Heute eine Differentialdiagnose erhalten. Anscheinend gibt es nun Hinweise für eine PSC an Stelle einer PBC. Wenn das sich bewahrheiten sollte, dann gute Nacht. Naja.
July 15, 2024 at 7:40 PM
Heute eine Differentialdiagnose erhalten. Anscheinend gibt es nun Hinweise für eine PSC an Stelle einer PBC. Wenn das sich bewahrheiten sollte, dann gute Nacht. Naja.
Our January 2026 issue is out now: www.thelancet.com/gastrohep
Content includes #MASH, #IBD, #PBC, #PSC, #ageing, #diet + more!
#GastroSky #MedSky #IBDSky
Content includes #MASH, #IBD, #PBC, #PSC, #ageing, #diet + more!
#GastroSky #MedSky #IBDSky
December 4, 2025 at 8:12 AM
Our January 2026 issue is out now: www.thelancet.com/gastrohep
Content includes #MASH, #IBD, #PBC, #PSC, #ageing, #diet + more!
#GastroSky #MedSky #IBDSky
Content includes #MASH, #IBD, #PBC, #PSC, #ageing, #diet + more!
#GastroSky #MedSky #IBDSky
Die Lebenserwartung bei primär sklerosierender Cholangitis (PSC) liegt nach der Diagnose durchschnittlich zwischen 10 und 20 Jahren, laut Cleveland Clinic. Bei primärer biliärer Cholangitis (PBC) kann die Lebenserwartung nach Auftreten der ersten Symptome etwa 10 Jahre betragen, so MSD Manuals.
June 13, 2025 at 9:20 PM
Die Lebenserwartung bei primär sklerosierender Cholangitis (PSC) liegt nach der Diagnose durchschnittlich zwischen 10 und 20 Jahren, laut Cleveland Clinic. Bei primärer biliärer Cholangitis (PBC) kann die Lebenserwartung nach Auftreten der ersten Symptome etwa 10 Jahre betragen, so MSD Manuals.
RARE, BUT UNSTOPPABLE!
This #RareDiseaseDay, we stand with the warriors battling #RareLiverDisease! No more delays early detection, better treatments & life-saving research NOW!
These diseases may be rare, but our fight is mighty!
#PBC #PSC #AutoimmuneHepatitis #Alpha1 #LALD #BiliaryAtresia
This #RareDiseaseDay, we stand with the warriors battling #RareLiverDisease! No more delays early detection, better treatments & life-saving research NOW!
These diseases may be rare, but our fight is mighty!
#PBC #PSC #AutoimmuneHepatitis #Alpha1 #LALD #BiliaryAtresia
February 28, 2025 at 12:39 AM
RARE, BUT UNSTOPPABLE!
This #RareDiseaseDay, we stand with the warriors battling #RareLiverDisease! No more delays early detection, better treatments & life-saving research NOW!
These diseases may be rare, but our fight is mighty!
#PBC #PSC #AutoimmuneHepatitis #Alpha1 #LALD #BiliaryAtresia
This #RareDiseaseDay, we stand with the warriors battling #RareLiverDisease! No more delays early detection, better treatments & life-saving research NOW!
These diseases may be rare, but our fight is mighty!
#PBC #PSC #AutoimmuneHepatitis #Alpha1 #LALD #BiliaryAtresia
MASH, PBC ve PSC gibi kronik karaciğer hastalıklarının tedavisinde kullanılmak üzere vücudun doğal biyolojik ritmini taklit eden "Linafexor (CS0159)" adlı yeni nesil bir ilaç adayı geliştirdiler.
FAZ 3'e girildi.
FAZ 3'e girildi.
June 22, 2026 at 1:55 PM
MASH, PBC ve PSC gibi kronik karaciğer hastalıklarının tedavisinde kullanılmak üzere vücudun doğal biyolojik ritmini taklit eden "Linafexor (CS0159)" adlı yeni nesil bir ilaç adayı geliştirdiler.
FAZ 3'e girildi.
FAZ 3'e girildi.
A well-written review of new and established therapies for PBC and PSC that covers:
✅️Drug mechanisms
✅️Clinical trial results/efficacy
✅️Side effects
#Liversky #GiSky
pubmed.ncbi.nlm.nih.gov/39480026/#:~....
