Ah yes, the famously medium-spectrum doxycycline.
It only covers
Staphylococci
Pneumococci
Beta haemolytic Streptococci
Actinomyces
Mycoplasma
Chlamydophila
Legionella
H.influenzae
Moraxella catarrhalis
ESBL E.coli UTI
Pseudomonas UTI(maybe!)
Burkholderia pseudomallei
Vibrio
H.pylori
1/2
It only covers
Staphylococci
Pneumococci
Beta haemolytic Streptococci
Actinomyces
Mycoplasma
Chlamydophila
Legionella
H.influenzae
Moraxella catarrhalis
ESBL E.coli UTI
Pseudomonas UTI(maybe!)
Burkholderia pseudomallei
Vibrio
H.pylori
1/2
August 23, 2025 at 11:02 PM
Ah yes, the famously medium-spectrum doxycycline.
It only covers
Staphylococci
Pneumococci
Beta haemolytic Streptococci
Actinomyces
Mycoplasma
Chlamydophila
Legionella
H.influenzae
Moraxella catarrhalis
ESBL E.coli UTI
Pseudomonas UTI(maybe!)
Burkholderia pseudomallei
Vibrio
H.pylori
1/2
It only covers
Staphylococci
Pneumococci
Beta haemolytic Streptococci
Actinomyces
Mycoplasma
Chlamydophila
Legionella
H.influenzae
Moraxella catarrhalis
ESBL E.coli UTI
Pseudomonas UTI(maybe!)
Burkholderia pseudomallei
Vibrio
H.pylori
1/2
Good morning Brisbane! What a nice view to prepare my very first talk at #LISSSD25 !
Looking forward to meeting people at the conference.
#GPS_project #pneumococci #Genomics
Looking forward to meeting people at the conference.
#GPS_project #pneumococci #Genomics
May 31, 2025 at 10:16 PM
Good morning Brisbane! What a nice view to prepare my very first talk at #LISSSD25 !
Looking forward to meeting people at the conference.
#GPS_project #pneumococci #Genomics
Looking forward to meeting people at the conference.
#GPS_project #pneumococci #Genomics
[New paper alert 🚨 ] What happens when pneumococci 'slip' and 'add' just one extra A in a promoter spacer of a sugar scavenging gene? 🧬
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
Naturally acquired promoter variation influences Streptococcus pneumoniae infection outcomes
Barton et al. identify Streptococcus pneumoniae promoters containing repetitive nucleotide
sequences that promote DNA strand slippage and accumulation of promoter sequence mutations.
This drives popul...
www.cell.com
September 3, 2025 at 10:00 AM
[New paper alert 🚨 ] What happens when pneumococci 'slip' and 'add' just one extra A in a promoter spacer of a sugar scavenging gene? 🧬
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
New paper alert! In depth characterisation of non-encapsulated pneumococci in saliva: stability, detection and recovery. Important findings for using saliva samples for carriage studies. @microbiologysociety.org @annewyllie.bsky.social www.microbiologyresearch.org/content/jour...
Storage stability of non-encapsulated pneumococci in saliva is dependent on null-capsule clade, with strains carrying aliC and aliD showing a competitive disadvantage during culture enrichment
Non-encapsulated Streptococcus pneumoniae (NESp) represent up to 19% of circulating pneumococci and exhibit high rates of genetic exchange and antimicrobial resistance. Saliva is increasingly used as ...
www.microbiologyresearch.org
August 4, 2025 at 1:42 PM
New paper alert! In depth characterisation of non-encapsulated pneumococci in saliva: stability, detection and recovery. Important findings for using saliva samples for carriage studies. @microbiologysociety.org @annewyllie.bsky.social www.microbiologyresearch.org/content/jour...
I just got my sixth Covid booster shot, and my annual flu shot. And if I hadn’t got my pneumococci shot 4 years ago, I was big en one now.
The best of it? They were all free. I live in Europe, they know now the cost of pandemic (again).
The best of it? They were all free. I live in Europe, they know now the cost of pandemic (again).
No shit, Sherlock.
Free vaccines cheaper than consequences of low vaccination rate: Alberta Medical Association
www.ctvnews.ca/edmonton/art...
Free vaccines cheaper than consequences of low vaccination rate: Alberta Medical Association
www.ctvnews.ca/edmonton/art...
