March 7, 2026 at 7:06 PM
July 14, 2025 at 7:04 PM
September 18, 2025 at 5:49 AM
New paper from the lab: feedback from piriform cortex to the olfactory bulb carries identity and reward contingency signals in a multimodal (odor and sound) rule-reversal task. Feedback is re-formatted within seconds and reflects changes in the perceived rules of engagement.
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal - Nature Communications
Hernandez-Trejo, Ciuparu, and Garcia da Silva et al. report that the piriform-to-olfactory bulb feedback in the mouse carries multimodal identity and reward contingency signals, which are re-formatted...
doi.org
January 23, 2025 at 11:27 AM
New paper from the lab: feedback from piriform cortex to the olfactory bulb carries identity and reward contingency signals in a multimodal (odor and sound) rule-reversal task. Feedback is re-formatted within seconds and reflects changes in the perceived rules of engagement.
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Very proud of this paper, which spans three decades of work. (1/17) onlinelibrary.wiley.com/doi/10.1111/...
Piriform cortex is an ictogenic trigger zone in the primate brain
Objective Area tempestas, a functionally defined region in the anterior piriform cortex, was identified as a crucial ictogenic trigger zone in the rat brain in the 1980s. However, whether the primat...
onlinelibrary.wiley.com
March 22, 2025 at 3:04 PM
Very proud of this paper, which spans three decades of work. (1/17) onlinelibrary.wiley.com/doi/10.1111/...
“As the amygdala, putamen and piriform cortex (all involved in olfactory function and emotional well-being) showed associations with depression and anxiety scores, we hypothesise that post-COVID olfactory dysfunction and depression and anxiety are interrelated”
October 30, 2025 at 11:12 AM
“As the amygdala, putamen and piriform cortex (all involved in olfactory function and emotional well-being) showed associations with depression and anxiety scores, we hypothesise that post-COVID olfactory dysfunction and depression and anxiety are interrelated”
In my own observations under the microscope, I have seen similar findings of white matter abnormalities consistent with myelin degradation following #COVID infection. These changes also appear to be associated with an increased local neuroinflammatory response. (2/2)
#LongCovid #NeuroCovid
#LongCovid #NeuroCovid
May 27, 2026 at 10:31 AM
In my own observations under the microscope, I have seen similar findings of white matter abnormalities consistent with myelin degradation following #COVID infection. These changes also appear to be associated with an increased local neuroinflammatory response. (2/2)
#LongCovid #NeuroCovid
#LongCovid #NeuroCovid
thinking about piriform and how it essentially got reduced to just "ccleaner"
also thinking of how staples of cnet of yore all got absorbed by gen digital
avast antivirus, ccleaner (the entirety of piriform), tuneup utilities (via AVG [via Avast])
also thinking of how staples of cnet of yore all got absorbed by gen digital
avast antivirus, ccleaner (the entirety of piriform), tuneup utilities (via AVG [via Avast])
September 13, 2026 at 2:31 AM
thinking about piriform and how it essentially got reduced to just "ccleaner"
also thinking of how staples of cnet of yore all got absorbed by gen digital
avast antivirus, ccleaner (the entirety of piriform), tuneup utilities (via AVG [via Avast])
also thinking of how staples of cnet of yore all got absorbed by gen digital
avast antivirus, ccleaner (the entirety of piriform), tuneup utilities (via AVG [via Avast])
Recruitment of grid-like responses in human entorhinal and piriform cortices by odor landmark-based navigation
www.cell.com/current-biol...
www.cell.com/current-biol...
www.cell.com
September 28, 2023 at 10:12 PM
Recruitment of grid-like responses in human entorhinal and piriform cortices by odor landmark-based navigation
www.cell.com/current-biol...
www.cell.com/current-biol...
I miss the old NT3.1 defrag. I know that's chkdsk, but still the visual defragger was fun. It's what made me get that defrag program from piriform before they discontinued it. Now there's no need with SSDs. How the younger generations will suffer.
January 7, 2025 at 1:25 AM
I miss the old NT3.1 defrag. I know that's chkdsk, but still the visual defragger was fun. It's what made me get that defrag program from piriform before they discontinued it. Now there's no need with SSDs. How the younger generations will suffer.
