#PSD95
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sgiando.bsky.social
We differentiated mESCs into mature forebrain organoids. They express excitatory and inhibitory synapse markers (Vglut1, Vgat, Psd95, Gephyrin) and show spontaneous calcium activity that TTX blocks, indicating action-potential-dependent network activity. 2/5
September 30, 2026 at 9:33 AM
nsrhighlights.bsky.social
In mouse hippocampal CA1, synapse-related markers followed different developmental and prenatal-valproate patterns depending on layer and dorsoventral position.

https://doi.org/10.1016/j.neures.2026.105066
#NeuroscienceResearch #Neuroscience #Synapses
Japanese painterly NSR cover showing a recognizable layered CA1 arc; separate PSD95-like and gephyrin-like puncta concepts; and three layers arranged across four developmental time markers. The canonical explorer uses a transparent coordinate grid to compare puncta across CA1 layers. A small washi banner reads Neuroscience Research.
September 8, 2026 at 12:15 PM
nsrhighlights.bsky.social
海馬CA1の変化を平均してしまうと、層ごとの違いは消えてしまいます。マウス組織を層の座標に沿って調べると、シナプスに関わる目印の発達と、胎生期バルプロ酸曝露後の変化は場所ごとに異なりました。

https://doi.org/10.1016/j.neures.2026.105066
#NeuroscienceResearch #Neuroscience #Synapses
Japanese painterly NSR cover showing a recognizable layered CA1 arc; separate PSD95-like and gephyrin-like puncta concepts; and three layers arranged across four developmental time markers. The canonical explorer uses a transparent coordinate grid to compare puncta across CA1 layers. A small washi banner reads Neuroscience Research.
September 8, 2026 at 12:15 PM
rridrobot.bsky.social
@thermofishersci.bsky.social's resource, RRID:AB_2534069, was just reported to be used in the paper. RRIDs improve reproducibility in scientific research. #OpenResearch #STMpublishing #accelerateopenscience
Predominant NR1-positive puncta with limited PSD95 colocalization and close GluA2–EAAT2 apposition in the preBötzinger complex
Read the full paper: Predominant NR1-positive puncta with limited PSD95 colocalization and close GluA2–EAAT2 apposition in the preBötzinger complex
doi.org
August 9, 2026 at 7:00 AM
rridrobot.bsky.social
A paper using RRID:AB_2535794 from @thermofishersci.bsky.social was just published. We value the author's support of reproducibility. #OpenScience #ReproducibleResearch #methodsmatter
Novel PSD95 reporter mice reveal medium spiny neuron subtype-specific synapse loss in PD and L-dopa induced dyskinesia and identify microglia mediated synapse removal as a therapeutic target for dyskinesia
Read the full paper: Novel PSD95 reporter mice reveal medium spiny neuron subtype-specific synapse loss in PD and L-dopa induced dyskinesia and identify microglia mediated synapse removal as a therapeutic target for dyskinesia
doi.org
July 16, 2026 at 7:01 AM
prepub-neurodegen.bsky.social
Novel PSD95 reporter mice reveal medium spiny neuron subtype-specific synapse loss in PD and L-dopa induced dyskinesia and identify microglia mediated synapse removal as a therapeutic target for dyskinesia #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.07.05.736610v1
July 10, 2026 at 7:02 AM
biorxiv-neursci.bsky.social
Novel PSD95 reporter mice reveal medium spiny neuron subtype-specific synapse loss in PD and L-dopa induced dyskinesia and identify microglia mediated synapse removal as a therapeutic target for dyskinesia https://www.biorxiv.org/content/10.64898/2026.07.05.736610v1
July 10, 2026 at 4:16 AM
biorxivpreprint.bsky.social
Novel PSD95 reporter mice reveal medium spiny neuron subtype-specific synapse loss in PD and L-dopa induced dyskinesia and identify microglia mediated synapse removal as a therapeutic target for dyskinesia https://www.biorxiv.org/content/10.64898/2026.07.05.736610v1
July 10, 2026 at 4:16 AM
rpeptide.bsky.social
This Nature Neuroscience research finds phosphorylated Tau impairs neurovascular coupling before neuronal loss or cognitive decline, pinpointing a nitric oxide deficit as the mechanism. Study conducted using rPeptide's Tau-441 P301L Mutant. 🔬

