Fast and Tortuous nuclei 😄
journals.asm.org/doi/10.1128/...
Super happy to be part of this story with my friend and colleague Sylvain Brun in @ijmonod.bsky.social !
Have a look at the movies to see nuclei traveling and stretching like crazy;)
journals.asm.org/doi/10.1128/...
Super happy to be part of this story with my friend and colleague Sylvain Brun in @ijmonod.bsky.social !
Have a look at the movies to see nuclei traveling and stretching like crazy;)
Fast and tortuous: extreme deformations and fast movements of the cell nucleus are driven by microtubules in the model fungus Podospora anserina | mBio
Here, using live-cell fluorescence imaging, we report the remarkable and complex behavior
of male nuclei during sexual reproduction in the model fungus Podospora anserina. In particular, during their ...
journals.asm.org
September 1, 2026 at 9:03 PM
Fast and Tortuous nuclei 😄
journals.asm.org/doi/10.1128/...
Super happy to be part of this story with my friend and colleague Sylvain Brun in @ijmonod.bsky.social !
Have a look at the movies to see nuclei traveling and stretching like crazy;)
journals.asm.org/doi/10.1128/...
Super happy to be part of this story with my friend and colleague Sylvain Brun in @ijmonod.bsky.social !
Have a look at the movies to see nuclei traveling and stretching like crazy;)
In addition, some fungal NLRs have a particular property that we call "high-internal conservation" (HIC), where the repetitive Cterm of the gene seems to evolve under concerted evolution but still displays hyperdiverse sites. HIC is tricky to study... 5/n
www.microbiologyresearch.org/content/jour...
www.microbiologyresearch.org/content/jour...
Reconstructing NOD-like receptor alleles with high internal conservation in Podospora anserina using long-read sequencing
NOD-like receptors (NLRs) are intracellular immune receptors that detect pathogen-associated cues and trigger defence mechanisms, including regulated cell death. In filamentous fungi, some NLRs mediat...
www.microbiologyresearch.org
August 7, 2026 at 9:49 PM
In addition, some fungal NLRs have a particular property that we call "high-internal conservation" (HIC), where the repetitive Cterm of the gene seems to evolve under concerted evolution but still displays hyperdiverse sites. HIC is tricky to study... 5/n
www.microbiologyresearch.org/content/jour...
www.microbiologyresearch.org/content/jour...
Podosporologists have been studying vegetative fusion between different individuals (allorecognition) since the 50s! So we know there are 9 allorecognition genes in P. anserina, and 4 of those are NLRs. But there are >60 other NLR genes in #Podospora genomes. What are those doing? 3/n
August 7, 2026 at 9:49 PM
Podosporologists have been studying vegetative fusion between different individuals (allorecognition) since the 50s! So we know there are 9 allorecognition genes in P. anserina, and 4 of those are NLRs. But there are >60 other NLR genes in #Podospora genomes. What are those doing? 3/n
Previous studies took more of a macroevolutionary perspective, or did not look at NLRs specifically. So we focused on #Podospora anserina and its relatives, model systems for studying the molecular mechanisms of self/nonself recognition. 2/n
August 7, 2026 at 9:49 PM
Previous studies took more of a macroevolutionary perspective, or did not look at NLRs specifically. So we focused on #Podospora anserina and its relatives, model systems for studying the molecular mechanisms of self/nonself recognition. 2/n
It's out!! Using population and comparative genomics of Podospora fungi, we show that a class of genes called #NLRs display evolutionary signatures that are consistent with an immune function, much like in plants and animals! 1/n 🍄
#popgen #balancingselection #introgression
doi.org/10.1093/gbe/...
#popgen #balancingselection #introgression
doi.org/10.1093/gbe/...
NOD-Like Receptor Genes Undergo Diversity-Enhancing Evolution in a Fungal Species Complex
Abstract. Fungi harbor diverse arrays of genes encoding NOD-like receptors (NLRs), key intracellular immune proteins found in plants, animals, and bacteria
doi.org
August 7, 2026 at 9:49 PM
It's out!! Using population and comparative genomics of Podospora fungi, we show that a class of genes called #NLRs display evolutionary signatures that are consistent with an immune function, much like in plants and animals! 1/n 🍄
#popgen #balancingselection #introgression
doi.org/10.1093/gbe/...
#popgen #balancingselection #introgression
doi.org/10.1093/gbe/...