We help infants breathe again. There are many rare conditions affecting the nose of a newborn: piriform aperture stenosis, nasolacrimal cyst, inferior turbinate hypertrophy, choanal atresia, cleft lip/palate/face, arhinia, adenoid hypertrophy, tumours & neoplasm, etc. 1/2
December 13, 2024 at 12:35 PM
We help infants breathe again. There are many rare conditions affecting the nose of a newborn: piriform aperture stenosis, nasolacrimal cyst, inferior turbinate hypertrophy, choanal atresia, cleft lip/palate/face, arhinia, adenoid hypertrophy, tumours & neoplasm, etc. 1/2
Differential encoding of social identity, valence and unfamiliarity in the amygdala and piriform cortex https://www.biorxiv.org/content/10.1101/2025.07.04.663165v1
July 6, 2025 at 12:15 AM
Differential encoding of social identity, valence and unfamiliarity in the amygdala and piriform cortex https://www.biorxiv.org/content/10.1101/2025.07.04.663165v1
We first identified anatomically a direct projection from the piriform cortex to the auditory cortex. (2/5)
December 13, 2024 at 1:34 PM
We first identified anatomically a direct projection from the piriform cortex to the auditory cortex. (2/5)
#Epilepsy is thought to develop via pathological connections involving widespread #brain regions. James Niemeyer explores a @plosbiology.org study showing how these connections are formed, and how this interconnectivity can serve as treatment target 🧪 Paper: plos.io/4cqSfij Primer: plos.io/4aBtqhq
February 16, 2026 at 5:25 PM
#Epilepsy is thought to develop via pathological connections involving widespread #brain regions. James Niemeyer explores a @plosbiology.org study showing how these connections are formed, and how this interconnectivity can serve as treatment target 🧪 Paper: plos.io/4cqSfij Primer: plos.io/4aBtqhq
#Epilepsy is thought to develop via pathological connections involving widespread #brain regions. James Niemeyer explores a @plosbiology.org study showing how these connections are formed, and how this interconnectivity can serve as treatment target 🧪 Paper: plos.io/4cqSfij Primer: plos.io/4aBtqhq
February 16, 2026 at 10:06 AM
#Epilepsy is thought to develop via pathological connections involving widespread #brain regions. James Niemeyer explores a @plosbiology.org study showing how these connections are formed, and how this interconnectivity can serve as treatment target 🧪 Paper: plos.io/4cqSfij Primer: plos.io/4aBtqhq
Me: Draw a brain with the olfactory bulb and piriform cortex marked.
ChatGpt: The illustration of the human brain with the olfactory bulb and piriform cortex marked is now available.
Me: Yeah, it seems pretty reasonable. Thanks!
ChatGpt: The illustration of the human brain with the olfactory bulb and piriform cortex marked is now available.
Me: Yeah, it seems pretty reasonable. Thanks!
February 14, 2024 at 2:20 PM
Me: Draw a brain with the olfactory bulb and piriform cortex marked.
ChatGpt: The illustration of the human brain with the olfactory bulb and piriform cortex marked is now available.
Me: Yeah, it seems pretty reasonable. Thanks!
ChatGpt: The illustration of the human brain with the olfactory bulb and piriform cortex marked is now available.
Me: Yeah, it seems pretty reasonable. Thanks!
Piriform aperture stenosis. When the front door of the nose is super narrow. Here is a coronal section of a one week old infant. The bony opening of the nose in the front of the face is narrow. This can be a life threatening emergency as they are obligate nasal breathers. #ENTsurgery #ENTsecrets
May 4, 2025 at 8:51 PM
Piriform aperture stenosis. When the front door of the nose is super narrow. Here is a coronal section of a one week old infant. The bony opening of the nose in the front of the face is narrow. This can be a life threatening emergency as they are obligate nasal breathers. #ENTsurgery #ENTsecrets
New preprint by Tommaso: olfactory cortex (of zebrafish) represents not only odor information but also temporal context, and these multimodal representations are sharpened after learning. And check out Tommaso's new method for 2P imaging in awake adult zebrafish!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Joint experience-dependent representations of odors and temporal context in the zebrafish homolog of piriform cortex
Intelligent behavior requires experience-dependent internal representations of relevant information. We examined representational learning in telencephalic area pDp of adult zebrafish, the homolog of ...
www.biorxiv.org
September 8, 2026 at 9:55 AM
New preprint by Tommaso: olfactory cortex (of zebrafish) represents not only odor information but also temporal context, and these multimodal representations are sharpened after learning. And check out Tommaso's new method for 2P imaging in awake adult zebrafish!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
and getting crumbs on the seats while the driver bitched halfheartedly.
