Excited to share our latest study PLOSGenetics "Acetylation of the yeast Hsp40 chaperone protein Ydj1 fine-tunes proteostasis and translational fidelity". Thanks to Siddhi Omkar Megan Mitchem and Courtney Shrader 🔥https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011338
December 9, 2024 at 8:23 PM
Excited to share our latest study PLOSGenetics "Acetylation of the yeast Hsp40 chaperone protein Ydj1 fine-tunes proteostasis and translational fidelity". Thanks to Siddhi Omkar Megan Mitchem and Courtney Shrader 🔥https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011338
An antisense RNA regulates production of DnaA and affects sporulation in Bacillus subtilis
PLoSGenetics from Alan Grossman
journals.plos.org/plosgenetics...
PLoSGenetics from Alan Grossman
journals.plos.org/plosgenetics...
An antisense RNA regulates production of DnaA and affects sporulation in Bacillus subtilis
Author summary DnaA is the highly conserved replication initiator and transcription factor found in virtually all bacteria. The synthesis and activity of DnaA are highly regulated, and different types...
journals.plos.org
May 15, 2025 at 10:32 AM
An antisense RNA regulates production of DnaA and affects sporulation in Bacillus subtilis
PLoSGenetics from Alan Grossman
journals.plos.org/plosgenetics...
PLoSGenetics from Alan Grossman
journals.plos.org/plosgenetics...
This paper was so much fun to work on. Absolute rock star graduate students Almoro and Riccardo knocked it out of the park
journals.plos.org/plosgenetics...
journals.plos.org/plosgenetics...
March 27, 2024 at 12:19 PM
This paper was so much fun to work on. Absolute rock star graduate students Almoro and Riccardo knocked it out of the park
journals.plos.org/plosgenetics...
journals.plos.org/plosgenetics...
Sharing our lab’s first publication! Probing clinical isolates of Cryptococcus, a disease-causing fungus of the lungs and brain, we found multiple heat-mobile elements that ‘jump’ in the genome at body temperature (!) with the ability to drive adaptive changes. journals.plos.org/plosgenetics...
January 17, 2026 at 12:33 PM
Sharing our lab’s first publication! Probing clinical isolates of Cryptococcus, a disease-causing fungus of the lungs and brain, we found multiple heat-mobile elements that ‘jump’ in the genome at body temperature (!) with the ability to drive adaptive changes. journals.plos.org/plosgenetics...
Bacterial chromosomal gene positioning is likely shaped by selection on both mean and growth-dependent expression
#genomes #genetics #genes #evolution #evoSky #scienceSky
journals.plos.org/plosgenetics...
#genomes #genetics #genes #evolution #evoSky #scienceSky
journals.plos.org/plosgenetics...
Bacterial chromosomal gene positioning is likely shaped by selection on both mean and growth-dependent expression
Author summary Bacterial gene positioning affects gene expression because genes near the origin of chromosomal replication are replicated earlier than those near the terminus and thus have higher gene...
journals.plos.org
September 28, 2026 at 8:57 PM
Bacterial chromosomal gene positioning is likely shaped by selection on both mean and growth-dependent expression
#genomes #genetics #genes #evolution #evoSky #scienceSky
journals.plos.org/plosgenetics...
#genomes #genetics #genes #evolution #evoSky #scienceSky
journals.plos.org/plosgenetics...
I'm excited to share our latest work, now out in #PLOSGenetics! If you feel limited by linear models in TWAS or PWAS but don't think you can switch to nonlinear methods due to a lack of individual-level phenotype data, this paper is for you.
🔗 journals.plos.org/plosgenetics...
Thread below 👇 (1/6)
🔗 journals.plos.org/plosgenetics...
Thread below 👇 (1/6)
May 7, 2025 at 6:12 PM
I'm excited to share our latest work, now out in #PLOSGenetics! If you feel limited by linear models in TWAS or PWAS but don't think you can switch to nonlinear methods due to a lack of individual-level phenotype data, this paper is for you.
🔗 journals.plos.org/plosgenetics...
Thread below 👇 (1/6)
🔗 journals.plos.org/plosgenetics...
Thread below 👇 (1/6)
Post-translational modifications of GlmR integrate metabolic and stress signals to maintain cell envelope homeostasis in Bacillus subtilis
#PLOSGenetics from @eswaralab.bsky.social
journals.plos.org/plosgenetics...
#PLOSGenetics from @eswaralab.bsky.social
journals.plos.org/plosgenetics...
Post-translational modifications of GlmR integrate metabolic and stress signals to maintain cell envelope homeostasis in Bacillus subtilis
Author summary Bacteria must integrate feedback from multiple metabolic processes and environmental cues to efficiently allocate carbon to produce essential building blocks such as nucleotides, amino ...
journals.plos.org
April 1, 2026 at 6:21 PM
Post-translational modifications of GlmR integrate metabolic and stress signals to maintain cell envelope homeostasis in Bacillus subtilis
#PLOSGenetics from @eswaralab.bsky.social
journals.plos.org/plosgenetics...