✅️Drug mechanisms
✅️Clinical trial results/efficacy
✅️Side effects
#Liversky #GiSky
pubmed.ncbi.nlm.nih.gov/39480026/#:~....
Primary Biliary Cholangitis and Primary Sclerosing Cholangitis Therapy Landscape - PubMed
Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are rare, and chronic cholestatic diseases that can progress to liver failure. The goals of treatment are to halt the progres...
pubmed.ncbi.nlm.nih.gov
March 3, 2025 at 1:19 AM
A well-written review of new and established therapies for PBC and PSC that covers:
✅️Drug mechanisms
✅️Clinical trial results/efficacy
✅️Side effects
#Liversky #GiSky
pubmed.ncbi.nlm.nih.gov/39480026/#:~....
✅️Drug mechanisms
✅️Clinical trial results/efficacy
✅️Side effects
#Liversky #GiSky
pubmed.ncbi.nlm.nih.gov/39480026/#:~....
Autoimmune Liver Disease and Type 2 Diabetes May Be Linked
www.rarediseaseadvisor.com/news/autoimm...
www.rarediseaseadvisor.com/news/autoimm...
Autoimmune Liver Disease and Type 2 Diabetes May Be Linked
Type 2 diabetes reduces the risk of primary sclerosing cholangitis (PSC), while PBC increases the risk of type 2 diabetes, a study shows.
www.rarediseaseadvisor.com
February 25, 2026 at 8:16 PM
Autoimmune Liver Disease and Type 2 Diabetes May Be Linked
www.rarediseaseadvisor.com/news/autoimm...
www.rarediseaseadvisor.com/news/autoimm...
This #PBCAwarenessDay we’re shining a light on the differences between PBC and PSC and available support. Both affect the liver but they are distinct diseases. In the UK @PBCFoundation and @PSCSupport are here to help. You're not alone.
➡️ pscsupport.org.uk/psc-and-othe...
#PBCAwareness #PSCAwareness
➡️ pscsupport.org.uk/psc-and-othe...
#PBCAwareness #PSCAwareness
September 14, 2025 at 9:00 AM
This #PBCAwarenessDay we’re shining a light on the differences between PBC and PSC and available support. Both affect the liver but they are distinct diseases. In the UK @PBCFoundation and @PSCSupport are here to help. You're not alone.
➡️ pscsupport.org.uk/psc-and-othe...
#PBCAwareness #PSCAwareness
➡️ pscsupport.org.uk/psc-and-othe...
#PBCAwareness #PSCAwareness
February is Rare Disease Awareness Month.
Did you know a disease is considered rare in the U.S. when it affects fewer than 200,000 people?
Many liver conditions—like Alagille syndrome, PSC, PBC, Wilson disease, and biliary atresia—fall into this category.
#RareDisease #LiverHealth #MakeRareVisible
Did you know a disease is considered rare in the U.S. when it affects fewer than 200,000 people?
Many liver conditions—like Alagille syndrome, PSC, PBC, Wilson disease, and biliary atresia—fall into this category.
#RareDisease #LiverHealth #MakeRareVisible
February 2, 2026 at 8:38 AM
February is Rare Disease Awareness Month.
Did you know a disease is considered rare in the U.S. when it affects fewer than 200,000 people?
Many liver conditions—like Alagille syndrome, PSC, PBC, Wilson disease, and biliary atresia—fall into this category.
#RareDisease #LiverHealth #MakeRareVisible
Did you know a disease is considered rare in the U.S. when it affects fewer than 200,000 people?
Many liver conditions—like Alagille syndrome, PSC, PBC, Wilson disease, and biliary atresia—fall into this category.
#RareDisease #LiverHealth #MakeRareVisible
WORLD #LIVER DAY: Liver safety and liver disease aren’t separate problems.
Cases like #Ontozry show risks still emerge post-approval, while PBC/PSC reflect immune-driven damage.
Different triggers—same system under stress.
Read more on #Delta4's work in #PBC/#PSC: delta4.ai/development-...
Cases like #Ontozry show risks still emerge post-approval, while PBC/PSC reflect immune-driven damage.
Different triggers—same system under stress.
Read more on #Delta4's work in #PBC/#PSC: delta4.ai/development-...
