#Pad4
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evelynfloragray.bsky.social
working on new music ^.^
evelyn on her floor surrounded by music gear - a blue double humbucker telecaster, an alesis sample pad4, and a pedal board with various guitar pedals
May 27, 2025 at 12:47 AM
biorxiv-plants.bsky.social
Small Molecule Binding to EDS1/PAD4 in LRR-RP-Mediated Pattern-Triggered Immunity https://www.biorxiv.org/content/10.64898/2025.12.10.692544v1
December 13, 2025 at 3:01 AM
thailandmedical.bsky.social
PAD4 COVID-19 Link Could Change Future Treatments

www.thailandmedical.news/news/pad4-co...
PAD4 COVID-19 Link Could Change Future Treatments - Thailand Medical News
www.thailandmedical.news
February 22, 2026 at 5:32 AM
thailandmedical.bsky.social
Brazilian Researchers Find That PAD4 Inhibitors Could Weaken COVID-19 Immune Defense Despite Improving Symptoms

www.thailandmedical.news/news/brazili...
Brazilian Researchers Find That PAD4 Inhibitors Could Weaken COVID-19 Immune Defense Despite Improving Symptoms - Thailand Medical News
www.thailandmedical.news
April 20, 2025 at 6:31 AM
natplants.nature.com
N&V about papers in @ScienceMagazine: "TIR-mediated immunity: Small molecules unlock broad-spectrum plant resistance" rdcu.be/d5riU

... have elucidated the mechanism by which TIR NADase-derived 2′cADPR and pRib-AMP/ADP activate EDS1–PAD4–ADR1 (EPA) signalling, thereby inducing immune responses.
January 6, 2025 at 2:32 PM
trentpetersclarke.bsky.social
Cellular Consequences, Citrullination Substrates, and Antigenicity of Targeting PAD4 to Cell Surfaces | ACS Central Science

doi.org/10.1021/acsc...
Cellular Consequences, Citrullination Substrates, and Antigenicity of Targeting PAD4 to Cell Surfaces
Abstract. Protein arginine deiminase-4 (PAD4) catalyzes hydrolysis of arginine to citrulline in proteins that promote widespread cellular changes that can
doi.org
July 25, 2026 at 5:31 PM
taejoonw.bsky.social
Our latest study on PAD4 in arthritis (doi.org/10.1002/art....) is highlighted in Nature Reviews Rheumatology. Excited!
natrevrheum.nature.com Nature Reviews Rheumatology @natrevrheum.nature.com · May 6
Research Highlight ✨| Targeting anti-PAD4 autoantibodies in RA

Read the original article here: bit.ly/3EVOLpU

@taejoonw.bsky.social
May 8, 2025 at 4:33 PM
aga-cmgh.bsky.social
➡️ Inflammation and thrombosis play crucial roles in pancreatic necrosis. Targeting ADAMTS13 activity enhancement with the combination of PAD4 inhibition may better alleviate acute pancreatitis.
🔗 https://ow.ly/9xQ150ZQz46
September 25, 2026 at 2:15 PM
ljwalport.bsky.social
For my 1st post I'm pleased to share results of a fab collaboration with the Christophorou Lab (Babraham Insitute) - now in print!

We develop a set of cyclic peptide tools to explore the cellular function of PAD4/PADI4 - let us know if you'd like to try them out.

www.nature.com/articles/s41...
A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV regulation - Nature Communications
Walport & coworkers report cell-active, potent and selective cyclic peptide modulators for the enzyme peptidylarginine deiminase PADI4/PAD4, including an inhibitor, an activator and an affinity mo...
www.nature.com
November 12, 2024 at 11:46 AM
natrevrheum.nature.com
ICYMI: New content online:
Targeting anti-PAD4 autoantibodies in RA
Nature Reviews Rheumatology, Published online: 06 May 2025; doi:10.1038/s41584-025-01264-3Findings implicate anti-PAD4 antibodies in the pathogenesis of rheumatoid arthritis.
bit.ly
May 11, 2025 at 12:32 PM
atranscendedman.bsky.social
University of Turin researchers studied mice and human cells and found SARS-CoV-2 boosts PAD4, a protein that alters other proteins.

