www.science.org/doi/10.1126/...
"SLC25A34 is proposed to import oxaloacetate into mitochondria, dually supporting the tricarboxylic acid cycle and cytosolic acetyl–coenzyme A (acetyl-CoA) production."
"SLC25A34 is proposed to import oxaloacetate into mitochondria, dually supporting the tricarboxylic acid cycle and cytosolic acetyl–coenzyme A (acetyl-CoA) production."
Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling
Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature, but how these diverse signals are molecularly integrated remains unknown. We showed that these cues...
www.science.org
October 2, 2026 at 10:56 PM
www.science.org/doi/10.1126/...
"SLC25A34 is proposed to import oxaloacetate into mitochondria, dually supporting the tricarboxylic acid cycle and cytosolic acetyl–coenzyme A (acetyl-CoA) production."
"SLC25A34 is proposed to import oxaloacetate into mitochondria, dually supporting the tricarboxylic acid cycle and cytosolic acetyl–coenzyme A (acetyl-CoA) production."
oxaloacetatecfs.com/products/oxa... The manufacturer has told me they hope to reduce the price as demand establishes and grows. They ship quite promptly usually, usually arrives in UK in four days.
Oxaloacetate CFS – 500mg
Clinically Proven to Significantly Reduce Fatigue in ME/CFS Patients. Peer-reviewed clinical trials showed up to 33% reduction in fatigue for ME/CFS patients and up to 47% reduction in fatigue for Lon...
oxaloacetatecfs.com
September 25, 2026 at 9:33 AM
oxaloacetatecfs.com/products/oxa... The manufacturer has told me they hope to reduce the price as demand establishes and grows. They ship quite promptly usually, usually arrives in UK in four days.
Hi Andrew, could I ask you about how you get oxaloacetate? Is it prescription based, is it pricey? Where do you get it? I understand the mechanistic relevance of the compound for ME, so I'm curious to experiment if that's something one could responsibly do unsupervised. Any advice is very welcome!
September 25, 2026 at 9:25 AM
Hi Andrew, could I ask you about how you get oxaloacetate? Is it prescription based, is it pricey? Where do you get it? I understand the mechanistic relevance of the compound for ME, so I'm curious to experiment if that's something one could responsibly do unsupervised. Any advice is very welcome!
Fighting a bug and insufficient Oxaloacetate making me an extra groggy boy. I bought some weaker formulation OAA but even that seems slow to ship. Waah.
September 25, 2026 at 9:10 AM
Fighting a bug and insufficient Oxaloacetate making me an extra groggy boy. I bought some weaker formulation OAA but even that seems slow to ship. Waah.
Loss of TCA cycle turning promotes stem cell function
The citric acid cycle (TCA cycle) is the common terminal pathway for the oxidation of all nutrients. Citrate oxidation to oxaloacetate produces CO2, and citrate synthase (CS) uses nutrient-derived ace...
www.biorxiv.org
September 23, 2026 at 12:03 PM
Any spare Oxaloacetate I can buy from you?
It's currently on back order due to demand. Thanks!
#Oxaloacetate
It's currently on back order due to demand. Thanks!
#Oxaloacetate
September 16, 2026 at 8:13 AM
Any spare Oxaloacetate I can buy from you?
It's currently on back order due to demand. Thanks!
#Oxaloacetate
It's currently on back order due to demand. Thanks!
#Oxaloacetate
Organic acid accumulation can disrupt mitochondrial function, but how? This study shows that the accumulation of oxaloacetate damages mitochondrial structure by inhibiting the MICOS complex, thereby preventing MIC60-dependent membrane remodeling.
🧪 #AcademicSky #mitochondria
plos.io/4ixTUFV
🧪 #AcademicSky #mitochondria
plos.io/4ixTUFV
September 3, 2026 at 4:10 PM
Organic acid accumulation can disrupt mitochondrial function, but how? This study shows that the accumulation of oxaloacetate damages mitochondrial structure by inhibiting the MICOS complex, thereby preventing MIC60-dependent membrane remodeling.
🧪 #AcademicSky #mitochondria
plos.io/4ixTUFV
🧪 #AcademicSky #mitochondria
plos.io/4ixTUFV
Organic acid accumulation can disrupt mitochondrial function, but how? This study shows that the accumulation of oxaloacetate damages mitochondrial structure by inhibiting the MICOS complex, thereby preventing MIC60-dependent membrane remodeling.
🧪 #AcademicSky #mitochondria
plos.io/4ixTUFV
🧪 #AcademicSky #mitochondria
plos.io/4ixTUFV
September 2, 2026 at 12:10 PM
Organic acid accumulation can disrupt mitochondrial function, but how? This study shows that the accumulation of oxaloacetate damages mitochondrial structure by inhibiting the MICOS complex, thereby preventing MIC60-dependent membrane remodeling.