April 19, 2026 at 7:00 AM
WORLD #LIVER DAY: Liver safety and liver disease aren’t separate problems.
Cases like #Ontozry show risks still emerge post-approval, while PBC/PSC reflect immune-driven damage.
Different triggers—same system under stress.
Read more on #Delta4's work in #PBC/#PSC: delta4.ai/development-...
Cases like #Ontozry show risks still emerge post-approval, while PBC/PSC reflect immune-driven damage.
Different triggers—same system under stress.
Read more on #Delta4's work in #PBC/#PSC: delta4.ai/development-...
💚 Our liver and mind are deeply connected.💚
Living with chronic liver disease, #hepatitis B, C, or D, #livercancer, #MASLD, #MASH, #alcohol-related liver disease, or rare conditions like #Alpha-1, #PBC, #PSC, or #LALD... can impact not only the body — but also mental and emotional well-being.
Living with chronic liver disease, #hepatitis B, C, or D, #livercancer, #MASLD, #MASH, #alcohol-related liver disease, or rare conditions like #Alpha-1, #PBC, #PSC, or #LALD... can impact not only the body — but also mental and emotional well-being.
October 10, 2025 at 9:23 AM
💚 Our liver and mind are deeply connected.💚
Living with chronic liver disease, #hepatitis B, C, or D, #livercancer, #MASLD, #MASH, #alcohol-related liver disease, or rare conditions like #Alpha-1, #PBC, #PSC, or #LALD... can impact not only the body — but also mental and emotional well-being.
Living with chronic liver disease, #hepatitis B, C, or D, #livercancer, #MASLD, #MASH, #alcohol-related liver disease, or rare conditions like #Alpha-1, #PBC, #PSC, or #LALD... can impact not only the body — but also mental and emotional well-being.
There is some ongoing work on environmental factors playing a role in PSC and PBC like in the link below. We still don't know why PSC develops, which makes it difficult to develop strategies to prevent it!
High-Resolution Exposomics and Metabolomics Reveals Specific Associations in Cholestatic Liver Diseases - PubMed
Progress in development of prognostic and therapeutic options for the rare cholestatic liver diseases, primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), is hampered by limite...
pubmed.ncbi.nlm.nih.gov
November 28, 2024 at 8:36 PM
There is some ongoing work on environmental factors playing a role in PSC and PBC like in the link below. We still don't know why PSC develops, which makes it difficult to develop strategies to prevent it!
🧬 PSC vs. PBC: What’s the difference?
They might sound similar, but Primary Sclerosing Cholangitis and Primary Biliary Cholangitis are distinct conditions with different paths. Understanding the differences is key to getting the right care & support 👉️ buff.ly/X5TGSzg
They might sound similar, but Primary Sclerosing Cholangitis and Primary Biliary Cholangitis are distinct conditions with different paths. Understanding the differences is key to getting the right care & support 👉️ buff.ly/X5TGSzg
February 4, 2026 at 10:01 AM
🧬 PSC vs. PBC: What’s the difference?
They might sound similar, but Primary Sclerosing Cholangitis and Primary Biliary Cholangitis are distinct conditions with different paths. Understanding the differences is key to getting the right care & support 👉️ buff.ly/X5TGSzg
They might sound similar, but Primary Sclerosing Cholangitis and Primary Biliary Cholangitis are distinct conditions with different paths. Understanding the differences is key to getting the right care & support 👉️ buff.ly/X5TGSzg
If you’re 18+ and have PSC or PBC (or had a transplant) we’d love to hear from you! Your insights will help researchers design a study focused on wellbeing & understanding patient experiences.
🔗 redcap.ualberta.ca/surveys/?s=T... @UAlberta_DoM @uncdeptmedicine @PBCFoundation #LetsBeatPSC
🔗 redcap.ualberta.ca/surveys/?s=T... @UAlberta_DoM @uncdeptmedicine @PBCFoundation #LetsBeatPSC
December 16, 2025 at 9:31 AM
If you’re 18+ and have PSC or PBC (or had a transplant) we’d love to hear from you! Your insights will help researchers design a study focused on wellbeing & understanding patient experiences.