#PLOSGenetics from @eswaralab.bsky.social
journals.plos.org/plosgenetics...
Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...
Epigenetic relay: Polycomb-directed DNA methylation in mammalian development
In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of prom...
journals.plos.org
September 15, 2025 at 7:04 PM
Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...
Polyploidy & Arabidopsis! We found tetraploid-characteristic haplotypes to be made of novel ‘mosaics’ forged from multiple allelic sources in our new paper:
journals.plos.org/plosgenetics...
journals.plos.org/plosgenetics...
February 11, 2025 at 9:31 PM
Polyploidy & Arabidopsis! We found tetraploid-characteristic haplotypes to be made of novel ‘mosaics’ forged from multiple allelic sources in our new paper:
journals.plos.org/plosgenetics...
journals.plos.org/plosgenetics...
Transcription ahead of chromatin regulation?
Activation in endoderm occurs prior to K27me3 removal, plus much more. A tribute to our amazing collaborators
@wbickmor.bsky.social and the amazing Rob Illingworth, without whom this data would have gathered dust!
journals.plos.org/plosgenetics...
Activation in endoderm occurs prior to K27me3 removal, plus much more. A tribute to our amazing collaborators
@wbickmor.bsky.social and the amazing Rob Illingworth, without whom this data would have gathered dust!
journals.plos.org/plosgenetics...
February 2, 2025 at 1:48 PM
Transcription ahead of chromatin regulation?
Activation in endoderm occurs prior to K27me3 removal, plus much more. A tribute to our amazing collaborators
@wbickmor.bsky.social and the amazing Rob Illingworth, without whom this data would have gathered dust!
journals.plos.org/plosgenetics...
Activation in endoderm occurs prior to K27me3 removal, plus much more. A tribute to our amazing collaborators
@wbickmor.bsky.social and the amazing Rob Illingworth, without whom this data would have gathered dust!
journals.plos.org/plosgenetics...
Frozen in permafrost for 46,000 years...
It was thawed in a lab dish and simply woke up, began eating, and started reproducing.
A novel nematode species from the Siberian permafrost shares adaptive mechanisms for cryptobiotic survival with C. elegans dauer larva🧪
journals.plos.org/plosgenetics...
It was thawed in a lab dish and simply woke up, began eating, and started reproducing.
A novel nematode species from the Siberian permafrost shares adaptive mechanisms for cryptobiotic survival with C. elegans dauer larva🧪
journals.plos.org/plosgenetics...
September 4, 2026 at 3:31 PM
Frozen in permafrost for 46,000 years...
It was thawed in a lab dish and simply woke up, began eating, and started reproducing.
A novel nematode species from the Siberian permafrost shares adaptive mechanisms for cryptobiotic survival with C. elegans dauer larva🧪
journals.plos.org/plosgenetics...
It was thawed in a lab dish and simply woke up, began eating, and started reproducing.
A novel nematode species from the Siberian permafrost shares adaptive mechanisms for cryptobiotic survival with C. elegans dauer larva🧪
journals.plos.org/plosgenetics...
I've just had a jaw-to-the-floor moment with this new paper from the Hines lab. They describe a yellow-white switch in bees, which maps to the same TF as the yellow-white switch in Colias butterflies, previously described by the @chriswheat.bsky.social lab. journals.plos.org/plosgenetics...
March 16, 2026 at 7:56 PM
I've just had a jaw-to-the-floor moment with this new paper from the Hines lab. They describe a yellow-white switch in bees, which maps to the same TF as the yellow-white switch in Colias butterflies, previously described by the @chriswheat.bsky.social lab. journals.plos.org/plosgenetics...
Happy to see Kevin Robe’s work on ZIP transporters published. We found evidences that ZIP2 and ZIP8 are involved in Cu and Fe acquisition respectively and confirmed the role of ZIP3 and ZIP5 in Zn acquisition. journals.plos.org/plosgenetics...
July 24, 2025 at 6:03 PM
Happy to see Kevin Robe’s work on ZIP transporters published. We found evidences that ZIP2 and ZIP8 are involved in Cu and Fe acquisition respectively and confirmed the role of ZIP3 and ZIP5 in Zn acquisition. journals.plos.org/plosgenetics...
Almost 10 years ago @mendelrandom.bsky.social @greally.bsky.social and myself wrote a review on this journals.plos.org/plosgenetics...
January 15, 2025 at 8:09 AM
Almost 10 years ago @mendelrandom.bsky.social @greally.bsky.social and myself wrote a review on this journals.plos.org/plosgenetics...
Parallel regulatory circuits orchestrate biofilm formation in response to c-di-GMP levels and growth phase
[in Vibrio cholerae]
#PLOSgenetics from Fitnat Yildiz
with David Grainger
journals.plos.org/plosgenetics...
[in Vibrio cholerae]
#PLOSgenetics from Fitnat Yildiz
with David Grainger
journals.plos.org/plosgenetics...