t.ly/f6pI5

#Neuroscience #Tauopathy #AlzheimersResearch
Tau induces PSD95–neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration - Nature Neuroscience
Park et al. demonstrate in tauopathy models that tau disrupts the interaction between neuronal nitric oxide synthase and PSD95, uncoupling glutamatergic synaptic activity from nitric oxide production ...
t.ly
July 8, 2026 at 12:54 PM
epsteinweb.bsky.social
EFTA00799259.jpg
#epsteinweb #efta00799259
https://epsteinweb.org
Available in the iOS app store now!
https://apps.apple.com/us/app/epstein-web/id6758880661
EFTA00799222 | EFTA00799259 C1q : Necessary for Al3-Induced Synapse Loss In Vivo Model of Acute Synapse Loss WT mic I Synapsin + PSD95 Colocalized Puncta 200-i Also see similar protection using Cl blocking antibody EFTA00799259 Epstein Web iOS app on the App Store.
May 6, 2026 at 1:58 PM
epsteinweb.bsky.social
EFTA00799255.jpg
#epsteinweb #efta00799255
https://epsteinweb.org
Available in the iOS app store now!
https://apps.apple.com/us/app/epstein-web/id6758880661
EFTA00799222 | EFTA00799255 C3 Deficiency Protects Against Synapse Loss in APP/PS1 Mice (4 m and 16 m) Synaptophysin + PSD95 Co-Localized Puncta in CM APP/PS1xC3 KO 150NS Synaptophysin PSD95 WT APP,PS1APPIPS1 CAO ,C3k0 EFTA00799255
May 6, 2026 at 1:57 PM
epsteinweb.bsky.social
EFTA00799253.jpg
#epsteinweb #efta00799253
https://epsteinweb.org
Available in the iOS app store now!
https://apps.apple.com/us/app/epstein-web/id6758880661
EFTA00799222 | EFTA00799253 Early Increased Deposition to PSD95+ Synapse in Hippocampus of AD Mice 400 S, 300 200 (,?, 100 EFTA00799253
May 6, 2026 at 1:57 PM
epsteinweb.bsky.social
EFTA00799251.jpg
#epsteinweb #efta00799251
https://epsteinweb.org
Available in the iOS app store now!
https://apps.apple.com/us/app/epstein-web/id6758880661
EFTA00799222 | EFTA00799251 Early, Region Specific Loss of Synapses in AD Models Hippocampus of 3 month J20 Mice Synaptophysin PSD95 Dentate Gyrus co 150— ** El o_ + 100.(% WT J20 _c a_ cr) 0 a_ 1* 50- 0 CA1 CA3 DG N=3 per genotype "*P <0.01 for CA1 by Bonferroni post-test EFTA00799251
May 6, 2026 at 1:57 PM
epsteinweb.bsky.social
EFTA00799246.jpg
#epsteinweb #efta00799246
https://epsteinweb.org
Available in the iOS app store now!
https://apps.apple.com/us/app/epstein-web/id6758880661
EFTA00799222 | EFTA00799246 Brain: Complement Proteins Tag Synapses for Elimination by Microglia The Classical Complement Cascade microbe, debris, etc. C1q PSD95 C3 convertase it lk Phagocytosis IB Lysis &Membrane Attack Complex M EFTA00799246
May 6, 2026 at 1:57 PM
bigearthdata.ai
HSV-1 strain H129 co-opts neuronal synaptic transmission machinery for its transsynaptic spread
->Nature | More on "Herpes virus neuronal spread mechanism" at BigEarthData.ai
HSV-1 strain H129 co-opts neuronal synaptic transmission machinery for its transsynaptic spread
Extended Data Fig. 1 Neurons cultured in a microfluidic chamber stabilize by DIV21 exhibiting consistent synapse density and response. a, Timeline depicting the experiment flow. b–d, Synapse density of neurons cultured in the microfluidic chamber. b, Confocal images show VAMP2 (magenta) and PSD95 (green) colocalizing at different times. Solid line marks microgroove borders; dashed rectangle (right panel) shows VP26-mCherry signal only. c, TEM images of different synapse types of DIV21 cultured neurons. The asymmetrical synapses, including axo-dendritic (first panel), axo-somatic (the second panel) and axo-axonic synapse (the third panel), and the symmetrical synapse (fourth panel) are shown. d, Quantification of synapse density. Synapse density was quantified based on IFA and TEM data shown in b and c, shown as the first four columns and the last column correspondingly. Data were analyzed by one-way ANOVA, Tukey test. e–g, Action potential firing pattern and membrane potential. e, Traces show the AP firing pattern as a response to step current injections (140pA, 500 ms) during the indicated culture times. Quantification of fire rate (f) and membrane potential (g). Data were analyzed by one-way ANOVA, Tukey test. Data are represented as mean ± s.e.m. ns: no significant and ****p < 0.0001. AT, axon terminal;...
www.nature.com
April 14, 2026 at 11:15 PM
antibodies-dot-com.bsky.social
Pan-neuronal markers help you see the full neuronal landscape 🧠

