#LookAndSee #MusicSky #Music #MusicChallenge
432
The Staircase (Mystery) - Siouxie & the Banshees
music.youtube.com/watch?v=PbpK...
432
The Staircase (Mystery) - Siouxie & the Banshees
music.youtube.com/watch?v=PbpK...
June 17, 2026 at 4:43 AM
#LookAndSee #MusicSky #Music #MusicChallenge
432
The Staircase (Mystery) - Siouxie & the Banshees
music.youtube.com/watch?v=PbpK...
432
The Staircase (Mystery) - Siouxie & the Banshees
music.youtube.com/watch?v=PbpK...
🔦 Spotlight on link.springer.com/article/10.1...
🧠 Using the LeiCNS-PK3.0 PBPK model, they predicted mouse #brainECF #pharmacokinetics for 10 drugs
✅ Accurate for 7 drugs
✅ First mechanistic #CNS PBPK #model in mice
✅ Strong translational potential
#TranslationalPharmacology #DrugDevelopment
🧠 Using the LeiCNS-PK3.0 PBPK model, they predicted mouse #brainECF #pharmacokinetics for 10 drugs
✅ Accurate for 7 drugs
✅ First mechanistic #CNS PBPK #model in mice
✅ Strong translational potential
#TranslationalPharmacology #DrugDevelopment
October 3, 2025 at 12:13 PM
🔦 Spotlight on link.springer.com/article/10.1...
🧠 Using the LeiCNS-PK3.0 PBPK model, they predicted mouse #brainECF #pharmacokinetics for 10 drugs
✅ Accurate for 7 drugs
✅ First mechanistic #CNS PBPK #model in mice
✅ Strong translational potential
#TranslationalPharmacology #DrugDevelopment
🧠 Using the LeiCNS-PK3.0 PBPK model, they predicted mouse #brainECF #pharmacokinetics for 10 drugs
✅ Accurate for 7 drugs
✅ First mechanistic #CNS PBPK #model in mice
✅ Strong translational potential
#TranslationalPharmacology #DrugDevelopment
In silico PBPK and in vitro microphysiological systems are useful predictive tools but require in vivo data for validation and species bridging. They are not standalone substitutes /6
May 20, 2026 at 7:17 PM
In silico PBPK and in vitro microphysiological systems are useful predictive tools but require in vivo data for validation and species bridging. They are not standalone substitutes /6
🧪 Our new paper on the #pharmacokinetics of P-glycoprotein substrates in #brainECF shows how #invitro transport data can guide #invivo 🧠🐭🚶♀️predictions, but that high variability still limits the robustness of these predictions.
🔗 link.springer.com/article/10.1...
👉LeiCNS-PK3.4 PBPK model #CNS #brain
🔗 link.springer.com/article/10.1...
👉LeiCNS-PK3.4 PBPK model #CNS #brain
October 3, 2025 at 9:35 AM
🧪 Our new paper on the #pharmacokinetics of P-glycoprotein substrates in #brainECF shows how #invitro transport data can guide #invivo 🧠🐭🚶♀️predictions, but that high variability still limits the robustness of these predictions.
🔗 link.springer.com/article/10.1...
👉LeiCNS-PK3.4 PBPK model #CNS #brain
🔗 link.springer.com/article/10.1...
👉LeiCNS-PK3.4 PBPK model #CNS #brain
Brilliance in action!
www.youtube.com/watch?v=pbpk...
www.youtube.com/watch?v=pbpk...
Progressive HUMILIATES Piers Morgan, He CONCEDES Heated Trump Debate!
YouTube video by Pondering Politics
www.youtube.com
November 20, 2024 at 12:38 AM
Brilliance in action!
www.youtube.com/watch?v=pbpk...
www.youtube.com/watch?v=pbpk...
From open-source platforms to industry-leading software, PBPK modelling offers a tool for every stage of drug development. Davies Otieno guided participants through the strengths and applications of platforms including Simcyp, GastroPlus, PK-Sim, MATLAB/SimBiology and mrgsolve.
