#Oxaloacetate
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osayko.bsky.social
For Christmas I got myself oxaloacetate and threw one down the hatch. Yay, #LongCOVID.
December 25, 2024 at 9:09 PM
ezra.zone
New RCT of oxaloacetate in ME/CFS at Bateman Horne was just published – it showed some positive effect on fatigue, but they used the Chalder Fatigue Scale. And it is still so expensive that I don't know if it's even worth trying.

www.frontiersin.org/journals/neu...
Frontiers | RESTORE ME: a RCT of oxaloacetate for improving fatigue in patients with myalgic encephalomyelitis/chronic fatigue syndrome
BackgroundThe energy metabolite oxaloacetate is significantly lower in the blood plasma of ME/CFS subjects. A previous open-label trial with oxaloacetate sup...
www.frontiersin.org
November 30, 2024 at 2:17 AM
mecfsscience.org
1) Had a look at the REGAIN, a randomized trial of the supplement oxaloacetate for Long Covid.

The primary outcome (Chalder Fatigue Scale) had a clear null result, suggesting oxaloacetate did not improve fatigue.
July 19, 2025 at 12:20 PM
tomkindlon.bsky.social
Double-blinded, controlled study of oxaloacetate for improving fatigue in ME/CFS

www.frontiersin.org/journals/neu...

Great to see this sort of trial being done. Results seem quite modest given it's so expensive

#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME

1/
Background: The energy metabolite oxaloacetate is significantly lower in the blood plasma of ME/CFS subjects. A previous open-label trial with oxaloacetate supplementation demonstrated a significant reduction in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)-related fatigue. Methods: In this follow-up trial, 82 ME/CFS subjects were enrolled in a 3-month randomized, double-blinded, controlled study, receiving either 2,000 mg of oxaloacetate or control per day. The primary endpoints were safety and reduction in fatigue from baseline. Secondary and exploratory endpoints included functional capacity and general health status. Results: Anhydrous enol-oxaloacetate (oxaloacetate) was well tolerated at the tested doses. Oxaloacetate significantly reduced fatigue by more than 25% from baseline, while the control group showed a non-significant reduction of approximately 10%. Intergroup analysis showed a significant decrease in fatigue levels in the oxaloacetate group (p = 0.0039) with no notable change in the control group. A greater proportion of subjects in the oxaloacetate group achieved a reduction in fatigue greater than 25% compared to the control group (p < 0.05). Additionally, 40.5% of the oxaloacetate group were classified as “enhanced responders,” with an average fatigue reduction of 63%. Both physical and mental fatigue improved with oxaloacetate supplementation. Conclusion: Oxaloacetate is well tolerated and effectively helps reduce fatigue in ME/CFS patients.
December 1, 2024 at 6:52 PM
cortjohnson.bsky.social
RESTORE ME? Oxaloacetate Scores in Randomized Controlled ME/CFS Trial #MECFS www.healthrising.org/blog/2024/12...
RESTORE ME? Oxaloacetate Scores in Randomized Controlled ME/CFS Trial - Health Rising
Oxaloacetate significantly reduces fatigue in a chronic fatigue syndrome / ME/CFS clinical trial.
www.healthrising.org
December 28, 2024 at 10:49 PM
batemanhornecenter.bsky.social
In our latest blog, Suzanne Vernon, PhD, discusses the RESTORE ME study & oxaloacetate in ME/CFS.

📖 Dr. Vernon’s blog post:
bit.ly/4haLHDB
🎥 Watch Jarrod Younger's YouTube: bit.ly/3WcynGN
📖 Read Cort Johnson’s blog post: bit.ly/3PtUtRq

#MECFS #LongCOVID #ClinicalTrials #Oxaloacetate #BHC
January 10, 2025 at 4:21 PM
andrewgiffordphoto.bsky.social
Fighting a bug and insufficient Oxaloacetate making me an extra groggy boy. I bought some weaker formulation OAA but even that seems slow to ship. Waah.
September 25, 2026 at 9:10 AM
thailandmedical.bsky.social
Oxaloacetate Trial Offers Hope for Long COVID Brain Fog and Fatigue Relief

www.thailandmedical.news/news/oxaloac...
Oxaloacetate Trial Offers Hope for Long COVID Brain Fog and Fatigue Relief - Thailand Medical News
www.thailandmedical.news
July 23, 2025 at 2:48 AM
andrewgiffordphoto.bsky.social
Anyone here know whether this is the case and, if so, whether Oxaloacetate may be counter-productive for ME/LC?

