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September 20, 2026 at 4:36 AM
Nuevo Video
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Ya Resubi Mis Videos - Loquendo
Pensaban que no iba a subir nada chingó papa
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PAK4 phosphorylates YAP at T428, promoting its stabilization, nuclear accumulation and transcriptional activity to drive #HepaticStellateCell activation, while genetic or pharmacological PAK4 inhibition attenuates #LiverFibrosis.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
September 15, 2026 at 12:45 PM
PAK4 phosphorylates YAP at T428, promoting its stabilization, nuclear accumulation and transcriptional activity to drive #HepaticStellateCell activation, while genetic or pharmacological PAK4 inhibition attenuates #LiverFibrosis.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
PAK4: A vanguard of epithelial vertex remodeling. Raghavan Thiagarajan @raghavan-thiaga.bsky.social and Jakub Sedzinski @kuba-sedzinski.bsky.social @ucph.bsky.social discuss new work by @babliadhikary.bsky.social et al. (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...
August 24, 2026 at 1:45 PM
PAK4: A vanguard of epithelial vertex remodeling. Raghavan Thiagarajan @raghavan-thiaga.bsky.social and Jakub Sedzinski @kuba-sedzinski.bsky.social @ucph.bsky.social discuss new work by @babliadhikary.bsky.social et al. (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...
Really lovely work. The complementary stories in the @jcb.org from the Higashi + Miller labs and the Yu lab come together to create an even clearer and more interesting story
rupress.org/jcb/article/...
rupress.org/jcb/article/...
PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function
Adhikary et al. show that PAK4 drives dynamic vertex remodeling in cells and embryos through spatiotemporal regulation of myosin II. Inhibition of PAK4 dis
rupress.org
August 20, 2026 at 5:42 PM
Really lovely work. The complementary stories in the @jcb.org from the Higashi + Miller labs and the Yu lab come together to create an even clearer and more interesting story
rupress.org/jcb/article/...
rupress.org/jcb/article/...
Thanks @raghavan-thiaga.bsky.social and @kuba-sedzinski.bsky.social for writing the beautiful spotlight article on our PAK4 study.
Spotlight: @babliadhikary.bsky.social et al. (rupress.org/jcb/article/...) describe the role of PAK4 in vertex remodeling, thereby maintaining epithelial integrity and barrier function. @raghavan-thiaga.bsky.social and @kuba-sedzinski.bsky.social discuss the study: rupress.org/jcb/article/...
August 17, 2026 at 6:18 PM
Thanks @raghavan-thiaga.bsky.social and @kuba-sedzinski.bsky.social for writing the beautiful spotlight article on our PAK4 study.
Spotlight @jcb.org: @babliadhikary.bsky.social et al. (rupress.org/jcb/article/...) describe the role of PAK4 in vertex remodeling, thereby maintaining epithelial integrity & barrier function. @raghavan-thiaga.bsky.social and @kuba-sedzinski.bsky.social discuss the study: rupress.org/jcb/article/...
August 17, 2026 at 6:00 PM
Spotlight @jcb.org: @babliadhikary.bsky.social et al. (rupress.org/jcb/article/...) describe the role of PAK4 in vertex remodeling, thereby maintaining epithelial integrity & barrier function. @raghavan-thiaga.bsky.social and @kuba-sedzinski.bsky.social discuss the study: rupress.org/jcb/article/...
Spotlight: @babliadhikary.bsky.social et al. (rupress.org/jcb/article/...) describe the role of PAK4 in vertex remodeling, thereby maintaining epithelial integrity and barrier function. @raghavan-thiaga.bsky.social and @kuba-sedzinski.bsky.social discuss the study: rupress.org/jcb/article/...
August 17, 2026 at 6:00 PM
Spotlight: @babliadhikary.bsky.social et al. (rupress.org/jcb/article/...) describe the role of PAK4 in vertex remodeling, thereby maintaining epithelial integrity and barrier function. @raghavan-thiaga.bsky.social and @kuba-sedzinski.bsky.social discuss the study: rupress.org/jcb/article/...
PAK4 promotes hepatic stellate cell activation by phosphorylating YAP at T428, driving #LiverFibrosis, while PAK4 inhibition attenuates fibrosis, highlighting it as a promising #TherapeuticTarget for #ChronicLiverDisease.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
August 5, 2026 at 3:45 PM
PAK4 promotes hepatic stellate cell activation by phosphorylating YAP at T428, driving #LiverFibrosis, while PAK4 inhibition attenuates fibrosis, highlighting it as a promising #TherapeuticTarget for #ChronicLiverDisease.
