Found out today I don’t have to take the drug responsible for neuropathy any longer (Oxaliplatin). Also, the mass on my liver has shrunk in half since I started treatment. Eat shit, Cancer.
November 6, 2025 at 10:14 PM
Found out today I don’t have to take the drug responsible for neuropathy any longer (Oxaliplatin). Also, the mass on my liver has shrunk in half since I started treatment. Eat shit, Cancer.
Ein Präparat, das Oxaliplatin de.wikipedia.org/wiki/Oxalipl..., machte mir etwas zu schaffen, da es das Kälteempfinden seltsam verändert. So als würden kalte Dinge während der Berührung beständig kälter.
Nachdem ich dachte, ich hätte die Chemo rum, bekam ich eine #Polyneuropathie.
11/21
Nachdem ich dachte, ich hätte die Chemo rum, bekam ich eine #Polyneuropathie.
11/21
Oxaliplatin - Wikipedia
en.wikipedia.org
May 14, 2025 at 5:57 PM
Ein Präparat, das Oxaliplatin de.wikipedia.org/wiki/Oxalipl..., machte mir etwas zu schaffen, da es das Kälteempfinden seltsam verändert. So als würden kalte Dinge während der Berührung beständig kälter.
Nachdem ich dachte, ich hätte die Chemo rum, bekam ich eine #Polyneuropathie.
11/21
Nachdem ich dachte, ich hätte die Chemo rum, bekam ich eine #Polyneuropathie.
11/21
Is this your first day of chemo? Same.
Scared and nervous? Also same, but we can talk about it.
I'm on Oxaliplatin and Capecitabine.
What are those?
Scared and nervous? Also same, but we can talk about it.
I'm on Oxaliplatin and Capecitabine.
What are those?
December 5, 2024 at 2:32 PM
Is this your first day of chemo? Same.
Scared and nervous? Also same, but we can talk about it.
I'm on Oxaliplatin and Capecitabine.
What are those?
Scared and nervous? Also same, but we can talk about it.
I'm on Oxaliplatin and Capecitabine.
What are those?
The drug was oxaliplatin (eloxatin) and there is a known possible severe allergic reaction to platinum containing drugs.
Patients need to educate themselves and ask intelligent questions of their doctors.
Patients need to educate themselves and ask intelligent questions of their doctors.
September 9, 2026 at 4:15 PM
The drug was oxaliplatin (eloxatin) and there is a known possible severe allergic reaction to platinum containing drugs.
Patients need to educate themselves and ask intelligent questions of their doctors.
Patients need to educate themselves and ask intelligent questions of their doctors.
Infusion complete, home now. Doctors actually reduced my oxaliplatin dose by 25% so hopefully my side effects will be mitigated a bit this time.
I do feel a bit perkier already.
I do feel a bit perkier already.
Chemo cycle 7 today ( The Heptacycle!), the last one before liver surgery the week of Oct 20.
Dreading it, obviously. But new cycle means new #PowerShirt, which I picked up 80% off at a J Crew Factory outlet.
Thoughts, prayers, etc. welcome. I got this, just don't wanna do it.
Dreading it, obviously. But new cycle means new #PowerShirt, which I picked up 80% off at a J Crew Factory outlet.
Thoughts, prayers, etc. welcome. I got this, just don't wanna do it.
September 24, 2024 at 6:51 PM
Infusion complete, home now. Doctors actually reduced my oxaliplatin dose by 25% so hopefully my side effects will be mitigated a bit this time.
I do feel a bit perkier already.
I do feel a bit perkier already.
Good news, everybody!
My doctor dropped the oxaliplatin from my chemo cycle AND THAT MEANS my other drug (leucovorin) can be administered over half an hour instead of two! I'll be out of here SO QUICKLY today.
My doctor dropped the oxaliplatin from my chemo cycle AND THAT MEANS my other drug (leucovorin) can be administered over half an hour instead of two! I'll be out of here SO QUICKLY today.
January 23, 2024 at 2:16 PM
Good news, everybody!
My doctor dropped the oxaliplatin from my chemo cycle AND THAT MEANS my other drug (leucovorin) can be administered over half an hour instead of two! I'll be out of here SO QUICKLY today.
My doctor dropped the oxaliplatin from my chemo cycle AND THAT MEANS my other drug (leucovorin) can be administered over half an hour instead of two! I'll be out of here SO QUICKLY today.
