February 5, 2025 at 3:37 PM
Over the weekend, cancellation letters began arriving — abruptly terminating billions of rands in US-funded HIV and TB research at South African universities. Major programs like CAPRISA and Wits Clinical Trials Unit hit. 70% of SA’s HIV/TB grants come from the US NIH -@bhekisisa.org
[BREAKING] Trump ends SA’s HIV and TB research grants - Bhekisisa
Cancellation letters, which end millions of rands of South African universities’ US-government funded HIV and TB research grants with immediate effect, started to roll in over the weekend. Fears are r...
bhekisisa.org
March 23, 2025 at 6:47 PM
.#Vaccines, antibiotics, antiviral medications and anti-inflammatory drugs are all associated with a reduced risk of #dementia.
www.upi.com/Health_News/...
www.upi.com/Health_News/...
Controlling infections might reduce risk of dementia, study says - UPI.com
Preventing or treating infections could be a key means of warding off dementia, a new evidence review says.
www.upi.com
January 27, 2025 at 5:49 PM
Vaccines are a safe and effective way to build immunity against preventable diseases! #PITT_ID25
A #measles outbreak is growing in a Texas county with a dangerously low vaccination rate. kffhealthnewA rates.s.org/news/article/texas-measles-outbreak-gaines-county-public-health-measles-vaccine/
Measles Outbreak Mounts Among Children in One of Texas’ Least Vaccinated Counties - KFF Health News
With hospitalizations and at least nine confirmed cases, health officials race to contain a growing outbreak in a community with low vaccination.
kffhealthnews.org
February 10, 2025 at 12:24 PM
Vaccines are a safe and effective way to build immunity against preventable diseases! #PITT_ID25
Multidrug-resistant Gram-negative bacterial infections cause significant morbidity & mortality globally.
However, new diagnostic & antibiotic treatments provide hope that we can better address this important global health issue.
Find out more: tinyurl.com/4z64ch4b
However, new diagnostic & antibiotic treatments provide hope that we can better address this important global health issue.
Find out more: tinyurl.com/4z64ch4b
January 22, 2025 at 5:50 PM
Tetracyclines always been a fascinating antibiotic class. So many different evolutions, and antimicrobial activity that variably spans across Gram pos & neg bacteria, as well as malaria!
Cool review in @cmicomms.bsky.social by @jeffpears0n.bsky.social @bwdionne.bsky.social
#IDSky #clinmicro #AMR
Cool review in @cmicomms.bsky.social by @jeffpears0n.bsky.social @bwdionne.bsky.social
#IDSky #clinmicro #AMR
Tetracyclines, the Old and the New: a Narrative Review
Tetracyclines have remained a cornerstone of antimicrobial therapy for over seven decades, demonstrating broad-spectrum activity against a wide range …
www.sciencedirect.com
January 14, 2025 at 4:42 PM
Very interesting article showing that mothers can transmit antibiotic resistance genes to infants. #PITT_ID25
This study shows that mothers transmit antibiotic resistance genes (#ARG) to infants via the gut microbiome, even without antibiotic exposure, with mobile genetic elements driving persistence and transfer. #AMR
pubmed.ncbi.nlm.nih.gov/39921114/
pubmed.ncbi.nlm.nih.gov/39921114/
Transgenerational Gut Dysbiosis: Unveiling the Dynamics of Antibiotic Resistance through Mobile Genetic Elements from Mothers to Infants - PubMed
The initial microbial colonization of the gut is seeded by microbes transmitted from the mother's gut, skin, and vaginal tract. As the gut microbiome evolves, a few transmitted microbes persist throug...
pubmed.ncbi.nlm.nih.gov
February 14, 2025 at 1:58 AM
Very interesting article showing that mothers can transmit antibiotic resistance genes to infants. #PITT_ID25
“The only modifiable strategy to reduce 28-day mortality in adults presenting to the emergency department with bacteremia was an infectious disease consultation.” www.infectiousdiseaseadvisor.com/news/referra...
Referral to Infectious Disease Physician Reduces Mortality in Bacteremia
Referral to an infectious disease physician was the only modifiable strategy to reduce 28-day mortality among adults presenting to the ED with bacteremia.
www.infectiousdiseaseadvisor.com
February 3, 2025 at 2:52 PM
This is a cool study: a human perinatal infection challenge model!
Inoculate near-term pregnant women with commensal Neisseria lactamica to see if 1) colonises mothers & 2) transmits to infants
Answer is 1) yes mostly, & 2) no
#IDSky @lancetmicrobe.bsky.social
www.thelancet.com/journals/lan...
Inoculate near-term pregnant women with commensal Neisseria lactamica to see if 1) colonises mothers & 2) transmits to infants
Answer is 1) yes mostly, & 2) no
#IDSky @lancetmicrobe.bsky.social
www.thelancet.com/journals/lan...
