#CyclicdiGMP suppresses #CancerMetastasis by directly targeting #PSMD3, disrupting its interaction with TBK1, and inhibiting NF‑κB signaling, thereby curbing metastatic #BreastCancer progression with minimal toxicity. @TulaneMedicine

#OpenAccess in #STTT: doi.org/10.1038/s413...

Structure-Based Modeling of Environment-dependent Protonation States Across LNP Formulations with Atomistic CpHMD

Authors: Kyle J. Colston, Santiago C. Monsalve, Severin T. Schneebeli
DOI: 10.26434/chemrxiv-2025-psmd3

Scientists show #CyclicdiGMP inhibits #breastcancer #metastasis by binding #PSMD3, disrupting PSMD3–TBK1 interaction, and suppressing NF‑κB signaling, positioning PSMD3 as a therapeutic target. #Antimetastatic @tulanemedicine.bsky.social

#OpenAccess #STTT: doi.org/10.1038/s413...