December 4, 2024 at 8:05 PM
Humans may be genetically programmed to produce antibodies against peanut, suggests a new #ScienceTranslationalMedicine study showing nonallergic people harbor convergent, germline-encoded antibodies against the allergen Ara h 2.
📄: scim.ag/3ZqVj76
📄: scim.ag/3ZqVj76
June 16, 2025 at 6:06 PM
Humans may be genetically programmed to produce antibodies against peanut, suggests a new #ScienceTranslationalMedicine study showing nonallergic people harbor convergent, germline-encoded antibodies against the allergen Ara h 2.
📄: scim.ag/3ZqVj76
📄: scim.ag/3ZqVj76
A soft, robotic device can autonomously navigate the trachea to support rapid and self-guided intubation outside of hospitals and could expand and democratize intubation for emergency responders and resource-limited environments. #ScienceTranslationalMedicine https://scim.ag/4n0bxxt
September 15, 2025 at 6:00 PM
A soft, robotic device can autonomously navigate the trachea to support rapid and self-guided intubation outside of hospitals and could expand and democratize intubation for emergency responders and resource-limited environments. #ScienceTranslationalMedicine https://scim.ag/4n0bxxt
It’s #norovirus week in #ScienceTranslationalMedicine! Two papers show that we can vaccinate against norovirus in older adults and that vaccines have the potential to be broadly protective. Good news for anyone afraid of norovirus (me!).
www.science.org/toc/stm/curr...
www.science.org/toc/stm/curr...
Contents | Science Translational Medicine 17, 788
www.science.org
March 7, 2025 at 2:26 AM
It’s #norovirus week in #ScienceTranslationalMedicine! Two papers show that we can vaccinate against norovirus in older adults and that vaccines have the potential to be broadly protective. Good news for anyone afraid of norovirus (me!).
www.science.org/toc/stm/curr...
www.science.org/toc/stm/curr...
This week’s new issue of #ScienceTranslationalMedicine has arrived! https://scim.ag/4b1XAvS
December 24, 2025 at 10:00 PM
This week’s new issue of #ScienceTranslationalMedicine has arrived! https://scim.ag/4b1XAvS
Sleep impairment mediated the attention deficits associated with early adversity in human children.
#ScienceTranslationalMedicine
www.science.org/doi/full/10....
#ScienceTranslationalMedicine
www.science.org/doi/full/10....
December 16, 2024 at 6:28 PM
Sleep impairment mediated the attention deficits associated with early adversity in human children.
#ScienceTranslationalMedicine
www.science.org/doi/full/10....
#ScienceTranslationalMedicine
www.science.org/doi/full/10....
A topical combo of the mite-killing compound flavesone and the ovicidal drug abametapir quickly wipes out mites and eggs that cause #scabies with a single dose and cures infections more quickly than ivermectin in pigs. #ScienceTranslationalMedicine https://scim.ag/4yZS0CV
A single-dose topical therapy cures scabies in a human-relevant porcine model
A single-dose topical therapy combining a metalloprotease inhibitor and a β-triketone cures scabies in a porcine model.
scim.ag
October 5, 2026 at 10:33 PM
A topical combo of the mite-killing compound flavesone and the ovicidal drug abametapir quickly wipes out mites and eggs that cause #scabies with a single dose and cures infections more quickly than ivermectin in pigs. #ScienceTranslationalMedicine https://scim.ag/4yZS0CV
A nanobody antivenom cocktail protected mice against death from Indian cobra and king cobra venom, including when delivered up to 20 minutes after envenoming.
Read more in #ScienceTranslationalMedicine: https://scim.ag/4yvByKx
Read more in #ScienceTranslationalMedicine: https://scim.ag/4yvByKx
September 10, 2026 at 3:00 PM
A nanobody antivenom cocktail protected mice against death from Indian cobra and king cobra venom, including when delivered up to 20 minutes after envenoming.