My experience at 2000mg daily has been entirely positive, for moderate ME - energy, cognition, capacity, mood etc. all improved.

#Oxaloacetate #pwME #MECFS #LongCovid #Mitochondria
biorxiv-cellbio.bsky.social bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Jan 31
Oxaloacetate damages mitochondria by perturbing MIC60-dependent membrane remodeling https://www.biorxiv.org/content/10.64898/2026.01.28.702225v1
February 6, 2026 at 8:49 PM
andrewgiffordphoto.bsky.social
Impressive Oxaloacetate results claimed from randomised, placebo-controlled trial:

"25%+ ave improvement in fatigue symptoms
Significant gains in both physical & mental fatigue
A standout 63% fatigue improvement in an “enhanced responder” subgroup—40.5% of participants"

#pwME #MECFS #Oxaloacetate
June 18, 2025 at 6:55 AM
kaufmanmd.bsky.social
We just published another paper documenting the efficacy of oxaloacetate in reducing symptoms in patients with Long Covid.

www.frontiersin.org/journals/neu...
Frontiers | REGAIN: a randomized controlled clinical trial of oxaloacetate for improving the symptoms of long COVID
BackgroundLong COVID is characterized by fatigue, cognitive dysfunction, and other persistent symptoms. This randomized, double-blind, controlled trial evalu...
www.frontiersin.org
July 18, 2025 at 7:12 AM
bhanlon15.bsky.social
Bateman Horne Center: 'Understanding the Potential of Oxaloacetate for Long COVID and ME/CFS'

A Q&A with Suzanne Vernon, PhD and Jennifer Bell, FNP-C

batemanhornecenter.org/understandin...
Understanding the Potential of Oxaloacetate for Long COVID and ME/CFS
The REGAIN study, published in Frontiers in Neuroscience, explored the effects of oxaloacetate (OAA), a naturally occurring compound, on individuals living with Long COVID. Conducted as a randomized…
batemanhornecenter.org
August 21, 2025 at 5:56 PM
d-j.bsky.social
"oxaloacetate" in Studie gegen Fatigue bei #MECFS wirksam.

pmc.ncbi.nlm.nih.gov/articles/PMC...
RESTORE ME: a RCT of oxaloacetate for improving fatigue in patients with myalgic encephalomyelitis/chronic fatigue syndrome
The energy metabolite oxaloacetate is significantly lower in the blood plasma of ME/CFS subjects. A previous open-label trial with oxaloacetate supplementation demonstrated a significant reduction in ...
pmc.ncbi.nlm.nih.gov
December 28, 2024 at 9:43 AM
batemanhornecenter.bsky.social
Following high community interest, we’ve published a deeper look at the Oxaloacetate (OAA) study in ME/CFS.
Learn how targeting cellular energy may support both fatigue and cognition.

🔗 Read the full blog: https://bit.ly/4opeqbw
#MECFS #Oxaloacetate #Research #BatemanHorneCenter
White pills on a blue background with the text: "New Blog Post: Deep Dive into the research behind Oxaloacetate (OAA) and its potential role in ME/CFS."
October 24, 2025 at 9:22 PM
natmicrobiol.nature.com
Some keen Observations in Our October issue!