🧪 #AcademicSky #mitochondria
plos.io/4ixTUFV
🧪 #AcademicSky #mitochondria
plos.io/4ixTUFV
Organic acid accumulation can disrupt mitochondrial function, but how? This study shows that the accumulation of oxaloacetate damages mitochondrial structure by inhibiting the MICOS complex, thereby preventing MIC60-dependent membrane remodeling.
🧪 #AcademicSky #mitochondria
plos.io/4ixTUFV
🧪 #AcademicSky #mitochondria
plos.io/4ixTUFV
September 1, 2026 at 8:10 AM
Organic acid accumulation can disrupt mitochondrial function, but how? This study shows that the accumulation of oxaloacetate damages mitochondrial structure by inhibiting the MICOS complex, thereby preventing MIC60-dependent membrane remodeling.
🧪 #AcademicSky #mitochondria
plos.io/4ixTUFV
🧪 #AcademicSky #mitochondria
plos.io/4ixTUFV
Link mal wieder vergessen: oxaloacetatecfs.com?srsltid=AfmB...
Oxaloacetate CFS
Oxaloacetate CFS
oxaloacetatecfs.com
August 31, 2026 at 12:49 PM
Link mal wieder vergessen: oxaloacetatecfs.com?srsltid=AfmB...
So now I have to decide if I should buy Oxaloacetate CFS (the ME person’s version) but that is most definitely made a shipped from the US and it costs $$$ so would definitely be very bad to do trade war wise.
August 30, 2026 at 6:20 PM
So now I have to decide if I should buy Oxaloacetate CFS (the ME person’s version) but that is most definitely made a shipped from the US and it costs $$$ so would definitely be very bad to do trade war wise.
A novel role for Oxaloacetate Decarboxylase FAHD1 in cardiomyocyte maturation https://www.biorxiv.org/content/10.64898/2026.08.14.744855v1
August 17, 2026 at 10:30 AM
A novel role for Oxaloacetate Decarboxylase FAHD1 in cardiomyocyte maturation https://www.biorxiv.org/content/10.64898/2026.08.14.744855v1
A novel role for Oxaloacetate Decarboxylase FAHD1 in cardiomyocyte maturation https://www.biorxiv.org/content/10.64898/2026.08.14.744855v1
August 17, 2026 at 10:30 AM
A novel role for Oxaloacetate Decarboxylase FAHD1 in cardiomyocyte maturation https://www.biorxiv.org/content/10.64898/2026.08.14.744855v1
4mg. Any more and PEM-like symptoms.
Oxaloacetate has been the game changer for me, but it's expensive. There are discount codes, which help. I can only do this cos Sharon bank rolls me.
Oxaloacetate has been the game changer for me, but it's expensive. There are discount codes, which help. I can only do this cos Sharon bank rolls me.
August 12, 2026 at 11:59 AM
4mg. Any more and PEM-like symptoms.
Oxaloacetate has been the game changer for me, but it's expensive. There are discount codes, which help. I can only do this cos Sharon bank rolls me.
Oxaloacetate has been the game changer for me, but it's expensive. There are discount codes, which help. I can only do this cos Sharon bank rolls me.
Private tests show I have leaky mitochondria membranes, so I try to support this and mito function as priority; Oxaloacetate (£), LDN and breath holds. Plus a dozen mito energy & function supplements. I'm v.lucky that Sharon my partner subsidises this. I eat lots fish, nuts & seeds for the omegas.
August 7, 2026 at 3:52 PM
Private tests show I have leaky mitochondria membranes, so I try to support this and mito function as priority; Oxaloacetate (£), LDN and breath holds. Plus a dozen mito energy & function supplements. I'm v.lucky that Sharon my partner subsidises this. I eat lots fish, nuts & seeds for the omegas.
Thanks Jamie! Do you have a sea view at least, or an option to glance it with a shorter walk? Something restorative about just seeing it, I find :)
My wonder supplement is the very expensive Oxaloacetate, which I couldn't afford were it not for Sharon supporting on living costs.
My wonder supplement is the very expensive Oxaloacetate, which I couldn't afford were it not for Sharon supporting on living costs.
July 9, 2026 at 12:54 PM
Thanks Jamie! Do you have a sea view at least, or an option to glance it with a shorter walk? Something restorative about just seeing it, I find :)
My wonder supplement is the very expensive Oxaloacetate, which I couldn't afford were it not for Sharon supporting on living costs.
My wonder supplement is the very expensive Oxaloacetate, which I couldn't afford were it not for Sharon supporting on living costs.
I have also started one new medication and several new supplements including oxaloacetate so it could be a lot of things behind the improvement. I also stayed upstairs for about 4 months after my gallbladder (and got my inflamed gallbladder removed) so again, many factors.
July 3, 2026 at 3:21 PM
I have also started one new medication and several new supplements including oxaloacetate so it could be a lot of things behind the improvement. I also stayed upstairs for about 4 months after my gallbladder (and got my inflamed gallbladder removed) so again, many factors.