🔗 redcap.ualberta.ca/surveys/?s=T... @UAlberta_DoM @uncdeptmedicine @PBCFoundation #LetsBeatPSC
🔗 redcap.ualberta.ca/surveys/?s=T... @UAlberta_DoM @uncdeptmedicine @PBCFoundation #LetsBeatPSC
UPDATE 📢 Following our previous post about the national shortage of Rifampicin in the UK, PSC Support and @PBCFoundation have released a joint statement.
Also available to read on our website.
➡️ buff.ly/f4VFqpj
#LetsBeatPSC #PBC #PrimaryBiliaryCholangitis #Liver #PSCItch #PBCItch
Also available to read on our website.
➡️ buff.ly/f4VFqpj
#LetsBeatPSC #PBC #PrimaryBiliaryCholangitis #Liver #PSCItch #PBCItch
September 18, 2025 at 1:00 PM
UPDATE 📢 Following our previous post about the national shortage of Rifampicin in the UK, PSC Support and @PBCFoundation have released a joint statement.
Also available to read on our website.
➡️ buff.ly/f4VFqpj
#LetsBeatPSC #PBC #PrimaryBiliaryCholangitis #Liver #PSCItch #PBCItch
Also available to read on our website.
➡️ buff.ly/f4VFqpj
#LetsBeatPSC #PBC #PrimaryBiliaryCholangitis #Liver #PSCItch #PBCItch
Attached RCT found bezafibrate effective for itch due to various fibrosing cholangopathies; editorial pointed out its easier to use than rifampicin
Is anyone aware of experience/reports using bezafibrate for cholestatic itch due to malignancy? I can't find any
www.gastrojournal.org/article/S001...
Is anyone aware of experience/reports using bezafibrate for cholestatic itch due to malignancy? I can't find any
www.gastrojournal.org/article/S001...
Fibrates for Itch (FITCH) in Fibrosing Cholangiopathies: A Double-Blind, Randomized, Placebo-Controlled Trial
Pruritus may seriously impair quality of life in patients with cholestatic diseases
such as primary or secondary sclerosing cholangitis (PSC, SSC) and primary biliary
cholangitis (PBC). Pharmacologic ...
www.gastrojournal.org
February 19, 2025 at 7:35 AM
Attached RCT found bezafibrate effective for itch due to various fibrosing cholangopathies; editorial pointed out its easier to use than rifampicin
Is anyone aware of experience/reports using bezafibrate for cholestatic itch due to malignancy? I can't find any
www.gastrojournal.org/article/S001...
Is anyone aware of experience/reports using bezafibrate for cholestatic itch due to malignancy? I can't find any
www.gastrojournal.org/article/S001...
We're working with researchers to develop a new study called TRANSFORM EMPOWER. If you have PSC or PBC (or have had a transplant) & are 18+ we'd love your input! Share your thoughts in our short, anonymous survey to help us design this study better. buff.ly/YRg150J #LetsBeatPSC
December 6, 2025 at 9:01 AM
We're working with researchers to develop a new study called TRANSFORM EMPOWER. If you have PSC or PBC (or have had a transplant) & are 18+ we'd love your input! Share your thoughts in our short, anonymous survey to help us design this study better. buff.ly/YRg150J #LetsBeatPSC
... mitochondria rna damage, plus immune gaps for fibronectin, opening the door to endopthelial damage and excessive blood clotting.
maybe there's some overlap in damaged immune systems either opening the door to PSC/PBC or to MECFS and the other following.
maybe there's some overlap in damaged immune systems either opening the door to PSC/PBC or to MECFS and the other following.
November 28, 2024 at 8:41 PM
... mitochondria rna damage, plus immune gaps for fibronectin, opening the door to endopthelial damage and excessive blood clotting.
maybe there's some overlap in damaged immune systems either opening the door to PSC/PBC or to MECFS and the other following.
maybe there's some overlap in damaged immune systems either opening the door to PSC/PBC or to MECFS and the other following.
Join us tomorrow in Freiburg for the 10th German-Romanian Symposium for Gastroenterology!
🔹 09:10 – The changing landscape in AIH, PSC, PBC | Martina Mueller-Schilling
🔹 17:50 – Artificial intelligence for real-time polyp differentiation | @alexsworking.bsky.social
🔗 https://bit.ly/4koXpwz
🔹 09:10 – The changing landscape in AIH, PSC, PBC | Martina Mueller-Schilling
🔹 17:50 – Artificial intelligence for real-time polyp differentiation | @alexsworking.bsky.social
🔗 https://bit.ly/4koXpwz
May 29, 2025 at 7:00 AM
Join us tomorrow in Freiburg for the 10th German-Romanian Symposium for Gastroenterology!
