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With tests in mice, researchers identify a new drug candidate delivered as a single, low dose to treat schistosomiasis infection across the parasite’s lifespan.

Learn more in #ScienceTranslationalMedicine: https://scim.ag/4dsJSmk
Transient receptor potential channel activation targets multiple stages of the schistosome parasite
An antihelminthic agent that activates a parasite TRP channel targets multiple schistosome life cycle stages.
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October 8, 2026 at 3:00 PM
science.org
The new issue of #ScienceTranslationalMedicine has arrived!

This week features an essay from the winner of the 2026 AAAS Martin and Rose Wachtel Cancer Research Award on how cancer reprograms peripheral nerves, a new drug candidate for schistosomiasis, and more. https://scim.ag/3Tlhk7y
The cover shows a pseudocolored scanning electron microscopy image of sensory neurons (yellow) cultured with cancer cells (purple) demonstrating the close interaction between them. Credit: Amit Lab/Kenneth Dunner Jr.
October 7, 2026 at 9:00 PM
science.org
A topical combo of the mite-killing compound flavesone and the ovicidal drug abametapir quickly wipes out mites and eggs that cause #scabies with a single dose and cures infections more quickly than ivermectin in pigs. #ScienceTranslationalMedicine https://scim.ag/4yZS0CV
A single-dose topical therapy cures scabies in a human-relevant porcine model
A single-dose topical therapy combining a metalloprotease inhibitor and a β-triketone cures scabies in a porcine model.
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October 5, 2026 at 10:33 PM
science.org
The BioInnovation Institute & #ScienceTranslationalMedicine Prize aims to recognize researchers who have developed innovative advances with translational potential to impact women’s health globally.

Apply by 1 November 2026: https://bit.ly/4yDRlH9
A promotional graphic for the "Prize for Innovations in Women's Health" by BII and Science Translational Medicine. The background features a pink and red abstract design resembling a cell. Text prompts viewers to "Apply now.
October 1, 2026 at 9:14 PM
science.org
An invasion of immune cells from skull bone marrow triggers inflammation that drives cognitive and mood decline with age in adults with chronic TBI, shows work that also identifies #fenofibrate as a promising therapy in a pilot trial. #ScienceTranslationalMedicine https://scim.ag/4ddo126
Cranial bone marrow–derived monocytes promote neuroinflammation in chronic traumatic brain injury
Aged cranial bone marrow–derived monocytes fuel chronic neuroinflammation after traumatic brain injury, a process reversed by fenofibrate.
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October 1, 2026 at 3:00 PM
science.org
Scientists trace how inflammatory immune cells from the skull bone marrow can exacerbate chronic traumatic brain injury, a two-pronged topical treatment cures scabies in large animals with a single dose, and more this week in #ScienceTranslationalMedicine. https://scim.ag/4dcEDqH
The cover image shows Sarcoptes scabiei var. hominis, the human itch mite that causes scabies. Credit: Eye of Science / Science Source
September 30, 2026 at 9:00 PM
science.org
A CRISPR-based, nanodroplet test can distinguish 15 species of nontuberculous #mycobacteria in clinical samples in just 3.5 hours, avoiding the need for long culture times that have long limited assays for mycobacteria. #ScienceTranslationalMedicine https://scim.ag/4iGFeEF
A rapid CRISPR-based nanodroplet assay enables direct clinical identification of mycobacteria species
A rapid CRISPR-based nanodroplet assay enables multiplex detection and subspecies-level identification of mycobacteria in clinical samples.
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September 24, 2026 at 5:00 PM
science.org
Don't miss the new issue of #ScienceTranslationalMedicine!

https://scim.ag/4iLeEu3
Shown is lung histology of neonatal mice born preterm (upper) or born to dams in which preterm birth was prevented with indomethacin plus ivermectin (lower). Credit: Jennifer L. Herington Vanderbilt University Medical Center
September 23, 2026 at 9:00 PM
science.org
The standard immunosuppressant mycophenolic acid has unknowingly been driving the emergence of resistance mutations in the high-priority fungal pathogen #Pjirovecii for almost 2 decades across outbreaks worldwide, shows a new study in #ScienceTranslationalMedicine. https://scim.ag/3UUR83U
Transmission electron micrograph of a section of human lung alveolus containing Pneumocystis jirovecii.
September 21, 2026 at 6:00 PM
topladave.bsky.social
A “lab-on-a-contact lens” measures concentrations of #serotonin in tear fluid in animals and in humans in a pilot trial—offering a flexible and noninvasive tool to quantify a key marker of stress responses and behaviors.