Controlled human infection model of Neisseria lactamica in late pregnancy investigating mother-to-infant transmission in the UK: a single-arm pilot trial
As the world’s first perinatal CHIM, this trial demonstrates that this model in pregnancy
is feasible, and that N lactamica Y92–1009 can safely and efficiently colonise pregnant
individuals. Lack of s...
www.thelancet.com
February 24, 2025 at 8:59 PM
H5N1 D1.1 predominates in N American migratory birds and has spread to mammals, including dairy cattle in Nevada, Arizona
Will it cause more severe illness in humans?
So far:
1 death in Louisiana
1 severe pediatric case (recovered) in British Columbia
2 mild cases Washington, Nevada (dairy worker)
Will it cause more severe illness in humans?
So far:
1 death in Louisiana
1 severe pediatric case (recovered) in British Columbia
2 mild cases Washington, Nevada (dairy worker)
Our analysis of the second incursion of H5N1 viruses (genotype D1.1) into dairy cattle in the US is now posted to virological virological.org/t/timing-and...
February 24, 2025 at 5:09 PM
Great follow-up study on Infective Endocarditis in People Who Inject Drugs. An article that exhibits the importance of representation in different types of longitudinal studies. #PITT_ID25
Infective Endocarditis in People Who Inject Drugs – a Five-Year Follow-up: “I´ve Seen the Needle and the Damage Done”
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
February 13, 2025 at 12:18 PM
CDC has issued a Health Alert Network advisory about a recently confirmed outbreak of Ebola disease in Uganda caused by the Sudan virus. Read the full advisory that includes CDC’s recommendations, testing, and biosafety considerations:
Health Alert Network (HAN) - 00521 | Ebola Outbreak Caused by Sudan virus in Uganda
buff.ly
February 6, 2025 at 8:45 PM
This year's #EarthDay theme is "Our Power, Our Planet," empowering everyone to take action for a sustainable future. ASM is committed to promoting research & advancing action on sustainable, microbe-based technologies to address climate change. Learn more! asm.org/Academy/Micr...
April 22, 2025 at 6:02 PM
HIV prevention is on the chopping block in the US.
Cutting the CDC’s Division of HIV Prevention would mean more infections, more costs, and more risk—everywhere.
We were on the verge of ending HIV transmission with injectable PrEP. Now, we’re being dragged back decades.
www.wsj.com/health/healt...
Cutting the CDC’s Division of HIV Prevention would mean more infections, more costs, and more risk—everywhere.
We were on the verge of ending HIV transmission with injectable PrEP. Now, we’re being dragged back decades.
www.wsj.com/health/healt...
March 19, 2025 at 2:45 PM
Happy to hear this! Great news! #PITT_ID25
Would you like some good news? A new vaccine has just been approved for protecting koalas from chlamydia, which is one of their leading causes of death.
Australia approves first vaccine to save koalas from chlamydia
A vaccine to protect Australia's koalas against chlamydia has been approved for the first time, a development that scientists believe could stop the spread of the deadly disease that has ravaged populations of the beloved endangered animal.
www.reuters.com
September 11, 2025 at 5:09 PM
Happy to hear this! Great news! #PITT_ID25
this is such a cool way to try to combat antimicrobial resistance! #PITT_ID25
Chinese colleagues present a method to combat MRSA by using exosomes to deliver siRNA into bacteria, silencing the gene responsible for #AMR. This approach could make MRSA treatable with conventional antibiotics, offering hope against multidrug-resistant infections.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
siRNA-AGO2 complex inhibits bacterial gene translation: A promising therapeutic strategy for superbug infection
Wang et al. report that the exosomal siRNA-AGO2 complex silences the target bacterial
gene by translational repression without mRNA degradation and consequently develop
a therapeutic strategy to impro...
www.cell.com
March 16, 2025 at 11:02 AM
this is such a cool way to try to combat antimicrobial resistance! #PITT_ID25
A great example of antibiotic stewardship: this meta-analysis concludes that antibiotic use is not generally appropriate for asymptomatic bacteriuria in kidney transplant recipients! #Pitt_ID25
Asymptomatic bacteriuria (ASB) is generally systematically screened and treated with antibiotics in kidney transplant recipients (KTRs). In OFID, authors explore the role of antibiotic therapy in management of ASB in KTRs. https://bit.ly/3JQye8M
Effectiveness and safety of antibiotics in kidney transplant recipients with asymptomatic bacteriuria: a systematic review and meta-analysis of randomized controlled trials
AbstractBackground. Asymptomatic bacteriuria (ASB) is generally systematically screened and treated with antibiotics in kidney transplant recipients (KTRs)
academic.oup.com
September 13, 2025 at 8:56 PM
A great example of antibiotic stewardship: this meta-analysis concludes that antibiotic use is not generally appropriate for asymptomatic bacteriuria in kidney transplant recipients! #Pitt_ID25
Keep your distance from wild birds and ALWAYS be diligent with your hand hygiene! #PITT_ID25
1197 US counties have been affected by H5N1 bird flu in wild birds, according to the CDC.
January 14, 2025 at 5:07 AM
Keep your distance from wild birds and ALWAYS be diligent with your hand hygiene! #PITT_ID25
More importance of vaccines!! #Pitt_ID25
Today is #WorldCancerDay!
