P2X7 receptor antagonism potentiates seizure-suppressive effects of anti-seizure medications in human resected epileptic brain tissue https://www.biorxiv.org/content/10.64898/2026.09.18.752730v1
September 25, 2026 at 4:15 AM
P2X7 receptor antagonism potentiates seizure-suppressive effects of anti-seizure medications in human resected epileptic brain tissue https://www.biorxiv.org/content/10.64898/2026.09.18.752730v1
ATP acts as i) cellular energy currency, ii) danger signal, & much more
ATP induces fast migration of leukocytes, w depends on P2X7, Panx1 channels, & CaMKII, w leads to actin cytoskeleton (cyan) changes
www.science.org/doi/full/10....
@focalplane.bsky.social #CellMigration #fluorescencefriday 🧪🔬
ATP induces fast migration of leukocytes, w depends on P2X7, Panx1 channels, & CaMKII, w leads to actin cytoskeleton (cyan) changes
www.science.org/doi/full/10....
@focalplane.bsky.social #CellMigration #fluorescencefriday 🧪🔬
December 20, 2024 at 12:05 PM
ATP acts as i) cellular energy currency, ii) danger signal, & much more
ATP induces fast migration of leukocytes, w depends on P2X7, Panx1 channels, & CaMKII, w leads to actin cytoskeleton (cyan) changes
www.science.org/doi/full/10....
@focalplane.bsky.social #CellMigration #fluorescencefriday 🧪🔬
ATP induces fast migration of leukocytes, w depends on P2X7, Panx1 channels, & CaMKII, w leads to actin cytoskeleton (cyan) changes
www.science.org/doi/full/10....
@focalplane.bsky.social #CellMigration #fluorescencefriday 🧪🔬
From Hungary
"we report for the first time the activation of P2X7 receptors following SARS-CoV-2 infection is involved in the induction of anxiety & mood alterations through inflammatory pathways"
www.sciencedirect.com/science/arti...
Image from Science for ME weekly update
#NeuroPASC #LongCovid
"we report for the first time the activation of P2X7 receptors following SARS-CoV-2 infection is involved in the induction of anxiety & mood alterations through inflammatory pathways"
www.sciencedirect.com/science/arti...
Image from Science for ME weekly update
#NeuroPASC #LongCovid
June 25, 2025 at 1:02 AM
From Hungary
"we report for the first time the activation of P2X7 receptors following SARS-CoV-2 infection is involved in the induction of anxiety & mood alterations through inflammatory pathways"
www.sciencedirect.com/science/arti...
Image from Science for ME weekly update
#NeuroPASC #LongCovid
"we report for the first time the activation of P2X7 receptors following SARS-CoV-2 infection is involved in the induction of anxiety & mood alterations through inflammatory pathways"
www.sciencedirect.com/science/arti...
Image from Science for ME weekly update
#NeuroPASC #LongCovid
Another manuscript from our group this week with the first structures of the human P2X7 receptor facilitating development of a novel scaffold for P2X7R antagonists:
urldefense.com/v3/__https:/...
@pacificnwcryoem.bsky.social
@ohsunews.bsky.social
@ohsubrain.bsky.social
urldefense.com/v3/__https:/...
@pacificnwcryoem.bsky.social
@ohsunews.bsky.social
@ohsubrain.bsky.social
September 15, 2025 at 6:11 PM
Another manuscript from our group this week with the first structures of the human P2X7 receptor facilitating development of a novel scaffold for P2X7R antagonists:
urldefense.com/v3/__https:/...
@pacificnwcryoem.bsky.social
@ohsunews.bsky.social
@ohsubrain.bsky.social
urldefense.com/v3/__https:/...
@pacificnwcryoem.bsky.social
@ohsunews.bsky.social
@ohsubrain.bsky.social
P2X7 antagonists showing promise for suppression of neuroinflammatory responses. Our paper out in Brain now. #ionchannels
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
P2X7R-mediated IL-1β release by human brain tissue: the impact of CNS-penetrant potential therapeutics
Cowley et al. show that CNS-penetrant, selective P2X7 receptor antagonists reduce the release of pro-inflammatory cytokines from human microglia and brain
academic.oup.com
February 23, 2026 at 8:56 AM
P2X7 antagonists showing promise for suppression of neuroinflammatory responses. Our paper out in Brain now. #ionchannels
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
A new chemical labelling tool lets researchers watch the inflammatory receptor P2X7 reorganise and cluster on immune cells at the nanoscale, revealing how inflammatory signals reshape receptor behaviour in real time.
buff.ly/MtXREaW
buff.ly/MtXREaW
January 16, 2026 at 9:01 PM
A new chemical labelling tool lets researchers watch the inflammatory receptor P2X7 reorganise and cluster on immune cells at the nanoscale, revealing how inflammatory signals reshape receptor behaviour in real time.