Free vaccines cheaper than consequences of low vaccination rate: Alberta Medical Association
If saving money is the Alberta government’s priority, the most cost-effective route is distributing the COVID-19 vaccine widely and freely – not charging $100 for it, says the Alberta Medical Associat...
www.ctvnews.ca
October 24, 2025 at 10:03 PM
I just got my sixth Covid booster shot, and my annual flu shot. And if I hadn’t got my pneumococci shot 4 years ago, I was big en one now.
The best of it? They were all free. I live in Europe, they know now the cost of pandemic (again).
The best of it? They were all free. I live in Europe, they know now the cost of pandemic (again).
Interested in pneumococci, genomics and metagenomics? Come and do a PhD with me, @alanmcn1.bsky.social and @meerac.bsky.social @ukhsa.bsky.social www.findaphd.com/phds/project...
Leveraging genomics for improved metagenomic surveillance of Streptococcus pneumoniae at University of Birmingham on FindAPhD.com
PhD Project - Leveraging genomics for improved metagenomic surveillance of Streptococcus pneumoniae at University of Birmingham, listed on FindAPhD.com
www.findaphd.com
May 29, 2025 at 1:23 PM
Interested in pneumococci, genomics and metagenomics? Come and do a PhD with me, @alanmcn1.bsky.social and @meerac.bsky.social @ukhsa.bsky.social www.findaphd.com/phds/project...
And prevents attack on immune memory cells: wider protection against diseases.
By reducing active infections, the burden of disease in the population is reduced e.g. Pneumococci-vax in children reducing disease in adults.
5/8
By reducing active infections, the burden of disease in the population is reduced e.g. Pneumococci-vax in children reducing disease in adults.
5/8
March 21, 2026 at 8:46 AM
And prevents attack on immune memory cells: wider protection against diseases.
By reducing active infections, the burden of disease in the population is reduced e.g. Pneumococci-vax in children reducing disease in adults.
5/8
By reducing active infections, the burden of disease in the population is reduced e.g. Pneumococci-vax in children reducing disease in adults.
5/8
Using a mouse model, researchers discovered that following influenza virus infection, S. pneumoniae replication is predominantly activated in the larynx, indicating that the larynx serves as a key site for activation of commensal pneumococci. #JVirology: asm.social/306
July 8, 2026 at 6:44 PM
Using a mouse model, researchers discovered that following influenza virus infection, S. pneumoniae replication is predominantly activated in the larynx, indicating that the larynx serves as a key site for activation of commensal pneumococci. #JVirology: asm.social/306
Serotype 3 pneumococci have a heavily hydrated capsule with surface electonegativity that confers mucoidy and resistance to antibody, complement and phagocytes. Vaccines are less protective and infections are often more severe. Serotype 3 is now the leading cause of vaccine breakthroughs worldwide.
April 27, 2026 at 9:11 PM
Serotype 3 pneumococci have a heavily hydrated capsule with surface electonegativity that confers mucoidy and resistance to antibody, complement and phagocytes. Vaccines are less protective and infections are often more severe. Serotype 3 is now the leading cause of vaccine breakthroughs worldwide.
Usual “IN MICE” caveat but holy fuck there might be progress happening on reversing antibiotic resistance (via Swedish news bragging about Karolinska Institutet) molmed.biomedcentral.com/articles/10....
Bacteriophage-derived endolysins restore antibiotic susceptibility in β-lactam- and macrolide-resistant Streptococcus pneumoniae infections - Molecular Medicine
Streptococcus pneumoniae, the pneumococcus, is a cause of major illness globally. Invasive pneumococcal disease (IPD) is characterized by pneumococci invading blood (bacteremia), lungs (pneumonia), or...
molmed.biomedcentral.com
August 12, 2025 at 1:09 AM
Usual “IN MICE” caveat but holy fuck there might be progress happening on reversing antibiotic resistance (via Swedish news bragging about Karolinska Institutet) molmed.biomedcentral.com/articles/10....
I have a funded PhD opportunity through MIBTP to look at pneumococci in adults with Dr Mike Cox (also check out two other projects with Mike and Prof. Joan Geoghegan on other respiratory pathobionts) link here: warwick.ac.uk/fac/cross_fa... Happy to be contacted with questions. Reposts appreciated 👍
Dr David William Cleary
Dr David William Cleary
warwick.ac.uk
November 18, 2024 at 2:22 PM
I have a funded PhD opportunity through MIBTP to look at pneumococci in adults with Dr Mike Cox (also check out two other projects with Mike and Prof. Joan Geoghegan on other respiratory pathobionts) link here: warwick.ac.uk/fac/cross_fa... Happy to be contacted with questions. Reposts appreciated 👍
I just heard that Alexander Tomasz died on Monday. I didn't know him, but I met him once while I was a graduate student working on pneumococci. He did pioneering work on pneumococcal competence, discovering competence factor. His work on autolysins and penicillin binding proteins was tremendous.