EFS in MATTERHORN: A Ph3 RCT of durvalumab plus 5-fluorouracil, leucovorin, oxaliplatin & docetaxel chemotherapy (FLOT) in resectable gastric/gastroesophageal junction cancer (GC/GEJC) - @YJanjigianMD et al. #ASCO25 LBA5 meetings.asco.org/abstracts-pr... #NCT04592913 #stcsm #esocsm
Program Guide – ASCO Meeting Program Guide
meetings.asco.org
April 23, 2025 at 7:24 PM
EFS in MATTERHORN: A Ph3 RCT of durvalumab plus 5-fluorouracil, leucovorin, oxaliplatin & docetaxel chemotherapy (FLOT) in resectable gastric/gastroesophageal junction cancer (GC/GEJC) - @YJanjigianMD et al. #ASCO25 LBA5 meetings.asco.org/abstracts-pr... #NCT04592913 #stcsm #esocsm
Out latest article on ChemCatChem
doi.org/10.1002/cctc...
doi.org/10.1002/cctc...
Red‐Light Photocatalytic Activation of Pt(IV) Anticancer Prodrugs Using Methylene Blue
Methylene blue acts as a photocatalyst in the presence of biologically relevant electron donors, enabling red-light conversion of two Pt(IV) complexes into cisplatin and oxaliplatin. Spectroscopy and...
doi.org
November 26, 2024 at 8:04 AM
Out latest article on ChemCatChem
doi.org/10.1002/cctc...
doi.org/10.1002/cctc...
I GET SO GAY OFF THAT OXALIPLATIN
August 11, 2026 at 2:51 PM
I GET SO GAY OFF THAT OXALIPLATIN
New insights into chemo-induced neuropathy! Oxaliplatin triggers pain hypersensitivity via ion channel dysregulation Targeting T-type calcium channels (Cav3) especially Cav3.2 reverses mechanical pain but regulates cold allodynia in a sex-dependent way bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
BPS Publications
Background and Purpose The chemotherapy agent oxaliplatin can give rise to oxaliplatin-induced peripheral neuropathy (OIPN). Here, we investigated whether T-type calcium channels (Cav3) contribute t...
bpspubs.onlinelibrary.wiley.com
December 5, 2024 at 8:02 PM
New insights into chemo-induced neuropathy! Oxaliplatin triggers pain hypersensitivity via ion channel dysregulation Targeting T-type calcium channels (Cav3) especially Cav3.2 reverses mechanical pain but regulates cold allodynia in a sex-dependent way bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
Mechanical forces inducing oxaliplatin resistance in pancreatic cancer can be targeted by autophagy inhibition #PancreaticCancer 🧪 www.nature.com/articles/s42...
Mechanical forces inducing oxaliplatin resistance in pancreatic cancer can be targeted by autophagy inhibition - Communications Biology
Inhibiting mechanically induced autophagy with HCQ improves oxaliplatin efficacy in pancreatic tumors, especially when combined with losartan. This combination, not only increases oxaliplatin’s potenc...
www.nature.com
November 28, 2024 at 8:24 PM
Mechanical forces inducing oxaliplatin resistance in pancreatic cancer can be targeted by autophagy inhibition #PancreaticCancer 🧪 www.nature.com/articles/s42...
Oxaliplatin is an IV platinum-containing antineoplastic agent. The primary mechanism is it damages cellular DNA and prevents cellular replication which slows/halts/kills rapidly dividing cancer cells.
December 5, 2024 at 2:32 PM
Oxaliplatin is an IV platinum-containing antineoplastic agent. The primary mechanism is it damages cellular DNA and prevents cellular replication which slows/halts/kills rapidly dividing cancer cells.
meds I have been taking have stopped working and the cancer is growing. Not good news at all but, we are currently rechallenging my cancer with a previous med (Oxaliplatin) I have taken and we have a plan for a third line med as soon as we recognize that Ox is not working.
So, even though the (2/4)
So, even though the (2/4)
January 21, 2026 at 7:59 PM
meds I have been taking have stopped working and the cancer is growing. Not good news at all but, we are currently rechallenging my cancer with a previous med (Oxaliplatin) I have taken and we have a plan for a third line med as soon as we recognize that Ox is not working.
So, even though the (2/4)
So, even though the (2/4)
Update on my chemo treatments:
Because my platelet count is so low, my oncologist is stopping one of my three treatments (oxaliplatin) for my final three infusions. My cancer markers have been steadily in the normal range, so it's safe and should keep me on schedule to finish in late February.