Blocking PAD4 cut viral levels by at least 90% and calmed inflammatory signals, pointing to a new treatment target.

www.cell.com/iscience/ful...
Targeting peptidyl-arginine deiminase 4 suppresses SARS-CoV-2 replication and modulates the inflammatory response
SARS-CoV-2, the causative agent of COVID-19, remains a global concern due to gaps in understanding its pathogenesis. Peptidyl-arginine deiminases (PADs) are emerging as key regulators of viral replica...
www.cell.com
February 19, 2026 at 7:35 PM
acr-journals.bsky.social
Mouse model & in vitro study investigated the pathogenic role of anti-PAD4 autoantibodies in rheumatoid arthritis, suggesting a model where anti-PAD4 antibodies primarily target monocytes triggering an inflammatory cascade

Arthritis& Rheumatology
doi.org/10.1002/art....
#Medsky #Rheumsky #Immunosky
Anti-Peptidylarginine-4 Autoantibodies Derived from Patients with Rheumatoid Arthritis Exert Pathogenic Effects by Activating Monocytes and Exacerbating Inflammatory Arthritis. Graphical abstract created with BioRender
April 4, 2025 at 4:09 PM
natrevrheum.nature.com
Research Highlight ✨| Targeting anti-PAD4 autoantibodies in RA

Read the original article here: bit.ly/3EVOLpU

@taejoonw.bsky.social
May 6, 2025 at 2:19 PM
acr-journals.bsky.social
PAD4 is a promising therapeutic target to stop ACPA production. PAD4-immunized C3H mice showed inhibited T cell activation and ↓ antibody prod. to arginine and citrullinated peptides, suggesting PAD4 tolerization may "switch off" ACPAs in rheumatoid arthritis

A&R
doi.org/10.1002/art....
#immunosky
A tolerogenic plasmid inhibits autoantibody production triggered by immunization with human peptidyl arginine deiminase 4. Graphical abstract created with BioRender
June 27, 2025 at 8:35 PM
insermpacacorse.bsky.social
PR: tolériser le système immunitaire contre PAD4 ↓ ACPAs et inflammation 🧩🔬 Une piste prometteuse #autoimmunité #rhumatologie
pro.inserm.fr/une-piste-po...
Une piste pour traiter la polyarthrite rhumatoïde en « apprenant » au système immunitaire à ne pas attaquer l’enzyme PAD4.
pro.inserm.fr
July 10, 2025 at 7:45 AM
acr-journals.bsky.social
The ever-expanding connections between PAD4 and rheumatoid arthritis

Editorial on the below study in A&R
doi.org/10.1002/art....

Figure: Multiple roles of PAD4 in RA pathogenesis

#Medsky #Immunosky #Rheumsky
Multiple roles of PAD4 in RA pathogenesis. A. PAD4 in neutrophils citrullinates histones as part of NETosis and also citrullinates NFkappaB p65, leading to production of TNFa and IL-1β, which have inflammatory effects on many types of immune cells. Antigens in NETs are recognized by B cells that become ACPA-producing plasma cells. B. As newly described in Won et al, anti-PAD4 antibodies bind to monocytes, inducing IL-8, MCP-1, and MIP-1β, which recruit and activate neutrophils, monocytes, and lymphocytes. The T cells produce TNFa, IFNg, and IL-17, which stimulate synovial fibroblasts and provide help to B cells. C. In macrophages, PAD4 citrullinates histones enabling METosis. Like NETs, METs are recognized by B cells that will differentiate into plasma cells that secrete ACPAs. Figure created in BioRender
April 5, 2025 at 9:44 PM
lozanzi.bsky.social
#WeekendRead! #ZombieNeutrophils! #InterferonsFriendsOrFoes?! Stallings &co show @ Cell Host & Microbe that micobacterium drives the releases of NET from live neutrophils (that lose their 🧠!) thanks to PAD4 & type I #interferons, favoring #Myb growth! www.cell.com/cell-host-mi...
Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation
Sur Chowdhury et al. report that Mycobacterium tuberculosis (Mtb) infection results in the release of neutrophil extracellular traps (NETs) that promote Mtb replication and associate with tissue damage. Blocking NET release results in better control of Mtb replication, revealing a strategy for treating these deadly infections.
www.cell.com
December 8, 2024 at 5:36 PM
mpipz.bsky.social
Big news! 🎉 Dr. Fei Xiong has passed his PhD viva in Jane Parker’s Lab at @mpipz.bsky.social, defending his thesis: "Probing the link between EDS1-PAD4 and transcriptional reprogramming in Arabidopsis thaliana."

