Daiichi Sankyo reported that Enhertu (trastuzumab deruxtecan) met its primary endpoint in the DESTINY-Lung04 study, showing a clear and meaningful extension of progression-free surviva...
ipharmacenter.com
August 17, 2026 at 2:59 PM
🚨 #BREAKING : ASTRAZENECA PLC - TAGRISSO+ORPATHYS IMPROVED PFS & OS IN EGFRM LUNG, AS PER REUTERS
X
August 17, 2026 at 6:00 AM
DESTINY-Lung04: #Enhertu ha migliorato la PFS rispetto alla terapia di 1a linea nel NSCLC non squamoso avanzato con mutazione HER2. Un'opzione mirata di 1a linea da AstraZeneca (#$AZN) e #DaiichiSankyo ipharmacenter.com/post/astraze...
#Cancro #Oncologia #ESMO26 #OncoTwitter #OncoAlert
AstraZeneca–Daiichi Sankyo’s Enhertu Wins DESTINY-Lung04; HUTCHMED’s Tagrisso–Orpathys Pair Wins SAFFRON in MET-Selected EGFR NSCLC
AstraZeneca and Daiichi Sankyo reported that Enhertu (trastuzumab deruxtecan) met its primary endpoint in the DESTINY-Lung04 study, showing a clear and meaningful extension of progression-free surviva...
ipharmacenter.com
August 17, 2026 at 3:00 PM
DESTINY-Lung04: #Enhertu mejoró la PFS frente a la terapia de 1.ª línea en NSCLC no escamoso avanzado con mutación HER2. Una opción dirigida de 1.ª línea de AstraZeneca (#$AZN) y #DaiichiSankyo ipharmacenter.com/post/astraze... #Oncologia #CancerDePulmon #ESMO26 #OncoTwitter #OncoAlert
AstraZeneca–Daiichi Sankyo’s Enhertu Wins DESTINY-Lung04; HUTCHMED’s Tagrisso–Orpathys Pair Wins SAFFRON in MET-Selected EGFR NSCLC
AstraZeneca and Daiichi Sankyo reported that Enhertu (trastuzumab deruxtecan) met its primary endpoint in the DESTINY-Lung04 study, showing a clear and meaningful extension of progression-free surviva...
ipharmacenter.com
August 17, 2026 at 2:58 PM
AstraZeneca's Tagrisso combo hits survival goals in lung cancer trial
AstraZeneca's Tagrisso combo hits survival goals in lung cancer trial
The SAFFRON Phase III trial showed Tagrisso plus Orpathys significantly extended progression-free and overall survival in EGFR-mutated lung cancer patients who had progressed on Tagrisso alone.
dlvr.it
August 17, 2026 at 6:40 AM
☢️ HUTCHMED secures full approval in China for its lung cancer drug ORPATHYS®, a targeted therapy for a specific genomic alteration. Big win for biopharma fighting lung cancer. #HCM

Get ahead with today's top stories 👇

https://marketshareai.uk/news/lse/hcm/2352T

#HCM #AIM #FTSE
January 14, 2025 at 7:10 AM
Feed: "Clinical Trials Arena"
By: gullapalli on Thursday, August 21, 2025
Hutchmed finalises subject enrolment for Orpathys and Tagrisso combo trial
Hutchmed has completed subject enrolment in the Phase III SANOVO trial in China, of the combination of Orpathys and Tagrisso.
www.clinicaltrialsarena.com
August 21, 2025 at 10:36 PM