Why are so many proteins hyper-phosphorylated during mitosis?
Well, extensive phosphorylation renders individual proteins more soluble & disrupts protein-protein interactions.
So global hyper-phosphorylation may 𝐟𝐥𝐮𝐢𝐝𝐢𝐳𝐞 the cytoplasm - to mechanically aide the process of cell division.
Well, extensive phosphorylation renders individual proteins more soluble & disrupts protein-protein interactions.
So global hyper-phosphorylation may 𝐟𝐥𝐮𝐢𝐝𝐢𝐳𝐞 the cytoplasm - to mechanically aide the process of cell division.
December 2, 2024 at 7:58 PM
Why are so many proteins hyper-phosphorylated during mitosis?
Well, extensive phosphorylation renders individual proteins more soluble & disrupts protein-protein interactions.
So global hyper-phosphorylation may 𝐟𝐥𝐮𝐢𝐝𝐢𝐳𝐞 the cytoplasm - to mechanically aide the process of cell division.
Well, extensive phosphorylation renders individual proteins more soluble & disrupts protein-protein interactions.
So global hyper-phosphorylation may 𝐟𝐥𝐮𝐢𝐝𝐢𝐳𝐞 the cytoplasm - to mechanically aide the process of cell division.
1/5 How much phosphorylation can a single kinase deposit? In our new study with @typaslab.bsky.social out in @nature.com, phage T7's kinase (T7K) modifies almost all the E. coli proteome + more densely than all ~500 kinases do our own proteomes 🤯 www.nature.com/articles/s41...
Pervasive phosphorylation by phage T7 kinase disarms bacterial defences - Nature
The T7 bacteriophage deactivates bacterial defence systems through T7K phosphorylation of nearly all host and phage proteins during infection.
www.nature.com
August 20, 2026 at 5:15 AM
1/5 How much phosphorylation can a single kinase deposit? In our new study with @typaslab.bsky.social out in @nature.com, phage T7's kinase (T7K) modifies almost all the E. coli proteome + more densely than all ~500 kinases do our own proteomes 🤯 www.nature.com/articles/s41...
Researchers have constructed a map of how light remodels patterns in a process called phosphorylation in the eye of the fruit fly, illuminating the core #biochemistry that enables these flies to adapt to oscillating light and dim conditions. #ScienceSignaling https://scim.ag/4jmYN5a
Light-induced remodeling of the Drosophila phosphoproteome regulates visual adaptation through the Trp channel
A phosphorylation site in Trp is identified that enables Drosophila to respond to oscillating light.
scim.ag
October 2, 2026 at 3:00 PM
Researchers have constructed a map of how light remodels patterns in a process called phosphorylation in the eye of the fruit fly, illuminating the core #biochemistry that enables these flies to adapt to oscillating light and dim conditions. #ScienceSignaling https://scim.ag/4jmYN5a
Hot off the press! Our paper, “Global comparative structural analysis of responses to protein phosphorylation”, is now out in Nature Communications!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Global comparative structural analysis of responses to protein phosphorylation - Nature Communications
Phosphorylation is central to protein regulation, yet its structural mechanisms remain poorly understood. Here, the authors conduct a global, systematic analysis of phosphorylated versus non-phosphory...
www.nature.com
October 27, 2025 at 10:29 AM
Hot off the press! Our paper, “Global comparative structural analysis of responses to protein phosphorylation”, is now out in Nature Communications!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
We wrote a thing or two on Oxidative Phosphorylation in Uncoupled Mitochondria 🔥 onlinelibrary.wiley.com/doi/10.1002/...
Oxidative Phosphorylation in Uncoupled Mitochondria
Brown adipose tissue (BAT) mediates non-shivering thermogenesis (NST) through activation of uncoupling protein 1 (UCP1). Due to the uncoupled nature of BAT, oxidative phosphorylation is an underappre....
onlinelibrary.wiley.com
July 7, 2025 at 7:30 AM
We wrote a thing or two on Oxidative Phosphorylation in Uncoupled Mitochondria 🔥 onlinelibrary.wiley.com/doi/10.1002/...
Now online! Salicylic acid engages central metabolic regulators SnRK1 and TOR to govern immunity by differential phosphorylation of NPR1
Salicylic acid engages central metabolic regulators SnRK1 and TOR to govern immunity by differential phosphorylation of NPR1
The immune signal SA triggers metabolic changes to activate SnRK1 while inhibiting TOR. These central metabolic kinases antagonistically phosphorylate the key immune regulator NPR1, thereby coupling cellular metabolic state to systemic acquired resistance.
dlvr.it
September 30, 2026 at 2:59 PM
Now online! Salicylic acid engages central metabolic regulators SnRK1 and TOR to govern immunity by differential phosphorylation of NPR1
🚨NEW PUBLICATION ALERT🚨: In a paper out now in
@science.org we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/....
@science.org we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/....
Engineering synthetic phosphorylation signaling networks in human cells
Protein phosphorylation signaling networks have a central role in how cells sense and respond to their environment. We engineered artificial phosphorylation networks in which reversible enzymatic phos...
science.org
January 7, 2025 at 8:24 AM
🚨NEW PUBLICATION ALERT🚨: In a paper out now in
@science.org we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/....