September 18, 2024 at 4:27 PM
I just heard that Alexander Tomasz died on Monday. I didn't know him, but I met him once while I was a graduate student working on pneumococci. He did pioneering work on pneumococcal competence, discovering competence factor. His work on autolysins and penicillin binding proteins was tremendous.
Do you need a #bioinformatic tool to detect almost all serotypes in #pneumococci?
The new SeroBA v2.0 can detect 102 of 107 known pneumococcal serotypes
www.biorxiv.org/content/10.1...
The new SeroBA v2.0 can detect 102 of 107 known pneumococcal serotypes
www.biorxiv.org/content/10.1...
SeroBA(v2.0) and SeroBAnk: a robust genome-based serotyping scheme and comprehensive atlas of capsular diversity in Streptococcus pneumoniae
The unprecedented number of Streptococcus pneumoniae (the pneumococcus) genomes sequenced in recent years has accelerated the discovery of novel serotypes and highlighted the genetic diversity both be...
www.biorxiv.org
May 1, 2025 at 3:43 PM
Do you need a #bioinformatic tool to detect almost all serotypes in #pneumococci?
The new SeroBA v2.0 can detect 102 of 107 known pneumococcal serotypes
www.biorxiv.org/content/10.1...
The new SeroBA v2.0 can detect 102 of 107 known pneumococcal serotypes
www.biorxiv.org/content/10.1...
Reaching out to the youth with this addition to my lecture slides
February 10, 2025 at 6:14 PM
Reaching out to the youth with this addition to my lecture slides
Checkout this preprint from Bevika Sewgoolam! She used CRISPRi-seq to determine antibiotic-stress signatures, specifically of pneumococci treated with fluoroquinolone antibiotics. It's a really powerful approach revealing a surprising antibiotic combination therapy. www.biorxiv.org/content/10.1...
Genome-wide antibiotic-CRISPRi profiling identifies LiaR activation as a strategy to resensitize fluoroquinolone-resistant Streptococcus pneumoniae
Streptococcus pneumoniae is a human pathogen that has become increasingly resistant to the synthetic fluoroquinolone antibiotics that target bacterial topoisomerases. To identify pathways that are ess...
www.biorxiv.org
October 31, 2024 at 8:46 AM
Checkout this preprint from Bevika Sewgoolam! She used CRISPRi-seq to determine antibiotic-stress signatures, specifically of pneumococci treated with fluoroquinolone antibiotics. It's a really powerful approach revealing a surprising antibiotic combination therapy. www.biorxiv.org/content/10.1...
"[To #exalt] the virulence of the pneumococci by symbiotic growth with B influenzae would appear to follow."
"Purulent Bronchitis: Its Influenzal and Pneumococcic Origin." The Lancet, vol. 189, no. 4882, 1917, pp. 445-448. ScienceDirect.
#vss365
"Purulent Bronchitis: Its Influenzal and Pneumococcic Origin." The Lancet, vol. 189, no. 4882, 1917, pp. 445-448. ScienceDirect.
#vss365
PURULENT BRONCHITIS: ITS INFLUENZAL AND PNEUMOCOCCAL BACTERIOLOGY.
www.sciencedirect.com
March 31, 2026 at 3:04 PM
It’s so dangerous to do any kind of surgery without giving tetanus and the pneumococci vaccine.
February 22, 2025 at 8:01 AM
It’s so dangerous to do any kind of surgery without giving tetanus and the pneumococci vaccine.
Epithelial innate immune sensing of pneumococci is inherently restricted to a small cellular minority across species and infection niches https://www.biorxiv.org/content/10.64898/2026.06.10.731054v1
June 11, 2026 at 2:20 AM
Epithelial innate immune sensing of pneumococci is inherently restricted to a small cellular minority across species and infection niches https://www.biorxiv.org/content/10.64898/2026.06.10.731054v1
ijmr.org.in/pre-post-vac...