🔹 09:10 – The changing landscape in AIH, PSC, PBC | Martina Mueller-Schilling
🔹 17:50 – Artificial intelligence for real-time polyp differentiation | @alexsworking.bsky.social
🔗 https://bit.ly/4koXpwz
🔹 09:10 – The changing landscape in AIH, PSC, PBC | Martina Mueller-Schilling
🔹 17:50 – Artificial intelligence for real-time polyp differentiation | @alexsworking.bsky.social
🔗 https://bit.ly/4koXpwz
#ASMB Assembly Biosciences Reports Second Quarter 2026 Financial Results and Recent Updates
https://www.stocktitan.net/news/ASMB/assembly-biosciences-reports-second-quarter-2026-financial-results-xjqg9hdkw6qa.html
https://www.stocktitan.net/news/ASMB/assembly-biosciences-reports-second-quarter-2026-financial-results-xjqg9hdkw6qa.html
Assembly Biosciences Reports Second Quarter 2026 Financial Results and Recent Updates
Assembly Biosciences (Nasdaq: ASMB) reported second quarter 2026 results and pipeline updates, highlighting expansion of ABI-6250 into cholestatic liver diseases, including PBC and PSC, with a Phase 2 study expected to start in Q1 2027 and another Phase 2 in chronic HDV targeted by year-end 2026.The company completed a $115 million gross financing and reported cash, cash equivalents and marketable securities of $320.4 million at June 30, 2026, with cash runway projected into 2029 including a planned $75 million Gilead extension payment in Q4 2026. Q2 2026 collaboration revenue from Gilead rose to $13.4 million from $9.6 million, R&D expenses declined to $14.9 million from $16.1 million, and net loss narrowed to $3.9 million (–$0.20 per share) from $10.2 million (–$1.33) a year earlier. Gilead selected GS-1179 to advance in the HSV HPI program, with Phase 2 initiation in recurrent genital herpes expected by year-end 2026.
www.stocktitan.net
August 13, 2026 at 8:00 PM
#ASMB Assembly Biosciences Reports Second Quarter 2026 Financial Results and Recent Updates
https://www.stocktitan.net/news/ASMB/assembly-biosciences-reports-second-quarter-2026-financial-results-xjqg9hdkw6qa.html
https://www.stocktitan.net/news/ASMB/assembly-biosciences-reports-second-quarter-2026-financial-results-xjqg9hdkw6qa.html
#health #ecology #SDGs
Autoimmune liver diseases,
which mostly affect women,
include
primary biliary cholangitis (PBC),
primary sclerosing cholangitis (PSC),
and autoimmune hepatitis (AIH).
Risk factors:
PBC: air pollution, cadmium,
PSC: agricultural chemicals,
AIH, PBC: insufficient sunlight.
Autoimmune liver diseases,
which mostly affect women,
include
primary biliary cholangitis (PBC),
primary sclerosing cholangitis (PSC),
and autoimmune hepatitis (AIH).
Risk factors:
PBC: air pollution, cadmium,
PSC: agricultural chemicals,
AIH, PBC: insufficient sunlight.
February 9, 2026 at 2:11 AM
86 vs 84 patients by treatment group. The risk of treatment failure is higher in placebo-treated than UDCA.
UDCA and newer drugs appear effective in PBC, which is great. I work with PBC's "sister" disease, PSC, where new drugs as well as UDCA unfortunately don't seem to work
UDCA and newer drugs appear effective in PBC, which is great. I work with PBC's "sister" disease, PSC, where new drugs as well as UDCA unfortunately don't seem to work
April 25, 2025 at 1:17 PM
86 vs 84 patients by treatment group. The risk of treatment failure is higher in placebo-treated than UDCA.
UDCA and newer drugs appear effective in PBC, which is great. I work with PBC's "sister" disease, PSC, where new drugs as well as UDCA unfortunately don't seem to work
UDCA and newer drugs appear effective in PBC, which is great. I work with PBC's "sister" disease, PSC, where new drugs as well as UDCA unfortunately don't seem to work