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
The authors included RRIDs in their in Biomedicines paper! RRIDs improve reproducibility in scientific research. #methodsmatter #accelerateopenscience #RRID
Phosphoproteomic Profiling Identifies PAK4 S474 Phosphorylation Affects Docetaxel Chemosensitivity via Modulation of Microtubule Stabilization in Breast Cancer
Read the full paper: Phosphoproteomic Profiling Identifies PAK4 S474 Phosphorylation Affects Docetaxel Chemosensitivity via Modulation of Microtubule Stabilization in Breast Cancer
doi.org
July 31, 2026 at 7:02 AM
The authors included RRIDs in their in Biomedicines paper! RRIDs improve reproducibility in scientific research. #methodsmatter #accelerateopenscience #RRID
PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function. New study from Babli Adhikary @babliadhikary.bsky.social @umich.edu, Tomohito Higashi (Fukushima Medical University) and colleagues:
rupress.org/jcb/article/...
#Cytoskeleton #Adhesion #Physiology
rupress.org/jcb/article/...
#Cytoskeleton #Adhesion #Physiology
July 27, 2026 at 1:45 PM
PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function. New study from Babli Adhikary @babliadhikary.bsky.social @umich.edu, Tomohito Higashi (Fukushima Medical University) and colleagues:
rupress.org/jcb/article/...
#Cytoskeleton #Adhesion #Physiology
rupress.org/jcb/article/...
#Cytoskeleton #Adhesion #Physiology
Science Briefing
PAK4 and Afadin Cooperate to Maintain Epithelial Integrity via Vertex Remodeling Personalized briefing Discovery of the day · Cell Biology PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function Dear Abdel Halim Harrath, this is your personalized…
PAK4 and Afadin Cooperate to Maintain Epithelial Integrity via Vertex Remodeling Personalized briefing Discovery of the day · Cell Biology PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function Dear Abdel Halim Harrath, this is your personalized…
Science Briefing
PAK4 and Afadin Cooperate to Maintain Epithelial Integrity via Vertex Remodeling Personalized briefing Discovery of the day · Cell Biology PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function Dear Abdel Halim Harrath, this is your personalized scientific intelligence briefing — curated for your work in Cell Biology. Key finding Biology · Cell Biology Discovery of the day…
blog.sciencebriefing.com
July 23, 2026 at 11:04 AM
Science Briefing
PAK4 and Afadin Cooperate to Maintain Epithelial Integrity via Vertex Remodeling Personalized briefing Discovery of the day · Cell Biology PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function Dear Abdel Halim Harrath, this is your personalized…
PAK4 and Afadin Cooperate to Maintain Epithelial Integrity via Vertex Remodeling Personalized briefing Discovery of the day · Cell Biology PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function Dear Abdel Halim Harrath, this is your personalized…
PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function
rupress.org/jcb/article-...
rupress.org/jcb/article-...
PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function
Adhikary et al. show that PAK4 drives dynamic vertex remodeling in cells and embryos through spatiotemporal regulation of myosin II. Inhibition of PAK4 dis
rupress.org
July 21, 2026 at 11:27 AM
PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function
rupress.org/jcb/article-...
rupress.org/jcb/article-...
A wonderful collaboration between Tomo Higashi and Ann Miller's labs about how the kinase PAK4 regulates cell junction remodeling to allow cell rearrrangment 🧪
@babliadhikary.bsky.social, Higashi et al. show that PAK4 drives dynamic vertex remodeling in cells and embryos through spatiotemporal regulation of #myosin II. Inhibition of PAK4 disrupts tissue packing and compromises junctional continuity and barrier function. rupress.org/jcb/article/...
July 20, 2026 at 11:00 PM
A wonderful collaboration between Tomo Higashi and Ann Miller's labs about how the kinase PAK4 regulates cell junction remodeling to allow cell rearrrangment 🧪
4. PAK4-deficient cells exhibited abnormal accumulation of junctional Myosin II, likely due to reduced myosin phosphatase activity.
These findings indicate that PAK4 and Afadin cooperate to maintain epithelial integrity and barrier function by promoting vertex remodeling.
These findings indicate that PAK4 and Afadin cooperate to maintain epithelial integrity and barrier function by promoting vertex remodeling.
July 20, 2026 at 10:28 PM
4. PAK4-deficient cells exhibited abnormal accumulation of junctional Myosin II, likely due to reduced myosin phosphatase activity.
These findings indicate that PAK4 and Afadin cooperate to maintain epithelial integrity and barrier function by promoting vertex remodeling.
These findings indicate that PAK4 and Afadin cooperate to maintain epithelial integrity and barrier function by promoting vertex remodeling.
3. Inhibition or knockout of PAK4 increased the number of higher-order vertices, caused junctional discontinuities, and impaired barrier function.
July 20, 2026 at 10:28 PM
3. Inhibition or knockout of PAK4 increased the number of higher-order vertices, caused junctional discontinuities, and impaired barrier function.