Parallel regulatory circuits orchestrate biofilm formation in response to c-di-GMP levels and growth phase
Author summary Biofilm formation enhances the environmental fitness of bacteria and relies on the second messenger c-di-GMP; the cellular levels of c-di-GMP are controlled by diguanylate cyclases (DGC...
journals.plos.org
September 16, 2025 at 10:26 AM
Parallel regulatory circuits orchestrate biofilm formation in response to c-di-GMP levels and growth phase
[in Vibrio cholerae]
#PLOSgenetics from Fitnat Yildiz
with David Grainger
journals.plos.org/plosgenetics...
[in Vibrio cholerae]
#PLOSgenetics from Fitnat Yildiz
with David Grainger
journals.plos.org/plosgenetics...
Capturing Heterogeneity in Gene Expression Studies by Surrogate Variable Analysis (R::sva)
Control the impact of Unmeasured/Unmodeled factors
"to disentangle correlated and overlapping differential expression signals"
Dr. John Storey lab #PLOSGenetics 2009
journals.plos.org/plosgenetics...
Control the impact of Unmeasured/Unmodeled factors
"to disentangle correlated and overlapping differential expression signals"
Dr. John Storey lab #PLOSGenetics 2009
journals.plos.org/plosgenetics...
December 6, 2024 at 7:57 PM
Capturing Heterogeneity in Gene Expression Studies by Surrogate Variable Analysis (R::sva)
Control the impact of Unmeasured/Unmodeled factors
"to disentangle correlated and overlapping differential expression signals"
Dr. John Storey lab #PLOSGenetics 2009
journals.plos.org/plosgenetics...
Control the impact of Unmeasured/Unmodeled factors
"to disentangle correlated and overlapping differential expression signals"
Dr. John Storey lab #PLOSGenetics 2009
journals.plos.org/plosgenetics...
Our manuscript characterising tissue-specific consequences of tagged protein fusions in CRISPR-engineered mice is now online @PLOSGenetics. journals.plos.org/plosgenetics.... Thanks again to all coauthors, reviewers and editors for a smooth publication process. Brief summary below.
August 26, 2025 at 12:20 PM
Our manuscript characterising tissue-specific consequences of tagged protein fusions in CRISPR-engineered mice is now online @PLOSGenetics. journals.plos.org/plosgenetics.... Thanks again to all coauthors, reviewers and editors for a smooth publication process. Brief summary below.
Quantitative analysis of relationship between mutation rate and speed of adaptation under antibiotic exposure in Escherichia coli
-in #PLoSGenetics
journals.plos.org/plosgenetics...
-in #PLoSGenetics
journals.plos.org/plosgenetics...
Quantitative analysis of relationship between mutation rate and speed of adaptation under antibiotic exposure in Escherichia coli
Author summary Bacteria evolve to survive in changing environments, but how does the rate of genetic mutations influence their ability to adapt, especially to antibiotics? In this study, we explored h...
journals.plos.org
March 29, 2025 at 2:41 PM
Quantitative analysis of relationship between mutation rate and speed of adaptation under antibiotic exposure in Escherichia coli
-in #PLoSGenetics
journals.plos.org/plosgenetics...
-in #PLoSGenetics
journals.plos.org/plosgenetics...
This is an echo of prior work by Zaitlen et al. 2013 (journals.plos.org/plosgenetics...) which used a multivariate approach to model relatedness and again found heritability estimates that were much lower than in twins.
July 12, 2025 at 2:25 AM
This is an echo of prior work by Zaitlen et al. 2013 (journals.plos.org/plosgenetics...) which used a multivariate approach to model relatedness and again found heritability estimates that were much lower than in twins.
DNA duplication in Burkholderia thailandensis induces biofilm formation by activating a two-component regulatory system
-in #PLoSGenetics
journals.plos.org/plosgenetics...
-in #PLoSGenetics
journals.plos.org/plosgenetics...
DNA duplication in Burkholderia thailandensis induces biofilm formation by activating a two-component regulatory system
Author summary Transposable elements naturally accumulate within genomes in all kingdoms of life. When present in the same orientation, a pair of homologous elements can act as substrates for DNA reco...
journals.plos.org
May 21, 2025 at 11:51 AM
DNA duplication in Burkholderia thailandensis induces biofilm formation by activating a two-component regulatory system
-in #PLoSGenetics
journals.plos.org/plosgenetics...
-in #PLoSGenetics
journals.plos.org/plosgenetics...
1/2 Many years ago, @plantylisasmith.bsky.social identified an Arabidopsis hybrid incompatibility due to interaction between different alleles at the OAK receptor-like kinase (RLK) locus, but it was unknown why there is so much sequence diversity at this locus
journals.plos.org/plosgenetics...
journals.plos.org/plosgenetics...
September 10, 2025 at 9:42 AM
1/2 Many years ago, @plantylisasmith.bsky.social identified an Arabidopsis hybrid incompatibility due to interaction between different alleles at the OAK receptor-like kinase (RLK) locus, but it was unknown why there is so much sequence diversity at this locus
journals.plos.org/plosgenetics...
journals.plos.org/plosgenetics...