Feed: "Oxaloacetate CFS - The Latest In Oxaloacetate Research"
By: Alan Cash on Tuesday, June 30, 2026
By: Alan Cash on Tuesday, June 30, 2026
Daratumumab Pilot Study Offers New Insights into ME/CFS
A new pilot study has added to the growing evidence that the immune system may play an important role in ME/CFS for some patients. Researchers investigated daratumumab, a medication that targets long-lived plasma cells, the immune cells responsible for producing antibodies. Their hypothesis is that, in a subgroup of pe
oxaloacetatecfs.com
July 1, 2026 at 1:40 AM
Feed: "Oxaloacetate CFS - The Latest In Oxaloacetate Research"
By: Alan Cash on Tuesday, June 30, 2026
By: Alan Cash on Tuesday, June 30, 2026
Feed: "Oxaloacetate CFS - The Latest In Oxaloacetate Research"
By: Alan Cash on Monday, June 29, 2026
By: Alan Cash on Monday, June 29, 2026
Terra Biological LLC Expands Access to Oxaloacetate CFS Through HSA and FSA Funds
SAN DIEGO, Calif. — June 2026 — Terra Biological LLC today announced that eligible customers can now seamlessly use Health Savings Account (HSA) and Flexible Spending Account (FSA) funds to purchase Oxaloacetate CFS™, a medical food clinically proven to lower fatigue in patients with Long COVID and Myalgic Encephalomye
oxaloacetatecfs.com
June 30, 2026 at 1:24 AM
Feed: "Oxaloacetate CFS - The Latest In Oxaloacetate Research"
By: Alan Cash on Monday, June 29, 2026
By: Alan Cash on Monday, June 29, 2026
Na+-translocating oxaloacetate decarboxylase from Vibrio cholerae: the functional tautomeric form of the substrate and the proton pathways in catalysis https://www.biorxiv.org/content/10.64898/2026.06.08.730933v1
June 11, 2026 at 1:46 AM
Na+-translocating oxaloacetate decarboxylase from Vibrio cholerae: the functional tautomeric form of the substrate and the proton pathways in catalysis https://www.biorxiv.org/content/10.64898/2026.06.08.730933v1
Na+-translocating oxaloacetate decarboxylase from Vibrio cholerae: the functional tautomeric form of the substrate and the proton pathways in catalysis https://www.biorxiv.org/content/10.64898/2026.06.08.730933v1
June 11, 2026 at 1:46 AM
Na+-translocating oxaloacetate decarboxylase from Vibrio cholerae: the functional tautomeric form of the substrate and the proton pathways in catalysis https://www.biorxiv.org/content/10.64898/2026.06.08.730933v1
Feed: "Oxaloacetate CFS - The Latest In Oxaloacetate Research"
By: Alan Cash on Tuesday, May 19, 2026
By: Alan Cash on Tuesday, May 19, 2026
Three ME/CFS Conferences in One Month
At Oxaloacetate CFS, one of the most rewarding parts of our work is connecting directly with the clinicians, researchers, and patients who are dedicated to advancing the understanding of ME/CFS. This past month has been especially meaningful for our team as we’ve attended three major conferences focused on complex chro
oxaloacetatecfs.com
May 21, 2026 at 7:18 PM
Feed: "Oxaloacetate CFS - The Latest In Oxaloacetate Research"
By: Alan Cash on Tuesday, May 19, 2026
By: Alan Cash on Tuesday, May 19, 2026
Feed: "Oxaloacetate CFS - The Latest In Oxaloacetate Research"
By: Alan Cash on Wednesday, May 20, 2026
By: Alan Cash on Wednesday, May 20, 2026
We're off to England for the Invest in ME Research 18th International ME Conference
The Oxaloacetate CFS team is heading to England for the 18th International ME Conference 2026 hosted by Invest in ME Research, and after reviewing this year’s agenda, we’re more excited than ever about the direction ME/CFS research is heading. A Strong Focus on Clinical Trials and Real-World Treatments One of the major
oxaloacetatecfs.com
May 21, 2026 at 7:18 PM
Feed: "Oxaloacetate CFS - The Latest In Oxaloacetate Research"
By: Alan Cash on Wednesday, May 20, 2026
By: Alan Cash on Wednesday, May 20, 2026
Going cold turkey on sleep meds. Daridorexant got me through 15 months of awful, but now ineffective. Antihistamine based drugs so short term. My ME seems reasonably stable thanks to Oxaloacetate and am rarely tired and wired so fingers crossed. A first night of restless nightmares down, thanks LDN.
May 14, 2026 at 9:43 AM
Going cold turkey on sleep meds. Daridorexant got me through 15 months of awful, but now ineffective. Antihistamine based drugs so short term. My ME seems reasonably stable thanks to Oxaloacetate and am rarely tired and wired so fingers crossed. A first night of restless nightmares down, thanks LDN.