Yongxiu Yang and collaborators introduce a multiscale PBPK-PD model of #oxytocin-induced #uterine excitation and contraction 🔬 💻️
Read the #research📜
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Read the #research📜
physoc.onlinelibrary.wiley.com/doi/10.1113/...
September 24, 2026 at 9:15 AM
Yongxiu Yang and collaborators introduce a multiscale PBPK-PD model of #oxytocin-induced #uterine excitation and contraction 🔬 💻️
Read the #research📜
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Read the #research📜
physoc.onlinelibrary.wiley.com/doi/10.1113/...
💊 #PBPK #modeling replaced ≥10 clinical studies for asciminib (Scemblix®) NDA—bridging doses, predicting DDIs, and informing labels. A powerful case for #model-informed #drug #development!
📌 www.mdpi.com/1999-4923/17...
#PBPK #Pharmacokinetics #DrugDevelopment #CML
📌 www.mdpi.com/1999-4923/17...
#PBPK #Pharmacokinetics #DrugDevelopment #CML
September 21, 2026 at 10:13 AM
💊 #PBPK #modeling replaced ≥10 clinical studies for asciminib (Scemblix®) NDA—bridging doses, predicting DDIs, and informing labels. A powerful case for #model-informed #drug #development!
📌 www.mdpi.com/1999-4923/17...
#PBPK #Pharmacokinetics #DrugDevelopment #CML
📌 www.mdpi.com/1999-4923/17...
#PBPK #Pharmacokinetics #DrugDevelopment #CML
It's National Coding Week.
While CELT Global Health's preclinical work creates long-acting versions of existing medicines, our in silico team are a key part of that.
We spoke to our Teoreler team, our free online PBPK simulation application: www.liverpool.ac.uk/celt-global-...
@unitaid.bsky.social
While CELT Global Health's preclinical work creates long-acting versions of existing medicines, our in silico team are a key part of that.
We spoke to our Teoreler team, our free online PBPK simulation application: www.liverpool.ac.uk/celt-global-...
@unitaid.bsky.social
September 17, 2026 at 12:13 PM
It's National Coding Week.
While CELT Global Health's preclinical work creates long-acting versions of existing medicines, our in silico team are a key part of that.
We spoke to our Teoreler team, our free online PBPK simulation application: www.liverpool.ac.uk/celt-global-...
@unitaid.bsky.social
While CELT Global Health's preclinical work creates long-acting versions of existing medicines, our in silico team are a key part of that.
We spoke to our Teoreler team, our free online PBPK simulation application: www.liverpool.ac.uk/celt-global-...
@unitaid.bsky.social
RRIDs were included in this in Pharmaceutics paper. RRIDs improve reproducibility in scientific research. #OpenResearch #methodsmatter #reproducibility
Moxifloxacin-Mediated Downregulation of Intestinal P-Glycoprotein Alters the Pharmacokinetics of Dabigatran Etexilate: Mechanistic Insights in Rats and PBPK Model-Informed Dose Optimization
Read the full paper: Moxifloxacin-Mediated Downregulation of Intestinal P-Glycoprotein Alters the Pharmacokinetics of Dabigatran Etexilate: Mechanistic Insights in Rats and PBPK Model-Informed Dose Optimization
doi.org
September 2, 2026 at 7:01 AM
RRIDs were included in this in Pharmaceutics paper. RRIDs improve reproducibility in scientific research. #OpenResearch #methodsmatter #reproducibility
Towards a ML-powered Multiscale Computational Platform Based on QSP and PBPK Modeling to Support the Development of mRNA-based Therapies https://www.medrxiv.org/content/10.64898/2026.08.25.26361215v1
August 28, 2026 at 11:10 PM
Towards a ML-powered Multiscale Computational Platform Based on QSP and PBPK Modeling to Support the Development of mRNA-based Therapies https://www.medrxiv.org/content/10.64898/2026.08.25.26361215v1
Teoreler is a free online simulation tool to describe the pharmacokinetics of drugs using different PBPK models.
It's been developed by CELT Global Health's pharmacometrics team, and is completely based in browser with no downloads required for use.
www.liverpool.ac.uk/celt-global-...
It's been developed by CELT Global Health's pharmacometrics team, and is completely based in browser with no downloads required for use.
www.liverpool.ac.uk/celt-global-...
August 14, 2026 at 11:25 AM
Teoreler is a free online simulation tool to describe the pharmacokinetics of drugs using different PBPK models.
It's been developed by CELT Global Health's pharmacometrics team, and is completely based in browser with no downloads required for use.
www.liverpool.ac.uk/celt-global-...
It's been developed by CELT Global Health's pharmacometrics team, and is completely based in browser with no downloads required for use.
www.liverpool.ac.uk/celt-global-...