✍️ The Guichet Lab published a new article
📖 mBio
📃 Fast and tortuous: extreme deformations and fast movements of the cell nucleus are driven by microtubules in the model fungus Podospora anserina
🔗 doi.org/10.1128/mbio...
📖 mBio
📃 Fast and tortuous: extreme deformations and fast movements of the cell nucleus are driven by microtubules in the model fungus Podospora anserina
🔗 doi.org/10.1128/mbio...
August 4, 2026 at 12:58 PM
✍️ The Guichet Lab published a new article
📖 mBio
📃 Fast and tortuous: extreme deformations and fast movements of the cell nucleus are driven by microtubules in the model fungus Podospora anserina
🔗 doi.org/10.1128/mbio...
📖 mBio
📃 Fast and tortuous: extreme deformations and fast movements of the cell nucleus are driven by microtubules in the model fungus Podospora anserina
🔗 doi.org/10.1128/mbio...
✍️ The Guichet lab contributed to a new article
📖 BBA
📃 Kinesin-3 and the cargo adaptor Hook1 regulate early endosome and peroxisome motility and are required for mitochondrial and endoplasmic reticulum spatial organization during polarized fungal cell growth in Podospora anserina
🔗 buff.ly/wmcwQny
📖 BBA
📃 Kinesin-3 and the cargo adaptor Hook1 regulate early endosome and peroxisome motility and are required for mitochondrial and endoplasmic reticulum spatial organization during polarized fungal cell growth in Podospora anserina
🔗 buff.ly/wmcwQny
July 30, 2026 at 2:32 PM
✍️ The Guichet lab contributed to a new article
📖 BBA
📃 Kinesin-3 and the cargo adaptor Hook1 regulate early endosome and peroxisome motility and are required for mitochondrial and endoplasmic reticulum spatial organization during polarized fungal cell growth in Podospora anserina
🔗 buff.ly/wmcwQny
📖 BBA
📃 Kinesin-3 and the cargo adaptor Hook1 regulate early endosome and peroxisome motility and are required for mitochondrial and endoplasmic reticulum spatial organization during polarized fungal cell growth in Podospora anserina
🔗 buff.ly/wmcwQny
#MicroSky: Fungal metabolism: Deleting NADPH dehydrogenase genes in Podospora reshapes fungal metabolism: boost fruiting body formation, alter redox balance, increase oxidative stress sensitivity, and rewire energy and lipid metabolism. By Qiu et al doi.org/10.1111/1751...
July 23, 2026 at 10:00 AM
#MicroSky: Fungal metabolism: Deleting NADPH dehydrogenase genes in Podospora reshapes fungal metabolism: boost fruiting body formation, alter redox balance, increase oxidative stress sensitivity, and rewire energy and lipid metabolism. By Qiu et al doi.org/10.1111/1751...
No, Podospora haha
July 7, 2026 at 6:46 PM
No, Podospora haha
Hi-C data from the filamentous fungus Podospora anserina and associated 3D models to visualize the spatial organization of its chromosomes https://www.biorxiv.org/content/10.64898/2026.06.14.732207v1
June 18, 2026 at 10:35 PM
Hi-C data from the filamentous fungus Podospora anserina and associated 3D models to visualize the spatial organization of its chromosomes https://www.biorxiv.org/content/10.64898/2026.06.14.732207v1
Hi-C data from the filamentous fungus Podospora anserina and associated 3D models to visualize the spatial organization of its chromosomes https://www.biorxiv.org/content/10.64898/2026.06.14.732207v1
June 18, 2026 at 10:35 PM
Hi-C data from the filamentous fungus Podospora anserina and associated 3D models to visualize the spatial organization of its chromosomes https://www.biorxiv.org/content/10.64898/2026.06.14.732207v1
That sounds fine, too. Do you know the Podospora anserina story? It’s wonderful.
pubmed.ncbi.nlm.nih.gov/7407910/
www.cell.com/trends/micro...
pubmed.ncbi.nlm.nih.gov/7407910/
www.cell.com/trends/micro...
Podospora anserina
Podospora anserina is a coprophilous ascomycete fungus that has been used as a model
organism since the 1930s. It has been reported from numerous types of herbivore dung
globally, but recent genetic a...
www.cell.com
May 22, 2026 at 1:35 PM
That sounds fine, too. Do you know the Podospora anserina story? It’s wonderful.
pubmed.ncbi.nlm.nih.gov/7407910/
www.cell.com/trends/micro...
pubmed.ncbi.nlm.nih.gov/7407910/
www.cell.com/trends/micro...