Because my platelet count is so low, my oncologist is stopping one of my three treatments (oxaliplatin) for my final three infusions. My cancer markers have been steadily in the normal range, so it's safe and should keep me on schedule to finish in late February.
January 17, 2024 at 12:54 AM
Update on my chemo treatments:
Because my platelet count is so low, my oncologist is stopping one of my three treatments (oxaliplatin) for my final three infusions. My cancer markers have been steadily in the normal range, so it's safe and should keep me on schedule to finish in late February.
Because my platelet count is so low, my oncologist is stopping one of my three treatments (oxaliplatin) for my final three infusions. My cancer markers have been steadily in the normal range, so it's safe and should keep me on schedule to finish in late February.
I got DA-EPOCH-R and R-GemOx chemotherapy and the only day I got nausea was when they didn't give me Emend before my oxaliplatin. I got it on my next round and was fine.
September 21, 2026 at 4:11 AM
I got DA-EPOCH-R and R-GemOx chemotherapy and the only day I got nausea was when they didn't give me Emend before my oxaliplatin. I got it on my next round and was fine.
Why does Oxaliplatin, a common cancer drug, cause nerve issues?Many patients feel cold and cramps in their hands and feet.
Why is it different for man and women?Our latest paper reveals the answer!
www.sciencedirect.com/science/arti...
#TRP #CancerResearch #Health #MedicalScience #WomenInScience
Why is it different for man and women?Our latest paper reveals the answer!
www.sciencedirect.com/science/arti...
#TRP #CancerResearch #Health #MedicalScience #WomenInScience
Oxaliplatin reversibly and differentially affects electrogenic activity of small IB4(+) of male and female rat sensory neurons
Oxaliplatin-induced peripheral neuropathy (OIPN) is a prevalent drug side effect with unclear molecular mechanism and sex differences. We report that …
www.sciencedirect.com
January 23, 2025 at 8:59 AM
Why does Oxaliplatin, a common cancer drug, cause nerve issues?Many patients feel cold and cramps in their hands and feet.
Why is it different for man and women?Our latest paper reveals the answer!
www.sciencedirect.com/science/arti...
#TRP #CancerResearch #Health #MedicalScience #WomenInScience
Why is it different for man and women?Our latest paper reveals the answer!
www.sciencedirect.com/science/arti...
#TRP #CancerResearch #Health #MedicalScience #WomenInScience
🚀 New from @MICLABatUNIPI
Our latest paper in @daltontrans.rsc.org explores Pt(IV) prodrugs functionalized with α-TOS and nanoparticle encapsulation to boost cisplatin/oxaliplatin therapies.
Read here 👉 pubs.rsc.org/en/content/a...
Our latest paper in @daltontrans.rsc.org explores Pt(IV) prodrugs functionalized with α-TOS and nanoparticle encapsulation to boost cisplatin/oxaliplatin therapies.
Read here 👉 pubs.rsc.org/en/content/a...
Redefining platinum(IV) chemotherapy: α-tocopherol succinate functionalization and nanoparticle encapsulation to improve cisplatin- and oxaliplatin-based therapies
Platinum(iv) prodrugs offer a promising strategy to overcome the limitations of cisplatin and oxaliplatin, including systemic toxicity and acquired resistance. In this study, two novel α-tocopherol su...
pubs.rsc.org
August 18, 2025 at 8:51 PM
🚀 New from @MICLABatUNIPI
Our latest paper in @daltontrans.rsc.org explores Pt(IV) prodrugs functionalized with α-TOS and nanoparticle encapsulation to boost cisplatin/oxaliplatin therapies.
Read here 👉 pubs.rsc.org/en/content/a...
Our latest paper in @daltontrans.rsc.org explores Pt(IV) prodrugs functionalized with α-TOS and nanoparticle encapsulation to boost cisplatin/oxaliplatin therapies.
Read here 👉 pubs.rsc.org/en/content/a...
Also not sad to be dropping the oxaliplatin from my regimen (neuropathy in my fingers starting to creep in...). Saves two hours of treatment, cold sensitivity, and who knows what other side-effects. Look forward to finding out!
June 5, 2025 at 12:50 AM
Also not sad to be dropping the oxaliplatin from my regimen (neuropathy in my fingers starting to creep in...). Saves two hours of treatment, cold sensitivity, and who knows what other side-effects. Look forward to finding out!