Read more in #ScienceTranslationalMedicine: https://scim.ag/4yvByKx
Read more in #ScienceTranslationalMedicine: https://scim.ag/4yvByKx
An experimental gene therapy for sickle cell disease shows promise in large animals, researchers engineer an antiviral based on mRNA that shields small animals from SARS-CoV-2, and more in the new issue of #ScienceTranslationalMedicine. https://scim.ag/4myX8YA
August 13, 2025 at 9:00 PM
An experimental gene therapy for sickle cell disease shows promise in large animals, researchers engineer an antiviral based on mRNA that shields small animals from SARS-CoV-2, and more in the new issue of #ScienceTranslationalMedicine. https://scim.ag/4myX8YA
Although oxygen is essential for life, an emerging body of work shows controlled hypoxia can be therapeutic for many chronic conditions.
Check out the new #ScienceTranslationalMedicine Review exploring oxygen biology, high-altitude physiology, and more:
Check out the new #ScienceTranslationalMedicine Review exploring oxygen biology, high-altitude physiology, and more:
Hypoxia as a medicine
Although hypoxia is often pathologic, chronic continuous hypoxia has shown promise in many disease models, inspiring a roadmap for clinical translation.
scim.ag
February 8, 2025 at 3:07 PM
Although oxygen is essential for life, an emerging body of work shows controlled hypoxia can be therapeutic for many chronic conditions.
Check out the new #ScienceTranslationalMedicine Review exploring oxygen biology, high-altitude physiology, and more:
Check out the new #ScienceTranslationalMedicine Review exploring oxygen biology, high-altitude physiology, and more:
A 2023 Review in #ScienceTranslationalMedicine looks at the complex connections between astrocytes and other types of cells in the nervous system, including neurons, oligodendrocytes, and microglia.
Learn more: https://scim.ag/40sLCpB #ScienceMagArchives
Learn more: https://scim.ag/40sLCpB #ScienceMagArchives
Neuroinflammation: An astrocyte perspective
The diverse roles of astrocytes and their cell-cell interactions in neurologic diseases offer opportunities for their therapeutic targeting.
scim.ag
January 11, 2025 at 3:07 PM
A 2023 Review in #ScienceTranslationalMedicine looks at the complex connections between astrocytes and other types of cells in the nervous system, including neurons, oligodendrocytes, and microglia.
Learn more: https://scim.ag/40sLCpB #ScienceMagArchives
Learn more: https://scim.ag/40sLCpB #ScienceMagArchives
📢Our new paper is out in
@science.org #ScienceTranslationalMedicine
📢
Diabetic retinopathy (DR) is a leading cause of blindness. Patients show vascular changes in their retinas long before vision starts to deteriorate.
What triggers these early defects? Could targeting them prevent vision loss? 🧵
@science.org #ScienceTranslationalMedicine
📢
Diabetic retinopathy (DR) is a leading cause of blindness. Patients show vascular changes in their retinas long before vision starts to deteriorate.
What triggers these early defects? Could targeting them prevent vision loss? 🧵
October 23, 2025 at 8:14 AM
📢Our new paper is out in
@science.org #ScienceTranslationalMedicine
📢
Diabetic retinopathy (DR) is a leading cause of blindness. Patients show vascular changes in their retinas long before vision starts to deteriorate.
What triggers these early defects? Could targeting them prevent vision loss? 🧵
@science.org #ScienceTranslationalMedicine
📢
Diabetic retinopathy (DR) is a leading cause of blindness. Patients show vascular changes in their retinas long before vision starts to deteriorate.
What triggers these early defects? Could targeting them prevent vision loss? 🧵
Humans may be genetically programmed to produce antibodies against peanut, suggests a recent #ScienceTranslationalMedicine study showing nonallergic people harbor convergent, germline-encoded antibodies against the allergen Ara h 2.
Germline-encoded recognition of peanut underlies development of convergent antibodies in humans
Germline-encoded, epitope-specific antibodies underlie serum IgG recognition of the immunodominant peanut allergen Ara h 2 in humans.
scim.ag
July 12, 2025 at 2:07 PM
Humans may be genetically programmed to produce antibodies against peanut, suggests a recent #ScienceTranslationalMedicine study showing nonallergic people harbor convergent, germline-encoded antibodies against the allergen Ara h 2.