A recent shift in centromere size and DNA content in Podospora pseudocomata co-occurs with the loss of a fungal genome defense system https://www.biorxiv.org/content/10.64898/2025.12.02.690432v1
December 3, 2025 at 2:31 AM
A recent shift in centromere size and DNA content in Podospora pseudocomata co-occurs with the loss of a fungal genome defense system https://www.biorxiv.org/content/10.64898/2025.12.02.690432v1
A recent shift in centromere size and DNA content in Podospora pseudocomata co-occurs with the loss of a fungal genome defense system https://www.biorxiv.org/content/10.64898/2025.12.02.690432v1
December 3, 2025 at 2:31 AM
A recent shift in centromere size and DNA content in Podospora pseudocomata co-occurs with the loss of a fungal genome defense system https://www.biorxiv.org/content/10.64898/2025.12.02.690432v1
New #checklist dataset in @gbif.org: Morphological and phylogenetic characterisation of Podospora sichuanensis sp. nov. (Podosporaceae, Sordariales) https://www.gbif.org/dataset/b2296cdc-d6b1-4cdf-84f7-d348447a6d9e
August 2, 2025 at 8:30 AM
New #checklist dataset in @gbif.org: Morphological and phylogenetic characterisation of Podospora sichuanensis sp. nov. (Podosporaceae, Sordariales) https://www.gbif.org/dataset/b2296cdc-d6b1-4cdf-84f7-d348447a6d9e
Our description of the transcriptomic changes during sexual development in #Podospora anserina is out in @genomics.peercommunityin.org ! peercommunityjournal.org/articles/10....
@i2bcparissaclay.bsky.social @univparissaclay.bsky.social
@i2bcparissaclay.bsky.social @univparissaclay.bsky.social
Sexual reproduction is controlled by successive transcriptomic waves in Podospora anserina
peercommunityjournal.org
July 7, 2025 at 5:40 AM
Our description of the transcriptomic changes during sexual development in #Podospora anserina is out in @genomics.peercommunityin.org ! peercommunityjournal.org/articles/10....
@i2bcparissaclay.bsky.social @univparissaclay.bsky.social
@i2bcparissaclay.bsky.social @univparissaclay.bsky.social
Now published in Peer Community Journal, #genomics section: Sexual reproduction is controlled by successive transcriptomic waves in Podospora anserina
peercommunityjournal.org/articles/10....
peercommunityjournal.org/articles/10....
Sexual reproduction is controlled by successive transcriptomic waves in Podospora anserina
Bidard, Frédérique1, 2 ; Grognet, Pierre3 ; Lelandais, Gaëlle3 ; Imbeaud, Sandrine4, 5; Mucchielli-Giorgi, Marie-Hélène4, 6; Debuchy, Robert1; Berteaux-Lecellier, Véronique1, 7 ; Malagnac,…
peercommunityjournal.org
July 4, 2025 at 12:53 PM
Now published in Peer Community Journal, #genomics section: Sexual reproduction is controlled by successive transcriptomic waves in Podospora anserina
peercommunityjournal.org/articles/10....
peercommunityjournal.org/articles/10....
Are het-d and het-e capable of recognizing het-c because of shared ancestry? No! It turns out they are not that closely related, judging by phylogenies along the gene for a bunch of NLRs in Podospora. 7/n
July 2, 2025 at 6:10 PM
Are het-d and het-e capable of recognizing het-c because of shared ancestry? No! It turns out they are not that closely related, judging by phylogenies along the gene for a bunch of NLRs in Podospora. 7/n
In the model fungus #Podospora anserina, the het-d
and het-e NLRs are highly polymorphic genes, whose products recognize different alleles of another gene, het-c. If two confronting strains have incompatible het-e/d and het-c alleles, a rejection reaction occurs. 3/n
and het-e NLRs are highly polymorphic genes, whose products recognize different alleles of another gene, het-c. If two confronting strains have incompatible het-e/d and het-c alleles, a rejection reaction occurs. 3/n
July 2, 2025 at 6:10 PM
In the model fungus #Podospora anserina, the het-d
and het-e NLRs are highly polymorphic genes, whose products recognize different alleles of another gene, het-c. If two confronting strains have incompatible het-e/d and het-c alleles, a rejection reaction occurs. 3/n
and het-e NLRs are highly polymorphic genes, whose products recognize different alleles of another gene, het-c. If two confronting strains have incompatible het-e/d and het-c alleles, a rejection reaction occurs. 3/n
Happy to see this out! "Reconstructing NOD-like receptor alleles with high internal conservation in #Podospora anserina using long-read sequencing", now in @microbiologysociety.org! 🧬
Keep reading for a simple explanation 🧵 1/n
#Fungi #Allorecognition
www.microbiologyresearch.org/content/jour...