🦠 Cancer microbiome
🌊 Marine microbes in warming oceans
🌐 broad-range phages
🧬 genetically minimised Salmonella
🔧 Viral infection mechanisms
🧪 Oxaloacetate antiviral defence

and more, here: www.nature.com/nmicrobiol/v...
October 1, 2025 at 5:30 PM
frezzalab.bsky.social
Oxaloacetate, so central, so elusive: faseb.onlinelibrary.wiley.com/doi/10.1096/...
Detection of liver mitochondrial oxaloacetate by NMR spectroscopy and membrane potential‐dependent accumulation
Oxaloacetate is centrally positioned in the TCA cycle to regulate critical steps towards whole-body physiology. Nonetheless, studies of OAA metabolism in the liver are severely limited because OAA is....
faseb.onlinelibrary.wiley.com
April 6, 2025 at 6:10 AM
bhanlon15.bsky.social
Health Rising: “RESTORE ME? Oxaloacetate Scores in Randomized Controlled ME/CFS Trial”

www.healthrising.org/blog/2024/12...
RESTORE ME? Oxaloacetate Scores in Randomized Controlled ME/CFS Trial - Health Rising
Oxaloacetate significantly reduces fatigue in a chronic fatigue syndrome / ME/CFS clinical trial.
www.healthrising.org
December 17, 2024 at 4:56 PM
davidjoffe64.bsky.social
Creatinine monohydrate is good. But dose is important! Check the EGFR.

CO-Q10
Oxaloacetate

Mitochondrial support supplements, in essence.

But sounds like POTS is an issue.
August 17, 2025 at 9:10 PM
andrewgiffordphoto.bsky.social
On Sunday I drove three hours, Bristol to Cambs. Felt longer than it ever had. I'd not done this alone in 24 months. Oxaloacetate meant I could attempt this and glad I tried, as I've hardly seem my family in past five years. Very fried on arrival. Awaiting PEM/crash. Upped Oxaloacetate dose in case.
July 8, 2025 at 9:22 AM
unbewegter-beweger.eurosky.social
Finaler Wirkungsnachweis und Zulassung über eine Phase 3 Studie ist ein steiniger Weg, vor allem in DE, aber immerhin mal ein Hoffnungsschimmer für ME/CFS Pats:
www.frontiersin.org/journals/neu...
Frontiers | RESTORE ME: A RCT of Oxaloacetate for Improving Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
The energy metabolite oxaloacetate is significantly lower in the blood plasma of ME/CFS subjects. A previous open-label trial with oxaloacetate supplementati...
www.frontiersin.org
October 7, 2024 at 4:12 PM
biorxiv-cellbio.bsky.social
Oxaloacetate damages mitochondria by perturbing MIC60-dependent membrane remodeling https://www.biorxiv.org/content/10.64898/2026.01.28.702225v1
January 31, 2026 at 2:30 AM
batemanhornecenter.bsky.social
Fatigue & cognition are linked in #MECFS & #LongCOVID.

At #IACFSME2025, Dr. Suzanne Vernon (BHC Research Director) shared how oxaloacetate may restore energy metabolism & cognitive clarity by strengthening the fatigue-cognition axis.

Watch:
IACFSME 2025 Conference Susan Vernon, PhD
In this IACFSME 2025 conference highlight, Suzanne D. Vernon, PhD, Research Director at Bateman Horne Center, explains how oxaloacetate may strengthen the fa...
youtu.be
November 13, 2025 at 7:36 PM
osayko.bsky.social
So I’m on day 11 of oxaloacetate. I went from 500mg BID to 1000mg BID quite quickly as I was not experiencing any negative side effects even though I take it on an empty stomach. My remaining brain fog has essentially disappeared, which is quite exciting.
January 4, 2025 at 9:11 PM
mhagenauer.bsky.social
🧠🦠 ME/CFS & Long Covid folks:

What are your thoughts on this study? 🧵

www.frontiersin.org/journals/neu...
Frontiers | RESTORE ME: a RCT of oxaloacetate for improving fatigue in patients with myalgic encephalomyelitis/chronic fatigue syndrome
The energy metabolite oxaloacetate is significantly lower in the blood plasma of ME/CFS subjects. A previous open-label trial with oxaloacetate supplementati...
www.frontiersin.org
May 14, 2025 at 8:53 PM
chromatowski.bsky.social
Full text of the oxaloacetate paper for which the abstract was shared a couple months ago.
November 30, 2024 at 4:13 AM