#chemo session 13 today. Back to the irinotecan, avastin, 5FU combo. Last week was pretty decent, side-effect-wise, though my peripheral neuropathy progressed a bit (despite stopping oxaliplatin after session 11). Looking into complementary treatments for that (viz. acupuncture). 🤞
June 24, 2025 at 3:43 PM
#chemo session 13 today. Back to the irinotecan, avastin, 5FU combo. Last week was pretty decent, side-effect-wise, though my peripheral neuropathy progressed a bit (despite stopping oxaliplatin after session 11). Looking into complementary treatments for that (viz. acupuncture). 🤞
Doxorubicin. Interestingly, I'm pretty sure most of my weird side-effects came from Vincristine, like my eyelid getting droopy and my fingers wanting to twitch like they were fingering frets on a guitar or have one just randomly fully extend. Oxaliplatin, OTOH, was just straight-up nasty.
January 12, 2026 at 6:43 AM
Doxorubicin. Interestingly, I'm pretty sure most of my weird side-effects came from Vincristine, like my eyelid getting droopy and my fingers wanting to twitch like they were fingering frets on a guitar or have one just randomly fully extend. Oxaliplatin, OTOH, was just straight-up nasty.
MATTERHORN manuscript published today in the New England Journal of Medicine. #ASCO25 www.nejm.org/doi/full/10....
Perioperative Durvalumab in Gastric and Gastroesophageal Junction Cancer | NEJM
Perioperative FLOT (fluorouracil, leucovorin, oxaliplatin, and docetaxel) is a standard therapy for resectable gastric and gastroesophageal junction adenocarcinomas, but recurrence rates remain hig...
www.nejm.org
June 1, 2025 at 8:29 PM
MATTERHORN manuscript published today in the New England Journal of Medicine. #ASCO25 www.nejm.org/doi/full/10....
💊 Stomach cancer drug cuts death risk
In a trial of 948 people with stomach cancer in 20 countries, adding durvalumab to chemotherapy before and after surgery cut the risk of dying by 22% versus chemo alone.
🔗 www.thelancet.com/journals/lan...
#Cancer #Oncology #Science 🧪
In a trial of 948 people with stomach cancer in 20 countries, adding durvalumab to chemotherapy before and after surgery cut the risk of dying by 22% versus chemo alone.
🔗 www.thelancet.com/journals/lan...
#Cancer #Oncology #Science 🧪
Perioperative durvalumab plus fluorouracil, leucovorin, oxaliplatin, and docetaxel for resectable gastric and gastro-oesophageal junction adenocarcinoma (MATTERHORN): final results of overall survival...
Perioperative durvalumab plus FLOT improved overall survival versus placebo plus FLOT
and is a new standard treatment option for patients with resectable gastric or gastro-oesophageal
junction adenoca...
www.thelancet.com
September 11, 2026 at 4:53 AM
💊 Stomach cancer drug cuts death risk
In a trial of 948 people with stomach cancer in 20 countries, adding durvalumab to chemotherapy before and after surgery cut the risk of dying by 22% versus chemo alone.
🔗 www.thelancet.com/journals/lan...
#Cancer #Oncology #Science 🧪
In a trial of 948 people with stomach cancer in 20 countries, adding durvalumab to chemotherapy before and after surgery cut the risk of dying by 22% versus chemo alone.
🔗 www.thelancet.com/journals/lan...
#Cancer #Oncology #Science 🧪
What makes platinum-based drugs like Oxaliplatin so powerful against cancer? This chemotherapy agent disrupts DNA replication in cancer cells, triggering cell death & halting tumor growth. Dive into the science behind it in my latest short video!
youtu.be/9wJfqkhKCTk
youtu.be/9wJfqkhKCTk
How does Oxaliplatin Cancer Treatment Work?
YouTube video by Dr. Rob Swanda
youtu.be
October 14, 2025 at 5:00 PM
What makes platinum-based drugs like Oxaliplatin so powerful against cancer? This chemotherapy agent disrupts DNA replication in cancer cells, triggering cell death & halting tumor growth. Dive into the science behind it in my latest short video!
youtu.be/9wJfqkhKCTk
youtu.be/9wJfqkhKCTk
18 years ago yesterday (September 9), my father lost his battle with cancer at 61. Not to the cancer— to the chemotherapy drug Oxaliplatin which he was deadly allergic to and it cooked his lungs.
He died suffocating on a respirator.
Get allergy tests before you take IV drugs.
#cdnpoli #cancer
He died suffocating on a respirator.
Get allergy tests before you take IV drugs.
#cdnpoli #cancer
September 11, 2025 at 3:17 AM