buff.ly/MtXREaW
buff.ly/MtXREaW
Altered purinergic P2X7 and A2B receptors signaling limits macrophage-mediated host defense in schistosomiasis
www.sciencedirect.com/science/arti... #OpenAccess #ImmunoSky #MicroSky #Schistosoma
www.sciencedirect.com/science/arti... #OpenAccess #ImmunoSky #MicroSky #Schistosoma
November 18, 2024 at 12:36 AM
Altered purinergic P2X7 and A2B receptors signaling limits macrophage-mediated host defense in schistosomiasis
www.sciencedirect.com/science/arti... #OpenAccess #ImmunoSky #MicroSky #Schistosoma
www.sciencedirect.com/science/arti... #OpenAccess #ImmunoSky #MicroSky #Schistosoma
P2X7 receptor antagonism potentiates seizure-suppressive effects of anti-seizure medications in human resected epileptic brain tissue #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.18.752730v1
https://www.biorxiv.org/content/10.64898/2026.09.18.752730v1
September 25, 2026 at 7:02 AM
P2X7 receptor antagonism potentiates seizure-suppressive effects of anti-seizure medications in human resected epileptic brain tissue #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.18.752730v1
https://www.biorxiv.org/content/10.64898/2026.09.18.752730v1
P2X7 receptor antagonism potentiates seizure-suppressive effects of anti-seizure medications in human resected epileptic brain tissue https://www.biorxiv.org/content/10.64898/2026.09.18.752730v1
September 25, 2026 at 4:15 AM
P2X7 receptor antagonism potentiates seizure-suppressive effects of anti-seizure medications in human resected epileptic brain tissue https://www.biorxiv.org/content/10.64898/2026.09.18.752730v1
🎙️ Podcast shorturl.at/vNono
📹 YouTube shorturl.at/aeV1F
✍️ Show notes shorturl.at/FxPBw
#epilepsy #P2X7 #TBI #neuroscience #EpilepsyResearch #BrainInjury #Neuroprotection
📹 YouTube shorturl.at/aeV1F
✍️ Show notes shorturl.at/FxPBw
#epilepsy #P2X7 #TBI #neuroscience #EpilepsyResearch #BrainInjury #Neuroprotection
February 14, 2025 at 8:03 PM
🎙️ Podcast shorturl.at/vNono
📹 YouTube shorturl.at/aeV1F
✍️ Show notes shorturl.at/FxPBw
#epilepsy #P2X7 #TBI #neuroscience #EpilepsyResearch #BrainInjury #Neuroprotection
📹 YouTube shorturl.at/aeV1F
✍️ Show notes shorturl.at/FxPBw
#epilepsy #P2X7 #TBI #neuroscience #EpilepsyResearch #BrainInjury #Neuroprotection
Howdy! Today's paper spotlight comes from Chun Liang and was published in June. This paper shows that knocking out the ATP gated receptor P2X7 enhances hearing sensitivity but makes noise induced cochlea damage much worse! Adds info to those mysterious type II fibres 🔍 www.pnas.org/doi/10.1073/...
July 2, 2025 at 7:43 AM
Howdy! Today's paper spotlight comes from Chun Liang and was published in June. This paper shows that knocking out the ATP gated receptor P2X7 enhances hearing sensitivity but makes noise induced cochlea damage much worse! Adds info to those mysterious type II fibres 🔍 www.pnas.org/doi/10.1073/...
Possible role of pannexin 1/P2x7 purinoceptor in neuroprotective mechanism of ischemic postconditioning in mice #MECFS #LongCovid #PANX1 #P2X7 #SARSCoV2
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Possible role of pannexin 1/P2x7 purinoceptor in neuroprotective mechanism of ischemic postconditioning in mice
Previous studies have suggested a significant role of pannexin 1 (Panx1)/P2X7 receptor complex in cardioprotective mechanism of ischemic preconditioni…
www.sciencedirect.com
February 2, 2025 at 6:28 PM
Possible role of pannexin 1/P2x7 purinoceptor in neuroprotective mechanism of ischemic postconditioning in mice #MECFS #LongCovid #PANX1 #P2X7 #SARSCoV2
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Thomas Grutter (Université de Strasbourg)
"New labeling method for revealing endogenous P2X7 at single-molecule level in BV2 microglia"
🔍 Cutting-edge imaging meets purinergic biology.
#FPC2025 #Neuroimaging #P2X7 #SingleMolecule
"New labeling method for revealing endogenous P2X7 at single-molecule level in BV2 microglia"
🔍 Cutting-edge imaging meets purinergic biology.