An experimental base editing strategy for #SickleCellDisease achieves high editing efficiency in hematopoietic stem cells (HSCs) from healthy macaques and persists over time after autologous HSC transplant, according to a new study in #ScienceTranslationalMedicine. https://scim.ag/4oCplzC
August 14, 2025 at 3:00 PM
An experimental base editing strategy for #SickleCellDisease achieves high editing efficiency in hematopoietic stem cells (HSCs) from healthy macaques and persists over time after autologous HSC transplant, according to a new study in #ScienceTranslationalMedicine. https://scim.ag/4oCplzC
With tests in mice, researchers identify a new drug candidate delivered as a single, low dose to treat schistosomiasis infection across the parasite’s lifespan.
Learn more in #ScienceTranslationalMedicine: https://scim.ag/4dsJSmk
Learn more in #ScienceTranslationalMedicine: https://scim.ag/4dsJSmk
Transient receptor potential channel activation targets multiple stages of the schistosome parasite
An antihelminthic agent that activates a parasite TRP channel targets multiple schistosome life cycle stages.
scim.ag
October 8, 2026 at 3:00 PM
With tests in mice, researchers identify a new drug candidate delivered as a single, low dose to treat schistosomiasis infection across the parasite’s lifespan.
Learn more in #ScienceTranslationalMedicine: https://scim.ag/4dsJSmk
Learn more in #ScienceTranslationalMedicine: https://scim.ag/4dsJSmk
🎉 Congratulations to Courtney Schreiber, winner of the 2026 BII & #ScienceTranslationalMedicine Prize for Innovations in #WomensHealth for her innovative work in redefining clinical care and testing for women experiencing early pregnancy loss.
Learn more on #WorldHealthDay: https://scim.ag/48tyrYT
Learn more on #WorldHealthDay: https://scim.ag/48tyrYT
April 7, 2026 at 6:01 PM
🎉 Congratulations to Courtney Schreiber, winner of the 2026 BII & #ScienceTranslationalMedicine Prize for Innovations in #WomensHealth for her innovative work in redefining clinical care and testing for women experiencing early pregnancy loss.
Learn more on #WorldHealthDay: https://scim.ag/48tyrYT
Learn more on #WorldHealthDay: https://scim.ag/48tyrYT
This week’s new issue of #ScienceTranslationalMedicine has arrived! scim.ag/3UAiwAH
July 30, 2025 at 9:00 PM
This week’s new issue of #ScienceTranslationalMedicine has arrived! scim.ag/3UAiwAH
An anti-allergy vaccine protects mice from anaphylaxis for as long as one year, mRNA-ferrying nanoparticles treat fatty liver disease in animals and potentiate immunotherapy against liver tumors, and more this week in #ScienceTranslationalMedicine. https://scim.ag/3XxHAdi
December 3, 2025 at 10:12 PM
An anti-allergy vaccine protects mice from anaphylaxis for as long as one year, mRNA-ferrying nanoparticles treat fatty liver disease in animals and potentiate immunotherapy against liver tumors, and more this week in #ScienceTranslationalMedicine. https://scim.ag/3XxHAdi
Scientists trace how inflammatory immune cells from the skull bone marrow can exacerbate chronic traumatic brain injury, a two-pronged topical treatment cures scabies in large animals with a single dose, and more this week in #ScienceTranslationalMedicine. https://scim.ag/4dcEDqH
September 30, 2026 at 9:00 PM
Scientists trace how inflammatory immune cells from the skull bone marrow can exacerbate chronic traumatic brain injury, a two-pronged topical treatment cures scabies in large animals with a single dose, and more this week in #ScienceTranslationalMedicine. https://scim.ag/4dcEDqH
The new issue of #ScienceTranslationalMedicine is out!
Immunity to 2009 pandemic swine fly can protect ferrets from H5N1, a study of children in the Philippines identifies antibodies against dengue that could be a correlate of protection, and more.
scim.ag/4mam2h3
Immunity to 2009 pandemic swine fly can protect ferrets from H5N1, a study of children in the Philippines identifies antibodies against dengue that could be a correlate of protection, and more.
scim.ag/4mam2h3
July 23, 2025 at 9:01 PM
The new issue of #ScienceTranslationalMedicine is out!
