#Pjirovecii
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science.org
The standard immunosuppressant mycophenolic acid has unknowingly been driving the emergence of resistance mutations in the high-priority fungal pathogen #Pjirovecii for almost 2 decades across outbreaks worldwide, shows a new study in #ScienceTranslationalMedicine. https://scim.ag/3UUR83U
Transmission electron micrograph of a section of human lung alveolus containing Pneumocystis jirovecii.
September 21, 2026 at 6:00 PM
castltrastondrs.medsky.network
Among the opportunistic coinfections reported in #COVID19 patients, #Pjirovecii is one of the most concerning, as it shares similar clinical features with #COVID19 (bilateral multifocal infiltrates & profound #hypoxemia ) may worsen the prognosis & increase the mortality
* Plus–minus values are means ±SD. HIV denotes human immunodeficiency virus, IQR interquartile range, NA not applicable, and SARS-CoV-2 severe acute respiratory syndrome coronavirus 2. † There was a significant (P=0.01) difference in the mean age between patients in the dexamethasone group and those in the usual care group, but there were no significant differences between the groups in any other baseline characteristic. ‡ Among the women, 1 in the dexamethasone group and 3 in the usual care group were pregnant. § Race or ethnic group was recorded in the patient’s electronic health record. ¶ Data regarding the number of days since symptom onset were missing for 4 patients in the dexamethasone group and 13 patients in the usual care group; these patients were excluded from estimates of the median number of days since onset. ‖ Severe liver disease was defined as requiring ongoing specialist care. ** Severe kidney impairment was defined as an estimated glomerular filtration rate of less t
October 17, 2023 at 7:49 PM