#FPC2025 #Neuroimaging #P2X7 #SingleMolecule
June 30, 2025 at 1:30 PM
Thomas Grutter (Université de Strasbourg)
"New labeling method for revealing endogenous P2X7 at single-molecule level in BV2 microglia"
🔍 Cutting-edge imaging meets purinergic biology.
#FPC2025 #Neuroimaging #P2X7 #SingleMolecule
"New labeling method for revealing endogenous P2X7 at single-molecule level in BV2 microglia"
🔍 Cutting-edge imaging meets purinergic biology.
#FPC2025 #Neuroimaging #P2X7 #SingleMolecule
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor pubmed.ncbi.nlm.nih.gov/40954149/ #cryoem
September 16, 2025 at 11:29 AM
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor pubmed.ncbi.nlm.nih.gov/40954149/ #cryoem
Resident Natural Killer T Cells and Memory T Cells in Intrarenal Inflammation
journals.lww.com/jasn/fulltex...
journals.lww.com/jasn/fulltex...
ATP-Gated P2X7-Ion Channel on Kidney-Resident Natural... : Journal of the American Society of Nephrology
f P2X7 by NAD+ released from damaged cells, unless blocked by nanobodies.
Background
The P2X7 ion channel, a key sensor of sterile inflammation, has been implicated as a therapeutic target in GN, a...
journals.lww.com
March 13, 2025 at 10:19 AM
Resident Natural Killer T Cells and Memory T Cells in Intrarenal Inflammation
journals.lww.com/jasn/fulltex...
journals.lww.com/jasn/fulltex...
2) Lidocaine is mostly known as a local painkiller, but it also has anti-inflammatory effects (it's an inhibitor of the P2X7 receptor, an upstream regulator of NLRP3 inflammasome).
Treatment was delivered subcutaneously so that more lidocaine could reach the lymph nodes.
Treatment was delivered subcutaneously so that more lidocaine could reach the lymph nodes.
December 7, 2025 at 8:41 AM
2) Lidocaine is mostly known as a local painkiller, but it also has anti-inflammatory effects (it's an inhibitor of the P2X7 receptor, an upstream regulator of NLRP3 inflammasome).
Treatment was delivered subcutaneously so that more lidocaine could reach the lymph nodes.
Treatment was delivered subcutaneously so that more lidocaine could reach the lymph nodes.
Within Pur-Ther, we are looking into purinergic checkpoints like P2X7, CD73, and CD39, and their role in the tumor microenvironment.
Stay tuned for insights and discoveries shaping the future of immunotherapies! 🌟 🧑🔬 👨🔬 ⚗️
#PurinergicSignaling #P2X7 #ATP #Immunotherapy #TRANSCAN
Stay tuned for insights and discoveries shaping the future of immunotherapies! 🌟 🧑🔬 👨🔬 ⚗️
#PurinergicSignaling #P2X7 #ATP #Immunotherapy #TRANSCAN
February 11, 2025 at 11:32 AM
Within Pur-Ther, we are looking into purinergic checkpoints like P2X7, CD73, and CD39, and their role in the tumor microenvironment.
Stay tuned for insights and discoveries shaping the future of immunotherapies! 🌟 🧑🔬 👨🔬 ⚗️
#PurinergicSignaling #P2X7 #ATP #Immunotherapy #TRANSCAN
Stay tuned for insights and discoveries shaping the future of immunotherapies! 🌟 🧑🔬 👨🔬 ⚗️
#PurinergicSignaling #P2X7 #ATP #Immunotherapy #TRANSCAN
On-Cell Saturation Transfer Difference NMR Spectroscopy on Ion Channels: Characterizing Negative Allosteric Modulator Binding Interactions of P2X7 pubmed.ncbi.nlm.nih.gov/40886135/ #cryoem
September 1, 2025 at 7:11 AM
On-Cell Saturation Transfer Difference NMR Spectroscopy on Ion Channels: Characterizing Negative Allosteric Modulator Binding Interactions of P2X7 pubmed.ncbi.nlm.nih.gov/40886135/ #cryoem
The next #CryoEM Current Practices Webinar speaker will be Adam Oken from OHSU speaking on "Small-Molecule Modulation of the P2X7 Receptor Revealed by Cryo-EM" 3/27/2025 at 12 PM ET / 9AM PT.
Registration is at no-cost, but sign-up is required:
us02web.zoom.us/webinar/regi...
Registration is at no-cost, but sign-up is required:
us02web.zoom.us/webinar/regi...
March 14, 2025 at 10:19 PM
The next #CryoEM Current Practices Webinar speaker will be Adam Oken from OHSU speaking on "Small-Molecule Modulation of the P2X7 Receptor Revealed by Cryo-EM" 3/27/2025 at 12 PM ET / 9AM PT.