Read the paper in #ScienceTranslationalMedicine: scim.ag/4xpdube
Serotonin measurement by lab-on-a–contact lens in porcine and human tears
A reversible lab-on-a–contact lens quantifies tear serotonin, revealing a noninvasive biomarker of stress across mice, pigs, and humans.
scim.ag
September 18, 2026 at 2:36 PM
topladave.bsky.social
A "lab-on-a-contact lens" can measure the hormone serotonin in tears to gauge stress levels, researchers trace how an immune-suppressing drug has unexpectedly driven resistance in a fungal pathogen, and more this week in #ScienceTranslationalMedicine.

scim.ag/4iqVKbN
Contents | Science Translational Medicine 18, 867
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September 17, 2026 at 1:56 PM
science.org
A “lab-on-a-contact lens” measures concentrations of #serotonin in tear fluid in animals and in humans in a pilot trial—offering a flexible and noninvasive tool to quantify a key marker of stress responses and behaviors. #ScienceTranslationalMedicine https://scim.ag/4hsebvI
An image showing the lab-on-a-contact lens system printed on a contact lens.
September 17, 2026 at 1:34 PM
science.org
A "lab-on-a-contact lens" can measure the hormone serotonin in tears to gauge stress levels, researchers trace how an immune-suppressing drug has unexpectedly driven resistance in a fungal pathogen, and more this week in #ScienceTranslationalMedicine. https://scim.ag/4yFg6CV
The 16 September 2026 cover of Science Translational Medicine. The cover image illustrates a multiplexed CRISPR–assisted nanodroplet differential identification (CANDI) platform developed by Guo et al. to rapidly distinguish the causative pathogen underlying nontuberculous mycobacterial infection. This chip-based assay uses fluorescent barcodes (red and blue droplets) to detect Mycobacterium species and subspecies in clinical specimens (cyan droplets). Credit: Carol Song
September 16, 2026 at 9:00 PM
science.org
Auditory stimuli delivered in phase with peaks of EEG slow waves in the brain increased cerebrospinal fluid (#CSF) flow in healthy adults napping inside an MRI machine, offering insight to treating dysfunctional CSF flow.

Find out more in #ScienceTranslationalMedicine: https://scim.ag/4yttJ8b
Closed-loop auditory stimulation in phase with slow waves during sleep enhances cerebrospinal fluid flow in humans
Sleep slow-wave neurofeedback inside the MRI scanner can drive large-scale cerebrospinal fluid flow.
scim.ag
September 14, 2026 at 5:56 PM
topladave.bsky.social
A nanobody antivenom cocktail protected mice against death from Indian cobra and king cobra venom, including when delivered up to 20 minutes after envenoming.

Read more in #ScienceTranslationalMedicine: scim.ag/4xmBtIj
Oligoclonal nanobody-based recombinant antivenom protects mice challenged with venom from cobras and king cobras from India
A recombinant nanobody-based antivenom protects mice against experimental envenoming by venoms derived from cobras and king cobras from India.
scim.ag
September 10, 2026 at 5:37 PM
science.org
A nanobody antivenom cocktail protected mice against death from Indian cobra and king cobra venom, including when delivered up to 20 minutes after envenoming.

Read more in #ScienceTranslationalMedicine: https://scim.ag/4yvByKx
A photo of a king cobra.
September 10, 2026 at 3:00 PM
science.org
The new issue of #ScienceTranslationalMedicine has arrived!