That scent was Bakugou's, as deeply ingrained into his piriform cortex as his mothers' scents, or his pup's. And, just the way that the scent of either of his moms brought back his childhood, Bakugou's scent brought back
That scent was Bakugou's, as deeply ingrained into his piriform cortex as his mothers' scents, or his pup's. And, just the way that the scent of either of his moms brought back his childhood, Bakugou's scent brought back
July 7, 2026 at 10:02 PM
and getting crumbs on the seats while the driver bitched halfheartedly.
That scent was Bakugou's, as deeply ingrained into his piriform cortex as his mothers' scents, or his pup's. And, just the way that the scent of either of his moms brought back his childhood, Bakugou's scent brought back
That scent was Bakugou's, as deeply ingrained into his piriform cortex as his mothers' scents, or his pup's. And, just the way that the scent of either of his moms brought back his childhood, Bakugou's scent brought back
#Seizures originating from the #PiriformCortex can alter #brain function, but how does this happen? This study in mice shows that the piriform-entorhino-dentate pathway is a key mediator of brain-wide functional reorganization, with therapeutic implications @plosbiology.org 🧪 plos.io/4cqSfij
February 13, 2026 at 5:30 PM
#Seizures originating from the #PiriformCortex can alter #brain function, but how does this happen? This study in mice shows that the piriform-entorhino-dentate pathway is a key mediator of brain-wide functional reorganization, with therapeutic implications @plosbiology.org 🧪 plos.io/4cqSfij
#Seizures originating from the #PiriformCortex can alter #brain function, but how does this happen? This study in mice shows that the piriform-entorhino-dentate pathway is a key mediator of brain-wide functional reorganization, with therapeutic implications @plosbiology.org 🧪 plos.io/4cqSfij
February 13, 2026 at 2:00 PM
#Seizures originating from the #PiriformCortex can alter #brain function, but how does this happen? This study in mice shows that the piriform-entorhino-dentate pathway is a key mediator of brain-wide functional reorganization, with therapeutic implications @plosbiology.org 🧪 plos.io/4cqSfij
Some evidence for grokking in piriform cortex:
arxiv.org/abs/2411.03541
joint effort from Tanishq Kumar, Blake Bordelon, @neurovenki.bsky.social, @cpehlevan.bsky.social.
arxiv.org/abs/2411.03541
joint effort from Tanishq Kumar, Blake Bordelon, @neurovenki.bsky.social, @cpehlevan.bsky.social.
Do Mice Grok? Glimpses of Hidden Progress During Overtraining in Sensory Cortex
Does learning of task-relevant representations stop when behavior stops changing? Motivated by recent theoretical advances in machine learning and the intuitive observation that human experts continue...
arxiv.org
November 8, 2024 at 2:07 PM
Some evidence for grokking in piriform cortex:
arxiv.org/abs/2411.03541
joint effort from Tanishq Kumar, Blake Bordelon, @neurovenki.bsky.social, @cpehlevan.bsky.social.
arxiv.org/abs/2411.03541
joint effort from Tanishq Kumar, Blake Bordelon, @neurovenki.bsky.social, @cpehlevan.bsky.social.
🔊Major Breakthrough
Researchers from @UniklinikBonn @unibonn.bsky.social @rwth.bsky.social reveal how single neurons respond to smells, images & words!
This study in @natureportfolio.bsky.social bridges the gap between animal & human olfactory research!👃
📖 www.nature.com/articles/s41...
Researchers from @UniklinikBonn @unibonn.bsky.social @rwth.bsky.social reveal how single neurons respond to smells, images & words!
This study in @natureportfolio.bsky.social bridges the gap between animal & human olfactory research!👃
📖 www.nature.com/articles/s41...
Single-neuron representations of odours in the human brain - Nature
Human piriform and mediotemporal neurons encode odours, and signal how we perceive, rate and identify scents.
www.nature.com
November 12, 2024 at 10:50 AM
🔊Major Breakthrough
Researchers from @UniklinikBonn @unibonn.bsky.social @rwth.bsky.social reveal how single neurons respond to smells, images & words!
This study in @natureportfolio.bsky.social bridges the gap between animal & human olfactory research!👃
📖 www.nature.com/articles/s41...
Researchers from @UniklinikBonn @unibonn.bsky.social @rwth.bsky.social reveal how single neurons respond to smells, images & words!
This study in @natureportfolio.bsky.social bridges the gap between animal & human olfactory research!👃
📖 www.nature.com/articles/s41...