#PBPK #AtTheEquatorUG
#PBPK #AtTheEquatorUG
July 30, 2026 at 7:00 PM
From open-source platforms to industry-leading software, PBPK modelling offers a tool for every stage of drug development. Davies Otieno guided participants through the strengths and applications of platforms including Simcyp, GastroPlus, PK-Sim, MATLAB/SimBiology and mrgsolve.
#PBPK #AtTheEquatorUG
#PBPK #AtTheEquatorUG
🧠 Predicting how well #drug molecules cross the blood-brain barrier: Gülave et al. built a #MachineLearning model for the unbound brain-to-plasma partition coefficient (98 compounds).
link.springer.com/article/10.1...
👉Best algorithm: Random Forest
💡Great for #CNS drug discovery!
#BBB #PBPK #ML
link.springer.com/article/10.1...
👉Best algorithm: Random Forest
💡Great for #CNS drug discovery!
#BBB #PBPK #ML
October 1, 2025 at 12:20 PM
🧠 Predicting how well #drug molecules cross the blood-brain barrier: Gülave et al. built a #MachineLearning model for the unbound brain-to-plasma partition coefficient (98 compounds).
link.springer.com/article/10.1...
👉Best algorithm: Random Forest
💡Great for #CNS drug discovery!
#BBB #PBPK #ML
link.springer.com/article/10.1...
👉Best algorithm: Random Forest
💡Great for #CNS drug discovery!
#BBB #PBPK #ML
Yongxiu Yang and collaborators introduce a multiscale PBPK-PD model of #oxytocin-induced #uterine excitation and contraction 🔬 💻️
Read the #research📜
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Read the #research📜
physoc.onlinelibrary.wiley.com/doi/10.1113/...
September 24, 2026 at 9:15 AM
Yongxiu Yang and collaborators introduce a multiscale PBPK-PD model of #oxytocin-induced #uterine excitation and contraction 🔬 💻️
Read the #research📜
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Read the #research📜
physoc.onlinelibrary.wiley.com/doi/10.1113/...
💊 Morphine is a P-glycoprotein substrate, but do P-gp inhibitors meaningfully change #CNS exposure?
🧠 Likely not: A physiology-based pharmacokinetic #PBPK model predicts negligible impact across populations.
#BBB #DrugInteractions #morphine #modelling #brain
🔗 link.springer.com/article/10.1...
🧠 Likely not: A physiology-based pharmacokinetic #PBPK model predicts negligible impact across populations.
#BBB #DrugInteractions #morphine #modelling #brain
🔗 link.springer.com/article/10.1...
September 30, 2025 at 5:26 PM
💊 Morphine is a P-glycoprotein substrate, but do P-gp inhibitors meaningfully change #CNS exposure?
🧠 Likely not: A physiology-based pharmacokinetic #PBPK model predicts negligible impact across populations.
#BBB #DrugInteractions #morphine #modelling #brain
🔗 link.springer.com/article/10.1...
🧠 Likely not: A physiology-based pharmacokinetic #PBPK model predicts negligible impact across populations.
#BBB #DrugInteractions #morphine #modelling #brain
🔗 link.springer.com/article/10.1...
Using PBPK modeling, we show that dexamethasone has a negligible effect on apixaban and rivaroxaban pharmacokinetics. As a result, combining dexamethasone with DOACs in COVID-19 patients at low thrombotic risk seems feasible.
ascpt.onlinelibrary.wiley.com/action/oidcC...
ascpt.onlinelibrary.wiley.com/action/oidcC...
November 22, 2024 at 7:07 PM
Using PBPK modeling, we show that dexamethasone has a negligible effect on apixaban and rivaroxaban pharmacokinetics. As a result, combining dexamethasone with DOACs in COVID-19 patients at low thrombotic risk seems feasible.
ascpt.onlinelibrary.wiley.com/action/oidcC...
ascpt.onlinelibrary.wiley.com/action/oidcC...