#DYK that #vaccines can prevent infections that lead to certain types of cancer?
The #HPV vaccine protects against a virus linked to cervical, throat & other cancers, while the #HepatitisB vaccine helps prevent chronic liver infections that can lead to liver cancer.
#DYK that #vaccines can prevent infections that lead to certain types of cancer?
The #HPV vaccine protects against a virus linked to cervical, throat & other cancers, while the #HepatitisB vaccine helps prevent chronic liver infections that can lead to liver cancer.
How vaccines can protect from cancers: HPV & Hepatitis B | European Vaccination Information Portal
YouTube video by ECDC
youtu.be
February 4, 2025 at 6:50 PM
More importance of vaccines!! #Pitt_ID25
A very interesting read about the evolution of tetracyclines over the past seven decades! #PITT_ID25
🆕💫 Narrative Review @cmicomms.bsky.social
@jeffpears0n.bsky.social
Tetracyclines, the Old and the New
🔹Tetracycline 1953
✨Doxycycline 1967
🔹Minocycline 1971
🔹Tigecycline 2005
🔹Eravacycline 2018
🔹Omadacycline 2018
#IDsky #EMIMCC
www.sciencedirect.com/science/arti...
@jeffpears0n.bsky.social
Tetracyclines, the Old and the New
🔹Tetracycline 1953
✨Doxycycline 1967
🔹Minocycline 1971
🔹Tigecycline 2005
🔹Eravacycline 2018
🔹Omadacycline 2018
#IDsky #EMIMCC
www.sciencedirect.com/science/arti...
January 14, 2025 at 6:17 PM
A very interesting read about the evolution of tetracyclines over the past seven decades! #PITT_ID25
🆕💫PROTECT RCT
Ceftriaxone to prevent early-onset pneumonia in comatose patients after out-of-hospital cardiac arrest: a pilot randomized controlled trial and resistome assessment (PROTECT) #IDsky #EMIMCC @pulmcrit.bsky.social
journal.chestnet.org/article/S001...
Ceftriaxone to prevent early-onset pneumonia in comatose patients after out-of-hospital cardiac arrest: a pilot randomized controlled trial and resistome assessment (PROTECT) #IDsky #EMIMCC @pulmcrit.bsky.social
journal.chestnet.org/article/S001...
Ceftriaxone to prevent early-onset pneumonia in comatose patients after out-of-hospital cardiac arrest: a pilot randomized controlled trial and resistome assessment (PROTECT)
This trial was inconclusive regarding the impact of ceftriaxone prophylaxis to reduce
the incidence of EOP after OHCA but ceftriaxone was associated with less frequent
administration of open-label ant...
journal.chestnet.org
August 30, 2025 at 7:56 PM
Klebsiella pneumoniae remains a notorious bug that keeps challenging us in clinical practice—its resistance mechanisms are complex and relentless. This article offers valuable insights. A must-read for the ID community—please share. #idsky
Recent years have seen a dramatic rise in carbapenem-resistant K. pneumoniae which is now recognized as one of the most formidable MDR pathogens worldwide.
🆕🔥The mechanisms of antibiotic resistance & drug resistance transmission of Klebsiella pneumoniae #idsky
www.nature.com/articles/s41...
🆕🔥The mechanisms of antibiotic resistance & drug resistance transmission of Klebsiella pneumoniae #idsky
www.nature.com/articles/s41...
August 30, 2025 at 7:56 PM
Continuation versus temporary interruption of immunomodulatory agents during infections in patients with inflammatory rheumatic diseases: a randomized controlled trial
⭐ Editor's Choice
#IDSky
⭐ Editor's Choice
#IDSky
Continuation versus temporary interruption of immunomodulatory agents during infections in patients with inflammatory rheumatic diseases: a randomized controlled trial
Immunomodulatory agents (IA) are commonly used to treat inflammatory rheumatic diseases (IRDs). Guidelines typically recommend temporarily interrupting IA during infections, but evidence supporting this approach is limited and continuation may be equally safe or even preferable.
bit.ly
August 31, 2025 at 2:31 PM