Registration is at no-cost, but sign-up is required:
us02web.zoom.us/webinar/regi...
Registration is at no-cost, but sign-up is required:
us02web.zoom.us/webinar/regi...
Mitochondrial ROS connects P2X7-mediated Ca2+ influx with IL-1α release by monocytes upon chronic tissue damage
Veronica Miguel
doi.org/10.1016/j.kint.2024.12.002
Original article: doi.org/10.1016/j.kint.2024.10.024
#KICommentary #MedSky #NephSky
Veronica Miguel
doi.org/10.1016/j.kint.2024.12.002
Original article: doi.org/10.1016/j.kint.2024.10.024
#KICommentary #MedSky #NephSky
February 24, 2025 at 5:50 PM
Mitochondrial ROS connects P2X7-mediated Ca2+ influx with IL-1α release by monocytes upon chronic tissue damage
Veronica Miguel
doi.org/10.1016/j.kint.2024.12.002
Original article: doi.org/10.1016/j.kint.2024.10.024
#KICommentary #MedSky #NephSky
Veronica Miguel
doi.org/10.1016/j.kint.2024.12.002
Original article: doi.org/10.1016/j.kint.2024.10.024
#KICommentary #MedSky #NephSky
Purinergic receptor P2X7 regulates interleukin-1α mediated inflammation in #chronickidneydisease in a reactive oxygen species-dependent manner
doi.org/10.1016/j.kint.2024.10.024
#OpenAccess #CKD #NephSky #MedSky
doi.org/10.1016/j.kint.2024.10.024
#OpenAccess #CKD #NephSky #MedSky
January 7, 2025 at 9:17 PM
Purinergic receptor P2X7 regulates interleukin-1α mediated inflammation in #chronickidneydisease in a reactive oxygen species-dependent manner
doi.org/10.1016/j.kint.2024.10.024
#OpenAccess #CKD #NephSky #MedSky
doi.org/10.1016/j.kint.2024.10.024
#OpenAccess #CKD #NephSky #MedSky
A new collaborative study led by FutureNeuro researchers at RCSI offers hope for predicting and preventing the development of epilepsy following traumatic brain injury.
The research identifies an important role for a brain receptor called P2X7.
More ➡️ www.rcsi.com/dublin/news-...
#RCSIdiscover
The research identifies an important role for a brain receptor called P2X7.
More ➡️ www.rcsi.com/dublin/news-...
#RCSIdiscover
New research offers hope for preventing epilepsy after traumatic brain injury
A new international study has unveiled critical insights in understanding post-traumatic epilepsy, a condition that can develop following traumatic brain injury.
www.rcsi.com
January 27, 2025 at 9:20 AM
A new collaborative study led by FutureNeuro researchers at RCSI offers hope for predicting and preventing the development of epilepsy following traumatic brain injury.
The research identifies an important role for a brain receptor called P2X7.
More ➡️ www.rcsi.com/dublin/news-...
#RCSIdiscover
The research identifies an important role for a brain receptor called P2X7.
More ➡️ www.rcsi.com/dublin/news-...
#RCSIdiscover
UB-MBX-46 is a potent and selective antagonist of the human P2X7 receptor developed by structure-based drug design www.biorxiv.org/content/10.1101/2025.02.12.637899v1 #cryoem
February 17, 2025 at 8:10 AM
UB-MBX-46 is a potent and selective antagonist of the human P2X7 receptor developed by structure-based drug design www.biorxiv.org/content/10.1101/2025.02.12.637899v1 #cryoem
New paper out: Establishment and behavioural characterization of a novel constitutive P2X7 receptor knockout mouse line.: von Mücke-Heim, Iven-Alex; Oldekamp, Judit; Metzger, Michael W; et al.
Purinergic signalling Vol. 21, no. 5, p. 1077 - 1092 | Thanks for sharing #dzne #papers
Purinergic signalling Vol. 21, no. 5, p. 1077 - 1092 | Thanks for sharing #dzne #papers
Establishment and behavioural characterization of a novel constitutive P2X7 receptor knockout mouse line.
von Mücke-Heim, Iven-Alex; Oldekamp, Judit; Metzger, Michael W; et al.
Purinergic signalling Vol. 21, no. 5, p. 1077 - 1092
dlvr.it
November 30, 2025 at 11:52 AM
一時金の受領IRがない期間が8か月目に突入。昨年の額が小さいため、P2X7から数えると16か月。
March 6, 2024 at 9:39 AM
一時金の受領IRがない期間が8か月目に突入。昨年の額が小さいため、P2X7から数えると16か月。