From the lab to the clinic, PBPK modelling is transforming drug development. Participants explored how it informs dose optimisation, predicts drug interactions, and supports regulatory decisions. #PBPK #DrugDevelopment #Pharmacometrics #QuantitativePharmacology #AtTheEquatorUG
July 30, 2026 at 3:50 PM
From the lab to the clinic, PBPK modelling is transforming drug development. Participants explored how it informs dose optimisation, predicts drug interactions, and supports regulatory decisions. #PBPK #DrugDevelopment #Pharmacometrics #QuantitativePharmacology #AtTheEquatorUG
The Eastern Cluster workshop on Applications of Mathematical Models in Quantitative Pharmacology, with a focus on Physiologically Based Pharmacokinetic (PBPK) Modelling, has officially begun. In attendance are participants from Busitema University &Soroti University. #PBPK @catrionawaitt.bsky.social
July 30, 2026 at 1:15 PM
The Eastern Cluster workshop on Applications of Mathematical Models in Quantitative Pharmacology, with a focus on Physiologically Based Pharmacokinetic (PBPK) Modelling, has officially begun. In attendance are participants from Busitema University &Soroti University. #PBPK @catrionawaitt.bsky.social
Using powerful real-world analogies, Joshua Kiptoo illustrated how PBPK modelling enables researchers to simulate drug behaviour before clinical studies, helping improve efficiency, safety, and decision-making in drug development.
#PBPK #Innovation #DrugDevelopment #Pharmacometrics
#PBPK #Innovation #DrugDevelopment #Pharmacometrics
July 30, 2026 at 6:50 PM
Using powerful real-world analogies, Joshua Kiptoo illustrated how PBPK modelling enables researchers to simulate drug behaviour before clinical studies, helping improve efficiency, safety, and decision-making in drug development.
#PBPK #Innovation #DrugDevelopment #Pharmacometrics
#PBPK #Innovation #DrugDevelopment #Pharmacometrics
What if mathematics could predict how drugs move through the body? Francis Ojara introduced participants to Physiologically Based Pharmacokinetic (PBPK) modelling, showing how anatomy, physiology, and drug properties can simulate drug behavior. #PBPK #Pharmacometrics @catrionawaitt.bsky.social
July 30, 2026 at 3:26 PM
What if mathematics could predict how drugs move through the body? Francis Ojara introduced participants to Physiologically Based Pharmacokinetic (PBPK) modelling, showing how anatomy, physiology, and drug properties can simulate drug behavior. #PBPK #Pharmacometrics @catrionawaitt.bsky.social
Have you used Teoreler, CELT's PBPK online simulation tool?
We'd not only appreciate your feedback, but if you have peer-reviewed publications that used Teoreler, we'd happily include them in our publications list on the page.
Find out more:
www.liverpool.ac.uk/centre-of-ex...
@unitaid.bsky.social
We'd not only appreciate your feedback, but if you have peer-reviewed publications that used Teoreler, we'd happily include them in our publications list on the page.
Find out more:
www.liverpool.ac.uk/centre-of-ex...
@unitaid.bsky.social
April 8, 2025 at 11:00 AM
Have you used Teoreler, CELT's PBPK online simulation tool?
We'd not only appreciate your feedback, but if you have peer-reviewed publications that used Teoreler, we'd happily include them in our publications list on the page.
Find out more:
www.liverpool.ac.uk/centre-of-ex...
@unitaid.bsky.social
We'd not only appreciate your feedback, but if you have peer-reviewed publications that used Teoreler, we'd happily include them in our publications list on the page.
Find out more:
www.liverpool.ac.uk/centre-of-ex...
@unitaid.bsky.social
Projenin bir sonraki aşamasında ise bu dijital model prensiplerinin insan PBPK modellerine aktarılarak nanopartiküllerin kan-beyin bariyerini geçme yeteneği gibi hassas süreçlerin incelenmesi planlanıyor.
June 1, 2026 at 10:14 AM
Projenin bir sonraki aşamasında ise bu dijital model prensiplerinin insan PBPK modellerine aktarılarak nanopartiküllerin kan-beyin bariyerini geçme yeteneği gibi hassas süreçlerin incelenmesi planlanıyor.
💊 #PBPK #modeling replaced ≥10 clinical studies for asciminib (Scemblix®) NDA—bridging doses, predicting DDIs, and informing labels. A powerful case for #model-informed #drug #development!
📌 www.mdpi.com/1999-4923/17...
#PBPK #Pharmacokinetics #DrugDevelopment #CML
📌 www.mdpi.com/1999-4923/17...