Excited to share my recent publication on changing trends of pneumococcal serotypes and AMR after PCV13 introduction in our geographical region
#AMR #VACCINE #PNEUMOCOCCI
Excited to share my recent publication on changing trends of pneumococcal serotypes and AMR after PCV13 introduction in our geographical region
#AMR #VACCINE #PNEUMOCOCCI
Pre- & post-vaccine trends in pneumococcal serotypes & antimicrobial resistance patterns - Indian Journal of Medical Research
[article]
ijmr.org.in
November 28, 2024 at 1:31 PM
ijmr.org.in/pre-post-vac...
Excited to share my recent publication on changing trends of pneumococcal serotypes and AMR after PCV13 introduction in our geographical region
#AMR #VACCINE #PNEUMOCOCCI
Excited to share my recent publication on changing trends of pneumococcal serotypes and AMR after PCV13 introduction in our geographical region
#AMR #VACCINE #PNEUMOCOCCI
New paper alert! Novel qPCR assay for identifying and typing non-encapsulated pneumococci, an important reservoir for genetic exchange. Assay reveals surprisingly high levels of NESp in saliva samples. @microbiologysociety.org @annewyllie.bsky.social www.microbiologyresearch.org/content/jour...
An abundance of aliC and aliD genes were identified in saliva using a novel multiplex qPCR to characterize group II non-encapsulated pneumococci with improved specificity
Pneumococcal surveillance studies are reporting increasing prevalence of non-encapsulated pneumococci (NESp). NESp are an important reservoir for genetic exchange among streptococci, including for ant...
www.microbiologyresearch.org
April 29, 2025 at 7:55 AM
New paper alert! Novel qPCR assay for identifying and typing non-encapsulated pneumococci, an important reservoir for genetic exchange. Assay reveals surprisingly high levels of NESp in saliva samples. @microbiologysociety.org @annewyllie.bsky.social www.microbiologyresearch.org/content/jour...
🧬 Bacteriophage-derived endolysins restore antibiotic susceptibility in β-lactam- and macrolide-resistant Streptococcus pneumoniae infections:
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Bacteriophage-derived endolysins restore antibiotic susceptibility in β-lactam- and macrolide-resistant Streptococcus pneumoniae infections - Molecular Medicine
Streptococcus pneumoniae, the pneumococcus, is a cause of major illness globally. Invasive pneumococcal disease (IPD) is characterized by pneumococci invading blood (bacteremia), lungs (pneumonia), or...
link.springer.com
May 16, 2025 at 1:45 PM
🧬 Bacteriophage-derived endolysins restore antibiotic susceptibility in β-lactam- and macrolide-resistant Streptococcus pneumoniae infections:
link.springer.com/article/10.1...
link.springer.com/article/10.1...
The SeroBA(v2.0) is now available in the GPS pipeline github.com/GlobalPneumo...
#GPS_project #pneumococci #serotype #bioinformatics
#GPS_project #pneumococci #serotype #bioinformatics
May 7, 2025 at 5:09 PM
The SeroBA(v2.0) is now available in the GPS pipeline github.com/GlobalPneumo...
#GPS_project #pneumococci #serotype #bioinformatics
#GPS_project #pneumococci #serotype #bioinformatics
Avery's demonstration that DNA is the transforming principle responsible for genetic inheritance.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES: INDUCTION OF TRANSFORMATION BY A DESOXYRIBONUCLEIC ACID FRACTION ISOLATED FROM PNEUMOCOCCUS TYPE III
1. From Type III pneumococci a biologically active fraction has been isolated in highly purified form which in exceedingly minute amounts is capable under appropriate cultural conditions of inducing t...
pmc.ncbi.nlm.nih.gov
July 8, 2025 at 5:44 PM
Avery's demonstration that DNA is the transforming principle responsible for genetic inheritance.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Oxidation of hemoglobin in the lung parenchyma facilitates the differentiation of pneumococci into encapsulated bacteria https://www.biorxiv.org/content/10.1101/2023.11.14.567109v1
Oxidation of hemoglobin in the lung parenchyma facilitates the differentiation of pneumococci into encapsulated bacteria https://www.biorxiv.org/content/10.1101/2023.11.14.567109v1
Pneumococcal pneumonia causes cytotoxicity in the lung parenchyma but the underlying mechanism invol
www.biorxiv.org
November 16, 2023 at 5:19 AM
Oxidation of hemoglobin in the lung parenchyma facilitates the differentiation of pneumococci into encapsulated bacteria https://www.biorxiv.org/content/10.1101/2023.11.14.567109v1