@science.org we describe a way to build synthetic phosphorylation circuits with customizable sense-and-response functions in human cells. Check it out at science.org/doi/10.1126/....
Is phosphorylation broadly relevant to mitochondrial protein function? In work led by @aj-smith.bsky.social, we silenced 10 mito phosphatases, mapped dynamic sites, and revealed functional implications for import, catalysis, and morphology.
www.biorxiv.org/content/10.6...
# Mitochondria
#HHMINews
www.biorxiv.org/content/10.6...
# Mitochondria
#HHMINews
Dynamic protein phosphorylation shapes mitochondrial catalysis, import, and architecture
Phosphorylation is a pervasive mitochondrial protein post-translational modification, yet the extent of its influence over mitochondrial functions remains unclear. To identify dynamic mitochondrial ph...
www.biorxiv.org
September 29, 2026 at 4:22 PM
Is phosphorylation broadly relevant to mitochondrial protein function? In work led by @aj-smith.bsky.social, we silenced 10 mito phosphatases, mapped dynamic sites, and revealed functional implications for import, catalysis, and morphology.
www.biorxiv.org/content/10.6...
# Mitochondria
#HHMINews
www.biorxiv.org/content/10.6...
# Mitochondria
#HHMINews
This suggests the brain regained its ability to clear toxic proteins. Tau phosphorylation, a damaging chemical change, also declined. The blood-brain barrier, which normally shields the brain from harmful substances, showed clear repair. Structural gaps closed. Leaky blood proteins stopped entering
December 28, 2025 at 5:09 PM
This suggests the brain regained its ability to clear toxic proteins. Tau phosphorylation, a damaging chemical change, also declined. The blood-brain barrier, which normally shields the brain from harmful substances, showed clear repair. Structural gaps closed. Leaky blood proteins stopped entering
Pro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation | EMBO reports
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Pro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation | EMBO reports
imageimageA reduction in oxidation phosphorylation is considered to be a hallmark of pro-inflammatory
macrophage polarization. This study shows that respiratory inhibition is not required
for macropha...
www.embopress.org
January 6, 2025 at 3:58 PM
Pro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation | EMBO reports
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Pervasive phosphorylation by phage T7 kinase disarms bacterial defenses https://www.biorxiv.org/content/10.1101/2024.12.20.629319v1
December 21, 2024 at 7:16 AM
Pervasive phosphorylation by phage T7 kinase disarms bacterial defenses https://www.biorxiv.org/content/10.1101/2024.12.20.629319v1
Aaand... my first cover!!
RpS6 phosphorylation (magenta) in a Udd (ribosome biogenesis factor) mutant ovary 🔬
RpS6 phosphorylation (magenta) in a Udd (ribosome biogenesis factor) mutant ovary 🔬
December 10, 2025 at 9:35 PM
Aaand... my first cover!!
RpS6 phosphorylation (magenta) in a Udd (ribosome biogenesis factor) mutant ovary 🔬
RpS6 phosphorylation (magenta) in a Udd (ribosome biogenesis factor) mutant ovary 🔬
A biochemical analysis in #ScienceSignaling examines how a family of enzymes called atypical protein kinase Cs can have opposing effects on the growth of tumor cells—answering a persistent question in the study of #cancer biology. https://scim.ag/4dCF2ms
S1P mimics phosphorylation to mediate PDK1-independent activation of aPKC with an opposing downstream effect
A bioactive lipid activates aPKC like phosphorylation does but switches the effect of aPKC on apoptosis.
scim.ag
September 30, 2026 at 3:00 PM
A biochemical analysis in #ScienceSignaling examines how a family of enzymes called atypical protein kinase Cs can have opposing effects on the growth of tumor cells—answering a persistent question in the study of #cancer biology. https://scim.ag/4dCF2ms
neurons, but when it undergoes a process called phosphorylation, it deforms and is ejected from neurons into the extracellular space, creating the tangles that are characteristic of Alzheimer’s and other neurodegenerative diseases. In their recent study published in Alzheimer’s & Dementia: The
May 5, 2025 at 4:04 PM
neurons, but when it undergoes a process called phosphorylation, it deforms and is ejected from neurons into the extracellular space, creating the tangles that are characteristic of Alzheimer’s and other neurodegenerative diseases. In their recent study published in Alzheimer’s & Dementia: The
Excited to share our paper with @savitski-lab.bsky.social, led by @tarabartolec.bsky.social, Karin Mitosch & Clément Potel, out now in @nature.com.
We show that T7 phage broadly disables bacterial defenses using a unique ‘loose cannon’ protein kinase.
www.nature.com/articles/s41...
We show that T7 phage broadly disables bacterial defenses using a unique ‘loose cannon’ protein kinase.
www.nature.com/articles/s41...
August 20, 2026 at 7:48 AM
Excited to share our paper with @savitski-lab.bsky.social, led by @tarabartolec.bsky.social, Karin Mitosch & Clément Potel, out now in @nature.com.