A recombinant nanobody cocktail protects mice against cobra venom, short bursts of pink noise can boost cerebrospinal fluid flow in sleeping adults, and more. https://scim.ag/4r0jqpr
The latest Science Translational Medicine cover for the 9 September 2026 issue. The cover image shows a king cobra.
September 9, 2026 at 9:30 PM
science.org
Mouse and human studies show sustained elevated levels of NETs in healing bone tissue can lead to nonunion, a condition that occurs in up to 15% of fracture patients.

Learn more in #ScienceTranslationalMedicine: https://scim.ag/4xxtadr
Sustained neutrophil extracellular traps cause fracture nonunion
Sustained NETs after fracture impair bone healing through cGas-STING–mediated disruption of callus angiogenesis and cause nonunion.
scim.ag
September 7, 2026 at 6:48 PM
science.org
PET and MRI imaging found elevated levels of TSPO protein in skull bone marrow of people with chronic back pain and knee osteoarthritis compared to healthy individuals, suggesting a potential new target in understanding and treating chronic pain. https://scim.ag/4iKQCze #ScienceTranslationalMedicine
Elevated translocator protein in skull bone marrow is linked to human chronic pain
The skull bone marrow is a neuroimmune site linked to chronic pain and its associated symptoms.
scim.ag
September 4, 2026 at 3:21 PM
science.org
This week’s new issue of #ScienceTranslationalMedicine has arrived! https://scim.ag/4x1pwrc
The cover image shows a skull map of average translocator protein (TSPO) radioligand uptake for a cohort of patients with chronic pain (signal intensity is color coded from green to red). Credit: The Loggia lab, Mass General Brigham
September 2, 2026 at 9:00 PM
science.org
Applying a minimally invasive microdialysis system, researchers capture nuanced patterns in aldosterone levels over 24 hours in patients with primary aldosteronism, which could inform timelier diagnostic strategies.

Learn more in #ScienceTranslationalMedicine: https://scim.ag/4xZGMOm
Tissue corticosteroid rhythms are dysregulated predominantly during sleep in primary aldosteronism
Ambulatory 24-hour microdialysis reveals disrupted corticosteroid rhythms in primary aldosteronism.
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August 31, 2026 at 6:00 PM
science.org
A new #ScienceTranslationalMedicine analysis decrypts the connection between UTIs and preterm birth, showing that UTIs trigger strong placental cytokine and immune signatures that correlate with birth outcomes in mice and a pregnancy cohort. https://scim.ag/3UTNas5
Urogenital immune signatures are associated with birth outcomes after maternal urinary tract infection
Immune responses to urinary tract infections distinguished preterm birth in mice and were linked to birth outcomes in a human pregnancy cohort.
scim.ag
August 27, 2026 at 3:00 PM
science.org
This week’s new issue of #ScienceTranslationalMedicine has arrived!

https://scim.ag/4gx1n5M
The cover shows proinflammatory crown-like structures (CLSs) in the gonadal adipose tissue of a mouse that was transitioned from a high- to low-fat diet; adipose tissue macrophages (ATMs) with a CWC22 splicing machinery defect appear as green, and DNA is shown in blue. Credit: Takuro Miyazaki/SHOWA Medical University
August 26, 2026 at 9:33 PM
science.org
By analyzing more than 800,000 single-cell profiles in tissues and blood, researchers assemble a massive biomolecular compendium of lupus nephritis that maps out its impact on cell populations and could inform future therapeutics. #ScienceTranslationalMedicine https://scim.ag/4qz1G4C
A population-scale transcriptional atlas of blood and tissue in lupus nephritis
A single-cell transcriptomic atlas identified stromal and immune populations in renal tissue associated with lupus nephritis disease activity.
scim.ag
August 24, 2026 at 6:00 PM
topladave.bsky.social
By parsing the DNA fragmentome, a team identifies cell-free DNA signatures that can give early warning during the first trimester of pregnancy complications in women with risk factors such as twinning and autoimmune disease.

Read more in #ScienceTranslationalMedicine: scim.ag/4wHkCj0
Cell-free DNA fragmentome analysis informs pregnancy outcome in patients with immune-mediated disease
Cell-free DNA fragmentome analysis discriminates high-risk pregnant individuals who later developed adverse outcomes from those who did not.
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August 21, 2026 at 1:57 PM