Congrats, Dr. Xiong! Wishing you success in the future! 🎓✨

#PhDone
The post shows a picture of Fei after successfully passing his viva on a green background with words congratulating him on acquiring the PhD title.
February 21, 2025 at 3:50 PM
trentpetersclarke.bsky.social
Happy to share our newest preprint as we ring in the new year!
Interested in the cell surface, challenging PTMs, and/or cancer biomarkers? This one has a bit of it all.

"Cellular consequences, citrullination substrates, and antigenicity resulting from wild-type and targeted PAD4 on cell surfaces"
Cellular consequences, citrullination substrates, and antigenicity resulting from wild-type and targeted PAD4 on cell surfaces
Protein arginine deiminase-4 (PAD4) catalyzes hydrolysis of arginine to citrulline in proteins that promotes widespread changes in cellular phenotypes through transcriptional regulation that can induc...
www.biorxiv.org
January 6, 2026 at 10:46 PM
loevenbruck.org
Amis franciliens ou de passage, je serai présent ce dimanche 13 avril au salon du livre de Paris (Grand Palais), et même deux fois, c'est dire :

- De 11:00 à 12:30 sur le stand des éditions Pocket (PAD2)
- De 14:30 à 16:30 sur le stand des éditions XO (PAD4)

C'est chouette.
Affiche du festival
April 8, 2025 at 8:41 AM
acr-journals.bsky.social
Proposed mechanism of rheumatoid arthritis disease exacerbation by anti-PAD4 antibodies

#Medsky #Rheumsky
Proposed mechanism of disease exacerbation by anti-PAD4 antibodies. This model is based on our complementary in vitro and in vivo data showing that anti-PAD4 antibodies preferentially bind monocytes in mice and humans (A), stimulate the release of pro-inflammatory chemokines by human monocytes (B), result in increased immune cell infiltration into arthritic joint in CIA mice (C), including an increased proportion of T cells producing IL-17A, TNF-α, and IFN-γ (D), which can induce an activated and invasive synovial fibroblast phenotype (E-F).
April 4, 2025 at 4:54 PM
natrevrheum.nature.com
New content online:
Targeting anti-PAD4 autoantibodies in RA
Nature Reviews Rheumatology, Published online: 06 May 2025; doi:10.1038/s41584-025-01264-3Findings implicate anti-PAD4 antibodies in the pathogenesis of rheumatoid arthritis.
bit.ly
May 6, 2025 at 12:31 PM
cp-cellreports.bsky.social
Modular mechanisms of immune priming and growth inhibition mediated by plant effector-triggered immunity
Modular mechanisms of immune priming and growth inhibition mediated by plant effector-triggered immunity
Chhillar et al. explore effector-triggered immunity (ETI) in plants, highlighting the distinct roles of EDS1 signaling modules. PAD4-ADR1 regulates immune priming and growth inhibition, while SAG101-NRG1 mediates cell death. Their findings offer…
dlvr.it
March 10, 2025 at 7:51 PM
biorxiv-plants.bsky.social
Immune regulators EDS1 and PAD4 constrain ADR1-dependent disease resistance in rice https://www.biorxiv.org/content/10.1101/2024.04.08.588512v1
Immune regulators EDS1 and PAD4 constrain ADR1-dependent disease resistance in rice https://www.biorxiv.org/content/10.1101/2024.04.08.588512v1
Arabidopsis basal immunity depends on cooperation between EDS1-PAD4 dimers and ADR1-family helper NL
www.biorxiv.org
April 8, 2024 at 10:02 PM
biorxivpreprint.bsky.social
Cellular consequences, citrullination substrates, and antigenicity resulting from wild-type and targeted PAD4 on cell surfaces https://www.biorxiv.org/content/10.64898/2026.01.05.696859v1
January 6, 2026 at 6:48 PM