#PBPK #Pharmacokinetics #DrugDevelopment #CML
September 21, 2026 at 10:13 AM
💊 #PBPK #modeling replaced ≥10 clinical studies for asciminib (Scemblix®) NDA—bridging doses, predicting DDIs, and informing labels. A powerful case for #model-informed #drug #development!
📌 www.mdpi.com/1999-4923/17...
#PBPK #Pharmacokinetics #DrugDevelopment #CML
📌 www.mdpi.com/1999-4923/17...
#PBPK #Pharmacokinetics #DrugDevelopment #CML
stormTB: A web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments. https://www.biorxiv.org/content/10.1101/2024.07.04.602069v1
stormTB: A web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments. https://www.biorxiv.org/content/10.1101/2024.07.04.602069v1
Introduction: Tuberculosis (TB) poses a significant threat to global health, with millions of new in
www.biorxiv.org
July 9, 2024 at 1:01 AM
stormTB: A web-based simulator of a murine minimal-PBPK model for anti-tuberculosis treatments. https://www.biorxiv.org/content/10.1101/2024.07.04.602069v1
Integrating AI/ML-based approaches with mechanistic modelling has lot of potential for molecule design in drug discovery. Happy to see this published!
doi.org/10.1111/cts....
#ChemSky #MedSky
doi.org/10.1111/cts....
#ChemSky #MedSky
Predicting Pharmacokinetics in Rats Using Machine Learning: A Comparative Study Between Empirical, Compartmental, and PBPK‐Based Approaches
A successful drug needs to combine several properties including high potency and good pharmacokinetic (PK) properties to sustain efficacious plasma concentration over time. To estimate required doses...
doi.org
March 27, 2025 at 10:09 AM
Integrating AI/ML-based approaches with mechanistic modelling has lot of potential for molecule design in drug discovery. Happy to see this published!
doi.org/10.1111/cts....
#ChemSky #MedSky
doi.org/10.1111/cts....
#ChemSky #MedSky
Participants learned how individual characteristics, population data, drug properties, formulation, and dosing protocols come together to generate meaningful simulations that support drug development.
#PBPK #DrugDevelopment #PrecisionMedicine
#PBPK #DrugDevelopment #PrecisionMedicine
July 30, 2026 at 7:31 PM
Participants learned how individual characteristics, population data, drug properties, formulation, and dosing protocols come together to generate meaningful simulations that support drug development.
#PBPK #DrugDevelopment #PrecisionMedicine
#PBPK #DrugDevelopment #PrecisionMedicine
Best times as a faculty member are seeing the culmination of a student's hard work! Congratulations, Ruiwen Chen, on defending your PhD yesterday.
July 16, 2025 at 11:44 AM
Best times as a faculty member are seeing the culmination of a student's hard work! Congratulations, Ruiwen Chen, on defending your PhD yesterday.
Prof. Kibuule noted that the future of innovative drug research depends on building the skills and expertise needed to apply emerging scientific approaches locally. #QuantitativePharmacology #PBPK #CapacityBuilding #AtTheEquatorUG @busitemauniversity.bsky.social @catrionawaitt.bsky.social
July 30, 2026 at 1:21 PM
Prof. Kibuule noted that the future of innovative drug research depends on building the skills and expertise needed to apply emerging scientific approaches locally. #QuantitativePharmacology #PBPK #CapacityBuilding #AtTheEquatorUG @busitemauniversity.bsky.social @catrionawaitt.bsky.social
In this latest study under @era4tb.bsky.social, researchers adopted physiologically‑based pharmacokinetic (PBPK) modelling and used a detailed computational model to project what those concentrations likely are in human lungs (both healthy and TB-infected).
👉 Read at: https://bit.ly/3KA2RQx
👉 Read at: https://bit.ly/3KA2RQx
December 11, 2025 at 7:30 AM
In this latest study under @era4tb.bsky.social, researchers adopted physiologically‑based pharmacokinetic (PBPK) modelling and used a detailed computational model to project what those concentrations likely are in human lungs (both healthy and TB-infected).
👉 Read at: https://bit.ly/3KA2RQx
👉 Read at: https://bit.ly/3KA2RQx