Keep reading for a simple explanation 🧵 1/n
#Fungi #Allorecognition
www.microbiologyresearch.org/content/jour...
Reconstructing NOD-like receptor alleles with high internal conservation in Podospora anserina using long-read sequencing
NOD-like receptors (NLRs) are intracellular immune receptors that detect pathogen-associated cues and trigger defence mechanisms, including regulated cell death. In filamentous fungi, some NLRs mediat...
www.microbiologyresearch.org
July 2, 2025 at 6:10 PM
Happy to see this out! "Reconstructing NOD-like receptor alleles with high internal conservation in #Podospora anserina using long-read sequencing", now in @microbiologysociety.org! 🧬
Keep reading for a simple explanation 🧵 1/n
#Fungi #Allorecognition
www.microbiologyresearch.org/content/jour...
Keep reading for a simple explanation 🧵 1/n
#Fungi #Allorecognition
www.microbiologyresearch.org/content/jour...
New PCI Genomics recommendation! Of this preprint: "Sexual reproduction is controlled by successive transcriptomic waves in Podospora anserina"
Recommendation by Sébastien Bloyer: doi.org/10.24072/pci...
Preprint from Bidard and colleagues: doi.org/10.1101/2024...
Recommendation by Sébastien Bloyer: doi.org/10.24072/pci...
Preprint from Bidard and colleagues: doi.org/10.1101/2024...
Transcriptomic reprogramming during fungal sexual reproduction
Despite the inherent challenge of finding suitable mating partners, most eukaryotes use sexual reproduction to produce offspring endowed with increase genetic diversity and fitness. The persistence…
doi.org
June 18, 2025 at 6:45 AM
New PCI Genomics recommendation! Of this preprint: "Sexual reproduction is controlled by successive transcriptomic waves in Podospora anserina"
Recommendation by Sébastien Bloyer: doi.org/10.24072/pci...
Preprint from Bidard and colleagues: doi.org/10.1101/2024...
Recommendation by Sébastien Bloyer: doi.org/10.24072/pci...
Preprint from Bidard and colleagues: doi.org/10.1101/2024...
I am very proud to be part of this story!
Nuclei undergo extreme stretching and travel at an incredible speed in the hyphae of our favorite #fungus #Podospora anserina.
www.biorxiv.org/content/10.1...
Nuclei undergo extreme stretching and travel at an incredible speed in the hyphae of our favorite #fungus #Podospora anserina.
www.biorxiv.org/content/10.1...
www.biorxiv.org
June 9, 2025 at 12:17 PM
I am very proud to be part of this story!
Nuclei undergo extreme stretching and travel at an incredible speed in the hyphae of our favorite #fungus #Podospora anserina.
www.biorxiv.org/content/10.1...
Nuclei undergo extreme stretching and travel at an incredible speed in the hyphae of our favorite #fungus #Podospora anserina.
www.biorxiv.org/content/10.1...
The fastest movements and the most extreme deformations of the cell nucleus are driven by microtrubules in the model fungus Podospora anserina https://www.biorxiv.org/content/10.1101/2025.06.08.658251v1
June 9, 2025 at 8:30 AM
The fastest movements and the most extreme deformations of the cell nucleus are driven by microtrubules in the model fungus Podospora anserina https://www.biorxiv.org/content/10.1101/2025.06.08.658251v1
The fastest movements and the most extreme deformations of the cell nucleus are driven by microtrubules in the model fungus Podospora anserina https://www.biorxiv.org/content/10.1101/2025.06.08.658251v1
June 9, 2025 at 8:30 AM
The fastest movements and the most extreme deformations of the cell nucleus are driven by microtrubules in the model fungus Podospora anserina https://www.biorxiv.org/content/10.1101/2025.06.08.658251v1