We show that T7 phage broadly disables bacterial defenses using a unique ‘loose cannon’ protein kinase.
www.nature.com/articles/s41...
We show that T7 phage broadly disables bacterial defenses using a unique ‘loose cannon’ protein kinase.
www.nature.com/articles/s41...
Pervasive phosphorylation by phage T7 kinase disarms bacterial defences www.nature.com/articles/s41...
Pervasive phosphorylation by phage T7 kinase disarms bacterial defences - Nature
The T7 bacteriophage deactivates bacterial defence systems through T7K phosphorylation of nearly all host and phage proteins during infection.
www.nature.com
August 19, 2026 at 4:03 PM
Pervasive phosphorylation by phage T7 kinase disarms bacterial defences www.nature.com/articles/s41...
Our paper on the strange ATP-dependent chromatin remodeler Smarcad1 paper is out and freely accessible. Differential regulation of its many activities by phosphorylation. Congrats to Briana and @nhoitsma.bsky.social 🧪https://www.sciencedirect.com/science/article/pii/S0021925824023950?via%3Dihub
Phosphorylation regulates the chromatin remodeler SMARCAD1 in nucleosome binding, ATP hydrolysis, and histone exchange
Maintaining the dynamic structure of chromatin is critical for regulating the cellular processes that require access to the DNA template, such as DNA …
www.sciencedirect.com
November 18, 2024 at 8:48 PM
Our paper on the strange ATP-dependent chromatin remodeler Smarcad1 paper is out and freely accessible. Differential regulation of its many activities by phosphorylation. Congrats to Briana and @nhoitsma.bsky.social 🧪https://www.sciencedirect.com/science/article/pii/S0021925824023950?via%3Dihub
An atlas of protein phosphorylation dynamics during interferon signaling @benhale.bsky.social
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
March 27, 2025 at 3:39 AM
An atlas of protein phosphorylation dynamics during interferon signaling @benhale.bsky.social
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Nature research paper: Pervasive phosphorylation by phage T7 kinase disarms bacterial defences
go.nature.com/4qvUWnZ
go.nature.com/4qvUWnZ
Pervasive phosphorylation by phage T7 kinase disarms bacterial defences - Nature
The T7 bacteriophage deactivates bacterial defence systems through T7K phosphorylation of nearly all host and phage proteins during infection.
go.nature.com
August 21, 2026 at 7:28 AM
Nature research paper: Pervasive phosphorylation by phage T7 kinase disarms bacterial defences
go.nature.com/4qvUWnZ
go.nature.com/4qvUWnZ
JrCDPK13L-mediated phosphorylation of JrERF113L promotes walnut resistance to Colletotrichum gloeosporioides (Haiyi Yu , Yuhui Dong , Kun Zhang , Jing Zhao , et al) doi.org/10.1093/plph... #PlantScience @aspbofficial
JrCDPK13L-mediated phosphorylation of JrERF113L promotes walnut resistance to Colletotrichum gloeosporioides
Abstract. Walnut anthracnose caused by Colletotrichum gloeosporioides poses a serious threat to the walnut industry. Calcium-dependent protein kinases (CDP
doi.org
October 3, 2026 at 2:12 PM
JrCDPK13L-mediated phosphorylation of JrERF113L promotes walnut resistance to Colletotrichum gloeosporioides (Haiyi Yu , Yuhui Dong , Kun Zhang , Jing Zhao , et al) doi.org/10.1093/plph... #PlantScience @aspbofficial
65 years after Peter Mitchell’s chemiosmotic theory, we report an association between ATP synthase and the electron transport chain. In the preprint led by @longzhou88.bsky.social, we describe a large supercomplex and show how the supramolecular organization contribute to oxidative phosphorylation 🧵
A Supercomplex Incorporating Both Electron Transport Chain and ATP Synthase
The mitochondrial oxidative phosphorylation system powering most aerobic organisms is typically depicted as two spatially segregated machineries(1): electron transport chain complexes I-IV (ETC CI-CIV
langtaosha.org.cn
April 7, 2026 at 6:38 AM
65 years after Peter Mitchell’s chemiosmotic theory, we report an association between ATP synthase and the electron transport chain. In the preprint led by @longzhou88.bsky.social, we describe a large supercomplex and show how the supramolecular organization contribute to oxidative phosphorylation 🧵
I am incredibly proud to share that my work has officially been published in Cell! @cp-cell.bsky.social
This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and Dan Jarosz labs @stanfordmedicine.bsky.social
www.cell.com/cell/fulltex...
This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and Dan Jarosz labs @stanfordmedicine.bsky.social
www.cell.com/cell/fulltex...
DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation
DNA binding and phosphorylation protect FOXP2, a transcription factor with the longest
polyQ track in the proteome, from aggregation during interphase and mitosis. Harnessing
these native solubility-p...
www.cell.com
April 21, 2025 at 12:01 PM
I am incredibly proud to share that my work has officially been published in Cell! @cp-cell.bsky.social
This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and Dan Jarosz labs @stanfordmedicine.bsky.social
www.cell.com/cell/fulltex...
This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and Dan Jarosz labs @stanfordmedicine.bsky.social
www.cell.com/cell/fulltex...