Immunity to 2009 pandemic swine fly can protect ferrets from H5N1, a study of children in the Philippines identifies antibodies against dengue that could be a correlate of protection, and more.
scim.ag/4mam2h3
Immunity to 2009 pandemic swine fly can protect ferrets from H5N1, a study of children in the Philippines identifies antibodies against dengue that could be a correlate of protection, and more.
scim.ag/4mam2h3
Searching for an alternative to doxycycline for Lyme disease, researchers screened 500 approved compounds and find piperacillin can kill B. burgdorefi in mice by disrupting peptidoglycan synthesis without impacting the gut microbiome.
Learn more in #ScienceTranslationalMedicine: scim.ag/3S8k0B1
Learn more in #ScienceTranslationalMedicine: scim.ag/3S8k0B1
A high-resolution screen identifies a preexisting beta-lactam that specifically treats Lyme disease in mice
Piperacillin, an FDA-approved beta-lactam, is effective at killing the Lyme disease–causing agent Borrelia burgdorferi.
scim.ag
May 16, 2025 at 7:20 PM
Searching for an alternative to doxycycline for Lyme disease, researchers screened 500 approved compounds and find piperacillin can kill B. burgdorefi in mice by disrupting peptidoglycan synthesis without impacting the gut microbiome.
Learn more in #ScienceTranslationalMedicine: scim.ag/3S8k0B1
Learn more in #ScienceTranslationalMedicine: scim.ag/3S8k0B1
This week's new issue of #ScienceTranslationalMedicine is out now!
A blood-based epigenetic signature could help identify brain insulin resistance in humans, researchers identify a population of T cells that may help maintain immune balance during pregnancy, and more.
scim.ag/45Dileb
A blood-based epigenetic signature could help identify brain insulin resistance in humans, researchers identify a population of T cells that may help maintain immune balance during pregnancy, and more.
scim.ag/45Dileb
August 6, 2025 at 9:03 PM
This week's new issue of #ScienceTranslationalMedicine is out now!
A blood-based epigenetic signature could help identify brain insulin resistance in humans, researchers identify a population of T cells that may help maintain immune balance during pregnancy, and more.
scim.ag/45Dileb
A blood-based epigenetic signature could help identify brain insulin resistance in humans, researchers identify a population of T cells that may help maintain immune balance during pregnancy, and more.
scim.ag/45Dileb
This week’s new issue of #ScienceTranslationalMedicine has arrived! https://scim.ag/3YvxNVm
December 17, 2025 at 10:08 PM
This week’s new issue of #ScienceTranslationalMedicine has arrived! https://scim.ag/3YvxNVm
This week's issue of #ScienceTranslationalMedicine has arrived!
New mRNA vaccines generate self-assembling nanoparticles to enhance immunity, dual-targeting "decoys" prevent metastasis and potentiate immunotherapy against melanoma in mice, and more. https://scim.ag/4n6wrKC
New mRNA vaccines generate self-assembling nanoparticles to enhance immunity, dual-targeting "decoys" prevent metastasis and potentiate immunotherapy against melanoma in mice, and more. https://scim.ag/4n6wrKC
October 15, 2025 at 9:25 PM
This week's issue of #ScienceTranslationalMedicine has arrived!
New mRNA vaccines generate self-assembling nanoparticles to enhance immunity, dual-targeting "decoys" prevent metastasis and potentiate immunotherapy against melanoma in mice, and more. https://scim.ag/4n6wrKC
New mRNA vaccines generate self-assembling nanoparticles to enhance immunity, dual-targeting "decoys" prevent metastasis and potentiate immunotherapy against melanoma in mice, and more. https://scim.ag/4n6wrKC
Extremely proud of Rebecca Wallings & Team in #TanseyLab3.0 for these high-impact findings in @sciencetranslationalmedicine www.science.org/doi/10.1126/...
The R1441C-Lrrk2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner in mice
The R1441C-Lrrk2 mutation causes age-acquired immune exhaustion in mouse macrophages in a sex-dependent manner.
www.science.org
November 24, 2024 at 8:56 PM
Extremely proud of Rebecca Wallings & Team in #TanseyLab3.0 for these high-impact findings in @sciencetranslationalmedicine www.science.org/doi/10.1126/...