CN Bio has been awarded an Innovate UK Grant to reduce animal use in pharmacokinetic studies. The funding will support the development of a standardised workflow to integrate advanced dual organ PhysioMimix® Gut/Liver data with powerful PBPK in silico modelling:
bit.ly/3RP08GJ
bit.ly/3RP08GJ
August 12, 2026 at 11:30 AM
CN Bio has been awarded an Innovate UK Grant to reduce animal use in pharmacokinetic studies. The funding will support the development of a standardised workflow to integrate advanced dual organ PhysioMimix® Gut/Liver data with powerful PBPK in silico modelling:
bit.ly/3RP08GJ
bit.ly/3RP08GJ
How do we know when a model is good enough? In a session led by Francis Ojara, participants explored how #PBPK models are evaluated, verified, & validated to determine whether they reliably represent drug behaviour & are fit for their intended purpose. #QuantitativePharmacology
August 1, 2026 at 8:59 PM
How do we know when a model is good enough? In a session led by Francis Ojara, participants explored how #PBPK models are evaluated, verified, & validated to determine whether they reliably represent drug behaviour & are fit for their intended purpose. #QuantitativePharmacology
The right tools turn complex science into actionable insights. MILK PBPK PhD scholar Davies Otieno introduced participants to key pharmacometrics software, demonstrating how computational tools predict drug exposure & support informed dosing decisions. #Pharmacometrics #PBPK @seniorcymo.bsky.social
August 1, 2026 at 8:28 PM
The right tools turn complex science into actionable insights. MILK PBPK PhD scholar Davies Otieno introduced participants to key pharmacometrics software, demonstrating how computational tools predict drug exposure & support informed dosing decisions. #Pharmacometrics #PBPK @seniorcymo.bsky.social
During his presentation, Joshua demonstrated how in vitro data and mechanistic models predict drug clearance and exposure to support smarter drug development. #IVIVE #PBPK #Pharmacometrics #DrugDevelopment
July 31, 2026 at 7:39 PM
During his presentation, Joshua demonstrated how in vitro data and mechanistic models predict drug clearance and exposure to support smarter drug development. #IVIVE #PBPK #Pharmacometrics #DrugDevelopment
Day 2, MILK PBPK PhD scholar Joshua Kiptoo introduced participants to In Vitro–In Vivo Extrapolation (IVIVE), demonstrating how in vitro data & mechanistic models predict drug clearance & exposure to support smarter drug development. #IVIVE #Pharmacometrics #DrugDevelopment @seniorcymo.bsky.social
July 31, 2026 at 12:24 PM
Day 2, MILK PBPK PhD scholar Joshua Kiptoo introduced participants to In Vitro–In Vivo Extrapolation (IVIVE), demonstrating how in vitro data & mechanistic models predict drug clearance & exposure to support smarter drug development. #IVIVE #Pharmacometrics #DrugDevelopment @seniorcymo.bsky.social
Day Two is here, and the energy is high The Pharmacometrics Africa Uganda Chapter is energized & ready for another day of learning, collaboration, and discovery as the Eastern Cluster workshop on Mathematical Models in Quantitative Pharmacology continues in Mbale. #QuantitativePharmacology #PBPK
July 31, 2026 at 9:21 AM
Day Two is here, and the energy is high The Pharmacometrics Africa Uganda Chapter is energized & ready for another day of learning, collaboration, and discovery as the Eastern Cluster workshop on Mathematical Models in Quantitative Pharmacology continues in Mbale. #QuantitativePharmacology #PBPK
Participants learned how individual characteristics, population data, drug properties, formulation, and dosing protocols come together to generate meaningful simulations that support drug development.
#PBPK #DrugDevelopment #PrecisionMedicine
#PBPK #DrugDevelopment #PrecisionMedicine
July 30, 2026 at 7:31 PM
Participants learned how individual characteristics, population data, drug properties, formulation, and dosing protocols come together to generate meaningful simulations that support drug development.
#PBPK #DrugDevelopment #PrecisionMedicine
#PBPK #DrugDevelopment #PrecisionMedicine
From open-source platforms to industry-leading software, PBPK modelling offers a tool for every stage of drug development. Davies Otieno guided participants through the strengths and applications of platforms including Simcyp, GastroPlus, PK-Sim, MATLAB/SimBiology and mrgsolve.
#PBPK #AtTheEquatorUG
#PBPK #AtTheEquatorUG
July 30, 2026 at 7:00 PM
From open-source platforms to industry-leading software, PBPK modelling offers a tool for every stage of drug development. Davies Otieno guided participants through the strengths and applications of platforms including Simcyp, GastroPlus, PK-Sim, MATLAB/SimBiology and mrgsolve.
#PBPK #AtTheEquatorUG
#PBPK #AtTheEquatorUG
Using powerful real-world analogies, Joshua Kiptoo illustrated how PBPK modelling enables researchers to simulate drug behaviour before clinical studies, helping improve efficiency, safety, and decision-making in drug development.
#PBPK #Innovation #DrugDevelopment #Pharmacometrics
#PBPK #Innovation #DrugDevelopment #Pharmacometrics
July 30, 2026 at 6:50 PM
Using powerful real-world analogies, Joshua Kiptoo illustrated how PBPK modelling enables researchers to simulate drug behaviour before clinical studies, helping improve efficiency, safety, and decision-making in drug development.