From confirming expression to tracking neuron numbers and mapping connectivity - the right markers matter.

No single marker fits all. Choose based on your goal.

Read more: www.antibodies.com/primary-anti...
Pan-Neuronal Markers | Antibodies.com
This guide covers protein markers for identifying all neurons regardless of their location in the nervous system, including NeuN, MAP tau and PSD95.
www.antibodies.com
April 7, 2026 at 7:30 AM
patrickmineault.bsky.social
And we can keep adding layers, like labelling proteins (e.g. PSD95 in PRISM and LICONN). I think the endgame is that the connectome data will be so rich that it'll be conceptually a different kind of object, an ultrastructome. 3/
March 31, 2026 at 3:20 PM
rridrobot.bsky.social
A preprint using: PSD95 Antibody (RRID:AB_3102405) from #edChemExpress was published.

SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #reproducibility #STMpublishing
Multi-component functionalized Bifidobacterium longum hydrogel for multi-target integrated therapy of colitis-associated anxiety and depression
www.biorxiv.org
March 17, 2026 at 12:01 PM
misicbata.bsky.social
7️⃣ Could short protein lifetime reflect greater synaptic flexibility necessary for more complex processing?

We find that short-lifetime PSD95 synapses (but not long-lifetime PSD95 nor SAP102) increase sc-fc coupling _specifically_ in awake (not anaesthetized) mice.
March 11, 2026 at 7:56 PM
misicbata.bsky.social
6️⃣ Recap till now:

More long-lifetime PSD95 synapse density = more variable signal = fewer functional connections

More SAP102 synapse density = high-amplitude events appear later = more structural connections

Short-lifetime PSD95 synapse density = ???
March 11, 2026 at 7:56 PM
misicbata.bsky.social
5️⃣ Does global network embedding also reflect synaptic architecture?

We find that SAP102 synapse density correlates with SC degree while long-lifetime PSD95 synapse density correlates with FC degree.

In both cases, longer synapse protein lifetime = stronger relationship.
March 11, 2026 at 7:56 PM
misicbata.bsky.social
4️⃣ Long-lifetime PSD5 synapse density is most associated with features of time-invariant stationarity, and SAP102 with features that pick up on the timing and presence of extreme events.

(short-lifetime PSD95 synapses are associated with next to nothing)
March 11, 2026 at 7:56 PM
misicbata.bsky.social
2️⃣ First we map 37 excitatory synapse types based on the synaptic scaffolding protein they express, broadly categorized as long-lifetime PSD95, short-lifetime PSD95, and SAP102 synapses.

(“Lifetime” refers to protein turnover rate - it’ll be important)
March 11, 2026 at 7:56 PM
heniek-htw.bsky.social
• Low-level exposure (1 mT) ELF-EMF increased the expression of genes related to neurogenesis (BDNF, TrkB, GAP43), synaptic activity (PSD95, SYN1), and neuronal survival (Bcl-2, Bcl-xL).

• High-level exposure (7 mT) decreased expression of these same pro-neuroplastic factors.
Dose-dependent impact of extremely low-frequency electromagnetic field (ELF-EMF) on the neuroplasticity in the hippocampus of adult rats
Extremely low-frequency electromagnetic field (ELF-EMF) therapy is gaining attention for its potential benefits in treating neurodegenerative conditio…
www.sciencedirect.com
February 23, 2026 at 5:40 PM
panastasiades.bsky.social
To better understand the mechanisms behind this process we teamed up with @cianodonnell.bsky.social and a great student in his lab @jajmca.bsky.social who helped us model the incorporation of PSD95 into nascent synapses and how this influences their number, strength and stability.
February 18, 2026 at 10:33 AM