We show:
1. PAK4 accumulates at multicellular vertices in MDCK cells and Xenopus embryos.
2. In Xenopus embryos, PAK4 showed dynamic accumulation at remodeling vertices.
1. PAK4 accumulates at multicellular vertices in MDCK cells and Xenopus embryos.
2. In Xenopus embryos, PAK4 showed dynamic accumulation at remodeling vertices.
July 20, 2026 at 10:28 PM
We show:
1. PAK4 accumulates at multicellular vertices in MDCK cells and Xenopus embryos.
2. In Xenopus embryos, PAK4 showed dynamic accumulation at remodeling vertices.
1. PAK4 accumulates at multicellular vertices in MDCK cells and Xenopus embryos.
2. In Xenopus embryos, PAK4 showed dynamic accumulation at remodeling vertices.
Thrilled to share my first publication from my PhD is now out in Journal of Cell Biology!!!! 😇 💖 Have you ever wondered how multicellular vertices are maintained and remodeled in an epithelia? 💭 Here, we investigate the role of junctional kinase PAK4 in vertex maintenance and remodeling!
@babliadhikary.bsky.social, Higashi et al. show that PAK4 drives dynamic vertex remodeling in cells and embryos through spatiotemporal regulation of #myosin II. Inhibition of PAK4 disrupts tissue packing and compromises junctional continuity and barrier function. rupress.org/jcb/article/...
July 20, 2026 at 10:28 PM
Thrilled to share my first publication from my PhD is now out in Journal of Cell Biology!!!! 😇 💖 Have you ever wondered how multicellular vertices are maintained and remodeled in an epithelia? 💭 Here, we investigate the role of junctional kinase PAK4 in vertex maintenance and remodeling!
@babliadhikary.bsky.social, Higashi et al. show that PAK4 drives dynamic vertex remodeling in cells and embryos through spatiotemporal regulation of #myosin II. Inhibition of PAK4 disrupts tissue packing and compromises junctional continuity and barrier function. rupress.org/jcb/article/...
July 20, 2026 at 4:01 PM
@babliadhikary.bsky.social, Higashi et al. show that PAK4 drives dynamic vertex remodeling in cells and embryos through spatiotemporal regulation of #myosin II. Inhibition of PAK4 disrupts tissue packing and compromises junctional continuity and barrier function. rupress.org/jcb/article/...
In @jcb.org, @babliadhikary.bsky.social et al. show that PAK4 drives dynamic vertex remodeling in cells and embryos through spatiotemporal regulation of #myosin II. Inhibition of PAK4 disrupts tissue packing and compromises junctional continuity and barrier function. rupress.org/jcb/article/...
July 20, 2026 at 4:01 PM
In @jcb.org, @babliadhikary.bsky.social et al. show that PAK4 drives dynamic vertex remodeling in cells and embryos through spatiotemporal regulation of #myosin II. Inhibition of PAK4 disrupts tissue packing and compromises junctional continuity and barrier function. rupress.org/jcb/article/...
The authors included RRIDs in their in Communications Biology paper! RRIDs improve reproducibility in scientific research. #OpenScience #reproducibility #accelerateopenscience
Targeting PAK4 promotes Gemcitabine-induced pyroptosis in pancreatic cancer via NLRP1/caspase-3/GSDME axis - Communications Biology
PAK4 promotes Mdm2-mediated NLRP1 ubiquitination and degradation by phosphorylating Mdm2 at Ser186, thereby suppressing GEM-induced pyroptosis via the NLRP1/caspase-9/caspase-3/GSDME axis in pancreatic cancer cells
doi.org
May 28, 2026 at 7:04 AM
The authors included RRIDs in their in Communications Biology paper! RRIDs improve reproducibility in scientific research. #OpenScience #reproducibility #accelerateopenscience
Senescence-Driven Remodeling Defines an Aggressive and Immunomodulatory Subtype of Endometriosis
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Senescence‐Driven Remodeling Defines an Aggressive and Immunomodulatory Subtype of Endometriosis
Senescence in ectopic endometrial cells promotes SASP-mediated M2 macrophage polarization and enhanced invasiveness of endometriotic lesions. PAK4 drives this process via PI3K/AKT signaling, while st....
onlinelibrary.wiley.com
March 29, 2026 at 11:11 PM
Senescence-Driven Remodeling Defines an Aggressive and Immunomodulatory Subtype of Endometriosis
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Korean universities patent new PAK4 degradation inducers - BioWorld MedTech: Korean universities patent new PAK4 degradation inducers BioWorld MedTech
Korean universities patent new PAK4 degradation inducers - BioWorld MedTech
Korean universities patent new PAK4 degradation inducers BioWorld MedTech
www.bioworld.com
January 21, 2026 at 6:59 PM
Korean universities patent new PAK4 degradation inducers - BioWorld MedTech: Korean universities patent new PAK4 degradation inducers BioWorld MedTech