#PBPK #Innovation #DrugDevelopment #Pharmacometrics
#PBPK #Innovation #DrugDevelopment #Pharmacometrics
How can mathematics predict what happens to a drug inside the human body? In an engaging session, MILK PBPK scholar Joshua Kiptoo introduced participants to the core components of Physiologically Based Pharmacokinetic modelling and its growing role in transforming drug development.
July 30, 2026 at 4:12 PM
How can mathematics predict what happens to a drug inside the human body? In an engaging session, MILK PBPK scholar Joshua Kiptoo introduced participants to the core components of Physiologically Based Pharmacokinetic modelling and its growing role in transforming drug development.
From the lab to the clinic, PBPK modelling is transforming drug development. Participants explored how it informs dose optimisation, predicts drug interactions, and supports regulatory decisions. #PBPK #DrugDevelopment #Pharmacometrics #QuantitativePharmacology #AtTheEquatorUG
July 30, 2026 at 3:50 PM
From the lab to the clinic, PBPK modelling is transforming drug development. Participants explored how it informs dose optimisation, predicts drug interactions, and supports regulatory decisions. #PBPK #DrugDevelopment #Pharmacometrics #QuantitativePharmacology #AtTheEquatorUG
Participants explored how the body can be represented using real physiological organs and tissues connected through blood circulation, with mathematical models used to simulate processes such as absorption, distribution, metabolism, and elimination. #PBPK #MathematicalModelling #AtTheEquatorUG
July 30, 2026 at 3:38 PM
Participants explored how the body can be represented using real physiological organs and tissues connected through blood circulation, with mathematical models used to simulate processes such as absorption, distribution, metabolism, and elimination. #PBPK #MathematicalModelling #AtTheEquatorUG
What if mathematics could predict how drugs move through the body? Francis Ojara introduced participants to Physiologically Based Pharmacokinetic (PBPK) modelling, showing how anatomy, physiology, and drug properties can simulate drug behavior. #PBPK #Pharmacometrics @catrionawaitt.bsky.social
July 30, 2026 at 3:26 PM
What if mathematics could predict how drugs move through the body? Francis Ojara introduced participants to Physiologically Based Pharmacokinetic (PBPK) modelling, showing how anatomy, physiology, and drug properties can simulate drug behavior. #PBPK #Pharmacometrics @catrionawaitt.bsky.social
Professor @catrionawaitt.bsky.social introduced participants to ADME (Absorption, Distribution, Metabolism, and Excretion), the processes that determine how a drug moves through the body and ultimately influences the concentration reaching its target. #ADME #Pharmacokinetics #DrugDevelopment #PBPK
July 30, 2026 at 3:18 PM
Professor @catrionawaitt.bsky.social introduced participants to ADME (Absorption, Distribution, Metabolism, and Excretion), the processes that determine how a drug moves through the body and ultimately influences the concentration reaching its target. #ADME #Pharmacokinetics #DrugDevelopment #PBPK
Prof. Kibuule noted that the future of innovative drug research depends on building the skills and expertise needed to apply emerging scientific approaches locally. #QuantitativePharmacology #PBPK #CapacityBuilding #AtTheEquatorUG @busitemauniversity.bsky.social @catrionawaitt.bsky.social
July 30, 2026 at 1:21 PM
Prof. Kibuule noted that the future of innovative drug research depends on building the skills and expertise needed to apply emerging scientific approaches locally. #QuantitativePharmacology #PBPK #CapacityBuilding #AtTheEquatorUG @busitemauniversity.bsky.social @catrionawaitt.bsky.social
Prof. Dan Kibuule, Dean of the Faculty of Health Sciences at @busitemauniversity.bsky.social, delivered the opening remarks, welcoming participants to two days of learning and knowledge exchange on mathematical models in #QuantitativePharmacology and #PBPK modelling. #Pharmacometrics #AtTheEquatorUG
July 30, 2026 at 1:19 PM
Prof. Dan Kibuule, Dean of the Faculty of Health Sciences at @busitemauniversity.bsky.social, delivered the opening remarks, welcoming participants to two days of learning and knowledge exchange on mathematical models in #QuantitativePharmacology and #PBPK modelling. #Pharmacometrics #AtTheEquatorUG
The Eastern Cluster workshop on Applications of Mathematical Models in Quantitative Pharmacology, with a focus on Physiologically Based Pharmacokinetic (PBPK) Modelling, has officially begun. In attendance are participants from Busitema University &Soroti University. #PBPK @catrionawaitt.bsky.social
July 30, 2026 at 1:15 PM
The Eastern Cluster workshop on Applications of Mathematical Models in Quantitative Pharmacology, with a focus on Physiologically Based Pharmacokinetic (PBPK) Modelling, has officially begun. In attendance are participants from Busitema University &Soroti University. #PBPK @catrionawaitt.bsky.social